Signal transduction and transcriptional and posttranscriptional control of iron-regulated genes in bacteria

Microbiology and Molecular Biology Reviews

Volumn 61, Issue 3, 1997, Pages 319-336

  Crosa, Jorge H ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; OUTER MEMBRANE PROTEIN;

BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; ESCHERICHIA COLI; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; IRON METABOLISM; NONHUMAN; PSEUDOMONAS; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIBRIO CHOLERAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LISTONELLA ANGUILLARUM; NEGIBACTERIA; PSEUDOMONAS; VIBRIO CHOLERAE;

EID: 0031407137     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/.61.3.319-336.1997     Document Type: Review

References (179)

1. Actis, L. A., W. Fish, J. H. Crosa, K. Kellerman, S. Ellenberger, F. Hauser, and J. Sanders-Loher. 1986. Characterization of anguibactin, a novel siderophore from Vibrio anguillarum 775(pJM1). J. Bacteriol. 167:57-65.
2. Actis, L. A., S. Potter, and J. H. Crosa. 1985. Iron-regulated outer membrane protein OM2 of Vibrio anguillarum is encoded by virulence plasmid pJM1. J. Bacteriol. 161:736-742.
3. Actis, L. A., M. E. Tolmasky, L. M. Crosa, and J. H. Crosa. 1995. Characterization and expression of FatB, an iron transport protein encoded by the pJM1 virulence plasmid. Mol. Microbiol. 17:197-204.
4. Actis, L. A., M. E. Tolmasky, D. Farrell, and J. H. Crosa. 1988. Genetic and molecular characterization of essential components of the Vibrio anguillarum plasmid-mediated iron transport system. J. Biol. Chem. 263:2853-2860.
5. Agre, P., P. Johnson, and S. McKnight. 1989. Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. Science 246:922-925.
6. Albright, L. M., E. Huala, and F. Ausubel. 1989. Procaryotic signal transduction mediated by sensor and regulator protein pairs. Annu. Rev. Genet. 23:311-336.
7. 70-type factors that respond to extracytoplasmic stimuli. Mol. Microbiol. 18:163-174.
8. Ankenbauer, R. S., and H. N. Quan. 1994. FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa: a phenolate siderophore receptor homologous to hydroxamate siderophore receptors. J. Bacteriol. 176:307-319.
9. Baggs, A., and J. B. Neilands. 1987. Ferric uptake regulation protein acts as a repressor, employing iron(II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli. Biochemistry 26:5471-5477.
10. Barton, H. A., Z. Johnson, C. D. Cox, A. I. Vasil, and M. L. Vasil. 1996. Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Mol. Microbiol. 21: 1001-1017.
11. Berish, S. A., S. Subbarao, C. Y. Chen, D. L. Trees, and S. A. Morse. 1993. Identification and cloning of a fur homolog from Neisseria gonorrhoeae. Infect. Immun. 61:4599-4606.
12. Bitter, W., J. D. Marugg, L. A. de Wager, J. Tommassen, and P. J. Weisbeek. 1991. The ferric pseudobactin receptor PupA of Pseudomonas putida WCS358: homology to TonB-dependent Escherichia coli receptors and specificity of the protein. Mol. Microbiol. 5:647-655.
13. Bitter, W., J. Tommassen, and P. J. Weisbeek. 1993. Identification and characterization of the exbB, exbD, and tonB genes of Pseudomonas putida WCS358: their involvement in ferric-pseudobactin transport. Mol. Microbiol. 7:117-130.
14. Boyd, J., M. N. Oso, and J. R. Murphy. 1990. Molecular cloning and DNA sequence analysis of a diphtheria toxin iron-dependent regulatory element (dtxR) from Corynebacterium diphtheriae. Proc. Natl. Acad. Sci. USA 87: 5968-5972.
15. Braun, V. 1995. Energy-coupled transport and signal transduction through the Gram-negative outer membrane via TonB-ExbB-ExbD-dependent receptor proteins. FEMS Microbiol. Rev. 16:295-307.
16. Brennan, R. G., L. H. Weaver, and B. W. Matthews. 1986. Use of protein sequence and structure to infer distant evolutionary relationships. Chem. Scripta 26B:251-255.
17. Brickman, T. J., and S. K. Armstrong. 1995. Bordetella pertussis fur gene restores iron repressibility of siderophore and protein expression to deregulated Bordetella bronchiseptica mutants. J. Bacteriol. 177:268-270.
18. Brickman, T. J., B. A. Ozenberger, and M. A. McIntosh. 1990. Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli. J. Mol. Biol. 212:669-682.
19. Bullen, J. J., H. J. Rogers, and E. Griffiths. 1978. Role of iron in bacterial infections. Curr. Top. Microbiol. Immunol. 80:1-35.
20. Butterton, J. R., J. A. Stoebner, S. M. Payne, and S. B. Calderwood. 1992. Cloning, sequencing, and transcriptional regulation of viuA, the gene encoding the ferric vibriobactin receptor of Vibrio cholerae. J. Bacteriol. 174: 3729-3738.
