Sex hormones and glucocorticoids: Interactions with the immune system

Annals of the New York Academy of Sciences

Volumn 876, Issue , 1999, Pages 102-118

  Da Silva, J A P ^a  

^a CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTROGEN; GLUCOCORTICOID; SEX HORMONE;

ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONFERENCE PAPER; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; NONHUMAN; PATHOGENESIS; SEX DIFFERENCE; T LYMPHOCYTE;

EID: 0032774277     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07628.x     Document Type: Conference Paper

References (78)

1. 1. MASI, A. T. 1994. Incidence of rheumatoid arthritis: Do the observed age-sex interaction patterns support a role of androgenic-anabolic (AA) steroid deficiency in its pathogenesis? Br. J. Rheumatol. 33: 697-699.
2. 2. SHERRER, Y. S. et al. 1987. Disability in rheumatoid arthritis: Comparison of prognostic factors across three populations. J. Rheumatol. 14: 705-709.
3. 3. DA SILVA, J. A. P. & G. M. HALL. 1992. The effects of gender and sex hormones on outcome in rheumatoid arthritis. Bailliere's Clin. Rheumatol. 6: 193-219.
4. 4. HALL, G. M. et al. 1994. A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis. Ann. Rheum. Dis. 53: 112-115.
5. 5. SPECTOR, T. D. & J. A. P. DA SILVA. 1992. Pregnancy and rheumatoid arthritis: An overview. Am. J. Reprod. Immunol. 28: 222-225.
6. 6. MASI, A. T., J. A. P. DA SILVA & M. CUTOLO. 1996. Perturbations of hypothalamic-pituitary-gonadal (HPG) axis and adrenal androgens (AA) functions in rheumatoid arthritis. Bailliere's Clin. Rheumatol. 10: 295-332.
7. 7. HALL, G. M. et al. 1996. A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br. J. Rheumatol. 35: 568-573.
8. 8. BIJLSMA, J. W. J. 1998. Do sex hormones modulate symptoms of inflammatory joint disease? Scand. J. Rheumatol. 27 (Suppl. 107): 60-62.
9. 9. PETRI, M. & C. ROBINSON. 1997. Oral contraceptives and systemic lupus erythematosus. Arthritis Rheum. 41: 797-803.
10. 10. VAN VOLLENHOVEN, R. F. et al. 1998. Treatment of SLE with DHEA: 50 patients treated up to 12 months. J. Rheumatol. 25: 285-289.
11. 11. ANSAR AHMED, S. & N. TALAL. 1990. Sex hormones and the immune system - part 2. Animal data. Bailliere's Clin. Rheumatol. 4: 13-31.
12. 12. DA SILVA, J. A. P. et al. 1994. Sex differences in inflammation induced cartilage damage in rodents. The influence of sex steroids. J. Rheumatol. 21: 330-337.
13. 13. WILDER, R. L. 1995. Neuroendocrine-immune system interactions and autoimmunity. Annu. Rev. Immunol. 13: 307-338.
14. 14. DA SILVA, J. A. P. 1995. Sex hormones, glucocorticoids and autoimmunity: Facts and hypotheses. Ann. Rheum. Dis. 54: 6-16.
15. 15. ALLEN, J. B. et al. 1983. Sex hormonal effects on the severity of streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 26: 560-563.
16. 16. OKAYASU, I., Y. M. KONG & N. R. ROSE. 1981. Effect of castration and sex hormones on experimental autoimmune thyroiditis. Clin. Immunol. Immunopathol. 20: 240-245.
17. 17. CARLSTEN, H. et al. 1992. Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialoadenitis in autoimmune MRS 1pr/1pr mice. Cell. Immunol. 144: 190-202.
18. 18. OLSEN, N. J. & W. J. KOVACS. 1996. Gonadal steroids and immunity. Endocr. Rev. 17: 369-384.
19. 19. HOMO-DELARCHE, F. et al. 1991. Sex steroids, glucocorticoids and autoimmunity. J. Steroid Biochem. Mol. Biol. 40: 619-637.
20. 20. TORPY, D. J. & G. P. CHROUSOS. 1996. The three-way interactions between the hypothalamic-pituitary-adrenal and gonadal axes and the immune system. Bailliere's Clin. Rheumatol. 10: 181-198.
21. 21. STERNBERG, E. M. et al. 1989. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis susceptible Lewis rats. Proc. Natl. Acad. Sci. USA 86: 2374-2378.
22. 22. STERNBERG, E. M. et al. 1989. A central nervous system defect in corticotropin releasing hormone biosynthesis is associated with susceptibility to streptococcal cell wall arthritis in Lewis rats. Proc. Natl. Acad. Sci. USA 86: 4771-4775.
23. 23. CHIKANZA, I. C. et al. 1992. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum. 35: 1281-1288.
24. 24. CASH, J. M. et al. 1992. Pituitary-adrenal axis responsiveness to ovine corticotropine releasing hormone in patients with rheumatoid arthritis treated with low dose prednisone. J. Rheumatol. 19: 1692-1696.
25. 25. NEECK, G. et al. 1990. Adrenal secretion of cortisol in patients with rheumatoid arthritis. J. Rheumatol. 17: 24-29.
