DNA repair mechanisms and acute myeloblastic leukemia

Hematological Oncology

Volumn 18, Issue 3, 2000, Pages 99-110

  Das Gupta, E P ^a   Seedhouse, C H ^a   Russell, N H ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Acute myeloblastic leukemia; Base excision repair; Double strand break repair; Microsatellite instability; Mismatch repair; Nucleotide excision repair

Indexed keywords

ACUTE MYELOBLASTIC LEUKEMIA; BASE MISPAIRING; DISEASE COURSE; DNA REPAIR; EXCISION REPAIR; MICROSATELLITE INSTABILITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 0033760782     PISSN: 02780232     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1069(200009)18:3<99::AID-HON662>3.0.CO;2-Z     Document Type: Review

References (67)

1. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
2. Deletion of a DNA polymerase β gene segment in T cells using type-specific gene targeting
3. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
4. Alkyl-purine-DNA-N-Glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate
5. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
6. Mutations in OGG1, a gene involved in the repair of oxidative damage, are found in human lung and kidney tumours
7. The roles of the eukaryotic DNA polymerases in DNA repair synthesis
8. Requirement of mammalian DNA polymerase-β in base excision repair
9. Mammalian nucleotide excision repair
10. Nucleotide excision repair in mammalian cells
11. Transcription-coupled repair and human disease
12. Molecular genetics and Fanconi anaemia: New insights into old problems
13. Is Fanconi anemia caused by a defect in the processing of DNA damage?
14. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
15. Leukemia patient-derived lymphoblastoid cell lines exhibit increased induction of leukemia-associated transcripts following high-does irradiation
16. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
17. Mechanisms and biological effects of mismatch repair
18. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction
19. Recognition of DNA alterations by the mismatch repair system
20. Purified human MSH2 protein binds to DNA containing mismatched nucleotides
21. Cloning and expression analysis of a meiosis-specific mutS homologue - The human MSH4 gene
22. hMSH5: A human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis
23. MutS homologues in mammalian cells
24. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
25. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
26. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
27. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
28. Mutation of a mutL homologue in hereditary colon cancer
29. Mismatch repair defects in human carcinogenesis
30. Microsatellite instability: Marker of a mutator phenotype in cancer
31. Microsatellite instability is associated with tumors that characterise the hereditary non-polyposis colorectal carcinoma syndrome
32. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
33. Semiautomated assessment of loss of heterozygosity and replication error in tumors
34. Microsatellite instability analysis: A multicentre study for reliability and quality control
35. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
36. Mismatch repair deficiencey leads to a unique model of colorectal tumorigenesis characterised by intratumoral heterogeneity
37. Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer
38. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
39. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
40. DNA mismatch repair and cancer
41. Mutations and loss of expression of a mismatch repair gene, hMLH1 in leukemia and lymphoma cell lines
42. Mutator phenotypes of common polymorphisms and missense mutations in MSH2
43. Rarity of microsatellite alterations in acute myeloid leukemia
44. Infrequent microsatellite instability during the evolution of myelodysplastic syndrome to acute myelocytic leukemia
45. Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype
46. Microsatellite instability and p53 mutations are associated with abnormal expression of the MSH2 gene in adult acute leukemia
47. Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to the replication error phenotype
48. Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer
49. Mismatch repair deficiency in phenotypically normal human cells
50. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
51. Microsatellite instability and mutations of the transforming-growth-factor-beta type II receptor gene in colorectal-cancer
52. Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells
53. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
54. APC mutations in colorectal tumors with mismatch repair deficiency
55. PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases
56. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency
57. Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium
58. Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines
59. Colorectal cancer with and without microsatellite instability involves different genes
60. BAX frameshift mutations in cell lines derived from haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability
61. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX
62. Mutations of the E2F4 gene in haematological malignancies having microsatellite instability
63. p53 in hematologic malignancies
64. The clinical significance of mutations of the P53 tumour suppressor gene in haematological malignancies
65. Role of postreplicative DNA mismatch re[air in the cytotoxic action of thioguanine
66. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells
67. Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian cell line