SirR, a novel iron-dependent repressor in Staphylococcus epidermidis

Infection and Immunity

Volumn 66, Issue 9, 1998, Pages 4123-4129

  Hill, Philip J ^a   Cockayne, Alan ^a   Landers, Patrick ^a   Morrissey, Julie A ^a   Sims, Catriona M ^a   Williams, Paul ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DIPHTHERIA TOXIN; HEME OXYGENASE; IRON; MANGANESE; OLIGONUCLEOTIDE; POLYPEPTIDE; REPRESSOR PROTEIN; SIDEROPHORE;

ARTICLE; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CORYNEBACTERIUM DIPHTHERIAE; CROSS REACTION; DNA SEQUENCE; GENE CONTROL; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OPERON; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STAPHYLOCOCCUS LUGDUNENSIS;

STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 0031715110     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.9.4123-4129.1998     Document Type: Article

References (49)

1. Arbuthnott, J. P., E. Arbuthnott, A. D. J. Arbuthnott, W. J. Pike, and A. Cockayne. 1992. Investigation of microbial growth in vivo: evaluation of a novel in vivo chamber implant system. FEMS Microbiol. Lett. 100:75-80.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology. Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
3. Bagg, A., and J. B. Neilands. 1987. Molecular mechanism of regulation of siderophore-mediated iron assimilation. Microbiol. Rev. 51:509-518.
4. Boyd, J., M. N. Oza, and J. R. Murphy. 1990. Molecular-cloning and DNA- sequence analysis of a diphtheria toxin iron-dependent regulatory element (DtxR) from Corynebacterium diphtheriae. Proc. Natl. Acad. Sci. USA 87: 5968-5972.
5. Bsat, N., and J. D. Helmann. 1997. Regulation of Bacillus subtilis iron uptake genes by Fur protein, abstr. H-193. In Abstracts of the 97th General Meeting of the American Society for Microbiology 1997. American Society for Microbiology, Washington, D.C.
6. Cockayne, A., P. J. Hill, N. B. L. Powell, K. Bishop, C. M. Sims, and P. Williams. 1998. Molecular cloning of a 32kDa lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter. Infect. Immun. submitted.
7. Crossley, K. B., and G. L. Archer. 1997. The staphylococci in human disease. Churchill Livingstone, New York, N.Y.
8. de Lorenzo, V., M. Herrero, F. Giovannini, and J. B. Neilands. 1988. Fur (ferric uptake regulation) protein and CAP (catabolite-activator protein) modulate transcription of fur gene in Escherichia coli. Eur. J. Biochem. 173:537-546.
9. Ding, X., H. Zeug, N. Schiering, D. Ringe, and J. R. Murphy. 1996. Identification of the primary metal ion-activation sites of the diphtheria, tox repressor by X-ray crystallography and site-directed mutational analysis. Nat. Struct. Biol. 3:382-387.
10. Dintilhac, A., G. Alloing, C. Granadel, and J.-P. Claverys. 1997. Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Mol. Microbiol. 25:727-739.
11. Dussurget, O., M. Rodriguez, and I. Smith. 1996. An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response. Mol. Microbiol. 22:535-544.
12. Ernst, J. F., R. L. Bennett, and L. I. Rothfield. 1978. Constitutive expression of the iron-enterochelin and ferrichrome uptake systems in a mutant strain of Salmonella typhimurium. J. Bacteriol. 135:928-934.
13. 2+-dependent DNA- binding represser, DtxR, in Corynebacterium diphtheriae. Infect. Immun. 57:3221-3225.
14. Francis, R. T., J. W. Booth, and R. R. Becker. 1995. Uptake of iron from hemoglobin and haptoglobin-hemoglobin complex by hemolytic bacteria. Int. J. Biochem. 17:767-773.
15. Groman, N. B., and K. Judge. 1979. Effect of metal ions on diphtheria toxin production. Infect. Immun. 26:1065-1070.
16. Gunter-Seeboth, K., and T. Schupp. 1995. Cloning and sequence-analysis of the Corynebacterium-diphtheriae dtxR homolog from Streptomyces lividans and S. pilosus encoding a putative iron represser protein. Gene 166:117-119.
17. Hardham, J. M., L. V. Stamm, S. F. Porcella, J. G. Frye, N. Y. Barnes, and J. K. Howell. 1997. Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog. Gene 197:47-64.
18. Hasan, A. A., J. Holland, A. Smith, and P. Williams. 1997. Elemental iron does repress transferrin, haemopexin and haemoglobin receptor expression in Haemophilus influenzae. FEMS Microbiol. Lett. 150:19-26.
19. Heidrich, C., K. Hantke, G. Bierbaum, and H. G. Sahl. 1996. Identification and analysis of a gene encoding a Fur-like protein of Staphylococcus epidermidis. FEMS Microbiol. Lett. 140:253-259.
20. Lee, J. H., T. Wang, K. Ault, J. Liu, M. P. Schmitt, and R. K. Holmes. 1997. Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin represser (DtxR) and iron. Infect. Immun. 65:4273-4280.
21. Litwin, C. M., S. A. Boyko, and S. B. Calderwood. 1992. Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene. J. Bacteriol. 174:1879-1903.
22. Litwin, C. M., and S. B. Calderwood. 1993. Role of iron in regulation of virulence genes. Clin. Microbiol. Rev. 6:137-149.
