SCOPUS 정보 검색 플랫폼

Perspectives in Drug Discovery and Design

Volumn 19, Issue , 2000, Pages 179-211

The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples

(4) Testa, B a Crivori, P a Reist, M a Carrupt, P A a

Author keywords

Adipose tissue storage; Blood brain barrier permeation; Gastrointestinal absorption; Lipophilicity; Metabolism; Permeation; Plasma protein binding; Renal clearance

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG;

BLOOD BRAIN BARRIER; DRUG ABSORPTION; DRUG BINDING; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG SELECTIVITY; DRUG TRANSFORMATION; GASTROINTESTINAL ABSORPTION; HYDROPHILICITY; KIDNEY CLEARANCE; LIPOPHILICITY; MACROMOLECULE; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0033820354 PISSN: 09282866 EISSN: None Source Type: Journal
DOI: 10.1023/A:1008741731244 Document Type: Review

Times cited : (207)

References (136)

1
- 0007979013
- Testa, B. (Ed.) Advances in Drug Research, Vol. 13, Academic Press, London
- (1984) , pp. 1-58
- Testa, B.¹

2
- 0000302145
- (1987) Trends Pharmacol. Sci. , vol.8 , pp. 381
- Testa, B.¹

3
- 0000270186
- Wolff, M.E. (Ed.) Burger's Medicinal Chemistry and Drug Discovery, Vol. 1, 5th ed., Wiley-Interscience, New York, NY
- (1995) , pp. 129-180
- Testa, B.¹

4
- 0345017903
- Wermuth, C.G. (Ed.) The Practice of Medicinal Chemistry, Academic Press, London
- (1996) , pp. 615-641
- Wermuth, C.G.¹ Testa, B.²

5
- 0007931657
- (1966) Farmaco , vol.24 , pp. 3
- Ariens, E.J.¹

6
- 0019444057
- (1981) Annu. Rev. Pharmacol. Toxicol. , vol.21 , pp. 31
- Lien, E.J.¹

7
- 0019767720
- (1982) Pharmacol. Ther. , vol.15 , pp. 131
- Seydel, J.K.¹ Schaper, K.J.²

8
- 0002544211
- Topliss, J.G. (Ed.) Quantitative Structure-Activity Relationships of Drugs, Academic Press, London
- (1983) , pp. 437-496
- Austel, V.¹ Kutter, E.²

9
- 0038644623
- Dearden, J.C. (Ed.) Quantitative Approaches to Drug Design, Elsevier, Amsterdam
- (1983) , pp. 163-181
- Seydel, J.K.¹

10
- 0022272076
- (1985) Environ. Health Perspect. , vol.61 , pp. 295
- Mayer, J.M.¹ Van de Waterbeemd, H.²

11
- 0025251932
- (1990) Acta Pharm. Jugosl. , vol.40 , pp. 315
- Testa, B.¹ Mayer, J.M.²

12
- 0029865450
- (1996) Med. Res. Rev. , vol.16 , pp. 243
- Smith, D.A.¹ Jones, B.C.² Walker, D.K.³

13
- 0030757952
- (1997) Med. Res. Rev. , vol.17 , pp. 303
- Testa, B.¹ Kier, L.B.² Carrupt, P.A.³

14
- 0001334426
- (1997) Med. Chem. Res. , vol.7 , pp. 340
- Testa, B.¹

15
- 0025894063
- (1991) Pharm. Res. , vol.8 , pp. 551
- Levy, R.H.¹ Boddy, A.V.²

16
- 0029865447
- (1996) Med. Res Rev. , vol.16 , pp. 233
- Testa, B.¹ Caldwell, J.²

17
- 0022000211
- (1985) J. Pharm. Pharmacol. , vol.37 , pp. 280
- Taylor, R.C.¹ Pownall, R.² Burke, W.³

18
- 0019471103
- (1981) J. Pharm. Pharmacol. , vol.33 , pp. 172
- Woods, P.B.¹ Robinson, M.L.²

19
- 0020414579
- (1982) Int. J. Clin. Pharmacol. Res. , vol.2 , pp. 185
- Cruickshank, J.M.¹

20
- 0014317008
- (1968) Biochemistry , vol.7 , pp. 2858
- Helmer, F.¹ Kiehs, K.² Hansch, C.³

21
- 0007985373
- Substituent Constants for Correlation Analysis in Chemistry and Biology, John Wiley and Sons, New York, NY
- (1979)
- Hansch, C.¹ Leo, A.²

22
- 0007938199
- The Hydrophobic Fragmental Constant, Elsevier, Amsterdam
- (1977)
- Rekker, R.F.¹

23
- 0025977916
- (1991) Med. Res. Rev. , vol.11 , pp. 35
- Testa, B.¹ Kier, L.B.²

24
- 0029881811
- (1996) Pharm. Res. , vol.13 , pp. 335
- Testa, B.¹ Carrupt, P.A.² Gaillard, P.³ Billois, F.⁴ Weber, P.⁵

25
- 0003670171
- Pliska, V., Testa, B. and van de Waterbeemd, H. (Eds.) Lipophilicity in Drug Action and Toxicology, VCH Publishers, Weinheim
- (1996) , pp. 49-71
- Testa, B.¹ Carrupt, P.A.² Gaillard, P.³ Tsai, R.S.⁴

26
- 0001938735
- Testa, B. (Ed.) Advances in Drug Research, Vol. 16, Academic Press, London
- (1987) , pp. 87-227
- Van de Waterbeemd, H.¹ Testa, B.²

27
- 0001712289
- (1992) J. Phys. Chem. , vol.96 , pp. 1455
- El Tayar, N.¹ Testa, B.² Carrupt, P.A.³

28
- 0000433456
- (1985) J. Sol. Chem. , vol.14 , pp. 153
- Taft, R.W.¹ Abboud, J.L.M.² Kamlet, M.J.³ Abraham, M.H.⁴

29
- 0025731738
- (1991) J. Pharm. Sci. , vol.80 , pp. 590
- El Tayar, N.¹ Tsai, R.S.² Testa, B.³ Carrupt, P.A.⁴ Leo, A.⁵

30
- 0027207281
- (1993) Pharm. Res. , vol.10 , pp. 913
- Rogers, J.A.¹ Choi, Y.W.²

31
- 0033013540
- (1999) Pharm. Res. , vol.16 , pp. 882
- Balon, K.¹ Riebesehl, B.U.² Muller, B.W.³

32
- 0032513503
- (1998) Int. J. Pharm. , vol.164 , pp. 129
- Beigi, F.¹ Gottschalk, I.² Lagerquist Hagglund, C.³ Haneskog, L.⁴ Brekkan, E.⁵ Osterberg, T.⁶ Lundhal, P.⁷

33
- 0032033427
- (1998) Eur. J. Med. Chem. , vol.33 , pp. 215
- Ducarme, A.¹ Neuwels, M.² Goldstein, S.³ Massingham, R.⁴

34
- 0031709543
- (1998) Pharm. Res. , vol.15 , pp. 1270
- Reichel, A.¹ Begley, D.J.²

35
- 0002192652
- Ngo, T.T. (Ed.) Molecular Interactions in Bioseparations, Plenum Press, New York, NY
- (1993) , pp. 151-167
- Alvarez, F.M.¹ Bottom, C.B.² Chikhale, P.³ Pidgeon, C.⁴

36
- 0018607849
- (1979) Eur. J. Med. Chem. , vol.14 , pp. 479
- Rekker, R.F.¹ De Kort, H.M.²

37
- 0000463007
- (1967) J. Org. Chem. , vol.32 , pp. 2583
- Hansch, C.¹ Anderson, S.M.²

38
- 0027478912
- (1993) Med. Res. Rev. , vol.13 , pp. 327
- Wiley, R.A.¹ Rich, D.H.²

