-
1
-
-
0018872131
-
Pharmacokinetic studies of 5-fluorouracil after oral and intravenous administration in man
-
Almersjö, E.E., Gustavsson, B.G., Regårdh, C.-G. and Wålen, P., Pharmacokinetic studies of 5-fluorouracil after oral and intravenous administration in man. Acta Pharmacol. Toxicol., 46 (1980) 326-336.
-
(1980)
Acta Pharmacol. Toxicol.
, vol.46
, pp. 326-336
-
-
Almersjö, E.E.1
Gustavsson, B.G.2
Regårdh, C.-G.3
Wålen, P.4
-
2
-
-
0348189638
-
Solubility of nonelectrolytes in polar solvents. V. Estimation of the solubility of aliphatic monofunctional compounds in water using a molecular surface area approach
-
Amidon, G.L., Yalkowsky, S.H., Anik, S.T. and Valvani, S.C., Solubility of nonelectrolytes in polar solvents. V. Estimation of the solubility of aliphatic monofunctional compounds in water using a molecular surface area approach. J. Phys. Chem., 79 (1975) 2239-2246.
-
(1975)
J. Phys. Chem.
, vol.79
, pp. 2239-2246
-
-
Amidon, G.L.1
Yalkowsky, S.H.2
Anik, S.T.3
Valvani, S.C.4
-
3
-
-
0027098054
-
Epithelial transport of drugs in cell culture, VII. Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cell
-
Anderberg, E.K., Nyström, C. and Artursson, P., Epithelial transport of drugs in cell culture, VII. Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cell., J. Pharm. Sci., 81 (1992) 879-887.
-
(1992)
J. Pharm. Sci.
, vol.81
, pp. 879-887
-
-
Anderberg, E.K.1
Nyström, C.2
Artursson, P.3
-
4
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I. A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
Artursson, P., Epithelial transport of drugs in cell culture. I. A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci., 79 (1990) 476-482.
-
(1990)
J. Pharm. Sci.
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
5
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson, P. and Karlsson, J., Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun., 175 (1991) 880-885.
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
6
-
-
0027312774
-
Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
-
Artursson, P., Ungell, A.-L. and Löfroth, J.-E., Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res., 10 (1993) 1123-1129.
-
(1993)
Pharm. Res.
, vol.10
, pp. 1123-1129
-
-
Artursson, P.1
Ungell, A.-L.2
Löfroth, J.-E.3
-
7
-
-
0021187201
-
Prodrugs of 5-fluorouracil. I. Hydrolysis kinetics and physicochemical properties of various N-acyl derivatives of 5-fluorouracil
-
Buur, A. and Bundgaard, H., Prodrugs of 5-fluorouracil. I. Hydrolysis kinetics and physicochemical properties of various N-acyl derivatives of 5-fluorouracil. Int. J. Pharm., 21 (1984) 349-364.
-
(1984)
Int. J. Pharm.
, vol.21
, pp. 349-364
-
-
Buur, A.1
Bundgaard, H.2
-
8
-
-
0021992828
-
Prodrugs of 5-fluorouracil. IV. Hydrolysis kinetics, bioactivation and physiochemical properties of various N-acyloxymethyl derivatives of 5-fluorouracil
-
Buur, A., Bundgaard, H. and Falch, E., Prodrugs of 5-fluorouracil. IV. Hydrolysis kinetics, bioactivation and physiochemical properties of various N-acyloxymethyl derivatives of 5-fluorouracil. Int. J. Pharm., 24 (1985) 43-60.
-
(1985)
Int. J. Pharm.
, vol.24
, pp. 43-60
-
-
Buur, A.1
Bundgaard, H.2
Falch, E.3
-
9
-
-
0022542459
-
Prodrugs of 5-fluorouracil. V. 1-alkoxycarbonyl derivatives as potential prodrug forms for improved rectal or oral delivery of 5-fluorouracil
-
Buur, A. and Bundgaard, H., Prodrugs of 5-fluorouracil. V. 1-Alkoxycarbonyl derivatives as potential prodrug forms for improved rectal or oral delivery of 5-fluorouracil. J. Pharm. Sci., 75 (1986a) 522-527.
-
(1986)
J. Pharm. Sci.
, vol.75
, pp. 522-527
-
-
Buur, A.1
Bundgaard, H.2
-
10
-
-
0342548628
-
Prodrugs of 5-fluorouracil. VI. Hydrolysis kinetics and bioactivation of 3-nicotinoyl-5-fluorouracil and various 1-substituted derivatives of 3-benzoyl-5-fluorouracil
-
Buur, A. and Bundgaard, H., Prodrugs of 5-fluorouracil. VI. Hydrolysis kinetics and bioactivation of 3-nicotinoyl-5-fluorouracil and various 1-substituted derivatives of 3-benzoyl-5-fluorouracil. Arch. Pharm. Chem. Sci. Ed., 14 (1986b) 99-112.