21. Calderwood, S. B., and J. J. Mekalanos. 1988. Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operator fusion plasmid. J. Bacteriol. 170:1015-1017.
22. 21a. Chai, S., and J. H. Crosa. Unpublished data.
23. Chakerian, A., V. Tesmer, S. Manly, J. Brackett, M. Lynch, J. Hoh, and K. Matthews. 1991. Evidence for a leucine zipper motif in lactose repressor protein. J. Biol. Chem. 266:1371-1374.
24. Champomier-Verges, M. C., A. Stintzi, and J. M. Meyer. 1996. Acquisition of iron by the non-siderophore-producing Pseudomonas fragi. Microbiology 142:1191-1199.
25. Chen, Q., L. A. Actis, M. E. Tolmasky, and J. H. Crosa. 1994. Chromosome-mediated 2,3-dihydroxybenzoic acid is a precursor in the biosynthesis of the plasmid-mediated siderophore anguibactin in Vibrio anguillarum. J. Bacteriol. 176:4226-4234.
26. Chen, Q., and J. H. Crosa. 1996. Antisense RNA, Fur, iron and the regulation of iron transport genes in Vibrio anguillarum. J. Biol. Chem. 271: 18885-18891.
27. Chen, Q., A. M. Wertheimer, M. E. Tolmasky, and J. H. Crosa. 1996. The AngR protein and the siderophore anguibactin positively regulate the expression of iron-transport genes in Vibrio anguillarum. Mol. Microbiol. 22:127-134.
28. Chou, P. Y., and G. D. Fasman. 1978. Empirical predictions of protein conformation. Annu. Rev. Biochem. 47:251-276.
29. Cox, C. D. 1980. Iron uptake with ferric pyochelin and ferric citrate by Pseudomonas aeruginosa. J. Bacteriol. 142:581-587.
30. Cox, C. D. 1982. Effect of pyochelin on the virulence of Pseudomonas aeruginosa. Infect. Immun. 36:17-23.
31. Cox, C. D., K. L. Rinehart, M. L. Moore, and J. C. Cook. 1981. Pyochelin: novel structure of an iron chelating growth promoter for Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 78:4256-4260.
32. Crosa, J. H. 1980. A plasmid associated with virulence in the marine fish pathogen Vibrio anguillarum specifies an iron-sequestering system. Nature 284:566-568.
33. Crosa, J. H. 1984. The relationship of plasmid-mediated iron transport and bacterial virulence. Annu. Rev. Microbiol. 38:69-89.
34. Crosa, J. H. 1989. Genetics and molecular biology of siderophore-mediated iron transport in bacteria. Microbiol. Rev. 53:517-530.
35. Crosa, J. H., L. Hodges, and M. Schiewe. 1980. Curing of a plasmid is correlated with an attenuation of virulence in the marine fish pathogen Vibrio anguillarum. Infect. Immun. 27:897-902.
36. Cunliffe, H. E., T. R. Merriman, and I. L. Lamont. 1995. Cloning and characterization of pvdS, a gene required for pyoverdin synthesis in Pseudomonas aeruginosa: PvdS is probably an alternative sigma factor. J. Bacteriol. 177:2744-2750.
37. Dean, C. R., and K. Poole. 1993. Cloning and characterization of the ferric enterobactin receptor gene (pfeA) of Pseudomonas aeruginosa. J. Bacteriol. 175:317-324.
38. Dean, C. R., and K. Poole. 1993. Expression of the ferric enterobactin receptor (PfeA) of Pseudomonas aeruginosa: involvement of a two-component regulatory system. Mol. Microbiol. 8:1095-1103.
39. Dean, C. R., S. Neshat, and K. Poole. 1996. PfeR, an enterobactin-responsive activator of ferric enterobactin receptor gene expression in Pseudomonas aeruginosa. J. Bacteriol. 178:5361-5369.
40. de Lorenzo, V., F. Giovannini, M. Herrero, and J. B. Neilands. 1988. Metal ion regulation of gene expression. Fur repressor-operator interaction at the promoter region of the aerobactin system of pColV-K30. J. Mol. Biol. 203:875-884.
41. de Lorenzo, V., F. Giovannini, M. Herrero, and J. B. Neilands. 1988. Fur (ferric uptake regulation) protein and CAP (catabolite-activator protein) modulate transcription of fur gene in Escherichia coli. Eur. J. Biochem. 173:537-546.
42. de Lorenzo, V., S. Wee, M. Herrero, and J. B. Neilands. 1987. Operator sequences of the aerobactin operon of plasmid ColV-K30 binding the ferric uptake regulation (fur) repressor. J. Bacteriol. 169:2624-2630.
43. Ding, X., H. Zeng, N. Schiering, D. Ringe, and J. R. Murphy. 1996. Identification of the primary metal ion-activation sites of the diphtheria tox repressor by X-ray crystallography and site-directed mutational analysis. Nat. Struct. Biol. 3:382-387.
