Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae

Journal of Experimental Medicine

Volumn 183, Issue 2, 1996, Pages 621-629

  Reidl, Joachim ^a   Mekalanos, John J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BETA LACTAMASE; BINDING PROTEIN; CYTOCHROME C3; EDETIC ACID; HEMIN; HEMOGLOBIN; LIPOPROTEIN; LIPOPROTEIN E(P4); NICOTINAMIDE ADENINE DINUCLEOTIDE; OUTER MEMBRANE PROTEIN; PROTOPORPHYRIN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DNA SEQUENCE; HAEMOPHILUS INFLUENZAE; MEMBRANE TRANSPORT; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL;

AEROBIOSIS; AMINO ACID SEQUENCE; ANAEROBIOSIS; BACTERIAL OUTER MEMBRANE PROTEINS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; BLOTTING, SOUTHERN; CLONING, MOLECULAR; ESTERASES; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; HAEMOPHILUS INFLUENZAE; HEMIN; LIPOPROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030046924     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.2.621     Document Type: Article

References (50)

1. Funkhouser, A., M.C. Steinhoff, and J. Ward. 1991. Haemophilus influenzae disease and immunization in developing countries. Rev. Infect. Dis. 13:542-554.
2. Turk, D.C. 1984. The pathogenicity of Haemophilus influenzae. J. Med. Microbiol. 18:1-16.
3. Evans, N.M., D.D. Smith, and A.J. Wicken. 1974. Hemin and nicotinamide adenine dinucleotide requirements of Haemophilus influenzae. J. Med. Microbiol. 7:359-365.
4. Granick, S., and H. Gilder. 1946. The porphyrin requirements of Haemophilus influenzae and some functions of the vinyl and propionic acid chains of heme. J. Gen. Physiol 30:1-13.
5. White, D.C., and S. Granick. 1963. Hemin biosynthesis in Haemophilus. J. Bacteriol. 85:842-850.
6. Sanders, J.D., L.D. Cope, and E.J. Hansen. 1994. Identification of a locus involved in the utilization of iron by Haemophilus influenzae. Infect. Immun. 62:4515-4525.
7. Schryvers, A.B., and S. Gray-Owen. 1992. Iron acquisition in Haemophilus influenzae: receptor for human transferrin. J. Infect. Dis. 165:103-104.
8. Gray-Owen, S.D., S. Loosmore, and A.B. Schryvers. 1995. Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae. Infect. Immun. 63:1201-1210.
9. Cope, L.D., R. Yogev, U. Muller-Eberhard, and E.J. Hansen. 1995. A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b. J. Bacteriol. 377:2644-2653.
10. Hanson, M.S., S.E. Pelzel, J. Larimer, U. Muller-Eberhard, and E.J. Hansen. 1992. Identification of a genetic locus of Haemophilus influenzae type b necessary for the binding and utilization of heme bound to human hemopexin. Proc. Natl. Acad. Sci. USA. 89:1973-1977.
11. Wong, J.C.Y., R. Patel, D. Kendall, P.W. Whitby, A. Smith, J. Holland, and P. Williams. 1995. Affinity, conservation, and surface exposure of hemopexin-binding proteins in Haemophilus influenzae Infect. Immun. 63:2327-2333
12. Hickman, M., D. Morton, and T. Stull. 1993. Isolation of a hemoglobin binding protein from Haemophilus influenzae. In Abstracts of the 93rd General Meeting of the American Society of Microbiology, Washington, DC. B-292:78. (Abstr.)
13. Elkins, C. 1995. Identification and purification of a conserved heme-regulated hemoglobin-binding outer membrane protein from Haemophilus ducreyi. Infect. Immun. 63:1241-1245.
14. Elkins, C., C.J. Chen, and C.E. Thomas. 1995. Characterization of the hgbA locus encoding a hemoglobin receptor from Haemophilus ducreyi. Infect. Immun. 63:2194-2200.
15. Lee, B.C. 1992. Isolation of an outer membrane hemin-binding protein of Haemophilus influenzae type b. Infect. Immun. 60:810-816.
16. Hanson, M.S., C. Slaughter, and E.J. Hansen. 1992. The hbpA gene of Haemophilus influenzae type b encodes a hemebinding lipoprotein conserved among heme-dependent Haemophilus species. Infect. Immun. 60:2257-2266.
17. Green, B.A., J.E. Farley, T. Quinn-Dey, R.A. Deich, and G.W. Zlotnick. 1991. The e (P4) outer membrane protein of Haemophilus influenzae: biologic activity of anti-e serum and cloning and sequencing of the structural gene. Infect. Immun. 59:3191-3198.
18. Schreiber, J.R., V.A. Barrus, and G.R. Siber. 1985. Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemaphilus influenzae type b. Infect. Immun. 47:142-148.
19. Casadaban, M.J. 1976. Transposition and fusion of the lac genes to select promoters in Escherichia coli using bacterio-phage lambda and mu. J. Mol. Biol. 104:541-555.
20. Barack, G.J., M.S. Chandler, R.J. Redfield, and J.F. Tomb. 1991. Genetic systems in Haemophilus influenzae. Methods Enzymol. 204:321-342.
21. Maniatis, T., E.F. Frisch, and J. Sambrook. 1982. Molecular Cloning. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. pp. 97-148.
