Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 2051-2060

  Battaglia, G ^a   Rassoulpour, A ^a   Wu, H Q ^a   Hodgkins, P S ^a   Kiss, C ^a   Nicoletti, F ^a   Schwarcz, R ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Excitotoxicity; Glia; Kynurenines; Metabotropic glutamate receptors; Neuroprotection

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2,4 PYRROLIDINEDICARBOXYLIC ACID; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE TRANSPORTER; GLUTAMIC ACID ANTAGONIST; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; LIGAND; METABOTROPIC RECEPTOR; PHOSPHOSERINE; QUISQUALIC ACID; RECEPTOR SUBTYPE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; MALE; MENTAL DISEASE; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSAMINATION;

AMINOBUTYRIC ACIDS; ANIMAL; ASPARTIC ACID; CALCIUM; CEREBRAL CORTEX; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLYCINE; IN VITRO; INTRACELLULAR FLUID; KYNURENIC ACID; LIGANDS; LIVER; MALE; MICRODIALYSIS; MICROINJECTIONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SODIUM; SUPPORT, U.S. GOV'T, P.H.S.; TRANSAMINASES;

EID: 0033789838     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752051.x     Document Type: Article

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