44. Earhart, C. F. 1987. Ferri-enterobactin transport in Escherichia coli, p. 67-84. In G. Winkelmann, D. van der Helm, and J. B. Neilands (ed.), Iron transport in microbes, plants and animals. VCH Publishers, Weinheim, Germany.
45. Enard, C., A. Diolez, and D. Expert. 1988. Systemic virulence of Erwinia chrysanthemi 3937 requires a functional iron assimilation system. J. Bacteriol. 170:2419-2426.
46. Enz, S., V. Braun, and J. H. Crosa. 1995. Transcription of the region encoding the ferric dicitrate-transport system in Escherichia coli: similarity between promoters for fecA and for extracytoplasmic function sigma factors. Gene 163:13-18.
47. Ernst, J. F., R. L. Bennett, and L. I. Rothfield. 1978. Constitutive expression of the iron enterochelin and ferrichrome uptake systems in a mutant strain of Salmonella typhimurium. J. Bacteriol. 135:928-934.
48. Farrell, D., P. Mikesell, L. Actis, and J. H. Crosa. 1990. A regulatory gene, angR, of the iron uptake system of Vibrio anguillarum: similarity with phage P22 cro and regulation by iron. Gene 86:45-51.
49. Foster, J. W., and H. K. Hall. 1992. Effect of Salmonella typhimurium ferric uptake regulator (fur) mutations on iron-and pH-regulated protein synthesis. J. Bacteriol. 174:4317-1323.
50. 2+-dependent DNA-binding repressor, DtxR, in Corynebacterium diphtheriae. Infect. Immun. 57:3221-3225.
51. Frost, G. E., and H. Rosenberg. 1973. The inducible citrate-dependent iron transport system in Escherichia coli K12. Biochim. Biophys. Acta 330:90-101.
52. Fuma, S., Y. Fujishima, N. Corbell, C. D'Souza, M. Nakano, P. Zuber, and K. Yamane. 1993. Nucleotide sequence of 5′ portion of sfrA that contains the region required for competence establishment in Bacillus subtilis. Nucleic Acids Res. 21:93-97.
53. Gensberg, K., K. Hughes, and A. W. Smith. 1992. Siderophore-specific induction of iron uptake in Pseudomonas aeruginosa. J. Gen. Microbiol. 138:2381-2387.
54. Gensberg, K., E. J. Doyle, D. J. Perry, and A. W. Smith. 1994. Uptake of BRL 41897A, a C(7) alpha-formamido substituted cephalosporin, via the ferri-pyichelin transport system of Pseudomonas aeruginosa. J. Antimicrob. Chemother. 34:697-705.
55. Georges, C., and J. M. Meyer. 1995. High-molecular-mass, iron-repressed cytoplasmic proteins in fluorescent Pseudomonas: potential peptide-synthetases for pyoverdine biosynthesis. FEMS Microbiol. Lett. 132:9-15.
56. Geraldo, R., C. Nieto, M. E. Fernandez-Tresguerres, and R. Diaz. 1989. Bacterial zipper. Nature 342:866.
57. Goldberg, M. B., S. A. Boyko, and S. B. Calderwood. 1990. Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli Fur system. J. Baeteriol. 172:6863-6870.
58. Goldberg, M. B., S. A. Boyko, and S. B. Calderwood. 1991. Positive transcriptinnal regulation of an iron-regulated virulence gene in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 88:1125-1129.
59. Goldberg, M. B., S. A. Boyko, J. R. Butterton, J. A. Stoebner, S. M. Payne, and S. B. Calderwood. 1992. Characterization of a Vibrio cholerae virulence factor homologous to the family of TonB-dependent proteins. Mol. Microbiol. 6:2407-2418.
60. Goldberg, M. B., V. J. DiRita, and S. B. Calderwood. 1990. Identification of an iron-regulated virulence determinant in Vibrio cholerae, using TnphoA mutagenesis. Infect. Immun. 58:55-60.
61. Griggs, E., and J. Konisky. 1989. Mechanism for iron-regulated transcription of the Escherichia coli cir gene: metal-dependent binding of Fur protein to promoters. J. Bacteriol. 171:1048-1054.
62. Gross, R., B. Arico, and R. Rappuoli. 1989. Families of bacterial signal transducing proteins. Mol. Microbiol. 3:1661-1667.
63. Guilvout, I., O. Mercereau-Puijalon, S. Bonnefoy, A. P. Pugsley, and E. Carniel. 1993. High-molecular-weight protein 2 of Yersinia enterocolitica is homologous to AngR of Vibrio anguillarum and belongs to a family of proteins involved in nonribosomal peptide synthesis. J. Bacteriol. 175:5488-5504.
64. Gunter, K., C. Toupet, and T. Schupp. 1993. Characterization of an iron-regulated promoter involved in desferrioxamine B synthesis in Streptomyces pilosus: repressor-binding site and homology to the diphtheria toxin gene promoter. J. Bacteriol. 175:3295-3302.
