mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons

European Journal of Neuroscience

Volumn 11, Issue 2, 1999, Pages 663-672

  Lafon Cazal, Mireille ^a  

^a CCIPE   (France)

Author keywords

Glutamate neuronal death; Metabotropic glutamate receptor expression; Mouse; Short and long term glutamate release

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; GLUTAMIC ACID; MESSENGER RNA; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PERTUSSIS TOXIN; PHOSPHOSERINE; PROTEIN;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; GRANULE CELL; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM CHANNELS; CELL DEATH; CELLS, CULTURED; CEREBELLUM; CYCLIC GMP; CYCLOLEUCINE; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; KAINIC ACID; MICE; MICROTUBULE-ASSOCIATED PROTEINS; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PHOSPHOSERINE; PROPIONIC ACIDS; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033047697     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00475.x     Document Type: Article

References (3)

1. Ambrosini, A., Bresciani, L., Fraechia, S., Brunello, N. & Racagni, G. (1995) Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent ncurotoxicity in mesencephalic neurons. Mol. Phannacol., 47, 1057-1063.
2. Baude, A., Nusser, Z., Roberts, J.D.B., Mulvihill, E., Mcllhinney, R.A.J. & Somogyi, P. (1993) The metabotropic glutamate receptor (mGluRla) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron, 11, 771-787.
3. Bruno, V., Copani, A., Battaglia, G., Raffaele, R., Shinozaki, H. & Nicoletti, F. (1994) Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Ear. J. Phannacol., 256, 109-112.