Charge and delocalisation effects on the lipophilicity of protonable drugs

Chemistry - A European Journal

Volumn 5, Issue 1, 1999, Pages 39-47

  Reymond, Frédéric ^a   Carrupt, Pierre Alain ^b   Testa, Bernard ^b   Girault, Hubert H ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Drug research; Ionic partition diagrams; ITIES; Lipophilicity

Indexed keywords

1,2 DICHLOROETHANE; 3,5,N,N TETRAMETHYLANILINE; AMFEPRAMONE; ANILINE DERIVATIVE; ANOREXIGENIC AGENT; ANTIMALARIAL AGENT; CENTRAL STIMULANT AGENT; CORONARY VASODILATING AGENT; DIETHYLANILINE; METHYLEPHEDRINE; OCTANOL; QUININE; TRIMETAZIDINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CYCLIC POTENTIOMETRY; DISSOCIATION CONSTANT; DRUG STRUCTURE; LIPOPHILICITY; PARTITION COEFFICIENT; PROTON TRANSPORT; SOLVATION;

EID: 0032924545     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3765(19990104)5:1<39::AID-CHEM39>3.0.CO;2-3     Document Type: Article

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