65. Gunter, K., and V. Braun. 1990. In vivo evidence for a FhuA outer membrane receptor interaction with the TonB inner membrane protein of Escherichia coli. FEBS Lett. 49:301-305.
66. Hall, H. K., and J. W. Foster. 1996. The role of fur in the acid tolerance response of Salmonella typhimurium is physiologically and genetically separable from its role in iron acquisition. J. Bacteriol. 178:5683-5691.
67. Hamood, A. N., J. A. Colmer, U. A. Ochsner, and M. L. Vasil. 1996. Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production. Mol. Microbiol. 21:97-110.
68. Hancock, R. E. W., K. Hantke, and V. Braun. 1976. Iron transport in Escherichia coli K-12: involvement of the colicin B receptor and of a citrate-inducible protein. J. Bacteriol. 127:1370-1375.
69. Hannavy, K., G. C. Barr, C. J. Dorman, J. Adamson, L. R. Mazengera, M. P. Gallagher, J. S. Evans, B. A. Levine, I. P. Trayer, and C. F. Higgins. 1990. TonB protein of Salmonella typhimurium. J. Mol. Biol. 216:897-910.
70. Hantke, K. 1981. Regulation of ferric transport in Escherichia coli K-12: isolation of a constitutive mutant. Mol. Gen. Genet. 182:288-292.
71. Hantke, K. 1984. Cloning of the repressor protein gene of iron regulated system in E. coli K-12. Mol. Gen. Genet. 197:337-341.
72. Hantke, K. 1987. Selection procedure for deregulated iron transport mutants (fur) in E. coli K-12: fur not only affects iron metabolism. Mol. Gen. Genet. 210:135-139.
73. Harle, C., I. Kim, A. Angerer, and V. Braun. 1995. Signal transfer through three compartments: transcription initiation of the Escherichia coli ferric citrate transport system from the cell surface. EMBO J. 14:1430-1438.
74. Heaton, M., and F. Neuhaus. 1992. Biosynthesis of D-alanyl-lipoteichoic acid: cloning, nucleotide sequence, and expression of the Lactobacillus casei gene for the D-alanine-activating enzyme. J. Bacteriol. 174:4707-4717.
75. Heinrichs, D., L. Young, and K. Poole. 1991. Pyochelin-mediated iron transport in Pseudomonas aeruginosa: involvement of a high-molecular-mass outer membrane protein. Infect. Immun. 59:3680-3684.
76. Heinrichs, D., and K. Poole. 1996. PchR, a regulator of ferripyochelin receptor gene (fptA) expression in Pseudomonas aeruginosa, functions both as an activator and as a repressor. J. Bacteriol. 178:2586-2592.
77. Heinrichs, D., and K. Poole. 1993. Cloning and sequence analysis of a gene (pchR) encoding an AraC family activator of pyochelin and ferripyochelin receptor synthesis in Pseudomonas aeruginosa. J. Bacteriol. 175:5882-5889.
78. Heller, K., R. J. Kadner, and K. Gunter. 1988. Suppression of the btuB451 mutation by mutation in the tonB gene suggests a direct interaction. Gene 64:147-153.
79. Hickcy, E. K., and N. P. Cianciotto. 1994. Cloning and sequencing of the Legionella pneumophila fur gene. Gene 143:117-121.
80. Hider, R. C. 1984. Siderophore mediated absorption of iron. Struct. Bonding 58:25-87.
81. Hoch, J., and T. J. Silhavy. 1995. Two-component signal transduction. ASM Press, Washington, D.C.
82. Hussein, S., K. Hantke, and V. Braun. 1981. Citrate-dependent iron transport system in Escherichia coli K12. Eur. J. Biochem. 117:431-437.
83. Inouye, M., and N. Delihas. 1988. Small RNAs in the prokaryotes: a growing list of diverse roles. Cell 53:5-7.
84. Jalal, M., D. Hossain, J. van der Helm, J. Sanders-Loehr, L. A. Actis, and J. H. Crosa. 1989. Structure of anguibactin, a unique plasmid-related bacterial siderophore from the fish pathogen Vibrio anguillarum. J. Am. Chem. Soc. 111:292-296.
85. Kadner, R. J. 1990. Vitamin B12 transport in Escherichia coli: energy coupling between membranes. Mol. Microbiol. 4:2027-2033.
86. Kadner, R. J., M. Lundrigan, and K. Heller. 1987. Sequences and interactions of proteins participating in the transport of iron and vitamin B12 in Escherichia coli, p. 85-97. In G. Winkelmann, D. van der Helm, and J. B. Neilands (ed.), Iron transport in microbes, plants and animals. VCH Publishers, Weinheim, Germany.
87. Karkhoff-Schweizer, R. R., A. B. Schryvers, and H. P. Schweizer. 1994. Cloning and sequence analysis of the fur gene encoding an iron-regulatory protein of Neisseria meningitidis. Gene 141:139-140.