39
- 0002134667
- Testa, B., Kyburz, E., Fuhrer, W. and Giger, R. (Eds.) Perspectives in Medicinal Chemistry, VCH Publishers, Weinheim
- (1993) , pp. 15-25
- Rich, D.H.¹

40
- 33845278408
- (1988) Acc. Chem. Res. , vol.21 , pp. 362
- Jiang, X.K.¹

41
- 0025826820
- (1991) J. Med. Chem. , vol.34 , pp. 1272
- Carrupt, P.A.¹ Testa, B.² Bechalany, A.³ El Tayar, N.⁴ Descas, P.⁵ Perrissoud, D.⁶

42
- 0033179099
- (1999) Pharm. Sci. Technol. Today , vol.2 , pp. 327
- Caron, G.¹ Reymond, F.² Carrupt, P.A.³ Girault, H.H.⁴ Testa, B.⁵

43
- 0024523097
- (1989) Quant. Struct.-Act, Relat. , vol.8 , pp. 17
- Leahy, D.E.¹ Taylor, P.J.² Wait, A.R.³

44
- 0000707503
- (1997) J. Chem. Soc., Perkin Trans. 2 , pp. 2639
- Pagliara, A.¹ Caron, G.² Lisa, G.³ Fan, W.⁴ Gaillard, P.⁵ Carrupt, P.A.⁶ Testa, B.⁷ Abraham, M.H.⁸

45
- 33748658297
- (1997) J. Chem. Soc., Faraday Trans. , vol.93 , pp. 401
- Steyaert, G.¹ Lisa, G.² Gaillard, P.³ Boss, G.⁴ Reymond, F.⁵ Girault, H.H.⁶ Carrupt, P.A.⁷ Testa, B.⁸

46
- 0027982335
- (1994) J. Pharm. Sci. , vol.83 , pp. 1085
- Abraham, M.H.¹ Chadha, H.S.² Whiting, G.S.³ Mitchell, R.C.⁴

47
- 0023902147
- (1988) J. Med. Chem. , vol.31 , pp. 656
- Young, R.C.¹ Mitchell, R.C.² Brown, T.H.³ Ganellin, C.R.⁴ Griffiths, R.⁵ Jones, M.⁶ Rana, K.K.⁷ Saunders, D.⁸ Smith, I.R.⁹ Sore, N.E.¹⁰ Wilks, T.J.¹¹

48
- 0026064678
- (1991) J. Pharm. Sci. , vol.80 , pp. 744
- El Tayar, N.¹ Tsai, R.S.² Testa, B.³ Carrupt, P.A.⁴ Hansch, C.⁵ Leo, A.⁶

49
- 0028108085
- (1994) J. Pharm. Sci. , vol.83 , pp. 1257
- Abraham, M.H.¹ Chadha, H.S.² Mitchell, R.C.³

50
- 13344277282
- (1996) J. Med. Chem. , vol.39 , pp. 982
- Von Geldern, T.W.¹ Hoffman, D.J.² Kester, J.A.³ Nellans, H.N.⁴ Dayton, B.D.⁵ Calzadilla, S.V.⁶ Marsh, K.C.⁷ Hernandez, L.⁸ Chiou, W.⁹ Dixon, D.B.¹⁰ Wu-Wong, J.R.¹¹ Opgenorth, T.J.¹²

51
- 0029739972
- (1996) J. Pharm. Sci. , vol.85 , pp. 819
- Yoshida, F.¹ Topliss, J.G.²

52
- 0029841293
- (1996) Helv. Chim. Acta , vol.79 , pp. 1683
- Caron, G.¹ Pagliara, A.² Carrupt, P.A.³ Gaillard, P.⁴ Testa, B.⁵

53
- 0029764147
- (1996) Pharm. Res. , vol.13 , pp. 1186
- Caron, G.¹ Carrupt, P.A.² Testa, B.³ Ermondi, G.⁴ Gasco, A.⁵

