Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1β in vascular smooth muscle cells

Journal of Biological Chemistry

Volumn 272, Issue 21, 1997, Pages 13484-13488

  Finder, Jonathan D ^a   Litz, Jennifer L ^a   Blaskovich, Michelle A ^a   McGuire, Terence F ^a   Qian, Yimin ^b   Hamilton, Andrew D ^b   Davies, Paul ^a   Sebti, Saïd M ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOL; FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE; GGTI 298; INTERLEUKIN 1BETA; MEVINOLIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; NITRIC OXIDE SYNTHASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTERY MUSCLE; ARTICLE; BLOOD VESSEL REACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REGULATION; PRENYLATION; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BENZAMIDES; ENZYME INDUCTION; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GTP-BINDING PROTEINS; INTERLEUKIN-1; LIVER; MALE; METHIONINE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; NITRITES; PROTEIN ISOPRENYLATION; PROTO-ONCOGENE PROTEINS; RAP GTP-BINDING PROTEINS; RAS PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFERASES;

EID: 0030999565     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.21.13484     Document Type: Article

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