Huntingtin immunoreactivity in the rat neostriatum: Differential accumulation in projection and interneurons

Experimental Neurology

Volumn 144, Issue 2, 1997, Pages 239-247

  Kosinski, Christoph M ^a   Cha, Jang Ho ^a   Young, Anne B ^a   Persichetti, Francesca ^a   MacDonald, Marcy ^a   Gusella, James F ^a   Penney Jr , John B ^a   Standaert, David G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; HUNTINGTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; HUNTINGTON CHOREA; IMMUNOREACTIVITY; INTERNEURON; MALE; NEOSTRIATUM; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

EID: 0031127812     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6441     Document Type: Article

References (39)

1. Albin R. L., Reiner A., Anderson K. D., Dure L. T., Handelin B., Balfour R., Whetsell W. Jr., Penney J. B., Young A. B. Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease. Ann. Neurol. 31:1992;425-430.
2. Aronin N., Chase K., Young C., Sapp E., Schwarz C., Matta N., Kornreich R., Landwehrmeyer B., Bird E., Beal M. F., Vonsattel J. P., Smith T., Carraway R., Boyce F. M., Young A. B., Penney J. B., DiFiglia M. CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain. Neuron. 15:1995;1193-1201.
3. Bao J., Sharp A. H., Wagster M. V., Becher M., Schilling G., Ross C. A., Dawson V. L., Dawson T. M. Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proc. Natl. Acad. Sci. USA. 93:1996;5037-5042.
4. Beal M. F., Brouillet E., Jenkins B. G., Ferrante R. J., Kowall N. W., Miller J. M., Storey E., Srivastava R., Rosen B. R., Hyman B. T. Neurochemical and histological characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13:1993;4181-4192.
5. Beal M. F., Ferrante R. J., Swartz K. J., Kowall N. W. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. J. Neurosci. 11:1991;1649-1659.
6. Burke J. R., Enghild J. J., Martin M. E., Jou Y. S., Myers R. M., Roses A. D., Vance J. M., Strittmatter W. J. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2:1996;347-350.
7. Cicchetti F., Parent A. Striatal interneurons in Huntington's disease: Selective increase in the density of calretinin-immunoreactive medium-sized neurons. Moving Disord. 11:1996;619-626.
8. DiFiglia M., Sapp E., Chase K., Schwarz C., Meloni A., Young C., Martin E., Vonsattel J. P., Carraway R., Reeves S. A. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron. 14:1995;1075-1081.
9. Duyao M. P., Auerbach A. B., Ryan A., Persichetti F., Barnes G. T., McNeil S. M., Vonsattel J. P., Gusella J. F., Joyner A. L. Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 269:1995;407-410.
10. Ferrante R. J., Kowall N. W., Beal M. F., Martin J. B., Bird E. D., Richardson E. P. Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease. J. Neuropathol. Exp. Neurol. 46:1987;12-27.
11. Gerfen C. R., Baimbridge K. G., Miller J. J. The neostriatal mosaic: Compartmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc. Natl. Acad. Sci. USA. 82:1985;8780-8784.
12. Goldberg Y. P., Nicholson D. W., Rasper D. M., Kalchman M. A., Koide H. B., Graham R. K., Bromm M., Kazemi-Esfarjani P., Thornberry N. A., Vaillancourt J. P., Hayden M. R. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet. 13:1996;442-449.
13. Gutekunst C. A., Levey A. I., Heilman C. J., Whaley W. L., Yi H., Nash N. R., Rees H. D., Madden J. J., Hersch S. M. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl. Acad. Sci. USA. 92:1995;8710-8714.
14. Harrington K. M., Kowall N. W. Parvalbumin immunoreactive neurons resist degeneration in Huntington's disease striatum. J. Neuropathol. Exp. Neurol. 50:1991;309.
15. Hedreen J. C., Folstein S. E. Early loss of neostriatal striosome neurons in Huntington's disease. J. Neuropathol. Exp. Neurol. 54:1995;105-120.
16. Huang P. L., Dawson T. M., Bredt D. S., Snyder S. H., Fishman M. C. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 75:1993;1273-1286.
17. Cell. 72:1993;971-983.
18. Ide K., Nukina N., Masuda N., Goto J., Kanazawa I. Abnormal gene product identified in Huntington's disease lymphocytes and brain. Biochem. Biophys. Res. Commun. 209:1995;1119-1125.
