Immune system in suicide-gene therapy

Lancet

Volumn 349, Issue 9044, 1997, Pages 2-3

  Freeman, S M ^a   Ramesh, R ^a   Marrogi, A J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER THERAPY; CELL DEATH; GENE THERAPY; HERPES SIMPLEX VIRUS; IMMUNOGENETICS; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SUICIDE GENE; TUMOR CELL; TUMOR REGRESSION;

EID: 0031023474     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)22001-5     Document Type: Note

References (10)

1. SM Freeman C McCune C Angel GN Abraham CN Abboud Treatment of ovarian cancer using HSV-TK gene-modified vaccine-key issues Hum Gene Ther 3 1992 342 349
2. SM Freeman CN Abboud KA Whartenby The “bystander effect”: tumor regression when a fraction of the tumor mass is genetically modified Cancer Research 53 1993 5274 5283
3. S Gangandeep, R Brew, B Green, SE Christmas, D Klatzmann, GJ Poston, AR Kinsella, Prodrug-activated gene therapy: Involvement of an immunological component in the “bystander effect”. Cancer Gene Therapy (in press).
4. M Caruso Y Panis S Gagandeep D Houssin JL Saltzmann D Klatzmann Regression of established macroscopic liver metastases after in situ transduction of a suicide gene Proc Natl Acad Sci USA 90 1993 7024 7028
5. RG Vile JA Nelson S Castleden H Chong IR Hart Systemic gene therapy of murine melanoma using tissue specific expression of the HSV-TK gene involves an immune component Cancer Res 54 1994 6228 6234
6. SM Freeman R Ramesh M Shastri A Munshi AK Jensen AJ Marrogi The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells Cancer Letters 92 1995 167 174
7. R Ramesh AJ Marrogi A Munshi CN Abboud Freeman SM In vivo analysis of the “Bystander Effect”: a cytokine cascade Exp Hematol 24 1996 829 838
8. SM Freeman KA Whartenby JL Freeman CN Abboud Marrogi AJ In-situ use of suicide genes for cancer therapy Sem Oncol 23 1996 31 45
9. R Ramesh, A Munshi, CN Abboud, AJ Marrogi, SM Freeman, Expression of co-stimulatory molecules: B7 and IC AM upregulation after treatment with a suicide gene. Cancer Gene Therapy (in press).
10. L Santodonato M Ferrantini L Gabriele Cure of mice with established metastatic Friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-a1 and herpes simplex thymidine kinase followed by ganciclovir Human Gene Therapy 7 1996 1 10