88. Kato, J., L. Chu, K. Kitano, J. D. DeVault, K. Kimbara, A. M. Chakrabarty, and T. K. Misra. 1989. Nucleotide sequence of a regulatory region controlling alginate synthesis in Pseudomonas aeruginosa: characterization of the algR2 gene. Gene 84:31-38.
89. Kim, I., A. Stiefel, S. Plantor, A. Angerer, and V. Braun. 1997. Transcription induction of the ferric citrate transport genes via the N-terminus of the FecA outer membrane protein, the Ton system and the electrochemical potential of the cytoplasmic membrane. Mol. Microbiol. 23:333-344.
90. Koster, M., J. van de Vossenberg, J. Leong, and P. J. Weisbeek. 1993. Identification and characterization of the pupB gene encoding an inducible ferric-pseudobactin receptor of Pseudomonas putida WCS358. Mol. Microbiol. 8:591-601.
91. Koster, M. J., J. van Klompenburg, W. Bitter, J. Leong, and P. J. Weisbeek. 1994. Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope. EMBO J. 13:2805-2813.
92. Koster, W. L., L. A. Actis, L. Waldbeser, M. E. Tolmasky, and J. H. Crosa. 1991. Molecular characterization of the iron transport system mediated by the pJM1 plasmid in Vibrio anguillarum 775. J. Biol. Chem. 266:23829-23833.
93. Leong, J., W. Bitter, M. Koster, V. Venturi, and P. J. Weisbeek. 1992. Molecular analysis of iron assimilation in plant growth-promoting Pseudomonas putida WCS358, p. 20. In Abstracts of the Third International Symposium on Iron Transport, Storage and Metabolism.
94. Leoni, L., A. Ciervo, N. Orsi, and P. Visca. 1996. Iron regulated transcription of the pvdA gene in Pseudomonas aeruginosa: effect of Fur and PvdS on promoter activity. J. Bacteriol. 178:2299-2313.
95. Li, X. Z., H. Nikaido, and K. Poole. 1995. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
96. Litwin, C. M., S. A. Boyko, and S. B. Calderwood. 1992. Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene. J. Bacteriol. 174:1897-1903.
97. Litwin, C. M., and S. B. Calderwood. 1993. Cloning and genetic analysis of the Vibrio vulnificus fur gene and construction of a fur mutant by in vivo marker exchange. J. Bacteriol. 168:228-236.
98. Lonetto, M., K. L. Brown, K. Rudd, and M. J. Buttner. 1994. Analysis of the Streptomyces coelicolor sigE gene reveals a new subfamily of eubacterial RNA polymerase σ factors involved in the regulation of extracytoplasmic functions. Proc. Natl. Acad. Sci. USA 91:7573-7577.
99. Martin, D. W., M. J. Schurr, M. H. Mudd, and V. Deretic. 1993. Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy. Mol. Microbiol. 9:497-506.
100. Martin, D. W., M. J. Schurr, M. H. Mudd, J. R. W. Govan, B. W. Holloway, and V. Deretic. 1993. Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc. Natl. Acad. Sci. USA 90:8377-8381.
101. Marugg, J. D., H. B. Nielander, A. J. G. Horrevoets, I. van Megen, I. van Genderen, and P. J. Weisbeek. 1988. Genetic organization and transcriptional analysis of a major gene cluster involved in siderophore biosynthesis in Pseudomonas putida WCS358. J. Bacteriol. 170:1812-1819.
102. Maxon, M., J. Wigboldus, N. Brot, and H. Weissbach. 1990. Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein. Proc. Natl. Acad. Sci. USA 87:7076-7079.
103. Merriman, T. R., M. E. Merriman, and I. L. Lamont. 1995. Nucleotide sequence of pvdD, a pyoverdin biosynthetic gene from Pseudomonas aeruginosa: pvdD has similarity to peptide synthases. J. Bacteriol. 177:252-258.
104. Meyer, J. M., D. Hohnadel, A. Khan, and P. Cornelis. 1990. Pyoverdin-facilitated iron uptake in Pseudomonas aeruginosa: immunological characterization of the ferripyoverdin receptor. Mol. Microbiol. 4:1401-1405.
105. Meyer, J. M., A. Stinzi, D. De Vos, P. Cornelis, R. Tappe, K. Taraz, and H. Budzikiewicz. 1997. Use of siderophores to type pseudomonads: the three Pseudomonas aeruginosa pyoverdine systems. Microbiol 143:35-43.
106. Michel, K. P., H. H. Thole, and E. K. Pistorius. 1996. IdiA, a 34 kDa protein in the cyanobacteria Synechococcus sp. strains PCC 6301 and PCC 7942, is required for growth under iron and manganese limitations. Microbiology 142:2635-2645.
107. Miyazaki, H., H. Kato, T. Nakazawa, and M. Tsuda. 1995. A positive regulatory gene, pvdS, for expression of pyoverdin biosynthetic genes in Pseudomonas aeruginosa PAO. Mol. Gen. Genet. 248:17-24.