19. Jou Y. S., Myers R. M. Evidence from antibody studies that the CAG repeat in the Huntington's disease gene is expressed in the protein. Hum. Mol. Genet. 4:1995;465-469.
20. 28. Brain. Res. 525:1990;209-214.
21. Landwehrmeyer G. B., McNeil S. M., Dure L. S., Ge P., Aizawa H., Huang Q., Ambrose C. M., Duyao M. P., Bird E. D., Bonilla E., deYoung M., Avila-Gonzales A. J., Wexler N. S., DiFiglia M., Gusella J. F., MacDonald M. E., Penney J. B., Young A. B., Vonsattel J. P. Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals. Ann. Neurol. 37:1995;218-230.
22. Li S. H., Schilling G., Young W. D., Li X. J., Margolis R. L., Stine O. C., Wagster M. V., Abbott M. H., Franz M. L., Ranen N. G. Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron. 11:1993;985-993.
23. Li X. J., Li S. H., Sharp A. H., Nucifora F. Jr., Schilling G., Lanahan A., Worley P., Snyder S. H., Ross C. A. A huntingtin-associated protein enriched in brain with implications for pathology. Nature. 378:1995;398-402.
24. Li X. J., Sharp A. H., Li S. H., Dawson T. M., Snyder S. H., Ross C. A. Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 93:1996;4839-4844.
25. Nasir J., Floresco S. B., O'Kusky J. R., Diewert V. M., Richman J. M., Zeisler J., Borowski A., Marth J. D., Phillips A. G., Hayden M. R. Targeted cell disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell. 81:1995;811-823.
26. Persichetti F., Ambrose C. M., Ge P., McNeil S. M., Srinidhi J., Anderson M. A., Jenkins B., Barnes G. T., Duyao M. P., Kanaley L. Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol. Med. 1:1995;374-383.
27. Persichetti F., Carlee L., Faber P. W., McNeil S. M., Ambrose C. M., Srinidhi J., Anderson M. A., Barnes G. T., Gusella J. F., McDonald M. E. Differential expression of normal and mutant Huntington's disease gene alleles. Neurobiol. Dis. 3:1996;183-190.
28. Reiner A., Anderson K. D. The patterns of neurotransmitter and neuropeptide co-occurrence among striatal projection neurons: Conclusions based on recent findings. Brain. Res. Rev. 15:1990;251-265.
29. Richfield E. K., Maguire-Zeiss K. A., Vonkeman H. E., Voorn P. Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients. Ann. Neurol. 38:1995;852-861.
30. Sapp E., Ge P., Aizawa H., Bird E., Penney J., Young A. B., Vonsattel J. P., DiFiglia M. Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis. Neuroscience. 64:1995;397-404.
31. Schilling G., Sharp A. H., Loev S. J., Wagster M. V., Li S. H., Stine O. C., Ross C. A. Expression of the Huntington's disease (IT15) protein product in HD patients. Hum. Mol. Genet. 4:1995;1365-1371.
32. Seto-Ohshima A., Emson P. C., Lawson E., Mountjoy C. Q., Carrasco L. H. Loss of matrix calcium-binding protein-containing neurons in Huntington's disease. Lancet. ii:1988;1252-1254.
33. Sharp A. H., Loev S. J., Schilling G., Li S. H., Li X. J., Bao J., Wagster M. V., Kotzuk J. A., Steiner J. P., Lo A. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron. 14:1995;1065-1074.
34. Standaert D. G., Watson S. J., Houghten R. A., Saper C. B. Opioid peptide immunoreactivity in spinal and trigeminal dorsal horn neurons projecting to the parabrachial nucleus. J. Neurosci. 6:1986;1220-1226.
35. Strong T. V., Tagle D. A., Valdes J. M., Elmer L. W., Boehm K., Swaroop M., Kaatz K. W., Collins F. S., Albin R. L. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nature Genet. 5:1993;259-265.
36. Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E. C., Mandel J. L. Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nature Genet. 10:1995;104-110.
37. Trottier Y., Devys D., Imbert G., Saudou F., An I., Lutz Y., Weber C., Agid Y., Hirsch E. C., Mandel J. L. Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nature Genet. 10:1995;104-110.
38. Vonsattel J. P., Myers R. H., Stevens T. J., Ferrante R. J., Bird E. D., Richardson E. Jr. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44:1985;559-577.
39. Zeitlin S., Liu J. P., Chapman D. L., Papaioannou V. E., Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genet. 11:1995;155-163.