Optimizing glucocorticoid therapy in rheumatoid arthritis

Rheumatic Disease Clinics of North America

Volumn 26, Issue 4, 2000, Pages 859-880

  Da Silva, José António P ^a   Bijlsma, Johannes W J ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COLLAGENASE; CYCLOOXYGENASE 2; CYTOKINE; EOTAXIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; LEUKOTRIENE; LIPOCORTIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4; NITRIC OXIDE; PHOSPHOLIPASE A2; PREDNISOLONE; PROSTAGLANDIN; RANTES; SEX HORMONE; STROMELYSIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

CELL ADHESION; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ERYTHROCYTE SEDIMENTATION RATE; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFECTION; LEUKOCYTE MIGRATION; OSTEOPOROSIS; PEPTIC ULCER; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; TH1 CELL; TH2 CELL;

EID: 0033768903     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0889-857x(05)70173-3     Document Type: Review

References (94)

1. Abnormal glucocorticoid receptor/AP-1 interaction in steroid resistant asthma
2. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung
3. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: Preferential targetting of NF-kappaB and lack of I-kappaB involvement
4. Inhibition by glucocorficoids of the formation of interleukin-1α, interleukin-1β, and interleukin-6: Mediation by decreased mRNA stability
5. Recommendations for the prevention and treatment of glucocorticosteroid induced osteoporosis
6. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans
7. Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
8. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
9. Steroid hormone receptors: Many actors in search of a plot
10. Binding of sequence-specific proteins to the adenosine-plus uridine-rich sequences of the murine granulocyte-macrophage colony stimulating factor mRNA
11. Long-term glucocorticoid treatment of rheumatoid arthritis: Risk or benefit?
12. Prevention of glucocorticoid-induced osteoporosis
13. Corticoids in rheumatoid arthritis: How best to use them
14. The neuroendocrine immune basis of rheumatic diseases
15. Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine alone in early rheumatoid arthritis
16. Relationship between RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate
17. Plasma levels of IL-6, sIL-2R, TNFα and disease activity parameters after initial administration of prednisolone per os in patients with rheumatoid arthritis not previously treated with glucocorticoids
18. Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates
19. Glucocorticoid-mediated repression of cytokine gene transcription in human arthritis-SCID chimeras
20. Estrogen-induced alterations in the regulation of mineralocorticoid and glucocorticoid receptor messenger RNA expression in the female rat anterior pituitary gland and brain
21. A new hypothesis of modular glucocorticoid actions. Steroid treatment of rheumatic diseases revisited
22. Effect of glucocorticoid therapy on glucocorticoid receptors in patients with rheumatic diseases
23. MIF as a glucocorticoid-induced modulator of cytokine production
24. Adrenocortical function in prostate cancer patients: Effects of orchidectomy or different modes of estrogen treatment on basal levels and on the response to exogenous adrenocorticotropic hormone
25. The effects of hydrocortisone on in vitro lymphocyte proliferation and interleukin-2 and -4 production in corticosteroid sensitive and resistant subjects
26. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: Clinical implications
27. A mechanism for the anti-inflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion molecule I and intercellular adhesion molecule I
28. Acute suppression of circulating testosterone levels by cortisol in men
29. Androgen replacement therapy in males with rheumatoid arthritis
30. Relations between steroid hormones and cytokines in rheumatoid arthritis and systemic lupus erythematosus
31. Sex hormones and glucocorticoids: Interactions with the immune system
32. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin-2 and interleukin-4
33. Diurnal rhythm of salivary cortisol in patients with rheumatoid arthritis of recent onset
34. Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes
35. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages
36. Shift towards T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis
37. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: Acute and chronic effects
38. Sex differences in the sensitivity of the hypothalamic-pituitary-adrenal axis
39. A double-blind study of deflazacort and prednisone in patients with chronic inflammatory disorders
40. A randomized controlled trial of the effects of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis
41. Circadian variation in disease activity in rheumatoid arthritis