22. Chang, A.C.Y., and S.N. Cohen. 1978. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J. Bacteriol. 134:1141-1156.
23. Rose, R.E. 1988. The nucleotide sequence of pACYC184. Nucleic Acids Res. 16:355.
24. Rose, R.E. 1988. The nucleotide sequence of pACYC177. Nucleic Acids Res. 16:356.
25. Mullis, K.B., and F. Faloona. 1987. Specific synthesis of DNA in vitro via a polymerase chain reaction. Methods Enzymol. 155:335-340.
26. Southern, E.M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 51:503-517.
27. Mitchell, M.A., K. Skowronek, L. Kauc, and S.H. Goodgal. 1991. Electroporation of Haemophilus influenzae is effective for transformation of plasmid but not chromosomal DNA. Nucleic Acids Res. 19:3625-3628.
28. Tomb, J.F., G.J. Barack, M.S. Chandler, R.J. Redfield and H.O. Smith. 1989. Transposon mutagenesis, characterization, and cloning of transformation genes of Haemophilus influenzac Rd. J. Bacteriol. 171:3796-3802.
29. Reidl, J., and J.J. Mekalanos. 1995. Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini transposon to identify a phage-encoded virulence factor. Mol. Microbiol. 18:685-701.
30. Sanger, F., S. Nicklen, and A.R Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad Sci. USA. 74:5463-5467.
31. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
32. Twobin, H., T. Staehlin, and J. Gordon. 1979. Electrophoretic transfer of proteins. Proc. Natl. Acad. Sci. USA. 76: 4350-4354.
33. Jahn, D., E. Verkamp, and D. Söil. 1992. Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis Trends Biochem. Sci. 17:215-218.
34. Powell, K.A., R. Cox, M. McConville, and H.P. Charles. 1973. Mutations affecting porphyrin biosynthesis in Eschenchia coli. Enzyme. 16:65-73.
35. Verkamp, E., and B.K. Chelm. 1989. Isolation, nucleotide sequence, and preliminary characterization of the Escherichia coli K-12 hemA gene. J Bacteriol. 171:4728-4735.
36. McConville, M.L., and H.P. Charles. 1979. Mutants of Escherichia coli K-12 permeable to haemin. J Gen. Microbiol. 113: 165-168
37. Stojiljkovic, I., and K. Hantke. 1992. Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in gram-negative bacteria. EMBO (Eur. Mol. Biol. Organ.) J. 11:4359-4367.
38. Reuter, K., R. Slany, F. Ullnch, and H. Kersten. 1991. Structure and organization of E. coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. J. Bacteriol. 173:2256-2264.
39. Fleischmann, R.D., M.D. Adams, O. White, R.A. Clayton, E.F. Kirkness, A.R. Kerlavage, C.J. Bult, J.F. Tomb, B.A. Dougherty, J.M. Merrick, et al. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science (Wash. DC). 269:496-512.
40. Vaara, M. 1992. Agents that increase the permeability of the outer membrane. Microbiol. Rev. 56:395-411.
41. Henderson, D.P., and S.M. Payne. 1993. Cloning and characterization of the Vibrio cholerae genes encoding the utilization of iron from haemin and haemoglobin. Mol. Microbiol. 7: 461-469.
42. Stojiljkovic, I., and K. Hantke. 1994. Transport of haemin across the cytoplasmic membrane through a haemin-specific periplasmic binding-protein-dependent transport system in Yersinia enterocolitica. Mol. Microbiol. 13:719-732.
43. Stojiljkovic, I., V. Hwa, L. de Saint Martin, P. O'Gaora, X. Nassif, F. Heffron, and M. So. 1995. The Keisseria meninaitidis haemoglobin receptor: its role in iron utilization and virulence. Mol. Microbiol. 15:531-541.
44. Pearson, W.R., and D.J. Lipman. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA. 85:2444-2448.
45. Olson, E.R., D.S. Dunyak, L.M. Jurrs, and R.A. Poorman. 1991. Identification and characterization of dppA, an Escherichia coli gene encoding a periplasmic dipeptide transport protein. J. Bacteriol. 173:234-244.
46. Verkamp, E., V.M. Backman, J.M. Bjoernsson, and D. Soell. 1993. The periplasmic dipeptide permease system transports 5-aminolevulinic acid in Escherichia coli. J. Bacteriol. 175:1452-1456.
47. Gorr, T., T. Kleinschmidt, and H. Fricke. 1991. Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences. Nature (Lond.). 351:394-397.
48. Pollock, W.B., M. Loufti, M. Bruschi, J. Rapp-Giles, J.D. Wall, and G. Voordouw. 1991. Cloning, sequencing, and expression of the gene encoding the high-molecular-weight cytochrome c from Desulfovibrio vulgaris Hildenborough. J. Bacteriol. 173:220-228.
49. Zhang, L., and L. Guarente. 1995. Heme binds to a short sequence that serves a regulatory function in diverse proteins. EMBO (Eur. Mol. Biol. Organ.) J. 14:313-320.
50. Hoess, A., S. Watson, G.R. Siber, and R. Liddington. 1993. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 A resolution. EMBO (Eur. Mol. Biol. Organ.) J. 12:3351-3356.