Susceptibility to leprosy is linked to the human NRAMP1 gene

Journal of Infectious Diseases

Volumn 177, Issue 1, 1998, Pages 133-145

  Abel, Laurent ^b   Sánchez, Fabio O ^b   Oberti, Jean ^b   Thuc, Nguyen V ^b   Van Hoa, Le ^b   Lap, Vu D ^b   Skamene, Emil ^b   Lagrange, Philippe H ^b   Schurr, Erwin ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; ETHNIC GROUP; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; LEPROSY; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIOSIS; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL;

EID: 0031975989     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/513830     Document Type: Article

References (14)

1. Nordeen SK, Lopez-Bravo L, Sundaresan TK. Estimated number of leprosy cases in the world. WHO Bull 1992;70:707-10.
2. Abel L, Lap VD, Oberti J, et al. Complex segregation analysis of leprosy in Vietnam. Genet Epidemiol 1995;12:63-82.
3. Abel L, Demenais L. Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island. Am J Hum Genet 1988;42:256-66.
4. Ottenhoff TH, de Vries RR. HLA class II immune response and suppression genes in leprosy. Int J Lepr 1987;55:521-34.
5. Skamene E, Gros P, Forget A, Patel PJ, Nesbitt MM. Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics 1984;19:117-24.
6. Vidal S, Malo D, Vogan K, Skamene E, Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for BCG. Cell 1993;73:469-86.
7. 2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain. J Exp Med 1994;179:1683-7.
8. Malo D, Vogan K, Vidal S, et al. Haplotype mapping and sequence analysis of the mouse Nramp gene predicts susceptibility to infection with intracellular parasites. Genomics 1994;23:51-61.
9. Cellier M, Govoni G, Vidal S, et al. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med 1994;180: 1741-52.
10. Buu NT, Cellier M, Gros P, Schurr E. Identification of a highly polymorphic length variant in the 3′ UTR of NRAMP1. Immunogenetics 1995; 42:428-9.
11. Liu J, Fujiwara M, Buu NT, et al. Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet 1995;56: 845-53.
12. Liu J, Stanton V, Fujiwara M, et al. Large scale cloning of human chromosome 2 specific artificial chromosomes (YACs) using an interspersed-repetitive sequences (IRS) PCR approach. Genomics 1995;26:178-91.
13. Gingrich JC, Boehrer DM, Garnes JA, et al. Construction and characterization of human chromosome 2-specific cosmid, fosmid, and PAC clone libraries. Genomics 1996;32:65-74.
14. White JK, Shaw MA, Barton CH, et al. Genetic and physical mapping of 2q35 in the region of the NRAMP and IL8R genes: identification of a polymorphic repeat in exon 2 of NRAMP. Genomics 1994;24:295-302.