An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 15, 1999, Pages 8579-8584

  Miltenberger, R J ^a   Mynatt, R L ^a,d   Bruce, B D ^b   Wilkison, W O ^c,e   Woychik, R P ^a,f   Michaud, E J ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^e Zen Bio Inc   (United States)

^f PFIZER INC   (United States)

Author keywords

Melanocortin receptors; Pheomelanin

Indexed keywords

BETA ACTIN; GENE PRODUCT; MELANOCORTIN RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION REGULATION; GENE MUTATION; HAIR COLOR; HORMONE RECEPTOR INTERACTION; HYPERGLYCEMIA; HYPERINSULINEMIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RNA SYNTHESIS;

ANIMALS; BODY WEIGHT; GENE DOSAGE; GENE EXPRESSION; GLYCOSYLATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; OBESITY; PHENOTYPE; PIGMENTATION; PROMOTER REGIONS (GENETICS); PROTEIN SORTING SIGNALS; PROTEINS; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; RNA; SEQUENCE DELETION; SKIN;

AGOUTI; ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0033587767     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.15.8579     Document Type: Article

References (41)

1. Bultman, S. J., Michaud, E. J. & Woychik, R. P. (1992) Cell 71, 1195-1204.
2. Vage, D. I., Lu, D., Klungland, H., Lien, S., Adalsteinsson, S. & Cone, R. D. (1997) Nat. Genet. 15, 311-315.
3. Wang, Y., Westby, C. A., Johansen, M., Marshall, D. M. & Granholm, N. (1998) Pigment Cell Res. 11, 155-157.
4. Ollmann, M. M., Lamoreux, M. L., Wilson, B. D. & Barsh, G. S. (1998) Genes Dev. 12, 316-330.
5. Jackson, I. J. (1994) Annu. Rev. Genet. 28, 189-217.
6. Miltenberger, R. J., Mynatt, R. L., Wilkinson, J. E. & Woychik, R. P. (1997) J. Nutr. 127, 1902S-1907S.
7. Michaud, E. J., Mynatt, R. L., Miltenberger, R. J., Klebig, M. L., Wilkinson, J. E., Zemel, M. B., Wilkison, W. O. & Woychik, R. P. (1997) J. Endocrinol. 155, 207-209.
8. Michaud, E. J., Bultman, S. J., Stubbs, L. J. & Woychik, R. P. (1993) Genes Dev. 7, 1203-1213.
9. Duhl, D. M., Stevens, M. E., Vrieling, H., Saxon, P. J., Miller, M. W., Epstein, C. J. & Barsh, G. S. (1994) Development (Cambridge, U.K.) 120, 1695-1708.
10. Michaud, E. J., van Vugt, M. J., Bultman, S. J., Sweet, H. O., Davisson, M. T. & Woychik, R. P. (1994) Genes Dev. 8, 1463-1472.
11. Duhl, D. M., Vrieling, H., Miller, K. A., Wolff, G. L. & Barsh, G. S. (1994) Nat. Genet. 8, 59-65.
12. Klebig, M. L., Wilkinson, J. E., Geisler, J. G. & Woychik, R. P. (1995) Proc. Natl. Acad. Sci. USA 92, 4728-4732.
13. Perry, W. L., Hustad, C. M., Swing, D. A., Jenkins, N. A. & Copeland, N. G. (1995) Genetics 140, 267-274.
14. Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J. & Cone, R. D. (1997) Nature (London) 385, 165-168.
15. Kiefer, L. L., Ittoop, O. R., Bunce, K., Truesdale, A. T., Willard, D. H., Nichols, J. S., Blanchard, S. G., Mountjoy, K., Chen, W. J. & Wilkison, W. O. (1997) Biochemistry 36, 2084-2090.
16. Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) Cell 88, 131-141.
17. Yeo, G. S., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G. & O'Rahilly, S. (1998) Nat. Genet. 20, 111-112.
18. Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. (1998) Nat. Genet. 20, 113-114.
