Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

Protein Science

Volumn 9, Issue 9, 2000, Pages 1801-1809

  Velazquez Campoy, Adrian ^a   Luque, Irene ^a   Todd, Matthew J ^a   Milutinovich, Mark ^a   Kiso, Yoshiaki ^b   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Binding thermodynamics; Calorimetry; HIV 1 protease; HIV 1 protease inhibitors; KNI inhibitors; KNI 272

Indexed keywords

ASPARTIC ACID; ASPARTIC PROTEINASE; INDINAVIR; ISOQUINOLINE DERIVATIVE; KYNOSTATIN 272; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ARTICLE; BINDING AFFINITY; CALORIMETRY; DRUG BINDING; DRUG PROTEIN BINDING; ENERGY TRANSFER; ENTHALPY; ENTROPY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTEINASE INHIBITION; PROTON TRANSPORT; THERMODYNAMICS; VIRUS MUTANT; VIRUS RESISTANCE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0033815251     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.9.1801     Document Type: Article

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