54
- 0032510449
- (1998) J. Med. Chem. , vol.41 , pp. 853
- Pagliara, A.¹ Testa, B.² Carrupt, P.A.³ Jolliet, P.⁴ Morin, C.⁵ Morin, D.⁶ Urien, S.⁷ Tillement, J.P.⁸ Rihoux, J.P.⁹

55
- 0031517389
- Boyd, D.B. and Lipkowitz, K.B. (Eds.) Reviews in Computational Chemistry, Vol. 11, Wiley-VCH, New York, NY
- (1997) , pp. 241-315
- Carrupt, P.A.¹ Testa, B.² Gaillard, P.³

56
- 0030890218
- (1997) Helv. Chim. Acta , vol.80 , pp. 449
- Caron, G.¹ Gaillard, P.² Carrupt, P.A.³ Testa, B.⁴

57
- 0007880812
- QSAR: Hansch Analysis and Related Approaches, VCH Publishers, Weinheim
- (1993)
- Kubinyi, H.¹

58
- 0014847525
- (1970) J. Pharm. Sci. , vol.59 , pp. 1281
- Murthy, K.S.¹ Zograti, G.²

59
- 0032924545
- (1999) Chem. Eur. J. , vol.5 , pp. 39
- Reymond, F.¹ Carrupt, P.A.² Testa, B.³ Girault, H.H.⁴

60
- 37049080379
- (1991) J. Chem. Soc., Perkin Trans. 2 , pp. 1797
- Tsai, R.S.¹ Testa, B.² El Tayar, N.³ Carrupt, P.A.⁴

61
- 0028966069
- (1995) Int. J. Pharm. , vol.113 , pp. 47
- Takacs-Novak, K.¹ Jozan, M.² Szasz, G.³

62
- 0028827815
- (1995) Int. J. Pharm. , vol.125 , pp. 195
- Hatanaka, T.¹ Morigaki, S.² Aiba, T.³ Katayama, K.⁴ Koizumi, T.⁵

63
- 0031048588
- (1997) J. Pharm. Sci. , vol.86 , pp. 310
- Abraham, M.H.¹ Takacs-Novak, K.² Mitchell, R.C.³

64
- 0001651580
- (1997) Chem. Rev. , vol.97 , pp. 3385
- Pagliara, A.¹ Carrupt, P.A.² Caron, G.³ Gaillard, P.⁴ Testa, B.⁵

65
- 21144467893
- (1992) Chimia , vol.46 , pp. 299
- Van de Waterbeemd, H.¹ Kansy, M.²

66
- 0029840951
- (1996) J. Drug Targeting , vol.4 , pp. 103
- Ren, S.¹ Das, A.² Lien, E.J.³

67
- 0030588714
- (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 67
- Artursson, P.¹ Palm, K.² Luthman, K.³

68
- 0032949615
- (1999) J. Pharm. Sci. , vol.88 , pp. 28
- Irvine, J.D.¹ Takahashi, L.² Lockhart, K.³ Cheong, J.⁴ Tolan, J.W.⁵ Selick, H.E.⁶ Grove, R.⁷

69
- 0030458462
- (1996) J. Pharm. Sci. , vol.85 , pp. 1336
- Burton, P.S.¹ Conradi, R.A.² Ho, N.F.H.³ Hilgers, A.R.⁴ Borchardt, R.T.⁵

70
- 0029872476
- (1996) Int. J. Pharm. , vol.129 , pp. 223
- Buur, A.¹ Trier, L.² Magnusson, C.³ Armrsson, P.⁴

71
- 0031925268
- (1998) J. Pharm. Sci. , vol.87 , pp. 403
- Lennernas, H.¹

72
- 0031404654
- (1997) Pharm. Res. , vol.14 , pp. 1786
- Norinder, U.¹ Osterberg, T.² Artursson, P.³

73
- 0019513569
- (1981) J. Pharmacokinet. Biopharm. , vol.9 , pp. 191
- Pla-Delfina, J.M.¹ Moreno, J.²