42. Plasma prednisolone studies in rheumatic diseases
43. Evidence that the β-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor
44. Effects of various estrogens on circulating androgens and cortisol during replacement therapy in post-menopausal women
45. Joint destruction after glucocorticoids are withdrawn in early RA
46. A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo
47. Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis
48. Response to glucocorticoid treatment in rheumatoid arthritis: In vitro cell mediated immune assay predicts in vivo response
49. Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychological stress in healthy young men
50. Arthritis and Rheumatism Councel Low-Dose Glucocorticoid Study Group: The effect of glucocorticosteroids on joint destruction in rheumatoid arthritis
51. Cortisol catabolism by lymphocytes of patients with systemic lupus erythematosus and rheumatoid arthritis
52. Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance
53. Clinical aspects of glucocorticoid sensitivity
54. Macrophage migration inhibitory factor in rheumatoid arthritis. Evidence of a proinflammatory function and regulation by glucocorticoids
55. Dilemmas of low dosage glucocorticoid treatment in rheumatoid arthritis: Considerations of timing
56. Perturbations of the hypothalamic pituitary gonadal axis in rheumatoid arthritis
57. Neuroendocrine, immunologic and vascular systems interactions in rheumatoid arthritis: Physiopathogenetic and therapeutic perspectives
58. Effects of retinol and dexamethasone on cytokine-mediated control of metalloproteinases and their inhibitors in human articular chondrocytes and synovial cells in culture
59. Inhibition of the production of pro-inflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis
60. Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock
61. Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids
62. Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis
63. Genomic organization and transcriptional regulation of the RANTES chemokine gene
64. Glucocorticoids and Th-1, Th-2 type cytokines in rheumatoid arthritis, asthma, atopic dermatitis and AIDS
65. Identification of mRNAs associated with programmed cell death in immature thymocytes
66. Negative transcriptional regulation of human interleukin-2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT
67. Corticosteroid use and peptic ulcer disease: Role of non-steroidal anti-inflammatory drugs
68. Autoantibodies to lipocortin-1 are associated with impaired glucocorticoid responsiveness in rheumatoid arthritis
69. Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro
70. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: Evidence for post-transcriptional regulation
71. Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-kappaB
72. Mechanisms of glucocorticoid receptor down-regulation by glucocorticoids
73. Low-dose long-term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse advents
74. Low-dose corticosteroids in rheumatoid arthritis: A meta-analysis of their moderate-term effectiveness
75. Evidence for anti-inflammatory effect of normal circulating plasma cortisol
76. Effects of glucocorticoids in rheumatoid arthritis. Diminished glucocorticoid receptors do not result in glucocorticoid resistance
77. Glucocorticoid receptors in rheumatoid arthritis
78. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis
79. The influence of gender and sex steroids on glucocorticoid response to interleukin-6 in humans
80. Immunology of systemic rheumatoid disease
81. Cyclooxygenase 1 and 2 in rheumatic disease: Implications for non-steroidal anti-inflammatory drug therapy
82. Risk of infectious complications in patients taking glucocorticoids
83. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression
84. Adjuvant oestrogen therapy does not improve disease activity in postmenopausal female patients with RA
85. Disease modifying properties of low dose corticosteroids. A double blind placebo controlled study in early rheumatoid arthritis
86. Oral steroids as bridge therapy in rheumatoid arthritis patients starting with parenteral gold. A randomized double blind placebo-controlled trial
87. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo
88. The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon γ and interleukin 4 production
89. The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial pre-optic area
90. Retinoic acid potentiates the inhibitory effects of dexamethasone on AP-1 DNA binding in epithelial cells
91. Corticosteroid pulse therapy in active rheumatoid arthritis
92. Cyclosporin A and glucocorticoids interact synergistically in T lymphocytes: Implications for asthma therapy
93. Inhibition of the NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase
94. Efficacy and safety of low dose prednisolone in early rheumatoid arthritis