p53 Protein in sympathetic neurons: Cytoplasmic localization and no apparent function in apoptosis

Journal of Neuroscience Research

Volumn 43, Issue 5, 1996, Pages 594-601

  Sadoul, R ^a   Quiquerez, A L ^a   Martinou, I ^a   Fernandez, P A ^a   Martinou, J C ^a  

^a GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

apoptosis; cell death; NGF; sympathetic neurons; tumour suppressor

Indexed keywords

PROTEIN P53;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL DEATH; CELL FUNCTION; CELL TRANSFORMATION; CELL TYPE; CELLULAR DISTRIBUTION; CYTOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RECEPTOR UPREGULATION; SYMPATHETIC NERVE CELL; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL DEATH; CYTOPLASM; HUMANS; MICE; NERVE GROWTH FACTORS; NEURONS; RATS; SUPERIOR CERVICAL GANGLION; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029670172     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960301)43:5<594::AID-JNR9>3.0.CO;2-D     Document Type: Article

References (33)

1. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993): Thymocytes apoptosis induced by p53-dependent and independent apoptosis. Nature 362:849-852.
2. Davies A, Rosenthal A (1994): Neurons from mouse embryos with a null mutation in the tumor supressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci Lett 182: 112-114.
3. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Jr, Montgomery CA, Butel JS, Bradley A (1992): Mice deficient for P53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221.
4. Etzenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M (1995): Direct involvment of p53 in programmed cell death in oligodendrocytes. EMBO J 14:1136-1144.
5. Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C (1992): Wild-type p53 activates transcription in vitro. Nature 358:83-86.
6. Feldherr C, Cole C, Lanford RE, Akin D (1994): The effects of SV40 largeT antigen and p53 on nuclear transport capacity in BALB/c 3T3 cells. Exp Cell Res 213:164-171.
7. Fontura BMA, Sorokina EA, David E, Carroll RB (1992): p53 is covalently linked to 5.8S rRNA. Mol Cell Biol 12:5145-5151.
8. Freeman RS, Estus S, EM, Johnson J (1994): Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12: 343-355.
9. Garcia I, Martinou I, Tsujimoto Y, Martinou JC (1992): Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene Science 258:302-304.
10. Gurney EG, Harrison RO, Fenno J (1980): Monoclonal antibodies against simian virus 40 large-T antigens: evidence for distinct subclasses of large T antigen and similarities among non viral T antigens. J Virol 34:752-763.
11. Haffner R, Oren M (1995): Biochemical and biological effects of p53. Curr Opin Genet Dev 5:84-90.
12. Harlow E, Lane D (1988): "Antibodies, A Laboratory Manual." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
13. Hermeking H, Eick D (1994): Mediation of c-Myc-induced apoptosis by p53. Science 265:2091-2093.
14. Hinds PW, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B, Levine AJ (1990): Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ 1:571-580.
15. Li Y, Chopp M, Zaloga ZG, Niewenhuis C, Gautam S (1994): p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 25:849-855.
16. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993): p53 is required for radiation induced apoptosis in mouse thymocytes. Nature 362:847-849.
17. Marechal V, Elenbaas B, Pierce J, Nicolas JC, Levine AJ (1994): The ribosomal L5 protein is associated with MDM-2 and MDM-2-p53 complexes. Mol Cell Biol 14:7414-7420.
18. Martin DP, Schmidt RE, Distefano DP, Lowry OH, Carter JG, Johnson EMJ (1988): Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol 106:829-844.
19. Martinou I, Fernandez P-A, Missotten M, White E, Allet B, Sadoul R, Martinou J-C (1995). Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J Cell Biol 128:201-208.
20. Miyashita T, Reed J (1995): Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
21. Oppenheim RW (1991): Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
22. Pietenpol JA, Vogelstein B (1993): No room at the p53 inn. Nature 365:17-18.
23. Raff MC (1993): Social controls on cell survival and death: an extreme view. Nature 356:397-400.
24. Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E (1992): The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA 89:7742-7746.
25. Rogel A, Popliker M, Webb CG, Oren M (1985): p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos and tumors. Mol Cell Biol 5:2851-2855.
26. Rotter V, Abutbul H, Ben-Ze'ev A (1983): P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non transformed fibroblast. EMBO J 2:1041-1047.
27. Sadoul R, Catsicas S, Martinou JC (1994): Neuronal death: common mechanisms during development and disease. Semin Neurosci 6:343-346.
28. Sakhi S, Bruce A, Sun N, Tocco G, Baudry M, Schreiber SS (1994): P53 induction is associated with neuronal damage in the central nervous system. Proc Natl Acad Sci USA 91:7525-7529.
29. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J (1992): Induction of apoptosis by wild type in a human colon tumor derived cell line. Proc Natl Acad Sci USA 89:4495-4499.
30. cdc2 activation required for apoptosis. Science 263:1143-1145.
31. Tchang F, Gussee M, Soussi T, Méchali M (1993): Stabilization and expression of high levels of p53 during development in Xenopus laevis. Dev Biol 159:163-172.
32. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991): Wild type P53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352:345-346.
33. Zhu YM, Bradbury DA, Russel NH (1994): Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells. Br J Cancer 69:468-472.