Somatic hypermutation of immunoglobulin genes in human neonates

Clinical and Experimental Immunology

Volumn 108, Issue 2, 1997, Pages 366-374

  Ridings, J ^a   Nicholson, I C ^a   Goldsworthy, W ^a   Haslam, R ^a   Roberton, D M ^a   Zola, H ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

affinity maturation; immunoglobulin genes; immunoglobulin somatic mutation; neonatal antibody response

Indexed keywords

IMMUNOGLOBULIN M;

ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; INFANT; MOLECULAR CLONING; NEWBORN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; UMBILICAL CORD BLOOD;

EID: 0030950603     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.3631264.x     Document Type: Article

References (37)

1. Gathings WE, Kubagawa H, Cooper MD. A distinctive pattern of B cell immaturity in perinatal humans. Immunol Rev 1981; 57:107-26.
2. Kipps TJ. The CD5 B cell. Adv Immunol 1989; 47:117-85.
3. Janeway CA Jr, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994; 76:275-85.
4. Sanders ME, Makgoba MW, Sharrow SO et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-c production. J Immunol 1988; 140:140-17.
5. Zola H, Flego L, Macardle PJ, Donohoe PJ, Ranford J, Roberton D. The CD45RO (p180, UCHLI) marker: complexity of expression in peripheral blood. Cell Immunol 1992; 145:175-86.
6. Brugnoni D, Airo P, Graf D et al. Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn. Eur J Immunol 1994; 24:1919-24.
7. Fuleihan R, Ahern D, Geha RS. Decreased expression of the ligand for CD40 in newborn lymphocytes. Eur J Immunol 1994; 24:1925-8.
8. Zola H, Fusco M, Macardle PJ, Flego L, Roberton D. Expression of cytokine receptors by human cord blood lymphocytescomparison with adult lymphocytes. Pediatric Res 1995; 38:397-403.
9. Small TN, Keever C, Collins N, Dupont B, O'Reilly RJ, Flomenberg N. Characterization of B cells in severe combined immunodeficiency disease. Hum Immunol 1989; 25:181-93.
10. MacLennan ICM. Germinal centres. Ann Rev Immunol 1994; 12: 117-39.
11. + B cells express somatically mutated V kappa 4 genes. Eur J Immunol 1993; 23:1405-8.
12. + and CD5 B cells may express somatically mutated VH5- and VH6-encoded IgM receptors. J Immunol 1993; 131:6891-9.
13. + chronic lymphocytic leukemia B cells. J Exp Med 1995; 181:1507-17.
14. Cai J, Humphries C, Richardson A, Tucker PW. Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia. J Exp Med 1992; 176:1073-81.
15. Van Es JH, Gmelig Meyling FHJ, Logtenberg T. High frequency of somatically mutated IgM molecules in the human adult B cell repertoire. Eur J Immunol 1992; 22:2761-4.
16. Insel RA, Varade WS, Marin E. Human splenic IgM immunoglobulin transcripts are mutated at high frequency. Mol Immunol 1994; 31: 383-92.
17. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994; 180:329-39.
18. Liu YJ, Malisan F, de Bouteiller O et al. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 1996; 4:241-50.
19. Nicholson IC, Brisco MJ, Zola H. Memory B lymphocytes in human tonsil do not express surface IgD. J Immunol 1995; 154:1105-13.
20. Klein U, Kuppers R, Rajewsky K. Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J Exp Med 1994; 180:1383-93.
21. Kanof ME, Smith PD, Zola H. Preparation of human mononuclear cell populations and subpopulations. In: Unit 7.1. Coico R, Coligan JE, Margulies DH, Shevach EM, Strober W, Kruisbeek AM, eds. Current protocols in immunology. New York: John Wiley, 1996.
22. Brisco MJ, Condon J, Hughes E et al. Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. Australian and New Zealand Children's Cancer Study Group. Leukemia 1993; 7:1514-20.
23. Marks JD, Tristem M, Karpas A, Winter G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family specific oligonucleotide probes. Eur J Immunol 1991; 21:985-91.
24. Deane M, Pappas H, Norton JD. Immunoglobulin heavy chain gene fingerprinting reveals widespread oligoclonality in B-lineage acute lymphoblastic leukaemia. Leukemia 1991; 5:832-8.
25. Nicholson IC, Zola H. Rapid detection of immunoglobulin gene somatic hypermutation using heteroduplex formation. Mol Immunol 1994; 31:1213-8.
26. Berman JE, Mellis SJ, Pollock R et al. Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J 1988; 7:727-38.
27. Mortari F, Wang J-Y, Schroeder HW. Human cord blood antibody repertoire. J Immunol 1993; 150:1348-57.
28. Petit T, Gluckman E, Carosella E, Brossard Y, Brison O, Socie G. A highly sensitive polymerase chain reaction method reveals the ubiquitous presence of maternal cells in human umbilical cord blood. Exp Hematol 1995; 23:1601-5.
29. Matsubara T, Sumazaki R, Takita H. Mother-to-infant transmission of hepatitis C virus: a prospective study. Eur J Pediatr 1995; 154:973-8.
30. Berek C. Somatic mutation and memory. Curr Opin Immunol 1993; 5:218-22.
31. Jukes TH, King JL. Evolutionary nucleotide replacements of DNA. Nature 1979; 281:605-6.
32. Adams PT, Davenport RD, Reardon DA, Roth MS. Detection of circulating donor white blood cells in patients receiving multiple transfusions. Blood 1992; 80:551-5.
33. Lee TH, Donegan E, Slichter S, Busch MP. Transient increase in circulating donor leukocytes after allogeneic transfusions in immunocompetent recipients compatible with donor cell proliferation. Blood 1995; 85:1207-14.
34. Hutchinson DL, Turner JH, Schlesinger ER. Persistence of donor cells in neonates after fetal and exchange transfusion. Am J Obstet Gynec 1971; 109:281-4.
35. Chu YW, Marin E, Fuleihan R et al. Somatic mutation of human immunoglobulin V genes in the X-linked hyperIgM syndrome. J Clin Invest 1995; 95:1389-93.
36. Ziegner M, Steinhauser G, Berek C. Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol 1994; 24:2393-400.
37. Kabat EA, Wu TT, Perry HM, Gottesman KC, Foeller C. Sequences of proteins of immunological interest. Bethesda: US Department of Health and Human Services, 1991.