High-affinity recombinant phage antibodies to the pan-carcinoma marker epithelial glycoprotein-2 for tumour targeting

British Journal of Cancer

Volumn 78, Issue 11, 1998, Pages 1407-1416

  Roovers, R C ^a   Henderikx, P ^a   Helfrich, W ^b   Van Der Linden, E ^a   Reurs, A ^a   De Bruine A P ^c   Arends, J W ^a,c   De Leij, L ^b   Hoogenboom, H R ^b,c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Affinity; Epithelial glycoprotein 2; Phage display; Single chain Fv; Tumour targeting

Indexed keywords

ANTIBODY; ANTIBODY 17 1A; ANTIBODY 323/A3; ANTIBODY MOC 161; ANTIBODY MOC 31; EPITHELIAL GLYCOPROTEIN 2; GLYCOPROTEIN; RECOMBINANT PROTEIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BINDING KINETICS; COLON CARCINOMA; CONTROLLED STUDY; DRUG SPECIFICITY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MELANOMA; MOLECULAR CLONING; PHAGE DISPLAY; PRIORITY JOURNAL;

EID: 0031739218     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.700     Document Type: Article

References (36)

1. Adams GP, McCartney JE, Tai MS, Oppermann H, Huston JS, Stafford 3rd WF, Bookman MA, Fand I, Houston LL and Weiner LM (1993) Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. Cancer Res 53: 4026-4034
2. Balaban EP, Walker BS, Cox JV, Sein AA, Abrams PG, Salk D, Sheehan RG and Frenkel EP (1991) Radionuclide imaging of bone marrow metastases with a Tc-99m labeled monoclonal antibody to small cell lung carcinoma. Clin Nucl Med 16: 732-736
3. Begent RHJ, Verhaar MJ, Chester KA, Casey JL, Green AJ, Napier MP, Hope-Stone LD, Cushen N, Keep PA, Johnson CJ, Hawkins RE, Hilson AJW and Robson L (1996) Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nature Med 2: 979-984
4. Bradbury A, Ruberti F, Werge T, Amati V, Di Luzio A, Gonfloni S, Hoogenboom HR, Piccioli P, Biocca S and Cattaneo A (1995) The cloning of hybridoma V regions for their ectopic expression in intracellular and intercellular immunization. In Antibody Engineering, Borrebaeck CAK (ed.), pp. 295-362. Oxford University Press: New York
5. Caton AJ (1986) Comparative sequence analysis of CO17-1A antigen-specific monoclonal antibodies. Hybridoma 5: 11-16
6. Clackson T, Hoogenboom HR, Griffiths AD and Winter G (1991) Making antibody fragments using phage display libraries. Nature 352: 624-628
7. Dohlsten M, Abrahmsen L, Bjork P, Lando PA, Hedlund G, Forsberg G, Brodin T, Gascoigne NR, Forberg C, Lind P and Kalland T (1994) Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy. Proc Natl Acad Sci U S A 91: 8945-8949
8. Edwards DP, Grzyh KT, Dressler LG, Mansel RE, Zava DT, Sledge Jr GW and McGuire WL (1986) Monoclonal antibody identification and characterization of a Mr 43 000 membrane glycoprotein associated with human breast cancer. Cancer Res. 46: 1306-1317
9. Fagerberg J, Steinitz M, Wigzell H, Askelöf P and Mellstedt H (1995) Human anti-idiotypic antibodies induced a humoral and cellular immune response against a colorectal carcinoma-associated antigen in patients. Proc Natl Acad Sci USA 92: 4773-4777
10. Frodin JE, Harmenberg U, Biberfeld P, Christensson B, Lefvert AK, Rieger A, Shetye J, Wahren B and Mellstedt H (1988) Clinical effects of monoclonal antibodies (MAb 17-1A) in patients with metastatic colorectal carcinomas. Hybridoma 7: 309-321
11. Griffiths AD, Williams SC, Hartley O, Tomlinson IM, Waterhouse P, Crosby WL, Kontermann RE, Jones PT, Low NM, John Allison T, Prospero TD, Hoogenboom HR, Nissim A, Cox JPL, Harrison JL, Zaccolo M, Gherardi F, and Winter G (1944) Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 13: 3245-3260
12. Helfrich W, Van Geel M, Hauw The T and De Leij L (1994) Detection of a putative 30-kDa ligand of the cluster-2 antigen. Int J Cancer 8 (suppl.): 70-75
13. Helfrich W, Kroesen B-J, Roovers K, Westers L, Molema G, Hoogenboom HR and de Leij L (1998) Construction and characterisation of a bispecific diabody for retargeting T cells to human carcinomas. Int J Cancer 76: 232-239
14. Herlyn M, Steplewski Z, Herlyn D and Koprowski H (1979) Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 76: 1438-1442
15. Herlyn M, Steplewski Z, Herlyn D and Koprowski H (1986) CO 17-1A and related monoclonal antibodies: their production and characterization. Hybridoma 5: S3-10
16. Holliger P, Prospero T and Winter G (1993) 'Diabodies': small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 90: 6444-6448
17. Hoogenboom HR, Griffiths AD, Johnson KS, Chiswell DJ, Hudson P and Winter G (1991) Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res 19: 4133-4137
18. Jespers LS, Roberts A, Mahler SM, Winter G and Hoogenboom HR (1994) Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. Biotechnology 12: 899-903
19. Kabat EA, Wu TT, Reid-Miller M, Perry HM, Gottesman KS and Koeller C (1991) Sequences of Proteins of Immunological Interest, 5th edn. Public Health Service: National Institute of Health, Bethesda
20. Kortt AA, Lah M, Oddie GW, Gruen CL, Burns JE, Parce LA, Atwell JL, McCoy AJ, Howlett GJ, Metzger DW, Webster RG and Hudson PJ (1997) Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five and ten-residue linkers form dimers and with zero-residue linker a trimer. Protein Eng 10: 423-133
21. Kosterink JG, de-Jonge MW, Smit EF, Piers DA, Kengen RA, Postmus PE, Shochat D, Groen HJ. The HT and de-Leij L (1995) Pharmacokinetics and scintigraphy of indium-111-DTPA-MOC-31 in small-cell lung carcinoma. J Nucl Med 36: 2356-2362
22. Krebber A, Bornhauser S, Burmester J, Honegger A, Willuda J, Bosshard HR and Plückthun A (1997) Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J Immunol Methods 201: 35-55
23. Kroesen BJ, Buter J, Sleijfer DT, Janssen RAJ, Van der Graaf WTA, Hauw The T, De Leij L and Mulder NH (1994) Phase I study of intraveneously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2. Br J Cancer 70: 652-661
24. LeMaistre CF, Edwards DP, Krolick KA and McGuire WL (1987) An immunotoxin cytotoxic for breast cancer cells in vitro. Cancer Res 47: 730-734
25. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD and Winter G (1991) By-passing immunization; human antibodies from V-gene libraries displayed on phage. J Mol Biol 222: 581-597
26. Nieba L, Krebber A and Plückthun A (1996) Competition BIAcore for measuring true affinities: large differences from values determined from binding kinetics. Anal Biochem 234: 155-165
27. Riethmüller G, Schneider-Gädieke K, Schlimok G, Schmiegel G, Raab R, Höffken K, Gruber R, Pichlmaier H, Hirche H, Pichlmayer R, Buggisch P and Witte J (1994) Randomized trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 343: 1177-1183
28. Schier R, Bye J, Apell G, McCall A, Adams GP, Malmqvist M, Weiner LM and Marks JD (1996) Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection. J Mol Biol 255: 28-43
29. Souhami RL, Beverley PCL and Bobrow LG (1998) Proceedings of the First International Workshop on Small-Cell Lung-Cancer Antigens. Lung Cancer 4: 1-114
30. Strassburg CP, Kasai Y, Seng BA, Miniou P, Zaloudik J, Herlyn D, Koprowski H and Linnenbach AJ (1992) Baculovirus recombinant expressing a secreted form of a transmembrane carcinoma-associated antigen. Cancer Res 52: 815-821
31. Tai MS, McCartney JE, Adams GP, Jin D, Hudziak RM, Oppermann H, Laminet AA, Bookman MA, Wolf EJ, Liu S, Stafford III WF, Faud I, Houston L, Weiner LM and Huston JS (1995) Targeting c-erbB-2 expressing tumors using single-chain Fv monomers and dimers. Cancer Res 55: 5983s-5989s
32. Velders MP, Litvinov SV, Warnaar SO, Gorter A, Fleuren GJ, Zurawski Jr VR and Coney LR (1994) New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency. Cancer Res 54: 1753-1759
33. Velders MP, van-Rhijn CM, Briaire IH, Fleuren GJ, Warnaar SO and Litvinov SV (1995) Immunotherapy with low and high affinity monoclonal antibodies 17-1A and 323/A3 in a nude mouse xenograft carcinoma model. Cancer Res 55: 4398-4403
34. Winter G, Griffiths AD, Hawkins RE and Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12: 433-455
35. Wu AM, Chen W, Raubitschek A, Williams LE, Neummaier M, Fischer R, Hu S-Z, Odom-Maryon T, Wong JYC and Shively JE (1996) Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers. Immunotechnology 2: 21-36.
36. Zimmermann S, Wels W, Froesch BA, Gerstmayer B, Stahel RA and Zangemeister-Wittke U (1997) A novel immunotoxin recognising the epithelial glycoprotein-2 has potent antitumoural activity on chemotherapy-resistant lung cancer. Cancer Immunol Immunother 44: 1-9