Construction and characterization of a bispecific for retargeting T cells to human carcinomas

International Journal of Cancer

Volumn 76, Issue 2, 1998, Pages 232-239

  Helfrich, Wijnand ^a   Kroesen, Bart Jan ^a   Roovers, Roh C ^b   Westers, Lidia ^a   Molema, Grietje ^a   Hoogenboom, Hennie R ^b   De Leij, Lou ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BISPECIFIC ANTIBODY; CD3 ANTIGEN; EPITHELIAL GLYCOPROTEIN 2; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; FAST PROTEIN LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MONONUCLEAR CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; CHROMATOGRAPHY, GEL; COS CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN FRAGMENTS; LYMPHOCYTE ACTIVATION; NEOPLASMS; RECOMBINANT PROTEINS; SODIUM DODECYL SULFATE; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032513528     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980413)76:2<232::AID-IJC11>3.0.CO;2-E     Document Type: Article

References (23)

1. BOLHUIS, R.L., HOOGENBOOM, H.R. and GRATAMA, J.W., Targeting of peripheral blood T lymphocytes. Springer Semin. Immunopathol., 18, 211-226 (1996).
2. CLACKSON, T., HOOGENBOOM, H.R., GRIFFITHS, A.D. and WINTER, G., Making antibody fragments using phage display libraries. Nature (Lond.), 352, 624-628 (1991).
3. DE LEIJ, L., HELFRICH, W., STEIN, R. and MATTES, M.J., SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2. Int. J. Cancer, 57 (Suppl. 8), 60-63 (1994).
4. ELIAS, D.J., HIRSCHOWITZ, L., KLINE, L.E., KROENER, J.F., DILLMAN, R.O., WALKER, L.E., ROBB, J.A. and TIMMS, R.M., Phase I clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunconjugate in patients with non-small cell lung carcinoma. Cancer Res., 50, 4154-4159 (1990).
5. FITZGERALD, K., HOLLIGER, P. and WINTER, G., Improved tumour targeting by disulphide-stabilised diabodies expressed in Pichia Postoris. Protein Eng., 10, 1125-1129 (1997).
6. 2 antibody containing thioether-linked Fab′ gamma fragments. J. Immnnol., 139, 2367-2375 (1987).
7. HELFRICH, W., VAN GEEL, M., THE, T.H. and DE LEIJ, L., Detection of a putative 30-kDa ligand of the cluster-2 antigen. Int. J. Cancer., 57 (Suppl. 8), 70-75 (1994a).
8. HELFRICH, W., WITTOP KONING, P., THE, T.H. and DE LEIJ, L., Epitope mapping of SCLC-cluster-2 MAbs and generation of antibodies directed against new EGP-2 epitopes. Int. J. Cancer, 57 (Suppl. 8), 64-69 (1994b).
9. HOLLIGER, P., BRISSINCK, J., WILLIAMS, R.L., THIELEMANS, K. and WINTER, G., Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody. Protein Eng., 9, 299-305 (1996).
10. HOLLIGER, P., PROSPERO, T. and WINTER, G., "Diabodies": small bivalent and bispecific antibody fragments. Proc. nat. Acad. Sci. (Wash.), 90, 6444-6448 (1993).
11. KIPRIYANOV, S.M., MOLDENHAUER, G., and LITTLE, M., High level production of soluble single chain antibodies in small-scale Escherichia coli cultures. J. Immunol. Methods, 200, 69-77, (1997).
12. KOSTERINK, J., DE JONGE, M., SMITH, E., PIERS, D., KENGEN, R., POSTMUS, P., SHOCHAT, D., GROEN, H., THE, H. and DE LEIJ, L., Pharmacokinetics and scintigraphy of indium-111-DTPA-MOC-31 in small-cell lung carcinoma. J. nucl. Med., 36, 2356-2362 (1995).
13. KNAPPIK, A. and PLÜCKTHUN, A. Engineered turns of a recombinant antibody improve its in vivo folding. Protein Eng., 8, 81-89 (1995).
14. KROESEN, B.J., BUTER, J., SLEIJFER, D.T., JANSSEN, R.A.J., VAN DER GRAAF, W.T.A., THE, T.H., DE LEIJ, L. and MULDER, N.H., Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2. Brit. J. Cancer, 70, 652-661 (1994).
15. MACK, M., RIETHMÜLLER, G. and KUFER, P., A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. not. Acad. Sci. (Wash.), 92, 7021-7025 (1995).
16. MCGUINNESS, B., WALTER, G., FITZGERALD, K., SCHULER, P., MAHONEY, W., DUNCAN, A. and HOOGENBOOM, H., Phage diabody repertoires for selection of large numbers of bispecific antibody fragments. Nature (Biotechnol.), 14, 1149-1154 (1996).
17. MEERMAN, H.J. and GEORGIOU, G., Construction and characterization of a set of E. coli strains deficient in all known loci affecting the proteolytic stability of secreted recombinant proteins. Biotechnology, 12, 1107-1110 (1994).
18. PERISIC, O., WEBB, P.A., HOLLIGER, P., WINTER, G. and WILLIAMS, R.L., Crystal structure of a diabody, a bivalent antibody fragment. Structure, 2, 1217-1226 (1994).
19. RIETHMÜLLER, G., SCHNEIDER-GÄDICKE, E., SCHLIMOK, G., SCHMIEGEL, W., RAAB, R., HOFFKEN, K., GRUBER, R., PICHLMAIER, H., HIRCHE, H., PICHLMAYR, R., BUGGISCU, P., WITTE, J. and the GERMAN CANCER AID 17-1A STUDY GROUP, Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet, 343, 1177-1183 (1994).
20. WHITLOW, M., FILPULA, D., ROLLENCE, M.L., FENG, S.L. and WOOD, J.F., Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv. Protein Eng., 7, 1017-1026 (1994).
21. WU, A.M., CHEN, W., RAUBITSCHEK, A., WILLIAMS, L.E., NEUMMAIER, M., FISHER, R., HU, S.Z., ODOM-MARYON, T., WONG, J.Y.C. and SHIVELY, J.E. Tumor localization of anti-CEA single-chain Fvs: improved targetting by non-covalent dimers. Immunotechnology, 2, 21-36 (1996).
22. ZHU, Z. and CARTER, P., Identification of heavy chain residues in a humanized anti-CD3 antibody important for efficient antigen binding and T cell activation. J. Immunol., 155, 1903-1910 (1995).
23. ZHU, Z., ZAPATA, G., SHALABY, R., SNEDECOR, B., CHEN, H. and CARTER, P., High level secretion of a humanized bispecific diabody from Escherichia coli. Biotechnology, 14, 192-196 (1996).