Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyribonucleic acid synthesis by insulin-like growth factor-I

Endocrinology

Volumn 140, Issue 9, 1999, Pages 4228-4235

  Imai, Yumi ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYTOKINE; DNA; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CELL MIGRATION; DNA SYNTHESIS; LIGAND BINDING; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION;

EID: 0033304619     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.9.6980     Document Type: Article

References (44)

1. The pathogenesis of atherosclerosis: A perspective for the 1990s
2. Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth
3. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
4. Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity
5. Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II
6. Integrins: Versatility, modulation, and signaling in cell adhesion
7. Ligand occupancy of the α-V-β3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor
8. Insulin-like growth factors and their binding proteins: Biological actions
9. Role of tyrosine kinase activity in signal transduction by the insulin- like growth factor-I (IGF-I) receptor.Characterization of kinase-deficient IGF-I receptors and the action of an IGFI-mimetic antibody (α IR-3)
10. Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk
11. Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells
12. IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways
13. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways
14. Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
15. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
16. Regulation of chemotaxis by the platelet-derived growth factor receptor-β
17. PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF
18. Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture
19. Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus
20. Exposure to platelet-derived growth factor modulates the porcine aortic smooth muscle cell response to somatomedin-C
21. Wortmannin is a potens phosphatidylinositol 3kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
22. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
23. A synthetic inhibitor of the mitogen-activated protein kinase cascade
24. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor-1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
25. PI3K: Downstream AKTion blocks apoptosis
26. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
27. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
28. Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells
29. Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways
30. Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
31. Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
32. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
33. A role for phosphatidylinositol 3-kinase in the regulation of β 1 integrin activity by the CD2 antigen
34. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
35. Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals
36. Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis
37. Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes
38. C-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: Role in mast cell enhancement of degranulation, adhesion, and membrane ruffling
39. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
40. MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extra-cellular regulated kinase (ERK) and p38 kinase
41. The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils
42. Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors
43. Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance
44. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia