Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

Gene Therapy

Volumn 7, Issue 19, 2000, Pages 1672-1679

  Ju, D W ^a   Yang, Y ^b   Tao, Q ^a   Song, W G ^a   He, L ^a   Chen, G ^a   Gu, S ^a   Ting, C C ^b   Cao, X ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytosine deaminase; Gene therapy; Interleukin 18; Tetramer

Indexed keywords

BETA GALACTOSIDASE; CD4 ANTIGEN; CD8 ANTIGEN; CYTOSINE DEAMINASE; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 2; TETRAMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GENE THERAPY; GENE TRANSFER; GROWTH INHIBITION; HELPER CELL; IMMUNOSTIMULATION; INTERFERON PRODUCTION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MELANOMA; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SPLEEN LYMPHOCYTE; SUBCUTANEOUS TISSUE TUMOR; SUICIDE GENE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TUMOR IMMUNITY;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0033753830     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301291     Document Type: Article

References (43)

1. Genetic delivery of enzymes for cancer therapy
2. Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes
3. Immune system in suicide-gene therapy
4. Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice
5. Adenovirus-mediated combined suicide gene and interleukin-2 gene therapy for the treatment of established tumor and induction of antitumor immunity
6. Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma
7. Phenotypic analysis of antigen-specific T lymphocytes
8. Counting antigen-specific CD8 T cells: A re-evaluation of bystander activation during viral infection
9. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
10. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen
11. HLA-peptide tetrameric complexes
12. + T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy
13. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
14. A kinetic basis for T cell receptor repertoire selection during an immune response
15. + effector T cells is differentially regulated by IL-18 and IL-12
16. IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection
17. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
18. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
19. The tetramer model: A new view of class II MHC molecules in antigenic presentation to T cells
20. Glioma cells transduced with an Escherichia coli CD/HSV 1 tk fusion gene exhibit enhanced metabolic suicide and radiosensitivity
21. Double suicide gene cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
22. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma sustained antitumor immunity prolongs animal survival
23. Combination gene therapy for liver metastasis of colon carcinoma in vivo
24. Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for the combined transduction of the interleukin-4 gene
25. A new look at T cells
26. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
27. + T cells during the primary immune response to Epstein-Barr virus in vivo
28. Detection of antigen-specific T cells with multi-valent soluble class II MHC covalent peptide complexes
29. + T cells
30. CD4 T cells and their role in antitumor immune responses
31. + T cells in the antitumor immune response
32. Help for cytotoxic-T cell responses is mediated by CD40 signalling
33. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
34. + CD3-cells
35. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
36. Defective NK cell activity and Th1 response in IL-18-deficient mice
37. Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
38. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coli
39. The effect of human beta2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant. Implications for peptide-based vaccines
40. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection
41. In vivo gene therapy for alpha fetoprotein producing hepatocellular carcinoma by adenovirus mediated transfer of cytosine deaminase gene
42. Induction of antitumor immunity using bone marrow-generated dendritic cells
43. Intratumoral injection of GM-CSF gene encoded recombinant vaccinia virus elicits potent antitumor response in a murine melanoma model