74
- 0021083047
- (1983) Int. J. Pharm. , vol.17 , pp. 47
- Yoshimura, Y.¹ Kakeya, N.²

75
- 0032585545
- (1998) J. Med. Chem. , vol.41 , pp. 5382
- Palm, K.¹ Luthman, K.² Ungell, A.L.³ Strandlund, G.⁴ Beigi, F.⁵ Lundhal, P.⁶ Artursson, P.⁷

76
- 0031722109
- (1998) Pharm. Res. , vol.15 , pp. 1370
- Breitkreutz, J.¹

77
- 0032979004
- (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 49
- Norinder, U.¹ Osterberg, T.² Artursson, P.³

78
- 0031872134
- (1998) Pharm. Res. , vol.15 , pp. 972
- Krarup, L.H.¹ Christensen, I.T.² Hovgaard, L.³ Frokjaer, S.⁴

79
- 0032795192
- (1999) J. Pharm. Sci. , vol.88 , pp. 807
- Clark, D.E.¹

80
- 0032811868
- (1999) J. Pharm. Sci. , vol.88 , pp. 815
- Clark, D.E.¹

81
- 0031024171
- (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

82
- 0026646712
- (1992) J. Pharm. Sci. , vol.81 , pp. 603
- Guy, R.H.¹ Potts, R.O.²

83
- 0029618807
- (1995) Pharm. Res. , vol.12 , pp. 1628
- Potts, R.O.¹ Guy, R.H.²

84
- 0026648936
- (1992) Farmaco , vol.47 , pp. 869
- Ridout, G.¹ Houk, J.² Guy, R.H.³ Santus, G.C.⁴ Hadgraft, J.⁵ Hall, L.L.⁶

85
- 0023117115
- (1987) Int. J. Pharm. , vol.36 , pp. 67
- Ackerman, C.¹ Flynn, G.L.² Smith, W.M.³

86
- 0027530335
- (1993) Pharm. Res. , vol.10 , pp. 635
- Potts, R.O.¹ Guy, R.H.²

87
- 0028140550
- (1984) J. Pharmacol. Exp. Ther. , vol.268 , pp. 144
- Singh, P.¹ Roberts, M.S.²

88
- 0021052458
- (1983) J. Pharm. Sci. , vol.72 , pp. 1266
- Schoenwald, R.¹ Huang, H.S.²

89
- 0029871091
- (1996) J. Pharm. Pharmacol. , vol.48 , pp. 136
- Begley, D.J.¹

90
- 0015545469
- (1973) J. Pharm. Sci. , vol.62 , pp. 1
- Hansch, C.¹ Clayton, J.M.²

91
- 0023546523
- (1987) J. Pharm. Sci. , vol.76 , pp. 663
- Hansch, C.¹ Bjorkroth, J.P.² Leo, A.³

92
- 0021020662
- (1983) J. Nucl. Med. , vol.24 , pp. 1030
- Dischino, D.D.¹ Welch, M.J.² Kilbourn, M.R.³ Raichle, M.E.⁴

93
- 0024267858
- (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1233
- Van Bree, J.B.M.M.¹ De Boer, A.G.² Danhof, M.³ Ginsel, L.A.⁴ Breimer, D.D.⁵

94
- 0027729568
- (1993) Eur. J. Pharm. Sci. , vol.1 , pp. 49
- Jaehde, U.¹ Goto, T.² De Boer, A.G.³ Breimer, D.D.B.⁴

95
- 0019124032
- (1980) J. Med. Chem. , vol.23 , pp. 682
- Levin, V.A.¹

96
- 0022547803
- (1986) Int. J. Pharm. , vol.32 , pp. 79
- Rim, S.¹ Audus, K.L.² Borchardt, R.T.³

97
- 0028270064
- (1994) Pharm. Res. , vol.11 , pp. 412
- Chikhale, E.G.¹ Ng, K.Y.² Burton, P.S.³ Borchardt, R.T.⁴