108. Nau, C. D., and J. Konisky. 1989. Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene. J. Bacteriol. 171:1041-1047.
109. Neilands, J. B. 1982. Microbial envelope proteins related to iron. Annu. Rev. Microbiol. 36:285-309.
110. Niederhoffer, E. C., C. M. Naranjo, K. L. Bradley, and J. A. Fee. 1990. Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus. J. Bacteriol. 172:1930-1938.
111. Ochs, M., S. Vitinger, I. Kim, D. Welz, A. Angerer, and V. Braun. 1995. Regulation of citrate-dependent iron transport of Escherichia coli: FecR is required for transcription activation by FecI. Mol. Microbiol. 15:119-132.
112. Ochs, M., A. Angerer, and V. Braun. 1996. Surface signaling in transcriptional regulation of the ferric citrate transport system of Escherichia coli: mutational analysis of the alternative sigma factor FecI supports its essential role in fec transport gene transcription. Mol. Gen. Genet. 250:455-465.
113. Ochsner, U. A., and M. L. Vasil. 1996. Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes. Proc. Natl. Acad. Sci. USA 93:4409-4414.
114. Ochsner, U. A., Z. Johnson, I. L. Lamont, H. E. Cunliffe, and M. L. Vasil. 1996. Exotoxin A production in Pseudomonas aeruginosa requires the iron-regulated pvdS gene encoding an alternative sigma factor. Mol. Microbiol. 21:1019-1028.
115. O'Shea, E., R. Rutkowski, and P. Kim. 1989. Evidence that the leucine zipper is a coiled coil. Science 243:538-542.
116. O'Sullivan, D. J., D. N. Dowling, V. de Lorenzo, and F. O'Gara. 1994. Escherichia coli ferric uptake regulator (Fur) can mediate regulation of a pseudomonad iron-regulated promoter. FEMS Microbiol. Lett. 117:327-332.
117. Poole, K., L. Young, and S. Neshat. 1990. Enterobactin-mediated iron transport in Pseudomonas aeruginosa. J. Bacteriol. 172:6991-6996.
118. Poole, K., C. Dean, D. Heinrich, S. Neshat, K. Krebes, L. Young, and L. Kilburn. 1996. Siderophore-mediated iron transport in Pseudomonas aeruginosa, p. 371-383. In T. Nakazawa, K. Furukawa, D. Haas, and S. Silver (ed.), Molecular biology of pseudomonads. ASM Press, Washington, D.C.
119. Poole, K., D. Heinrich, and S. Neshat. 1993. Cloning and sequencing analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdin. Mol. Microbiol. 10:529-544.
120. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
121. Poole, K., S. Neshat, K. Krebes, and D. E. Heinrichs. 1993. Cloning and nucleotide sequencing analysis of the pyoverdin receptor gene fpvA of Pseudomonas aeruginosa. J. Bacteriol. 175:4597-4604.
122. Postle, K. 1990. TonB and the gram-negative dilemma. Mol. Microbiol. 4:2019-2025.
123. Postle, K., and R. F. Good. 1983. DNA sequence of the Escherichia coli tonB gene. Proc. Natl. Acad. Sci. USA 80:5235-5239.
124. Pressler, U., H. Slaudenmaier, L. Zimmermann, and V. Braun. 1988. Genetics of iron dicitrate transport system of Escherichia coli. J. Bacteriol. 170:2716-2724.
125. Prince, R. W., D. C. Cox, and M. L. Vasil. 1993. Coordinate regulation of siderophore and endotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J. Bacteriol. 175:2589-2598.
126. Pu, W., and K. Struhl. 1991. The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc. Natl. Acad. Sci. USA 88:6901-6905.
127. Kombel, I. T., B. J. McMorran, and I. L. Lamont. 1995. Identification of a DNA sequence motif required for expression of iron-regulated genes in pseudomonads. Mol. Gen. Genet. 246:519-528.
128. Rusnak, F., M. Sakaitani, D. Drueckhammer, J. Reichert, and C. Walsh. 1991. Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. Biochemistry 30:2916-2927.
129. Rutz, J. M., J. Liu, J. A. Lyons, J. Guramson, S. K. Armstrong, M. A. McIntosh, J. B. Feix, and P. E. Klebba. 1992. Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane. Science 258:471-475.
130. Salinas, P., and J. H. Crosa. 1995. Regulation of angR, a gene with regulatory and biosynthetic functions in the pJM1 plasmid-mediated iron uptake system of Vibrio anguillarum. Gene 160:17-23.
131. Salinas, P., M. E. Tolmasky, and J. H. Crosa. 1989. Regulation of the iron uptake system in Vibrio anguillarum: evidence for a cooperative effect between two transcriptional activators. Proc. Natl. Acad. Sci. USA 86:3529-3533.
132. Salinas, P., L. Waldbeser, and J. H. Crosa. 1993. Regulation of the expression of bacterial iron transport genes: possible role of an antisense RNA as a repressor. Gene 123:33-38.