26. 26. CROFFORD, L. J. et al. 1997. Circadian relationship between IL-6 and hypothalamus-pituitary-adrenocortical axis hormones: Failure to IL-6 to cause hypercorticalism in patients with early untreated rheumatoid arthritis. J. Clin. Endocrinol. Metab. 82: 1279-1283.
27. 27. GUDBJORNSSON, B. et al. 1996. Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids. J. Rheumatol. 23: 1596-6012.
28. 28. LE MEVEL, J. C. et al. 1978. Dynamic changes in plasma adrenocorticotropin after neurotropic stress in male and female rats. J. Endocrinol. 76: 359-360.
29. 29. KANT, G. J. et al. 1983. Comparison of stress response in male and female rats: Pituitary cyclic AMP and plasma prolactin, growth hormone and corticosterone. Psychoneuroendocrinology 8: 421-428.
30. 30. CHISARI, A. et al. 1995. Sex and strain variability in the rat hypothalamic-pituitary adrenal axis function. J. Endocrinol. Invest. 18: 25-33.
31. 31. DA SILVA, J. A. P. et al. 1993. Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. J. Endocrinol. 136: 389-397.
32. 32. VIAU, V. & M. J. MEANEY. 1991. Individual differences in the hypothalamic-pituitary-adrenal response to stress: Relationship to testosterone. Soc. Neurosci. Abstr. 17: 542.
33. 33. Handa, R. J. et al. 1994. Androgen regulation of adrenocorticotropin and corticosterone secretion in the male following novelty and foot shock stressors. Physiol. Behav. 55: 117-124.
34. 34. VIAU, V. & M. J. MEANEY. 1996. The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area. J. Neurosci. 16: 1866-1876.
35. 35. WILDER, R. L. 1996. Adrenal and gonadal steroid hormone deficiency in the etiopathogenesis of rheumatoid arthritis. J. Rheumatol. 23 (Suppl. 44): 10-12.
36. 36. VIAU, V. & M. J. MEANEY. 1991. Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat. Endocrinology 129: 2503-2511.
37. 37. BURGESS, L. H. & R. J. HANDA. 1992. Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats. Endocrinology 131: 1261-1269.
38. 38. CAREY, M. P. et al. 1995. The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J. Endocrinol. 144: 311-321.
39. 39. GENAZZANI, A. R. et al. 1975. Pattern of plasma ACTH, hGH and cortisol during the menstrual cycle. J. Clin. Endocrinol. Metab. 41: 431-437.
40. 40. NOLTON, W. E. & P. A. RUECKERT. 1981. Elevated free cortisol index in pregnancy. Possible regulatory mechanism. Am. J. Obstet. Gynecol. 139: 492-498.
41. 41. HELGASON, S. et al. 1981. Effects of various estrogens on circulating androgens and cortisol during replacement therapy in post-menopausal women. Maturitas 3: 301-308.
42. 42. ZACHMAN, M. et al. 1984. Influence of estrogen in high and low doses on plasma steroid concentrations in girls with tall stature and Turner syndrome. Acta Endocrinol. 106: 368-373.
43. 43. CARLSTROM, K. & R. STEGE. 1990. Adrenocortical function in prostatic cancer patients: Effects of orchidectomy or different modes of estrogen treatment on basal steroid levels and on the response to exogenous adrenocorticotropic hormone. Urol. Int. 45: 160-163.
44. 44. POLDERMAN, K. H., L. J. G. GOOREN & E. A. VAN DER VEEN. 1995. Effects of gonadal androgens and oestrogens on adrenal androgen levels. Clin. Endocrinol. 43: 415-421.
45. 45. DE WEERDT, O. & L. J. GOOREN. 1992. Patterns of serum cortisol levels in ovariectomized females with and without androgen administration. Horm. Metab. Res. 24: 82-84.
46. 46. ORTH, D. N., W. J. KOVACS & C. R. DEBOLD. 1992. The Adrenal Cortex. In Williams Textbook of Endocrinology, 8th edit. Wilson & D. W. Foster, Eds.: 489-619. W. B. Saunders Co. London.
47. 47. GALLUCCI, W. T. et al. 1993. Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis. Health Psychol. 12: 420-425.
48. 48. WALTMAN, C. et al. 1991. Spontaneous and glucocorticoid-inhibited adrenocorticotropic hormone and cortisol secretion are similar in healthy young and old men. J. Clin. Endocrinol. Metab. 73: 495-502.
49. 49. RABIN, D. et al. 1990. Hypothalamic-pituitary-adrenal function in patients with the premenstrual syndrome. J. Clin. Endocrinol. Metab. 71: 1158-1162.
50. 50. WATTS, A. G. & L. W. SWANSON. 1989. Diurnal variations in the content of preprocorticotropin-releasing hormone messenger ribonucleic acids in the hypothalamic paraventricular nucleus of rats of both sexes as measured by in situ hybridization. Endocrinology 125: 1734-1738.
51. 51. FREDERICKSEN, S. O. et al. 1991. Reduced concentrations of galanin, arginin vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizophrenics. Acta Psychiatr. Scand. 83: 273-277.
