Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: Reversal by lactate and pyruvate

European Journal of Neuroscience

Volumn 10, Issue 6, 1998, Pages 1986-1994

  Hodgkins, Paul S ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Energy metabolism; Excitotoxicity; Hypoglycaemia; Kynurenines; Monocarboxylates

Indexed keywords

2 OXOGLUTARIC ACID; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYANIDE; FORMAZAN; GLUCOSE; KYNURENIC ACID; KYNURENINE; LACTIC ACID; OXALOACETIC ACID; PYRUVIC ACID; SUCCINIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL ENERGY; CELL METABOLISM; CITRIC ACID CYCLE; ENERGY METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOLYSIS; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; TRANSAMINATION;

ANIMALS; BRAIN; ELECTRON TRANSPORT; ENERGY METABOLISM; FORMAZANS; GLUCOSE; KYNURENIC ACID; KYNURENINE; LACTIC ACID; MALE; NEURONS; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS;

EID: 0031868225     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00208.x     Document Type: Article

References (4)

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2. Beal, M.F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol., 31, 119-130.
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4. Benz, A.M., Izumi, Y., Clifford, D.B. & Zorumski, C.F. (1996) Effects of endogenous monocarboxylates (pyruvate and lactate) on the preservation of rat hippocampal slices under hypoglycemic conditions. Soc. Neurosci. Abstr., 22, 148.14.