19. Shutter, J. R., Graham, M., Kinsey, A. C., Scully, S., Luthy, R. & Stark, K. L. (1997) Genes Dev. 11, 593-602.
20. Fong, T. M., Mao, C. MacNeil, T., Kalyani, R., Smith, T., Weinberg, D., Tota, M. R. & Van der Ploeg, L. H. (1997) Biochem. Biophys. Res. Commun. 237, 629-631.
21. Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I. & Barsh, G. S. (1997) Science 278, 135-138.
22. Rossi, M., Kim, M. S., Morgan, D. G., Small, C. J., Edwards, C. M., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A., et al. (1998) Endocrinology 139, 4428-4431.
23. Willard, D. H., Bodnar, W., Harris, C., Kiefer, L., Nichols, J. S., Blanchard, S., Hoffman, C. Moyer, M., Burkhart, W., Weiel, J., et al. (1995) Biochemistry 34, 12341-12346.
24. Pallaghy, P. K., Nielsen, K. J., Craik, D. J. & Norton, R. S. (1994) Protein Sci. 3, 1833-1839.
25. Kiefer, L. L., Veal, J. M., Mountjoy, K. G. & Wilkison, W. O. (1998) Biochemistry 37, 991-997.
26. Perry, W. L., Nakamura, T., Swing, D. A., Secrest, L., Eagleson, B., Hustad, C. M., Copeland, N. G. & Jenkins, N. A. (1996) Genetics 144, 255-264.
27. Kwon, H. Y., Bultman, S. J., Loffler, C., Chen, W. J., Furdon, P. J., Powell, J. G., Usala, A. L., Wilkison, W., Hansmann, I. & Woychik, R. P. (1994) Proc. Natl. Acad. Sci. USA 91, 9760-9764.
28. Quillan, J. M., Sadee, W., Wei, E. T., Jimenez, C., Ji, L. & Chang, J. K. (1998) FEBS Lett. 428, 59-62.
29. Hogan, B., Costantini, F. & Lacy, E. (1986) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
30. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
31. Miller, M. W., Duhl, D. M., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M. & Barsh, G. S. (1993) Genes Dev. 7, 454-467.
32. Bultman, S. J., Klebig, M. L., Michaud, E. J., Sweet, H. O., Davisson, M. T. & Woychik, R. P. (1994) Genes Dev. 8, 481-490.
33. Zemel, M. B., Kim, J. H., Woychik, R. P., Michaud, E. J., Kadwell, S. H., Patel, I. R. & Wilkison, W. O. (1995) Proc. Natl. Acad. Sci. USA 92, 4733-4737.
34. Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S. & Wolff, G. L. (1994) FASEB J. 8, 479-488.
35. Hustad, C. M., Perry, W. L., Siracusa, L. D., Rasberry, C., Cobb, L., Cattanach, B. M., Kovatch, R., Copeland, N. G. & Jenkins, N. A. (1995) Genetics 140, 255-265.
36. Green, M. C. (1989) in Genetic Variants and Strains of the Laboratory Mouse, eds. Lyon, M. F. & Searle, A. G. (Oxford Univ. Press, Oxford), pp. 82-83.
37. Mynatt, R. L., Miltenberger, R. J., Klebig, M. L., Zemel, M. B., Wilkinson, J. E., Wilkinson, W. O. & Woychik, R. P. (1997) Proc. Natl. Acad. Sci. USA 94, 919-922.
38. Lu, D., Willard, D., Patel, I. R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R. P. & Wilkison, W. O. (1994) Nature (London) 371, 799-802.
39. Nagle, D. L., McGrail, S. H., Vitale, J., Woolf, E. A., Dussault, B. J., Jr., DiRocco, L., Holmgren, L., Montagno, J., Bork, P., Huszar, D., et al. (1999) Nature (London) 398, 148-152.
40. Gunn, T. M., Miller, K. A., He, L., Hyman, R. W., Davis, R. W., Azarani, A., Schlossman, S. F., Duke-Cohan, J. S. & Barsh, G. S. (1999) Nature (London) 398, 152-156.
41. Miller, K. A., Gunn, T. M., Carrasquillo, M. M., Lamoreux, M. L., Galbraith, D. B. & Barsh, G. S. (1997) Genetics 146, 1407-1415.