52. 52. BOHLER, H. C. L., JR. et al. 1990. Corticotropin releasing hormone mRNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nuclei of the female rat. Mol. Brain Res. 8: 259-262.
53. 53. VIAU, V. & M. J. MEANEY. 1992. Regulation of ACTH co-secretagogues during the estrous cycle in the rat. Soc. Neurosci. Abstr. 18: 643.
54. 54. ALMEIDA, O. F. X. et al. 1992. Hypothalamic corticotropin releasing hormone and opioid peptide neurons: Functional changes after adrenalectomy and/or castration. Brain Res. 571: 189-198.
55. 55. BINGAMAN, E. W. et al. 1994. Androgen inhibits the increases in hypothalamic corticotropin releasing hormone (CRH) and CRH immunoreactivity following gonadectomy. Neuroendocrinology 59: 228-234.
56. 56. SIMERLY, R. B. et al. 1990. Distribution of androgen and estrogen receptor mRNA containing cells in the rat brain. J. Comp. Neurol. 294: 76-95.
57. 57. VAMVAKOPOULOS, N. & G. P. CHROUSOS. 1993. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. J. Clin. Invest. 92: 1896-1902.
58. 58. BINGAMAN, E. W. et al. 1994. Localization of androgen receptor within peptidergic neurons of the rat forebrain. Brain Res. Bull. 35: 379-382.
59. 59. BURGESS, L. H. & R. J. HANDA. 1993. Estrogen-induced alterations in the regulation of mineralocorticoid and glucocorticoid messenger RNA expression in the female rat anterior pituitary gland and brain. Mol. Cell. Neurosci. 4: 191-198.
60. 60. TURNER, B. B. 1992. Sex differences in the binding of type I and type II corticosteroid receptors in rat hippocampus. Brain Res. 581: 229-236.
61. 61. CAREY, M. P. et al. 1995. The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J. Endocrinol. 144: 311-321.
62. 62. KERR, J. E. et al. 1993. Localization and hormonal regulation of androgen receptor and c-fos gene expression in the rat hippocampus. Soc. Neurosci. Abstr. 19: 820.
63. 63. CHROUSOS, G. P. 1992. Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. The corticotropin-releasing hormone perspective. Endocrinol. Metab. Clin. North Am. 21: 833-858.
64. 64. KARALIS, K. et al. 1995. Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease susceptible Lewis rats and inflammatory-resistant Fischer rats. Endocrinology 136: 3107-3112.
65. 65. CROFFORD, L. J. et al. 1993. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. J. Immunol. 141: 1-10.
66. 66. OTTEN, A. D., M. M. SANDERS & G. S. MCKNIGHT. 1988. The MMTV LTR promoter is induced by progesterone and dihydrotestosterone but not by estrogen. Mol. Endocrinol. 2: 143-147.
67. 67. BRINKMANN, A. O. et al. 1989. The human androgen receptor: Domain structure, genomic organization and regulation of expression. J. Steroid Biochem. 34: 307-310.
68. 68. SUGINO, N., C. M. TELLERIA & G. GIBORI. 1997. Progesterone inhibits 20α-hydroxysteroid dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor. Endocrinology 138: 4497-4500.
69. 69. VAMVAKOPOULOS, N. C. 1993. Tissue-specific expression of heat shock proteins 70 and 90. Potential implication for differential sensitivity of tissues to glucocorticoids. Mol. Cell. Endocrinol. 98: 49-54.
70. 70. RAMACHANDRAN, C. et al. 1988. Estrogenic regulation of uterine 90-kilodalton heat shock protein. Endocrinology 123: 956-961.
71. 71. BEATO, M. et al. 1989. DNA regulatory elements for steroid hormones. J. Steroid Biochem. 32: 737-747.
72. 72. CLAESSENS, F. et al. 1996. The androgen-specific probasin response element 2 interacts differentially with androgens and glucocorticoid receptors. J. Biol. Chem. 271: 19013-19016.
73. 73. CELIS, L. et al. 1993. Proteins interacting with an androgen-responsive unit in the C3(1) gene intron. Mol. Cell. Endocrinol. 94: 165-172.
74. 74. GRILLI, M., J. J. CHIU & M. J. LENARDO. 1993. NF-kB and Rel: Participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143: 1-62.
75. 75. DIDONATO, J. A., F. SAATCIOGLU & M. KARIN. 1996. Molecular mechanisms of immunosuppression and anti-inflammatory activities of glucocorticoids. Am. J. Respir. Care Med. 254: S11-S15.
76. 76. GALIEN, R. & T. GARCIA. 1997. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kB site. Nucleic Acids Res. 25: 2424-2429.
77. 77. SATO, N. et al. 1997. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-jun in the human prostate cancer cell line LNCaP. J. Biol. Chem. 272: 17485-17494.
78. 78. GRIFFIN, A. C. & C. C. WHITACRE. 1991. Sex and strain differences in the circadian rhythm fluctuation of endocrine and immune function in the rat: Implications for rodent models of autoimmune disease. J. Neuroimmunol. 35: 53-64.