133. Scholten, J. D., K. Chang, P. Babbit, H. Charest, M. Sylvestre, and D. Dunaway-Mariano. 1991. Novel enzymatic hydrolytic dehalogenation of a chlorinated aromatic. Science 253:182-185.
134. Sexton, R., P. R. Gill, Jr., M. J. Callanan, D. J. O'Sullivan, D. N. Dowling, and F. O'Gara. 1995. Iron-responsive gene expression in Pseudomonas fluorescens M114: cloning and characterization of a transcription-activating factor. PbrA. Mol. Microbiol. 15:297-306.
135. Simons, R. W., and N. Klechner. 1988. Biological regulation by antisense RNA in prokaryotes. Annu. Rev. Genet. 22:567-600.
136. Siyrosachati, S., and C. D. Cox. 1986. Siderophore-mediated iron acquisition from transferrin by Pseudomonas aeruginosa. Infect. Immun. 52:885-891.
137. Sokol, P. A., and D. E. Woods. 1983. Demonstration of an iron-siderophore protein in the outer membrane of Pseudomonas aeruginosa. Infect. Immun. 40:665-669.
138. Stachelhaus, T., and M. A. Marahiel. 1995. Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme Grsa. J. Biol. Chem. 270:6163-6169.
139. Stachelhaus, T., and M. A. Marahiel. 1995. Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis. FEMS Microbiol. Lett. 125:3-14.
140. Staggs, T. M., and R. D. Perry. 1991. Identification and cloning of a fur regulatory gene in Yersinia pestis. J. Bacteriol. 173:417-425.
141. Staggs, T. M., and R. D. Perry. 1992. Fur regulation in Yersinia species. Mol. Microbiol. 6:2507-2516.
142. Staudenmaier, H., B. Van Hove, Z. Yaraghi, and V. Braun. 1989. Nucleotide sequence of the fecBCDE genes and location of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli. J. Bacteriol. 171:2626-2633.
143. Stintzi, A., P. Cornelis, D. Hohnadel, J. M. Meyer, C. Dean, K. Poole, S. Kourambas, and V. Krishnapillai. 1996. Novel pyoverdin biosynthesis gene(s) of Pseudomonas aeruginosa PAO. Microbiology 142:1181-1190.
144. Stock, J. B., A. J. Ninfa, and A. M. Stock. 1989. Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol. Rev. 53:450-490.
145. Stoebner, J. A., and S. M. Payne. 1988. Iron-regulated hemolysin production, and utilization of heme and hemoglobin by Vibrio cholerae. Infect. Immun. 56:2891-2895.
146. Stoebner, J. A., J. R. Butterton, S. B. Calderwood, and S. M. Payne. 1992. Identification of the vibriobactin receptor of Vibrio cholerae. J. Bacteriol. 174:3270-3274.
147. Stojilkovic, I., M. Cobeljic, and K. Hantke. 1993. Escherichia coli K12 ferrous iron uptake mutants are impaired in their ability to colonize the human intestine. FEMS Microbiol. Lett. 108:111-116.
148. Tai, S. P. S., A. E. Krafft, P. Noothet, and R. K. Holmes. 1990. Coordinate regulation of siderophore and diphtheria toxin production by iron in Corynebacterium diphtheriae. Microb. Pathog. 9:267-273.
149. Talanian, R., C. McKnight, and P. Kim. 1990. Sequence-specific DNA binding by a short peptide dimer. Science 249:769-771.
150. Tao, X., N. Schiering, H. Y. Zeng, D. Ringe, and J. R. Murphy. 1994. Iron, DtxR, and the regulation of diphtheria toxin expression. Mol. Microbiol. 14:191-197.
151. Teintze, M., M. B. Hossain, C. L. Barnes, J. Leong, and D. van der Helm. 1981. Structure of ferric pseudobactin, a siderophore from a plant growth-promoting Pseudomonas. Biochemistry 20:6446-6457.
152. Thomas, C. E., and P. F. Sparling. 1994. Identification and cloning of a fur homologue from Neisseria meningitidis. Mol. Microbiol. 11:725-737.
153. Toh, H. 1991. Sequence analysis of firefly luciferase family reveals a conservative sequence motif. Protein Sequences Data Anal. 4:111-117.
154. Tolmasky, M. E., and J. H. Crosa. 1984. Molecular cloning and expression of genetic determinants for the iron uptake system mediated by the Vibrio anguillarum plasmid pJM1. J. Bacteriol. 160:860-866.
155. Tolmasky, M. E., and J. H. Crosa. 1991. Regulation of plasmid-mediated iron transport and virulence in Vibrio anguillarum. Biol. Metals 4:33-35.
156. Tolmasky, M. E., L. A. Actis, and J. H. Crosa. 1993. A single amino acid change in AngR, a protein encoded by pJM1-like virulence plasmids, results in hyperproduction of anguibactin. Infect. Immun. 61:3228-3233.
