Mismatch repair deficiency leads to a unique mode of colorectal tumorigenesis characterized by intratumoral heterogeneity

Oncogene

Volumn 16, Issue 10, 1998, Pages 1259-1265

  Habano, Wataru ^a   Sugai, Tamotsu ^a   Nakamura, Shin Ichi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Intratumoral heterogeneity; Mismatch repair gene; Subpopulation analysis

Indexed keywords

CELL DNA; PROTEIN P53;

ALLELE; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; FEMALE; GENE MUTATION; GERM LINE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0032510416     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201651     Document Type: Article

References (44)

1. Aaltonen LA, Peltomäki P, Leach FS, Sistonen P, Pylkkänen L, Mecklin J-P, Järvinen L, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B and de la Chapelle A. (1993). Science, 260, 812-816.
2. Bocker T, Schlegel J, Kullmann F, Stumm G, Zirngibl H, Epplen JT and Rüschoff J. (1996). J. Pathol., 179, 15-19.
3. Boland CR, Sato J, Appelman HD, Bresalier R and Feinberg AP. (1995). Nature Med., 1, 902-909.
4. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A, Tannergard P, Bollag RJ, Godwin AR, Ward DC, Nordenskjøld M, Fishel R, Kolodner R and Liskay RM. (1994). Nature, 368, 258-261.
5. Cawkwell L, Bell SM, Lewis FA, Dixon MF, Taylor GR and Quirke P. (1993). Br. J. Cancer, 67, 1262-1267.
6. Cawkwell L, Lewis FA and Quirke P. (1994). Br. J. Cancer, 70, 813-818.
7. Endo Y, Sugimura H and Kino I. (1995). Pathol. Int., 45, 602-604.
8. Eshleman JR and Markowitz SD. (1996). Hum. Mol. Genet., 5, 1489-1494.
9. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M and Kolodner R. (1993). Cell, 75, 1027-1038.
10. Griffiths DFR, Davies SJ, Williams D, Williams GT and Williams ED. (1988). Nature, 333, 461-463.
11. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M and Weissenbach J. (1994). Nature Genet., 7, 246-339.
12. Habano W, Sugai T, Nakamura S and Yoshida T. (1996). Lab. Invest., 74, 933-940.
13. Hahn M, Matzen SE, Serth J and Pingoud A. (1995). Bio. Techniques, 18, 1040-1047.
14. Han H-J, Maruyama M, Baba S, Park J-G and Nakamura Y. (1995). Hum. Mol. Genet., 4, 237-242.
15. Hemminki A, Peltomäki P, Mecklin J-P, Järvinen H, Salovaara R, Nyström-Lahti M, de la Chapelle A and Aaltonen LA. (1994). Nature Genet., 8, 405-410.
16. Ionov Y, Peinado MA, Malkhosyan S, Shibata D and Perucho M. (1993). Nature, 363, 558-561.
17. Jacoby RF, Marshall DJ, Kailas S, Schlack S, Harms B and Love R. (1995). Gastroenterology, 109, 73-82.
18. Kim H, Jen J, Vogelstein B and Hamilton SR. (1994). Am. J. Pathol., 145, 148-156.
19. Knudson Jr AG. (1971). Proc. Nat. Acad. Sci. USA, 68, 820-823.
20. Kobayashi M, Kawashima A, Mai M and Ooi A. (1996). Am. J. Pathol., 149, 1575-1584.
21. Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M, Ushiro K, Chiba M, Nomizu S, Konishi F, Utsunomiya J and Miyaki M. (1996). Gastroenterology, 111, 307-317.
22. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nyström-Lahti M, Guan X-Y, Zhang J, Meltzer PS, Yu J-W, Kao F-T, Chen D-J, Cerosaletti KM, Fournier REK, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin J-P, Jârvinen H, Petersen GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, de la Chapelle A, Kinzler KW and Vogelstein B. (1993). Cell, 75, 1215-1225.
23. Liu B, Parsons RE, Hamilton SR, Petersen GM, Lynch HT, Watson P, Markowitz S, Willson JKV, Green J, de la Chapelle A, Kinzler KW and Vogelstein B. (1994). Cancer Res., 34, 4590-4594.
24. Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopoulos N, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW and Vogelstein B. (1995). Nature Genet., 9, 48-55.
25. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nyström-Lahti M, Pylkkänen L, Heimdal K, Andersen TI, Moller P, Rognum TO, Fosså SD, Haldorsen T, Langmark F, Brogger A, de la Chapelle A and Børresen A-L. (1993). Cancer Res., 53, 5849-5852.
26. Lu S-L, Akiyama Y, Nagasaki H, Nomizu T, Ikeda E, Baba S, Ushiro K, Iwama T, Maruyama K and Yuasa Y. (1996). Jpn. J. Cancer Res., 87, 279-287.
27. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M and Willson JKV. (1995). Science, 268, 1336-1338.
28. Moslein G, Tester DJ, Lindor NM, Honchel R, Cunningham JM, French AJ, Halling KC, Schwab M, Goretzki P and Thibodeau SN. (1996). Hum. Mol. Genet., 5, 1245-1252.
29. Nakamura S, Kino I and Baba S. (1993). Gut, 34, 1240-1244.
30. Nakamura S, Goto J, Kitayama M and Kino I. (1994). Gastroenterology, 106, 100-107.
31. Nicolaides NC, Papadopoulos N, Liu B, Wei Y-F, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, de la Chapelle A, Vogelstein B and Kinzler KW. (1994). Nature, 371, 75-80.
32. Pan LX, Diss TC and Isaacson PG. (1995). Histopathology, 26, 201-217.
33. Papadopoulos N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomâki P, Mecklin J-P, de la Chapelle A, Kinzler KW and Vogelstein B. (1994). Science, 263, 1625-1629.
34. Parsons R, Li G-M, Longley MJ, Fang W, Papadopoulos N, Jen J, de la Chapelle A, Kinzler KW, Vogelstein B and Modrich P. (1993). Cell, 75, 1227-1236.
35. Parsons R, Myeroff LL, Liu B, Willson JKV, Markowitz SD, Kinzler KW and Vogelstein B. (1995). Cancer Res., 55, 5548-5550.
36. Risinger JI, Umar A, Boyd J, Berchuck A, Kunkel TA and Barrett JC. (1996). Nature Genet., 14, 102-105.
37. Rüschoff J, Bocker T, Schlegel J, Stumm G and Hofstaedter F. (1995). Virchows Arch., 426, 215-222.
38. Sasaki K, Hashimoto T, Kawachino K, Takahashi M. (1988). Cancer, 62, 2569-2575.
39. Sauter G, Deng G, Moch H, Kerschmann R, Matsumura K, De Vries S, George T, Fuentes J, Carroll P, Mihatsch MJ and Waldman FM. (1994). Am. J. Pathol., 144, 756-766.
40. Thibodeau SN, Bren G and Schaid D. (1993). Science, 260, 816-819.
41. Tomlinson IPM, Ilyas M and Bodmer WF. (1996). Br. J. Cancer, 74, 1514-1517.
42. Vasen HFA, Mecklin J-P, Meera Khan P and Lynch HT. (1991). Dis. Colon Rect., 34, 424-425.
43. Yoshida T, Nakamura S and Sugai T. (1996). J. Surg. Oncol., 63, 9-16.
44. Young J, Searle J, Buttenshaw R, Thomas L, Ward M, Chenevix-Trench G and Leggett B. (1995). Genes Chromosom. Cancer, 12, 251-254.