Novel enzymatic and immunological responses to oligonucleotides

Toxicology Letters

Volumn 82-83, Issue C, 1995, Pages 431-434

  Agrawaf, Sudhir ^a   Rustagi, Pradip K ^b   Shaw, Denise R ^b  

^a HYBRIDON INC   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antisense; Coagulation; Complement; Oligonucleotides; Phosphorothioate

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENT; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL CELL; BLOOD CLOTTING; CONFERENCE PAPER; CONTROLLED STUDY; GUINEA PIG; HEMOLYSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD COAGULATION; COMPLEMENT SYSTEM PROTEINS; GUINEA PIGS; HUMANS; MACACA MULATTA; OLIGONUCLEOTIDES, ANTISENSE; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES;

EID: 0029588561     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(95)03573-7     Document Type: Article

References (16)

1. The hybridization inhibition or antisense approach to the chemotherapy of AIDS
2. Modified oligonucleotides as therapeutic and diagnostic agents
3. Pharmacokinetics of antisense oligonucleotides
4. Pharmacokinetics of an anti-HIV antisense oligodeoxynucleotide phosphorothioate (GEM91) in HIV-infected subjects
5. A pharmacokinetic evaluation of 14-C-labeled afovirsen sodium in patients with genital warts
6. Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey
7. Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey
8. Effects of ISIS 2302, a phosphorothioate oligonucleotide, on in vitro and in vivo coagulation parameters
9. GEM-91, an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS
10. Complement and complement fixation
11. Selfstabilized antisense oligonucleotide phosphorothioates: synthesis, properties and anti-HIV activity
12. In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats
13. Study of antisense oligonucleotide phosphorothioates containing segments of 2′-O-methyloligoribonucleotides
14. In vivo stability, disposition and metabolism of a ‘hybrid’ oligonucleoside phosphorothioate in rats
15. Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration
16. Site specific excision from RNA by RNase H and mixed phosphate backbone oligodeoxynucleotides