Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections

Annual Review of Medicine

Volumn 49, Issue , 1998, Pages 275-287

  Skamene, Emil ^a   Schurr, Erwin ^a,b   Gros, Philippe ^a,b  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Genetic control; Host resistance; Human generics; Leprosy; Macrophage protein; Mycobacteria; Tuberculosis

Indexed keywords

ANIMAL CELL; DISEASE PREDISPOSITION; EPIDEMIC; GENE ISOLATION; GENETIC LINKAGE; HOST RESISTANCE; INFECTION RESISTANCE; LEISHMANIA; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SALMONELLA; TUBERCULOSIS;

ALLELES; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL INFECTIONS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DISEASE OUTBREAKS; DISEASE SUSCEPTIBILITY; GENETIC PREDISPOSITION TO DISEASE; GENOME, BACTERIAL; GENOME, HUMAN; GENOME, PROTOZOAN; HUMANS; IMMUNITY, NATURAL; LEISHMANIASIS; LEPROSTATIC AGENTS; LEPROSY; LINKAGE (GENETICS); MACROPHAGES; MEMBRANE PROTEINS; MICE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; SALMONELLA INFECTIONS; TUBERCULOSIS; WORLD HEALTH;

EID: 0031958788     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.49.1.275     Document Type: Review

References (18)

1. Malo D, Skamene E. 1994. Genetic control of host resistance to infection. Trends Genet. 10:365-81
2. McLeod R, Buschman E, Arbuckle LD, Skamene E. 1995. Immunogenetics in the analysis of resistance to intracellular pathogens. Curr. Opin. Immunol. 7: 539-52
3. Weatherall DJ. 1996. Host genetics and infectious disease. Parasitology 112: S23-29
4. Blackwell JM. 1996. Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology 112:567-74
5. Lander ES, Schork NJ. 1994. Genetic dissection of complex traits. Science 265: 2037-48
6. Stead WW, Senner JW, Reddick WT, Lofgren JP. 1990. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N. Engl. J. Med. 322: 422-27
7. Stead WW. 1992. Genetics and resistance to tuberculosis. Could resistance be enhanced by genetic engineering? Ann. Intern. Med. 116:937-41
8. Comstock GW. 1978. Tuberculosis in twins: a re-analysis of the Prophit survey. Am. Rev. Respir. Dis. 117:621-24
9. Schurr E, Morgan K, Gros P, Skamene E. 1991. Genetics of leprosy. Am. J. Trop. Med. Hyg. 44(Suppl.):4-11
10. Hill AVS. 1996. Genetics of infectious disease resistance. Curr. Opin. Genet. Dev. 6:348-53
11. Hill AVS. 1996. Genetic susceptibility to malaria and tuberculosis: genetic susceptibility and complex traits. 4th Int. Nature Genet. Conf. Genet. Susceptibility Complex Traits, Vancouver, BC
12. Newport MJ, Huxley CM, Huston S, et al. 1996. A mutation in the interferon-g-receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335: 1941-49
13. Jouanguy E, Lamhamedi S, Emile J-F, et al. 1996. Interferon-g-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N. Engl. J. Med. 335: 1956-61
14. Kamijo R, Le J, Shapiro D, et al. 1993. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with bacillus Calmette-Guérin and subsequent challenge with lipoolysaccharide. J. Exp. Med. 178: 1435-40
15. Schurr E, Skamene E. 1996. The role of the Bcg gene in mycobacterial infections. In Tuberculosis, ed. WN Rom, SM Garay, pp. 247-58. New York: Little, Brown
16. Gros P, Skamene E, Forget A. 1981. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127:2417-21
17. Skamene E, Gros P, Forget A, et al. 1982. Genetic regulation of resistance to intracellular pathogens. Nature 297:506-9
18. Gros P, Skamene E, Forget A. 1983. Cellular mechanisms of genetically-controlled host resistance to Mycobacterium bovis (BCG). J. Immunol. 131: 1966-73