Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: Role of bcl-2

Leukemia

Volumn 10, Issue 7, 1996, Pages 1143-1149

  Hedley, D W ^a   McCulloch, E A ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Acute myeloid leukemia; Apoptosis; bcl 2; Calcium ion; Cytosine arabinoside; Oxidative stress

Indexed keywords

CALCIUM ION; CYTARABINE; FLUORESCENT DYE; GLUTATHIONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL FUNCTION; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTO ONCOGENE;

EID: 0030054709     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Freireich J. Arabinosyl cytosine: a 20-year update. J Clin Oncol 1987; 5: 523-524.
2. Paterson ARP, Kolassa N, Cass CE. Transport of nucleoside drugs in animal cells. Pharm Ther 1981; 12: 515-536.
3. Kufe DW, Spriggs DR. Biochemical and cellular pharmacology of cytosine arabinoside. Semin Oncol 1985; 12: 34-48.
4. Mikita T, Beardsley GP. Functional consequences of arabinosylcytosine structural lesion in DNA. Biochemistry 1988; 27: 4698-4705.
5. Major P, Egan EM, Beardsley G, Minden M, Kufe D. Lethality of human myeloblasts correlates with incorporation of Ara-C into DNA. Proc Natl Acad Sci USA 1981; 78: 3225-3239.
6. Hu Z, Yang GS, Li M, Miyamoto N, Minden MD, McCulloch EA. Mechanism of cytosine arabinoside toxicity to the blast cells of acute myeloblastic leukemia: involvement of free radicals. Leukemia 1995; 9: 789-798.
7. Medley DW, Chow S. Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 1994; 15: 349-358.
8. Chused TM, Wilson HA, Greenblatt D, Ishida Y, Edison LJ, Tsien RY, Finkelman FD. Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti-IgM and anti-IgD. Cytometry 1987; 8: 396-404.
9. Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992; 80: 879-886.
10. Miyashita T, Reed JC, Sabido O, Roubi N, Vasselon C, Archimbaud E, Magaud J-P, Guyotat D. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 1993; 81: 151-157.
11. Hockenberg DM, Oitival ZN, Yin X-M, Millman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-251.
12. Hu Z-B, Minden MD, McCulloch EA. Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells. Leukemia 1995; 9: 1667-1673.
13. McCulloch EA. Stem cells in normal and leukemic hemopoiesis. (Henry Stratton Lecture 1982). Blood 1983; 62: 1-13.
14. Nara N, Curtis JE, Senn JS, Tritchler DL, McCulloch EA. The sensitivity to cytosine arabinoside of the blast progenitors of acute myeloblastic leukemia. Blood 1986; 67: 762-769.
15. Medley D, Hallahan A, Tripp E. Flow cytometric measurements of glutathione content of human cancer biopsies. Br J Cancer 1990; 61: 65-68.
16. Chow S, Medley D. Measurement of glutathione in clinical samples. Cytometry 1995; 21: 68-71.
17. Schweitzer B, Dicker A, Bertino J. Dihydrofolate reductase as a therapeutic target. FASEB J 1990; 4: 2441-2452.
18. Childs S, Ling V. The MDR superfamily of genes and its biological implications. In: DeVita V, Hellman S, Rosenberg S (ecls). Important Advances in Oncology. JB Lippincott: Philadelphia, pp 21-36.
19. Gerson SL, Trey JE. Modulation of nitrosourea resistance in myeloid leukemias. Blood 1988; 71: 1487-1494.
20. Hanawalt PC. Transcription-coupled repair and human disease. Science 1994; 266: 1957-1958.
21. Sancar A. Mechanisms of DNA excision repair. Science 1994; 266: 1954-1956.
22. Pritsche M, Haessler C, Bradner C. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 1993; 8: 307-318.
23. Lowe SW, Ruley HE, Jacks T, Houseman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74: 957-967.
24. Nelson WG, Kastan MB. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 1994; 14: 1815-1823.
25. Grillot DAM, Merino R, Nunez G. bcl-xl displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med 1995; 182: 1973-1983.
26. Boise LH, Gonzales-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G. hcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608.
27. Oitval ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
28. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. Bad, a heterodimeric partner of Bcl-xl and bcl-2, displaces bax and promotes cell death. Cell 1995; 80: 285-291.
29. Farber JL, Kyle ME, Coleman JB. Biology of disease - mechanisms of cell injury of activated oxygen species. Lab Invest 1990; 62: 670-679.
30. Boobis AR, Fawthrop DJ, Davies DS. Mechanisms of cell death. Trans Pharm Sci 1989; 10: 7-12.
31. Halliwell B. Oxidants and human disease: some new concepts. FASEB J 1987; 1: 358-364.
32. Meister A, Anderson M. Glutathione. Ann Rev Biochem 1983; 52: 711-760.
33. Reed DJ. Gluthione: toxicological implications. Ann Rev Pharmacol Toxicol 1990; 30: 603-631.
34. Morrow CS, Cowan KH. Glutathione S-transferases and drug resistance. Cancer Cells 1990; 2: 15-22.
35. O'Dwyer PJ, Yao K-S, Ford P, Godwin AK, Clayton. Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells. Cancer Res 1994; 54: 3082-3087.
36. + + fluxes. Proc Natl Acad Sci USA 1994; 91: 6569-6573.
37. + + homeostasis, cell death, proliferation and differentiation. Chem Biol Interact 1991; 77: 1-23.
38. Hu Z-B, Minden M, McCulloch E. Post-transcriptional regulation of bcl-2 in acute myeloblatic leukemia: significance for response to chemotherapy. Leukemia 1996; 10: 410-416.