Regulation of p38 mitogen-activated protein kinase during NK cell activation

European Journal of Immunology

Volumn 30, Issue 10, 2000, Pages 2791-2798

  Chini, Claudia C S ^a   Boos, Markus D ^a   Dick, Christopher J ^a   Schoon, Renee A ^a   Leibson, Paul J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Cellular activation; Mitogen activated protein kinase; NK cell; Second messenger; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL KILLING; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CYTOTOXICITY, IMMUNOLOGIC; ENZYME INHIBITORS; ENZYME PRECURSORS; FLAVONES; HUMAN; IMIDAZOLES; INDOLES; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALEIMIDES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASE; PYRIDINES; RECEPTORS, IGG; SRC-FAMILY KINASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033784986     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<2791::AID-IMMU2791>3.0.CO;2-D     Document Type: Article

References (49)

1. Signal transduction during natural killer cell activation: Inside the mind of a killer
2. Signal transduction during NK cell activation: Balancing opposing forces
3. Association of the p56(lck) protein tyrosine kinase with the FcγRIIIA/CD16 complex in human natural killer cells
4. FcγRIIIA-mediated signaling involves src-family lck in human natural killer cells
5. Physical and functional association of p56(lck) with FcγRIIIA (CD16) in natural killer cells
6. Association of a 70-kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cells
7. Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72(syk) kinase
8. Functional and physical interactions of Syk family kinases with the Vav protooncogene product
9. The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing
10. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
11. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
12. Cutting edge: A role for the adaptor protein tAT in human NK cell-mediated cytotoxicity
13. Fcγ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γ1 and PLC-γ2 in natural killer cells
14. Stimulation of FcγRIIIA results in PLC-γ1 tyrosine phosphorylation and p56(lck) activation
15. FcγR-dependent mitogen-activated protein kinase activation in leukocytes: A common signal transduction event necessary for expression of TNF-γ and early activation genes
16. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2
17. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases
18. The p38 signal transduction pathway. Activation and function
19. Stress-activated protein kinases: Activation, regulation and function
20. The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptor, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors
21. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells
22. + T cells and TH2 effector cells
23. CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1/PAK-1/p38 MAPK signaling pathway
24. T cell proliferation in response to interleukins 2 and 7 requires p38 MAP kinase activation
25. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
26. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
27. The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylatin
28. A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: Dependence on CD28 signaling and preferential inhibition of IL-10 production
29. p38 mitogen-activated protein kinase is involved in Fas ligand expression
30. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
31. Rac1/p38 MAPK signaling pathway controls β1 integrin-induced interleukin-8 production in human natural killer cells
32. Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function
33. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity
34. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity
35. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
36. Involvement of stress-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
37. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes
38. Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors
39. 2-terminal kinase 1, and p38 mitogen-activated protein kinase
40. Profound block in thymocyte development in mice lacking p56(lck)
41. Dominant-negative transgene defines a role for p56(lck) in thymopoiesis
42. Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56(lck)
43. Redundant rote of the Syk protein tyrosine kinase in mouse NK cell differentiation
44. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway
45. Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase ERK2
46. T-cell signal transduction and the role of protein kinase C
47. GTPases in antigen receptor signaling
48. Actions of the family small G proteins and 21-activated protein kinases on mitogen-activated protein kinase family members
49. Signal transduction during natural killer cell activation:inositol phosphate generation and regulation by cAMP