Is gut the 'motor' for producing hepatocellular dysfunction after trauma and hemorrhagic shock?

Journal of Surgical Research

Volumn 74, Issue 2, 1998, Pages 141-148

  Wang, Ping ^a   Ba, Zheng F ^a   Cioffi, William G ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a,b  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

Enterectomy; Indocyanine green clearance; Microvascular blood flow; Proinflammatory cytokines; SGOT; SGPT

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; INDOCYANINE GREEN; INTERLEUKIN 6; METHOXYFLURANE; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD FLOW VELOCITY; CONTROLLED STUDY; HEART OUTPUT; HEMORRHAGIC SHOCK; INTESTINE RESECTION; LASER DOPPLER FLOWMETRY; LIVER DYSFUNCTION; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032004348     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.5246     Document Type: Article

References (39)

1. Wang P., Hauptman J. G., Chaudry I. H. Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation. J. Surg. Res. 48:1990;464.
2. Wang P., Singh G., Rana M. W., Ba Z. F., Chaudry I. H. Preheparinization improves organ function after hemorrhage and resuscitation. Am. J. Physiol. 259:1990;R645.
3. Wang P., Ba Z. F., Zhou M., Tait S. M., Chaudry I. H. Pentoxifylline restores cardiac output and tissue perfusion following trauma-hemorrhage and decreases susceptibility to sepsis. Surgery. 114:1993;352.
4. Ayala A., Wang P., Ba Z. F., Perrin M. M., Ertel W., Chaudry I. H. Differential alterations in plasma IL-6 and TNF levels following trauma and hemorrhage. Am. J. Physiol. 260:1991;R167.
5. Kepros J. P., Wang P., Morrison M. H., Chaudry I. H. Mechanism of the beneficial effects of a novel nonanticoagulant heparin (GM1892) following hemorrhagic shock: Down-regulation of proinflammatory cytokine (TNF and IL-6) production. Surg. Forum. 46:1995;87.
6. Kerner J., Wang P., Chaudry I. H. Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. Am. J. Physiol. 269:1995;R869.
7. Wang W., Wang P., Chaudry I. H. Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation. Shock. 8:1997;33.
8. Wang W., Wang P., Chaudry I. H. Intestinal alkaline phosphates: Role in the depressed gut lipid transport after trauma-hemorrhagic shock. Shock. 8:1997;40.
9. Deitch E. A., Winterton J., Li M., Berg R. The gut as a portal of entry for bacteremia. Ann. Surg. 205:1987;681.
10. Deitch E. A. Multiple Organ Failure: Pathophysiology and potential future therapy. Ann. Surg. 216:1992;117.
11. Xu D., Lu Q., Deitch E. A. Calcium and phospholipase A2 appear to be involved in the pathogenesis of hemorrhagic shock-induced mucosal injury and bacterial translocation. Crit. Care Med. 23:1995;125.
12. Sori A. J., Rush B. F., Lysz T. W., Smith S., Machiedo G. W. The gut as source of sepsis after hemorrhagic shock. Am. J. Surg. 155:1988;187.
13. Russell D. H., Barreto J. C., Klemm K., Miller T. A. Hemorrhagic shock increases gut macromolecular permeability in the rat. Shock. 4:1995;50.
14. Chang T. -W. Improvement of survival from hemorrhagic shock by enterectomy in rats: Finding to implicate the role of the gut for irreversibility of hemorrhagic shock. J. Trauma. 42:1997;223.
15. Meakins J. L., Marshall J. C. The gastrointestinal tract: The 'motor' of MOF. Arch. Surg. 121:1986;197.
16. Moore F. A., Moore E. E., Poggetti R. S., Read R. A. Postinjury shock and early bacteremia: A lethal combination. Arch. Surg. 127:1992;893.
17. Morales J., Kibsey P., Thomas P. D., Poznansky M. J., Hamilton S. M. The effects of ischemia and ischemia-reperfusion on bacterial translocation, lipid peroxidation, and gut histology: Studies on hemorrhagic shock in pigs. J. Trauma. 33:1992;221.
18. Wang P., Ba Z. F., Lu M. -C., Ayala A., Harkema J. M., Chaudry I. H. Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution. Am. J. Physiol. 266:1994;R368.
19. Wang P., Chaudry I. H. Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhage. J. Surg. Res. 50:1991;163.
20. Wang P., Hauptman J. G., Chaudry I. H. Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation. Circ. Shock. 32:1990;307.
21. Hültner L., Szöts H., Welle M., Van Snick J., Moeller J., Dörmer P. Mouse bone marrow-derived interleukin 3-dependent mast cells and autonomous sublines produce interleukin 6. Immunology. 67:1989;408.
22. Chaudry I. H., Sayeed M. M., Baue A. E. Depletion and restoration of tissue ATP in hemorrhagic shock. Arch. Surg. 108:1974;208.
23. Pellicane J. V., DeMaria E. J., Abb-Elfattah A., Reines H. D., Vannice J. L., Carson K. W. Interleukin-1 receptor antagonist improves survival and preserves organ adenosine-5′-triphosphate after hemorrhagic shock. Surgery. 114:1993;278.
24. Johannigman J. A., Johnson D. J., Roettger R. The effect of hypothermia on liver adenosine triphosphate (ATP) recovery following combined shock and ischemia. J. Trauma. 32:1992;190.
25. Pearce F. J., Connett R. J., Drucker W. R. Phase-related changes in tissue energy reserves during hemorrhagic shock. J. Surg. Res. 39:1985;390.
26. Ayala A., Tu Y., Flye M. W., Chaudry I. H. Depressed splenic function after hemorrhage results from gastrointestinal tract stimulation of hepatic mediator release. Arch. Surg. 131:1996;1209.
27. Chaudry I. H., Ayala A. Immunological Aspects of Hemorrhage. 1992;Landes, Austin.
28. Chaudry I. H., Wang P., Singh G., Hauptman J. G., Ayala A. Rat and mouse models of hypovolemic-traumatic shock. Pathophysiology of Shock, Sepsis, and Organ Failure. 1993;Springer Verlag, Berlin. p. 371-383.
29. Deitch E. A., Xu D., Franko L., Ayala A., Chaudry I. H. Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock. 1:1994;141.
30. Huang L., Tan X., Crawford S. E., Hsueh W. Platelet-activating factor and endotoxin induce tumor necrosis factor gene expression in rat intestine and liver. Immunology. 83:1994;65.
31. Jiang J., Bahrami S., Leichtfried G., Redl H., Ohlinger W., Schlag G. Kinetics of endotoxin and tumor necrosis factor appearance in portal and systemic circulation after hemorrhagic shock in rats. Ann. Surg. 221:1995;100.
32. Wang P., Ayala A., Ba Z. F., Zhou M., Perrin M. M., Chaudry I. H. Tumor necrosis factor-α produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation. Am. J. Physiol. 265:1993;G126.
33. Jones S. C., Trejdosiewicz L. K., Banks R. E., Howdle P. D., Axon A. T. R., Dixon M. F., Whicher J. T. Expression of interleukin-6 by intestinal enterocytes. J. Clin. Pathol. 46:1993;1097.
34. Meyer T. A., Tiao G. M., James J. H., Noguchi Y., Ogle C. K., Fischer J. E., Hasselgren P. O. Nitric oxide inhibits LPS-induced IL-6 production in enterocytes. J. Surg. Res. 58:1995;570.
35. Meyer T. A., Noguchi Y., Ogle C. K., Tiao G., Wnag J. J., Fischer J. E., Hasselgren P. O. Endotoxin stimulates interleukin-6 production in intestinal epithelial cells. Arch. Surg. 129:1994;1290.
36. 2by subpopulations of guinea pig enterocytes: Effect of endotoxin and thermal injury. J. Trauma. 41:1996;298.
37. Shenkar R., Abraham E. Effects of hemorrhage on cytokine gene transcription. Lymphokine Cytokine Res. 12:1993;237.
38. O'Neill P. J., Ayala A., Wang P., Ba Z. F., Morrison M. H., Schultze A. E., Reich S. S., Chaudry I. H. Role of Kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation. Shock. 1:1994;43.
39. Wang P., Chaudry I. H. Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am. J. Physiol. 270:1996;R927.