23. Modun, B., P. Williams, W. J. Pike, A. Cockayne, J. P. Arbuthnott, R. Finch, and S. P. Denyer. 1992. Cell envelope proteins of Staphylococcus epidermidis grown in vivo in peritoneal chamber implant. Infect. Immun. 60:2551-2553.
24. Modun, B., D. Kendall, and P. Williams. 1994. Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein. Infect. Immun. 62:3850-3858.
25. Modun, B., A. Cockayne, R. G. Finch, and P. Williams. 1998. The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection. Microbiology 144:1005-1012.
26. Modun, B., R. W. Evans, C. L. Joannou, and P. Williams. 1998. Receptor- mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis. Infect. Immun. 66:3591- 3596.
27. Neilands, J. B. 1981. Microbial iron compounds. Annu. Rev. Biochem. 50: 715-731.
28. Oguiza, J. A., X. Tao, A. T. Marcos, J. F. Martin, and J. R. Murphy. 1995. Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum. J. Bacteriol. 177:465-467.
29. Pohl, E., X. Y. Qiu, L. M. Must, R. K. Holmes, and W. G. Y. Hol. 1997. Comparison of high-resolution structures of the diphtheria toxin represser in complex with cobalt and zinc at the cation-anion binding site. Protein Sci. 6:1114-1118.
30. Prince, R. W., C. D. Cox, and M. L. Vasil. 1993. Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J. Bacteriol. 175:2589-2598.
31. Qiu, X. Y., E. Pohl, R. K. Holmes, and W. J. G. Hol. 1996. High-resolution structure of the diphtheria-toxin represser complexed with cobalt and manganese reveals an SH3-like 3rd domain and suggests a possible role of phosphate as co-corepressor. Biochemistry 35:12292-12302.
32. Qiu, X. Y., C. L. M. J. Verlinde, S. P. Zhang, M. P. Schmitt, R. K. Holmes, and W. G. J. Hol. 1995. Three-dimensional structure of the diphtheria-toxin repressor in complex with divalent-cation co-repressers. Structure 3:87-100.
33. Schiering, N., X. Tao, J. R. Murphy, G. A. Petsko, and D. Ringe. 1994. Crystallization and preliminary-X-ray studies of the diphtheria tox repressor from Corynebacterium diphtheriae. J. Mol. Biol. 244:654-656.
34. Schmitt, M. P. 1997. Transcription of the Corynebacterium diphtheriae hmuO gene is regulated by iron and heme. Infect. Immun. 65:4634-4641.
35. Schmitt, M. P., E. M. Twiddy, and R. K. Holmes. 1992. Purification and characterization of the diphtheria-toxin repressor. Proc. Natl. Acad. Sci. USA 89:7576-7580.
36. Schmitt, M. P., and R. K. Holmes. 1993. Analysis of diphtheria-toxin represser-operator interactions and characterization of a mutant repressor with decreased binding-activity for divalent metals. Mol. Microbiol. 9:173-181.
37. Smith, D. G. E., M. H. Wilcox, P. Williams, R. G. Finch, and S. P. Denyer. 1991. Characterization of the cell envelope proteins of Staphylococcus epidermidis cultured in human peritoneal dialysate. Infect. Immun. 59:617-624.
38. Staggs, T. M., and R. D. Perry. 1991. Identification and cloning of a fur regulatory gene in Yersinia pestis. J. Bacteriol. 173:417-425.
39. Tao, X., J. Boyd, and J. R. Murphy. 1992. Specific binding of the diphtheria tox regulatory element DtxR to the tox operator requires divalent heavy-metal ions and a 9-base-pair interrupted palindromic sequence. Proc. Natl. Acad. Sci. USA 89:5897-5901.
40. Tao, X., and J. R. Murphy. 1994. Determination of the minimal essential nucleotide-sequence for diphtheria tox repressor binding by in-vitro affinity selection. Proc. Natl. Acad. Sci. USA 91:9646-9650.
41. Tao, X., N. Schiering, H. Y. Zeng, D. Ringe, and J. R. Murphy. 1994. Iron, DtxR and the regulation of diphtheria-toxin expression. Mol. Microbiol. 14:191-197.
42. Tao, X., and J. R. Murphy. 1993. Cysteine-102 is positioned in the metal- binding activation site of the Corynebacterium diphtheriae regulatory element DtxR. Proc. Natl. Acad. Sci. USA 90:8524-8528.
43. Thomas, C. E., and P. F. Sparling. 1994. Identification and cloning of a fur homologue from Neisseria meningitidis. Mol. Microbiol. 11:725-737.
44. Trivier, D., and R. J. Courcol. 1996. Iron depletion and virulence in Staphylococcus aureus. FEMS Microbiol. Lett. 141:117-127.
45. Wilcox, M. H., P. Williams, D. G. E. Smith, R. G. Finch, and S. P. Denyer. 1991. Variation in the expression of cell envelope proteins of coagulase- negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate. J. Gen. Microbiol. 137:2561-2570.
46. Williams, P., and E. Griffiths. 1992. Bacterial transferrin receptors - structure, function and contribution to virulence. Med. Microbiol. Immunol. 181:301-322.
47. Wang, Z. O., M. P. Schmitt, and R. K. Holmes. 1994. Characterization of mutations that inactivate the diphtheria toxin repressor gene (dtxR). Infect. Immun. 62:1600-1608.
48. Wooldridge, K. G., and P. H. Williams. 1993. Iron uptake mechanisms of pathogenic bacteria. FEMS Microbiol. Rev. 12:325-348.
49. Wooldridge, K. G., P. H. Williams, and J. M. Ketley. 1994. Iron-responsive genetic regulation in Campylobacter jejuni: cloning and characterization of a fur homolog. J. Bacteriol. 176:5852-5856.