-
(1986)
Arch. Pharm. Chem. Sci. Ed.
, vol.14
, pp. 99-112
-
-
Buur, A.1
Bundgaard, H.2
-
11
-
-
0343418384
-
Prodrugs of 5-fluorouracil. VIII. Improved rectal and oral delivery of 5-fluorouracil via various prodrugs. Structure-rectal absorption relationships
-
Buur, A. and Bundgaard, H., Prodrugs of 5-fluorouracil. VIII. Improved rectal and oral delivery of 5-fluorouracil via various prodrugs. Structure-rectal absorption relationships. Int. J. Pharm., 75 (1986c) 676-679.
-
(1986)
Int. J. Pharm.
, vol.75
, pp. 676-679
-
-
Buur, A.1
Bundgaard, H.2
-
12
-
-
0025125099
-
Penetration of 5-fluorouracil and prodrugs across the intestine of the albino rabbit: Evidence for shift in absorption site from the upper to the lower region of the gastrointestinal tract by prodrugs
-
Buur, A., Yamamoto, A. and Lee, V.H.L., Penetration of 5-fluorouracil and prodrugs across the intestine of the albino rabbit: evidence for shift in absorption site from the upper to the lower region of the gastrointestinal tract by prodrugs. J. Controlled Release, 14 (1990) 43-51.
-
(1990)
J. Controlled Release
, vol.14
, pp. 43-51
-
-
Buur, A.1
Yamamoto, A.2
Lee, V.H.L.3
-
13
-
-
0018095703
-
Fluorouracil therapy in patients: A pharmacokinetic comparison of various rates and routes of administration
-
Christophidis, N., Vajda, F.J.E., Lucas, I., Drummer, O., Moon, W.J. and Louis, W.J., Fluorouracil therapy in patients: a pharmacokinetic comparison of various rates and routes of administration. Clin. Pharmacokinet., 3 (1978) 330-336.
-
(1978)
Clin. Pharmacokinet.
, vol.3
, pp. 330-336
-
-
Christophidis, N.1
Vajda, F.J.E.2
Lucas, I.3
Drummer, O.4
Moon, W.J.5
Louis, W.J.6
-
14
-
-
0016215029
-
Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893)
-
Cohen, J.L., Irwin, L.E., Marshall, G.J., Darven, H. and Bateman, J.R., Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893). Cancer Chemother. Rep., 58 (1974) 723-732.
-
(1974)
Cancer Chemother. Rep.
, vol.58
, pp. 723-732
-
-
Cohen, J.L.1
Irwin, L.E.2
Marshall, G.J.3
Darven, H.4
Bateman, J.R.5
-
15
-
-
0025999171
-
The influence of peptide structure on transport across Caco-2 cells
-
Conradi, R.A., Hilgers, A.R., Ho, N.F.H. and Burton, P.S., The influence of peptide structure on transport across Caco-2 cells. Pharm. Res., 8 (1991) 1453-1460.
-
(1991)
Pharm. Res.
, vol.8
, pp. 1453-1460
-
-
Conradi, R.A.1
Hilgers, A.R.2
Ho, N.F.H.3
Burton, P.S.4
-
16
-
-
0028944297
-
Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of 0-cyclopropane carboxylic acid ester prodrugs of various β-blocking agents
-
Hovgaard, L., Brøndsted, H., Buur, A. and Bundgaard, H., Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of 0-cyclopropane carboxylic acid ester prodrugs of various β-blocking agents. Pharm. Res., 12 (1995) 387-392.
-
(1995)
Pharm. Res.
, vol.12
, pp. 387-392
-
-
Hovgaard, L.1
Brøndsted, H.2
Buur, A.3
Bundgaard, H.4
-
17
-
-
0026769788
-
Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolaterial membranes
-
Inui, K.-I., Yamamoto, M. and Saito, H., Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolaterial membranes. J. Pharmacol. Exp. Ther., 261 (1992) 195-201.
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.261
, pp. 195-201
-
-
Inui, K.-I.1
Yamamoto, M.2
Saito, H.3
-
18
-
-
0025803782
-
A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial (Caco-2) cells grown in permeable filter chambers
-
Karlsson, J. and Artursson, P., A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial (Caco-2) cells grown in permeable filter chambers. Int. J. Pharm., 71 (1991) 55-64.
-
(1991)
Int. J. Pharm.
