Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen

Immunity

Volumn 8, Issue 6, 1998, Pages 667-673

  Gütgemann, Ines ^a   Fahrer, Aude M ^a   Altman, John D ^a,b   Davis, Mark M ^a   Chien, Yueh Hsiu ^a  

^a STANFORD UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL MIGRATION; EFFECTOR CELL; GENE DELETION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION;

EID: 0032100767     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80571-3     Document Type: Article

References (43)

1. Altman, J.D., Reay, P.A., and Davis, M.M. (1993). Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 90, 10330-10334.
2. Altman, J.D., Moss, P.A.H., Goulder, P.J.R., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J., and Davis, M.M. (1996). Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94-96.
3. Blanas, E., Carbone, F.R., Allison, J., Miller, J.F., and Heath, W.R. (1996). Induction of autoimmune diabetes by oral administration of autoantigen. Science 274, 1707-1709.
4. Bruce, M.G., and Ferguson, A. (1986). Oral tolerance to ovalbumin in mice: studies of chemically modified and 'biologically filtered' antigen. Immunology 57, 627-630.
5. Chase, M.W. (1946). Inhibition of experimental drug allergy by prior feeding of sensitizing agent. Proc. Soc. Exp. Biol. Med. 61, 257-259.
6. Chen, Y., Kuchroo, V.K., Inobe, J., Hafler, D.A., and Weiner, H.L. (1994). Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237-1240.
7. Chen, Y., Inobe, J., Marks, R., Gonnella, P., Kuchroo, V.K., and Weiner, H.L. (1995). Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376, 177-180.
8. Chen, Y., Inobe, J., Kuchroo, V.K., Baron, J.L., Janeway, C.A., Jr., and Weiner, H.L. (1996). Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc. Natl. Acad. Sci. USA 93, 388-391.
9. Chen, Y., Inobe, J., and Weiner, H.L. (1997). Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell, Immunol. 178, 62-68.
10. Croft, M., Joseph, S.B., and Miner, K.T. (1997). Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells. J. Immunol. 159, 3257-3265.
11. Danielpour, D., Dart, L.L., Flanders, K.C., Roberts, A.B., and Sporn, M.B. (1989). Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J. Cell. Physiol. 138, 79-86.
12. Davis, M.M., and Chien, Y. (1993). Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes. Curr. Opin. Immunol. 5, 45-49.
13. Fazekas de St. Groth, B., Patten, P.A., Ho, W.Y., Rock, E.P., and Davis, M.M. (1992). An analysis of T cell receptor-ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis. In Molecular Mechanisms of Immunological Self-Recognition, F.W. Alt and A.H. Vogel, eds. (San Diego, CA: Academic Press), pp. 123-127.
14. Hedrick, S.M., Engel, I., McElligott, D.L., Fink, P.J., Hsu, M.L, Hansburg, D., and Matis, L.A. (1988). Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 239, 1541-1544.
15. Ho, W.Y., Cooke, M.P., Goodnow, C.C., and Davis, M.M. (1994). Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ Tcells. J. Exp. Med. 179, 1539-1549.
16. Jorgensen, J.L., Esser, U., Fazekas de St. Groth, B., Reay, P.A., and Davis, M.M. (1992). Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224-230.
17. Kearney, E.R., Pape, K.A., Loh, D.Y., and Jenkins, M.K. (1994). Visualization of peptide-specificTcell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339.
18. Lanoue, A., Bona, C., von Boehmer, H., and Sarukhan, A. (1997). Conditions that induce tolerance in mature CD4+ T cells. J. Exp. Med. 185, 405-414.
19. MacDonald, H.R., Baschieri, S., and Lees, R.K. (1991). Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding tostaphylococcal enterotoxin B in vivo.Eur. J. Immunol. 21, 1963-1966.
20. Marth, T., Strober, W., and Kelsall, B.L. (1996). High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J. Immunol. 157, 2348-2357.
21. McHeyzer-Williams, M.G., and Davis, M.M. (1995). Antigen-specific development of primary and memory T cells in vivo. Science 268, 106-111.
22. Mowat, A.M., and Viney, J.L. (1997). The anatomical basis of intestinal immunity, Immunol. Rev. 156, 145-166.
23. Pape, K.A., Kearney, E.R., Khoruts, A., Mondino, A., Merica, R., Chen, Z.M., Ingulli, E., White, J., Johnson, J.G., and Jenkins, M.K. (1997). Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cells for the study of T-cell activation in vivo, Immunol. Rev. 156, 67-78.
24. Pearson, C.I., Van Ewijk, W., and McDevitt, H.O. (1997). Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 185, 583-599.
25. Peng, H.J., Turner, M.W., and Strobel, S. (1990). The generation of a 'tolerogen' afterthe ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen. Clin. Exp. Immunol. 81, 510-515.
26. Perez, V.L., Van Parijs, L., Biuckians, A., Zheng, X.X., Strom, T.B., and Abbas, A.K. (1997). Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417.
27. Rocha, B., Grandien, A., and Freitas, A.A. (1995). Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181, 993-1003.
28. Rocken, M., Urban, J.F., and Shevach, E.M. (1992). Infection breaks T-cell tolerance. Nature 359, 79-82.
29. Rocken, M., Urban, J., and Shevach, E.M. (1994). Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J. Exp. Med. 179, 1885-1893.
30. Rooke, R., Waltzinger, C., Benoist, C., and Mathis, D. (1997). Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity 7, 123-134.
31. Schatz, P.J. (1993). Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli. Biotechnology (NY) 11, 1138-1143.
32. Swarbrick, E.T., Stokes, C.R., and Soothill, J.F. (1979). Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance. Gut 20, 121-125.
33. + Tcells but affect their long-term life span. Immunity 5, 217-228.
34. Tanchot, C., Lemonnier, F.A., Perarnau, B., Freitas, A.A., and Rocha, B. (1997). Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057-2062.
35. Testi, R., D'Ambrosio, D., De Maria, R., and Santoni, A. (1994). The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells, Immunol. Today 15, 479-483.
36. Van Houten, N., and Blake, S.F. (1996). Direct measurement of anergy of antigen-specific T cells following oral tolerance induction. J. Immunol. 157, 1337-1341.
37. Vella, A.T., McCormack, J.E., Linsley, P.S., Kappler, J.W., and Marrack, P. (1995). Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261-270.
38. Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., Al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E., and Hafler, D.A. (1994). Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809-837.
39. Weiner, H.L. (1997). Oral tolerance: immune mechanisms and treatment of autoimmune diseases, Immunol. Today 18, 335-343.
40. Wells, H.G. (1911). Studies on the chemistry of anaphylaxis. III. Experiments with isolated proteins, especially those of the hen's egg. J. Infect. Dis. 8, 147-171.
41. Wettstein, D.A., Boniface, J.J., Reay, P.A., Schild, H., and Davis, M.M. (1991). Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH. J. Exp. Med. 174, 219-228.
42. Whitacre, C.C., Gienapp, I.E., Meyer, A., Cox, K.L., and Javed, N. (1996). Treatment of autoimmune disease by oral tolerance to autoantigens. Clin. Immunol. Immunopathol. 80, S31-S39.
43. Zhong, G., Sousa, C.R., and Germain, R.N. (1997). Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro. J. Exp. Med. 186, 673-682.