Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

Molecular and Cellular Biology

Volumn 20, Issue 20, 2000, Pages 7613-7623

  Sorensen, C S ^a   Lukas, C ^a   Kramer, E R ^a   Peters, J M ^a   Bartek, J ^a   Lukas, J ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; PROTEIN P27; UBIQUITIN;

ANAPHASE; ARTICLE; CELL CYCLE; CELL DIVISION; DNA REPLICATION; DNA SYNTHESIS; DROSOPHILA; HUMAN; HUMAN CELL; MITOSIS; OSCILLATION; PHASE TRANSITION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANTIBODIES; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN E; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; INTERPHASE; LIGASES; MACROMOLECULAR SYSTEMS; MITOSIS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

DROSOPHILA; SACCHAROMYCES CEREVISIAE;

EID: 0033796454     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.20.7613-7623.2000     Document Type: Article

References (73)

1. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter
2. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
3. Mutations of mitotic checkpoint genes in human cancers
4. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
5. Cell cycle regulation of DNA replication initiator factor Dbf4p
6. pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F
7. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
8. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
9. hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms: Evidence for a transcriptional activation function of hPTTG
10. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
11. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex
12. Identification of XDRP1: A Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation
13. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
14. Cyclin is degraded by the ubiquitin pathway
15. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5
16. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers
17. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase
18. Early events in DNA replication require cyclin E and are blocked by p21CIP1
19. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
20. Redundant cyclin overexpression and gene amplification in breast cancer cells
21. How proteolysis drives the cell cycle
22. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
23. Inhibition of DNA synthesis by RB: Effects on G1/S transition and S-phase progression
24. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
25. Mitotic regulation of the APC activator proteins CDC20 and CDH1
26. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
27. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
28. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system
29. Fission yeast TPR-family protein nuc2 is required for G1-arrest upon nitrogen starvation and is an inhibitor of septum formation
30. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
31. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): Evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
32. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
33. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity
34. Cyclin E-induced S phase without activation of the pRb/E2F pathway
35. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
36. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
37. p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: Molecular mechanisms and implications for oncogenesis
38. Geminin, an inhibitor of DNA replication, is degraded during mitosis
39. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A
40. Principles of CDK regulation
41. Regulation of the APC and the exit from mitosis
42. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
43. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
44. Universal control mechanism regulating onset of M-phase
45. Cyclin-dependent regulation of G1 in mammalian fibroblasts
46. 1-to-S phase transition
47. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability
48. SCF and APC: The Yin and Yang of cell cycle regulated proteolysis
49. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
50. Cyclins, CDKs and cancer
51. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
52. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis
53. CENP-F is a ca. 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization
54. Cdc28 activates exit from mitosis in budding yeast
55. hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias
56. Involvement of Myc activity in a G1/S-promoting mechanism parallel to the pRb/E2F pathway
57. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
58. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
59. Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20
60. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
61. S-phase function of Drosophila cyclin A and its downregulation in G1 phase
62. p45SKP2 promotes p27Kipl degradation and induces S phase in quiescent cells
63. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells
64. AIM-1: A mammalian midbody-associated protein required for cytokinesis
65. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
66. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
67. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
68. Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc: A mammalian homolog of CDC20/Fizzy/slp1
69. Whose end is destruction: Cell division and the anaphase-promoting complex
70. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
71. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase
72. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression
73. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis