-
1
-
-
0018387446
-
-
Schiff, P. B.; Fant, J.; Horwitz, S. B. Nature 1979, 22, 665.
-
(1979)
Nature
, vol.22
, pp. 665
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
3
-
-
0029049468
-
-
(a) Bollag, D. M.; McQueney, P. A.; Zhu, J.; Hensens, O.; Koupal, L.; Liesch, J.; Goetz, M.; Lazarides, E.; Woods, C. M. Cancer Res. 1995, 55, 2325.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
4
-
-
20644456614
-
-
Patent DE 4138042, 1993
-
(b) Hoefle, G.; Bedorf, N.; Gerth, K.; Reichenbach, H. Patent DE 4138042, 1993.
-
-
-
Hoefle, G.1
Bedorf, N.2
Gerth, K.3
Reichenbach, H.4
-
5
-
-
0011200360
-
-
(c) Gerth, K.; Bedorf, N.; Höfle, G.; Irachik, H.; Reichenbach, H. J. Antib. 1996, 49, 960.
-
(1996)
J. Antib.
, vol.49
, pp. 960
-
-
Gerth, K.1
Bedorf, N.2
Höfle, G.3
Irachik, H.4
Reichenbach, H.5
-
6
-
-
0029776766
-
-
(d) Höfle, G.; Bedorf, N.; Steinmetz, H.; Schomburg, D.; Gerth, K.; Reichenbach, H. Angew. Chem. 1996, 35, 1567-1569.
-
(1996)
Angew. Chem.
, vol.35
, pp. 1567-1569
-
-
Höfle, G.1
Bedorf, N.2
Steinmetz, H.3
Schomburg, D.4
Gerth, K.5
Reichenbach, H.6
-
8
-
-
0032541259
-
-
For an excellent review of the biology and chemistry of epothilones (up to February 28, 1998), see: Nicolaou, K. C.; Roschangar, F.; Vourloumis, D. Angew. Chem., Int. Ed. Engl. 1998, 35, 2014-2045. Some more recent relevant papers include: (a) Schinzer, D.; Bauer, A.; Schieber, J. Synlett 1998, 861-864. (b) May, S. A.; Grieco, P. A. J. Chem. Soc., Chem. Commun. 1998, 1597-1598.
-
(1998)
Angew. Chem., Int. Ed. Engl.
, vol.35
, pp. 2014-2045
-
-
Nicolaou, K.C.1
Roschangar, F.2
Vourloumis, D.3
-
9
-
-
0001335104
-
-
For an excellent review of the biology and chemistry of epothilones (up to February 28, 1998), see: Nicolaou, K. C.; Roschangar, F.; Vourloumis, D. Angew. Chem., Int. Ed. Engl. 1998, 35, 2014-2045. Some more recent relevant papers include: (a) Schinzer, D.; Bauer, A.; Schieber, J. Synlett 1998, 861-864. (b) May, S. A.; Grieco, P. A. J. Chem. Soc., Chem. Commun. 1998, 1597-1598.
-
(1998)
Synlett
, pp. 861-864
-
-
Schinzer, D.1
Bauer, A.2
Schieber, J.3
-
10
-
-
0032493824
-
-
For an excellent review of the biology and chemistry of epothilones (up to February 28, 1998), see: Nicolaou, K. C.; Roschangar, F.; Vourloumis, D. Angew. Chem., Int. Ed. Engl. 1998, 35, 2014-2045. Some more recent relevant papers include: (a) Schinzer, D.; Bauer, A.; Schieber, J. Synlett 1998, 861-864. (b) May, S. A.; Grieco, P. A. J. Chem. Soc., Chem. Commun. 1998, 1597-1598.
-
(1998)
J. Chem. Soc., Chem. Commun.
, pp. 1597-1598
-
-
May, S.A.1
Grieco, P.A.2
-
11
-
-
0030755282
-
-
(a) Nicolaou, K. C.; He, Y.; Vourloumis, D.; Vallberg, H.; Roschanger, F.; Sarabia, F.; Ninkovic, S.; Yang, Z.; Trujillo, J. I. J. Am. Chem. Soc. 1997, 119, 7960-7973.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 7960-7973
-
-
Nicolaou, K.C.1
He, Y.2
Vourloumis, D.3
Vallberg, H.4
Roschanger, F.5
Sarabia, F.6
Ninkovic, S.7
Yang, Z.8
Trujillo, J.I.9
-
12
-
-
0001125046
-
-
(b) Yang, Z.; He, Y.; Vourloumis, D.; Vallberg, H.; Nicolaou, K. C. Angew. Chem. 1997, 36, 170.
-
(1997)
Angew. Chem.
, vol.36
, pp. 170
-
-
Yang, Z.1
He, Y.2
Vourloumis, D.3
Vallberg, H.4
Nicolaou, K.C.5
-
13
-
-
0030445213
-
-
(c) Nicolaou, K. C.; He, Y.; Vourloumis, D.; Vallberg, H.; Yang, Z. Angew. Chem., Int. Ed. Engl. 1996, 35, 2399-2401.
-
(1996)
Angew. Chem., Int. Ed. Engl.
, vol.35
, pp. 2399-2401
-
-
Nicolaou, K.C.1
He, Y.2
Vourloumis, D.3
Vallberg, H.4
Yang, Z.5
-
14
-
-
17744405184
-
-
(d) Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. Nature 1997, 387, 268-272.
-
(1997)
Nature
, vol.387
, pp. 268-272
-
-
Nicolaou, K.C.1
Winssinger, N.2
Pastor, J.3
Ninkovic, S.4
Sarabia, F.5
He, Y.6
Vourloumis, D.7
Yang, Z.8
Li, T.9
Giannakakou, P.10
Hamel, E.11
-
15
-
-
0030767001
-
-
(e) Nicolaou, K. C.; Ninkovic, S.; Sarabia, F.; Vourloumis, D.; He, Y.; Vallberg, H.; Finlay, M. R. V.; Yang, Z.; J. Am. Chem. Soc. 1997, 119, 7974-7991.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 7974-7991
-
-
Nicolaou, K.C.1
Ninkovic, S.2
Sarabia, F.3
Vourloumis, D.4
He, Y.5
Vallberg, H.6
Finlay, M.R.V.7
Yang, Z.8
-
16
-
-
0029849814
-
-
(a) Bertinato, P.; Sorensen, E. J.; Meng, D.; Danishefsky, S. J. J. Org. Chem. 1996, 61, 8000-8001.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 8000-8001
-
-
Bertinato, P.1
Sorensen, E.J.2
Meng, D.3
Danishefsky, S.J.4
-
17
-
-
0029802228
-
-
(b) Meng, D.; Sorensen, E. J.; Bertinato, P.; Danishefsky, S. J. J. Org. Chem. 1996, 61, 7998-7999.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 7998-7999
-
-
Meng, D.1
Sorensen, E.J.2
Bertinato, P.3
Danishefsky, S.J.4
-
18
-
-
0030889136
-
-
(c) Meng, D.; Su, D.-S.; Balog, A.; Bertinato, P.; Sorensen, E. J.; Danishefsky, S. J.; Zheng, Y.-H.; Chou, T.-C.; He, L.; Horwitz, S. B. J. Am. Chem. Soc. 1997, 119, 2733-2734.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 2733-2734
-
-
Meng, D.1
Su, D.-S.2
Balog, A.3
Bertinato, P.4
Sorensen, E.J.5
Danishefsky, S.J.6
Zheng, Y.-H.7
Chou, T.-C.8
He, L.9
Horwitz, S.B.10
-
19
-
-
0030514018
-
-
(d) Balog, A.; Meng, D.; Kamenecka, T.; Bertinato, P.; Su, D.-S.; Sorenson, E. J.; Danishefsky, S. J. Angew. Chem., Int. Ed. Engl. 1996, 35, 2801-2803.
-
(1996)
Angew. Chem., Int. Ed. Engl.
, vol.35
, pp. 2801-2803
-
-
Balog, A.1
Meng, D.2
Kamenecka, T.3
Bertinato, P.4
Su, D.-S.5
Sorenson, E.J.6
Danishefsky, S.J.7
-
20
-
-
0030950914
-
-
(e) Balog, A.; Bertinato, P.; Su, D.-S.; Meng, D.; Sorensen, E. J.; Danishefsky, S. J.; Zheng, Y.-H.; Chou, T.-C.; He, L.; Horwitz, S. B. Tetrahedron Lett. 1997, 38, 4529-4532.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 4529-4532
-
-
Balog, A.1
Bertinato, P.2
Su, D.-S.3
Meng, D.4
Sorensen, E.J.5
Danishefsky, S.J.6
Zheng, Y.-H.7
Chou, T.-C.8
He, L.9
Horwitz, S.B.10
-
21
-
-
0030894922
-
-
(a) Schinzer, D.; Limberg, A.; Bauer, A.; Böhm O. M.; Cordes, M. Angew. Chem., Int. Ed. Engl. 1997, 36, 523-524.
-
(1997)
Angew. Chem., Int. Ed. Engl.
, vol.36
, pp. 523-524
-
-
Schinzer, D.1
Limberg, A.2
Bauer, A.3
Böhm, O.M.4
Cordes, M.5
-
23
-
-
0030590984
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 9179-9182
-
-
Mulzer, J.1
Mantoulidis, A.2
-
24
-
-
0031584881
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 1359-1362
-
-
Claus, E.1
Pahl, A.2
Jones, P.G.3
Meyer, H.H.4
Kalesse, M.5
-
25
-
-
0001149958
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1997)
Synlett
, pp. 824
-
-
De Brabender, J.1
Rosset, S.2
Bernardinelli, G.3
-
26
-
-
0030666278
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 7725-7728
-
-
Mulzer, J.1
Mantoulidis, A.2
Öhler, E.3
-
27
-
-
0031983809
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 101-104
-
-
Chakraborty, T.K.1
Dutta, S.2
-
28
-
-
0032518648
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 209-212
-
-
Bijoy, P.1
Avery, M.A.2
-
29
-
-
0031584942
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1997)
Tetrahedron Lett.
, vol.39
, pp. 1363-1366
-
-
Gabriel, T.1
Wessjohann, L.2
-
30
-
-
0344468142
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1997)
Synlett
, pp. 1383-1384
-
-
Liu, Z.-Y.1
Yu, C.-Y.2
Yang, J.-D.3
-
31
-
-
0032537693
-
-
For other synthetic efforts to epothilone, see: (a) Mulzer, J.; Mantoulidis, A. Tetrahedron Lett. 1996, 37, 9179-9182. (b) Claus, E.; Pahl, A.; Jones, P. G.; Meyer, H. H.; Kalesse, M. Tetrahedron Lett. 1997, 38, 1359-1362. (c) De Brabender, J.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824. (d) Mulzer, J.; Mantoulidis, A. Öhler, E. Tetrahedron Lett. 1997, 38, 7725-7728. (e) Chakraborty, T. K.; Dutta, S. Tetrahedron Lett. 1998, 39, 101-104. (f) Bijoy, P.; Avery, M. A. Tetrahedron Lett. 1998, 39, 209-212. (g) Gabriel, T.; Wessjohann, L. Tetrahedron Lett. 1997, 39, 1363-1366. (h) Liu, Z.-Y.; Yu, C.-Y.; Yang, J.-D. Synlett 1997, 1383-1384. (i) Liu, Z.-Y.; Yu, C.-Y.; Wang, R.-F.; Li, G. Tetrahedron Lett. 1998, 39, 5261-5264.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 5261-5264
-
-
Liu, Z.-Y.1
Yu, C.-Y.2
Wang, R.-F.3
Li, G.4
-
33
-
-
0001291489
-
-
(b) Molander, G. A.; Etter, J. B.; Harring, L. S.; Thorel, P.-J. J. Am. Chem. Soc. 1991, 113, 8036-8045.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 8036-8045
-
-
Molander, G.A.1
Etter, J.B.2
Harring, L.S.3
Thorel, P.-J.4
-
34
-
-
20644472574
-
-
Altus Biologics Inc., Cambridge, MA
-
Altus Biologics Inc., Cambridge, MA.
-
-
-
-
36
-
-
33845554892
-
-
Evans, D. A.; Ennis, M. D.; Mathre, D. J. J. Am. Chem. Soc. 1982, 104, 1737-1739.
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 1737-1739
-
-
Evans, D.A.1
Ennis, M.D.2
Mathre, D.J.3
|