98
- 0028596605
- (1994) Eur. J. Pharm. Sci. , vol.2 , pp. 373
- Ter Laak, A.M.¹ Tsai, R.S.² Donne-op den Kelder, G.M.³ Carrupt, P.A.⁴ Testa, B.⁵ Timmerman, H.⁶

99
- 0017068438
- (1976) Mol. Pharmacol. , vol.12 , pp. 454
- Rodrigues de Miranda, J.F.¹ Eikelboom, T.D.² Van Os, G.A.J.³

100
- 0025763236
- (1991) Chem. Pharm. Bull. , vol.39 , pp. 720
- Kaibara, A.¹ Hirose, M.² Nakagawa, T.³

101
- 0023089703
- (1987) J. Pharm. Pharmacol. , vol.39 , pp. 79
- Laznicek, M.¹ Kvetina, J.² Mazak, J.³ Krch, V.⁴

102
- 0028895209
- (1995) Pharm. Res. , vol.12 , pp. 1535
- Demotes-Mainard Pehourcq, F.¹ Radouane, A.² Labat, L.³ Bannwarth, B.⁴

103
- 0031815338
- (1998) Mol. Pharmacol. , vol.54 , pp. 129
- Herve, F.¹ Caron, G.² Duche, J.C.³ Gaillard, P.⁴ Abd Rahman, N.⁵ Tsantili-Kakoulidou, A.⁶ Carrupt, P.A.⁷ D'Athis, P.⁸ Tillement, J.P.⁹ Testa, B.¹⁰

104
- 0007885582
- (1976) Eur. J. Med. Chem. , vol.11 , pp. 389
- Janssen, L.H.M.¹ Perrin, J.H.²

105
- 0028919908
- (1995) Biochem. J. , vol.306 , pp. 545
- Urien, S.¹ Giroud, Y.² Tsai, R.S.³ Carrupt, P.A.⁴ Bree, F.⁵ Testa, B.⁶ Tillement, J.P.⁷

106
- 0025916671
- Testa, B. (Ed.) Advances in Drug Research, Vol. 20, Academic Press, London
- (1991) , pp. 117-166
- Fichtl, B.¹ Nieciecki, A.V.² Walter, K.³

107
- 0028289107
- Testa, B. and Meyer, U.A. (Eds.) Advances in Drug Research, Vol. 25, Academic Press, London
- (1994) , pp. 55-86
- Bickel, M.H.¹

108
- 0030875019
- (1997) Brit. J. Clin. Pharmacol. , vol.43 , pp. 563
- Cheymol, G.¹ Poirier, J.M.² Carrupt, P.A.³ Testa, B.⁴ Weissenburgen, J.⁵ Levron, J.C.⁶ Snoeck, E.⁷

109
- 0024539781
- (1989) Chem. Pharm. Bull. , vol.37 , pp. 450
- Yoshida, H.¹ Okumura, K.² Kamiya, A.³ Hori, R.⁴

110
- 0024412720
- (1989) Chem. Pharm. Bull. , vol.37 , pp. 1109
- Okumura, K.¹ Yoshida, K.² Kamiya, A.³ Hori, R.⁴

111
- 0025111760
- (1990) Pharm. Res. , vol.7 , pp. 691
- Yokogawa, K.¹ Nakashima, E.² Ishizaki, J.³ Maeda, H.⁴ Nagano, T.⁵ Ichimura, F.⁶

112
- 0015634296
- (1973) Food Cosmet. Toxicol. , vol.11 , pp. 391
- Byard, J.L.¹ Goldberg, L.²

113
- 0017367544
- (1977) Xenobiotica , vol.7 , pp. 189
- Ball, L.M.¹ Renwick, A.G.² Williams, R.T.³

114
- 0015819789
- (1973) Toxicol. Appl. Pharmacol. , vol.26 , pp. 319
- Ashton, M.J.¹ Clark, B.² Jones, K.M.³ Moss, G.F.⁴ Neale, M.G.⁵ Ritchie, J.T.⁶

