Cure of progressive murine leishmaniasis: Interleukin 4 dominance is abolished by transient CD4+ T cell depletion and T helper cell type 1- selective cytokine therapy

Journal of Experimental Medicine

Volumn 189, Issue 12, 1999, Pages 1895-1905

  Heinzel, Frederick P ^a   Rerko, Ronald M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunity cellular; Interferon type II; Interleukin 12; T helper cells type 1 immunology; T helper cells type 2 immunology

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; OKT 4; OKT 8;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXICITY; FEMALE; HELPER CELL; IMMUNOTHERAPY; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; INTERLEUKIN-12; INTERLEUKIN-4; LEISHMANIA MAJOR; LEISHMANIASIS; MICE; MICE, INBRED STRAINS; TH1 CELLS; TH2 CELLS;

EID: 0033591687     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.12.1895     Document Type: Article

References (56)

1. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
2. Charlton, B., and K.J. Lafferty. 1995. The Th1/Th2 balance in autoimmunity. Curr. Opin. Immunol. 7:793-798.
3. Urban, J.F., Jr., N. Noben-Trauth, D.D. Donaldson, K.B. Madden, S.C. Morris, M. Collins, and F.D. Finkelman. 1998. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity. 8:255-264.
4. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, C.L. Karp, and D.D. Donaldson. 1998. Interleukin-13: central mediator of allergic asthma. Science. 282:2258-2261.
5. Grunig, G., M. Warnock, A.E. Wakil, R. Venkayya, F. Brombacher, D.M. Rennick, D. Sheppard, M. Mohrs, D.D. Donaldson, R.M. Locksley, and D.E. Corry. 1998. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 282:2261-2263.
6. Forsthuber, T., H.C. Yip, and P.V. Lehmann. 1996. Induction of TH1 and TH2 immunity in neonatal mice. Science. 271:1728-1730.
7. Falcone, M., and B.R. Bloom. 1997. A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis. J. Exp. Med. 185: 901-907.
8. Gavett, S.H., D.J. O'Hearn, X. Li, S.K. Huang, F.D. Finkelman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527-1536.
9. Choy, E.H., G.S. Panayi, and G.H. Kingsley. 1995. Therapeutic monoclonal antibodies. Br. J. Rheumatol. 34:707-715.
10. + T cells is required to suppress autoimmunity. J. Immunol. 149:3083-3088.
11. Ranges, G.E., S. Sriram, and S.M. Cooper. 1985. Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J. Exp. Med. 162:1105-1110.
12. Rep, M.H., B.W. van Oosten, M.T. Roos, H.J. Ader, C.H. Polman, and R.A. van Lier. 1997. Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-γ secreting TH1 cells in humans. J. Clin. Invest. 99:2225-2231.
13. Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
14. + T cell-intrinsic mechanism. J. Exp. Med. 188:2289-2299.
15. Liew, F., Y. Li, A. Severn, S. Millott, J. Schmidt, M. Salter, and S. Moncada. 1991. A possible novel pathway of regulation by murine T helper type-2 cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur. J. Immunol. 21:2489-2494.
16. Sypek, J.P., C.L. Chung, S. Mayor, J. Subramanyam, S. Goldman, D. Sieburth, S. Wolf, and R.G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797-1802.
17. Chatelain, R., K. Varkila, and R.L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182-1187.
18. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
19. Belkaid, Y., B. Butcher, and D.L. Sacks. 1998. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells. Eur. J. Immunol. 28:1389-1400.
20. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579-1584.
21. Nabors, G.S., L.C.C. Afonso, J.P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA. 92:3142-3146.
22. Zimmermann, S., O. Egeter, S. Hausmann, G.B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627-3630.
23. Jakob, T., P.S. Walker, A.M. Krieg, MC. Udey, and J.C. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 161:3042-3049.
24. Sadick, M.D., R.M. Locksley, C. Tubbs, and H.V. Raff. 1986. Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-γ in response to leishmania antigens in vitro. J. Immunol. 136:655-661.
25. Heinzel, P.P., A.M. Hujer, F.N. Ahmed, and R.M. Rerko. 1997. In vivo production and function of IL-12 p40 homodimers. J. Immunol. 158:4381-4388.
26. Gately, M.K., R.R. Warrier, S. Honasoge, D.M. Carvajal, D.A. Faherty, S.E. Connaughton, T.D. Anderson, U. Sarmiento, B.R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Imimmol. 6:157-167.