157. Tolmasky, M. E., L. A. Actis, and J. H. Crosa. 1995. A histidine decarboxylase gene encoded by the Vibrio anguillarum plasmid pJM1 is essential for virulence: histamine is a precursor in the biosynthesis of anguibactin. Mol. Microbiol. 15:87-95.
158. Tolmasky, M. E., L. A. Actis, and J. H. Crosa. 1988. Genetic analysis of the iron uptake region of the Vibrio anguillarum plasmid pJM1: molecular cloning of genetic determinants encoding a novel trans activator of siderophore biosynthesis. J. Bacteriol. 170:1913-1919.
159. Tolmasky, M. E., P. Salinas, L. A. Actis, and J. H. Crosa. 1988. Increased production of the siderophore anguibactin mediated by pJM1-like plasmids in Vibrio anguillarum. Infect. Immun. 56:1608-1614.
160. Tolmasky, M. E., A. M. Wertheimer, L. A. Actis, and J. H. Crosa. 1994. Characterization of the Vibrio anguillarum fur gene: role in regulation of expression of the FatA outer membrane protein and catechols. J. Bacteriol. 176:213-220.
161. Turner, R., and R. Tijan. 1989. Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 243:1689-1694.
162. van Hove, B., H. Staudenmaier, and V. Braun. 1990. Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. J. Bacteriol. 172:6749-6758.
163. Venturi, V., C. Ottewanger, J. Leong, and P. J. Weisbeek. 1993. Identification and characterization of a siderophore regulatory gene (pfrA) of Pseudomonas putida WCS358: homology to the alginate regulatory gene algQ of Pseudomonas ueruginosa. Mol. Microbiol. 10:63-73.
164. Venturi, V., C. Ottewanger, M. Bracke, and P. J. Weisbeek. 1995. Iron regulation of siderophore biosynthesis and transport in Pseudomonas putida WCS358: involvement of a transcriptional activator and of the Fur protein. Mol. Microbiol. 15:1081-1093.
165. Venturi, V., P. J. Weisbeek, and M. Roster. 1995. Gene regulation of siderophore-mediated iron acquisition in Pseudomonas: not only the Fur repressor. Mol. Microbiol. 17:603-610.
166. Vinson, C., P. Sigler, and L. McKnight. 1989. Scissor-grip model for DNA recognition by a family of leucine zipper proteins. Science 249:911-916.
167. 5-oxygenase in Pseudomonas aeruginosa. J. Bacteriol. 176:1128-1140.
168. Waggeg, W., and V. Braun. 1981. Ferric citrate transport in Escherichia coli requires outer membrane receptor protein FecA. J. Bacteriol. 145:156-163.
169. Waldbeser, L. S., Q. Chen, and J. H. Crosa. 1995. Antisense RNA regulá tion of the fatB iron transport protein gene in Vibrio anguillarum. Mol. Microbiol. 17:747-756.
170. Waldbeser, L., M. E. Tolmasky, L. A. Actis, and J. H. Crosa. 1993. Mechanisms for negative regulation by iron of the fatA outer membrane protein gene expression in Vibrio anguillarum 775. J. Biol. Chem. 268:10433-10439.
171. Walker, J. E., M. Saraste, M. J. Runswick, and J. N. Gay. 1982. Distantly related sequences in the a and b subunits of ATP-synthase, myosin kinases and
172. Walter, M., S. Potter, and J. H. Crosa. 1983. Iron uptake system mediated by Vibrio anguillarum plasmid pJM1. J. Bacteriol. 156:880-887.
173. Weinberg, E. D. 1984. Iron withholding: a defense against infection and neoplasia. Physiol. Rev. 64:65-100.
174. Wendenbaum, S., P. Demange, A. Dell, J. M. Meyer, and M. Abdallah. 1983. The structure of pyoverdin Pa, the siderophore of Pseudomonas aeruginosa. Tetrahedron Lett. 24:4877-4880.
175. Wertheimer, A. M., M. E. Tolmasky, L. A. Actis, and J. H. Crosa. 1994. Structural and functional analysis of mutant Fur proteins with impaired regulatory function. J. Bacteriol. 176:5116-5122.
176. Wolf, M., and J. H. Crosa. 1986. Evidence for the role of a siderophon in promoting Vibrio anguillarum infections. J. Gen. Microbiol. 132:2949-2952.
177. Wooldridge, K. G., P. H. Williams, and J. M. Ketley. 1994. Iron-responsive genetic regulation in Campylobacter jejuni: cloning and characterization of fur homolog. J. Bacteriol. 176:5852-5856.
178. Wriedt, K., A. Angerer, and V. Braun. 1995. Transcriptional regulation from the cell surface: conformational changes in the transmembrane protein FecR lead to altered transcription of the ferric citrate transport genes in Escherichia coli. J. Bacteriol. 177:3320-3322.
179. Yamamoto, S., N. Okujo, and Y. Sakakibara. 1994. Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii. Arch. Microbiol. 162:249-254.