115
- 0025380544
- (1990) Arzneim.-Forsch. , vol.40 , pp. 200
- Lachmann, G.¹ Siegemund, B.² Kusche, W.³

116
- 0022296149
- (1985) Drug Metab. Rev. , vol.16 , pp. 365
- Smith, D.A.¹ Brown, K.² Neale, M.G.³

117
- 0007935713
- (1990) Trends Genet. , vol.6 , pp. 9
- Gonzalez, F.J.¹ Nebert, D.W.²

118
- 0020335905
- (1982) Experientia , vol.38 , Issue.SUPPL. , pp. 879
- Bickel, M.H.¹

119
- 0021032573
- (1983) Veterinary Res. Commun. , vol.7 , pp. 277
- Jondorf, W.R.¹

120
- 0025145293
- (1990) Acta Pharm. Nord. , vol.2 , pp. 137
- Testa, B.¹

121
- 0024402381
- (1989) Chirality , vol.1 , pp. 7
- Testa, B.¹

122
- 0025804094
- (1991) Pharm. Res. , vol.8 , pp. 832
- Durrer, A.¹ Walther, B.² Racciatti, A.³ Boss, G.⁴ Testa, B.⁵

123
- 0015116132
- (1971) J. Med. Chem. , vol.14 , pp. 777
- Martin, Y.C.¹ Hansch, C.²

124
- 0002641548
- (1972) Drug Metab. Rev. , vol.1 , pp. 1
- Hansch, C.¹

125
- 0024623978
- (1989) J. Pharm. Pharmacol. , vol.41 , pp. 205
- Yu, P.H.¹

126
- 0025667309
- (1990) J. Pharm. Pharmacol. , vol.42 , pp. 882
- Yu, P.H.¹

127
- 0023915262
- (1988) J. Biol. Chem. , vol.263 , pp. 6671
- Morgenstern, R.¹ Lundqvist, G.² Hancock, V.³ DePierre, J.W.⁴

128
- 0007928681
- The Metabolism of Drugs and Other Xenobiotics. Biochemistry of Redox Reactions, Academic Press, London
- (1995)
- Testa, B.¹

129
- 0018145146
- (1978) Biochem. Pharmacol. , vol.27 , pp. 783
- Al-Gailany, K.A.S.¹ Houston, J.B.² Bridges, J.W.³

130
- 0019365070
- (1981) Pharmacol. Ther. , vol.12 , pp. 133
- Backes, W.L.¹ Canady, W.J.²

131
- 0020490567
- (1982) J. Biol. Chem. , vol.257 , pp. 4063
- Backes, W.L.¹ Hogaboom, M.² Canady, W.J.³

132
- 0027216434
- (1993) Arch. Biochem. Biophys. , vol.304 , pp. 27
- Backes, W.L.¹ Cawley, G.² Eyer, C.S.³ Means, M.⁴ Causey, K.M.⁵ Canady, W.J.⁶

133
- 0003670171
- Pliska, V., Testa, B. and van de Waterbeemd, H. (Eds.) Lipophilicity in Drug Action and Toxicology, VCH Publishers, Weinheim
- (1996) , pp. 253-261
- Walther, B.¹ Vis, P.² Taylor, A.³

134
- 0022282627
- (1986) Prog. Lip. Res. , vol.24 , pp. 177
- Fears, R.¹

135
- 0001113477
- (1998) Helv. Chim. Acta , vol.81 , pp. 330
- Giroud, Y.¹ Carrupt, P.A.² Pagliara, A.³ Testa, B.⁴ Dickinson, R.G.⁵

136
- 0032862884
- (1999) Helv. Chim. Acta , vol.82 , pp. 1630
- Caron, G.¹ Ermondi, G.² Boschi, D.³ Carrupt, P.A.⁴ Fruttero, R.⁵ Testa, B.⁶ Gasco, A.⁷

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.