, vol.71
, pp. 55-64
-
-
Karlsson, J.1
Artursson, P.2
-
19
-
-
0027146389
-
Transport of celiprolol across human intestinal epithelial (Caco-2) cells: Mediation of secretion by multiple transporters including P-glycoprotein
-
Karlsson, J., Kuo, S.-M., Ziemniak, J. and Artursson, P., Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol., 110 (1993) 1009-1016.
-
(1993)
Br. J. Pharmacol.
, vol.110
, pp. 1009-1016
-
-
Karlsson, J.1
Kuo, S.-M.2
Ziemniak, J.3
Artursson, P.4
-
20
-
-
0027141263
-
A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa
-
Kim, D.-C., Burton, P.S. and Borchardt, R.T., A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa. Pharm. Res., 10 (1993) 12.
-
(1993)
Pharm. Res.
, vol.10
, pp. 12
-
-
Kim, D.-C.1
Burton, P.S.2
Borchardt, R.T.3
-
21
-
-
0030023536
-
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
-
in press
-
Lennernäs, H., Palm, K., Fagerholm, U. and Artursson, P., Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int. J. Pharm., (in press, 1996).
-
(1996)
Int. J. Pharm.,
-
-
Lennernäs, H.1
Palm, K.2
Fagerholm, U.3
Artursson, P.4
-
22
-
-
0026042691
-
Absorption of thyrotropin-releasing hormone (TRH) and TRH prodrug in a human intestinal cell line (Caco-2)
-
Lundin, S., Möss, J., Bundgaard, H. and Artursson, P., Absorption of thyrotropin-releasing hormone (TRH) and TRH prodrug in a human intestinal cell line (Caco-2). Int. J. Pharm., 76 (1991) R1-R4.
-
(1991)
Int. J. Pharm.
, vol.76
-
-
Lundin, S.1
Möss, J.2
Bundgaard, H.3
Artursson, P.4
-
23
-
-
0343854288
-
A new method for the prediction of intestinal drug absorption based on molecular surface properties
-
in press
-
Palm, K., Luthman, K., Ungell, A-L., Strandlund, G. and Artursson, P., A new method for the prediction of intestinal drug absorption based on molecular surface properties. J. Pharm. Sci. (in press, 1996).
-
(1996)
J. Pharm. Sci.
-
-
Palm, K.1
Luthman, K.2
Ungell, A.-L.3
Strandlund, G.4
Artursson, P.5
-
24
-
-
0028871046
-
Correlation of solute flux across Caco-2 monolayers and colonie tissue in vitro
-
Rubas, W., Villagran, J., Cromwell, M., McLeod, A., Wassenberg, J. and Mrsny, R., Correlation of solute flux across Caco-2 monolayers and colonie tissue in vitro. S.T.P. Pharm. Sci., 5 (1995) 93-37.
-
(1995)
S.T.P. Pharm. Sci.
, vol.5
, pp. 93-137
-
-
Rubas, W.1
Villagran, J.2
Cromwell, M.3
McLeod, A.4
Wassenberg, J.5
Mrsny, R.6
-
25
-
-
0023756430
-
Intestinal 5-fluorouracil absorption: Use of ussing chambers to assess transport and metabolism
-
Smith, P., Mirabelli, C., Fondacaro, J., Ryan, F. and Dent, J., Intestinal 5-fluorouracil absorption: use of Ussing chambers to assess transport and metabolism. Pharm. Res. 5 (1988) 598-603.
-
(1988)
Pharm. Res.
, vol.5
, pp. 598-603
-
-
Smith, P.1
Mirabelli, C.2
Fondacaro, J.3
Ryan, F.4
Dent, J.5
-
27
-
-
0027976440
-
Oral absorption of lipidic amino acid conjugates
-
Toth, I., Hillery, A.M., Wood, I.P., Magnusson, C. and Artursson, P., Oral absorption of lipidic amino acid conjugates. Int. J. Pharm., 102 (1994) 223-230.
-
(1994)
Int. J. Pharm.
, vol.102
, pp. 223-230
-
-
Toth, I.1
Hillery, A.M.2
Wood, I.P.3
Magnusson, C.4
Artursson, P.5
-
28
-
-
0023902147
-
2 receptor histamine antagonists
-
2 receptor histamine antagonists. J. Med. Chem., 31 (1988) 656-671.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 656-671
-
-
Young, R.C.1
Mitchell, R.C.2
Brown, T.H.3
Ganellin, C.R.4
Griffiths, R.5
Jones, M.6
Rana, K.K.7
Saunders, D.8
Smith, I.R.9
Sore, N.E.10
Wilks, T.J.11
|