27. + T cell responses capable of exacerbating leishmaniasis in normally resistant C57BL/6 mice. J. Immunol. 155:730-739.
28. Brown, D.R., J.M. Green, N.H. Moskowitz, M. Davis, C.B. Thompson, and S.L. Reiner. 1996. Limited role of CD28-mediated signals in T helper subset differentiation. J. Exp. Med. 184:803-810.
29. Heinzel, F.P., R.M. Rerko, and A.M. Hujer. 1998. Under-production of interleukin-12 during progressive murine leishmaniasis is due to decreased CD40 activity. Cell. Immunol. 184:129-142.
30. Launois, P., K.G. Swihart, G. Milon, and J.A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol 158:3317-3324.
31. + T cells. Eur. J. Immunol. 24:343-347.
32. Wang, Z.E., S. Zheng, D.B. Corry, D.K. Dalton, R.A. Seder, S.L. Reiner, and R.M. Locksley. 1994. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA. 91:12932-12936.
33. Heinzel, F.P., R.M. Rerko, F. Hatam, and R.M. Locksley. 1993. Interleukin-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924-3931.
34. Brown, D.R., N.H. Moskowitz, N. Killeen, and S.L. Reiner. 1997. A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186:101-107.
35. Fowell, D.J. J. Magram, C.W. Turck, N. Killeen, and R.M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity. 6:559-569.
36. Cobbold, S.P., S. Qin, L.Y. Leong, G. Martin, and H. Waldmann. 1992. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol. Rev. 129:165-201.
37. Jones, D., M.M. Elloso, L. Showe, D. Williams, G. Trinchieri, and P. Scott. 1998. Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major. Infect. Immun. 66:3818-3824.
38. + T cells. Int. Immunity. 3:587-597.
39. Chace, J.H., J.S. Cowdery, and E.H. Field. 1994. Effect of anti-CD4 on CD4 subsets. I. Anti-CD4 preferentially deletes resting, naive CD4 cells and spares activated CD4 cells. J. Immunol. 152:405-412.
40. Dent, A.L.J. Hu-Li, W.E. Paul, and L.M. Staudt. 1998. T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc. Natl. Acad. Sci. USA. 95:13823-13828.
41. + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc. Natl. Acad. Sci. USA. 94:3189-3194.
42. + T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice. J Immunol. 154:6644-6654.
43. Swain, S.L. 1994. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity. 1:543-552.
44. Wang, Z., S.L. Reiner, F. Hatam, F.P. Heinzel, J. Bouvier, C.W. Turck, and R.M. Locksley. 1993. Targeted activation of CD8 cells and infection of β2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J. Immunol. 151:2077-2086.
45. Huber, M., E. Timms, T.W. Mak, M. Rollinghoff, and M. Lohoff. 1998. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect. Immun. 66:3968-3970.
46. Carteron, N.L., D. Wofsy, and W.E. Seaman. 1988. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells J. Immunol. 140:713-716.
47. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science. 274:421-423.
48. Nandan, D., and N.E. Reiner. 1995. Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infect. Immun. 63:4495-4500.
49. Brown, L.A., R.G. Titus, N. Nabavi, and L.H. Glimcher. 1996. Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response. J. Infect. Dis. 174: 1303-1308.
50. Corry, D.B., S.L. Reiner, P.S. Linsley, and R.M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142-4148.
51. Finkelman, F.D., K.B. Madden, A.W. Cheever, I.M. Katona, S.C. Morris, M.K. Gately, B.R. Hubbard, W.C. Gause, and J.F. Urban, Jr. 1994. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563-1572.
52. Germann, T., S. Guckes, M. Bongartz, H. Dlugonska, E. Schmitt, L. Kolbe, E. Kolsch, F.J. Podlaski, M.K. Gately, and E. Rude. 1995. Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE. Int. Immunol. 7:1649-1657.
53. Tian, J., M. Clare-Salzler, A. Herschenfeld, B. Middleton, D. Newman, R. Mueller, S. Arita, C. Evans, M.A. Atkinson, Y. Mullen, et al. 1996. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat. Med. 2:1348-1353.
54. Rocken, M., M. Racke, and E.M. Shevach. 1996. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today. 17:225-231.
55. Leonard, J.P., K.E. Waldburger, and S.J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381-386.
56. Racke, M.K., A. Bonomo, D.E. Scott, B. Cannella, A. Levine, C.S. Raine, E.M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961-1966.