메뉴 건너뛰기




Volumn 31, Issue 1, 1999, Pages 47-53

Molecular virology of the hepatitis C virus

Author keywords

Helicase; Hepatitis C virus; Interferon; IRES; RNA dependent RNA polymerase; Serine proteinase

Indexed keywords

HELICASE; RNA DIRECTED RNA POLYMERASE; SERINE PROTEINASE;

EID: 0033429914     PISSN: 01695185     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0168-8278(99)80374-2     Document Type: Conference Paper
Times cited : (75)

References (103)
  • 2
    • 0029143143 scopus 로고
    • Structure and function of the hepatitis C virus internal ribosome entry site
    • Wang C, Siddiqui A. Structure and function of the hepatitis C virus internal ribosome entry site. Curr Topics Microbiol Immunol 1995:203:99-115.
    • (1995) Curr Topics Microbiol Immunol , vol.203 , pp. 99-115
    • Wang, C.1    Siddiqui, A.2
  • 3
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in itro processing analysis
    • Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Shimotohno K. Gene mapping of the putative structural region of the hepatitis C virus genome by in itro processing analysis. Proc Natl Acad Sci USA 1991: 88: 5547-5551.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4    Shimotohno, K.5
  • 5
    • 0028233530 scopus 로고
    • Biosynthesis and biochemical properties of the hepatitis C virus core protein
    • Santolini E, Migliaccio G, La Monica N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol 1994: 68: 3631-3641.
    • (1994) J Virol , vol.68 , pp. 3631-3641
    • Santolini, E.1    Migliaccio, G.2    La Monica, N.3
  • 6
    • 0028265186 scopus 로고
    • Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2
    • Mizushima H, Hijikata M, Tanji Y, Kimura K, Shimotohno K. Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2 . J Virol 1994: 68: 2731-2734.
    • (1994) J Virol , vol.68 , pp. 2731-2734
    • Mizushima, H.1    Hijikata, M.2    Tanji, Y.3    Kimura, K.4    Shimotohno, K.5
  • 8
    • 0027163740 scopus 로고
    • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    • Hijikata M, Mizushima H, Akagi T, Mori S, Kakiuchi N, Kato N et al. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol 1993: 67: 4665-4675.
    • (1993) J Virol , vol.67 , pp. 4665-4675
    • Hijikata, M.1    Mizushima, H.2    Akagi, T.3    Mori, S.4    Kakiuchi, N.5    Kato, N.6
  • 9
    • 0027476809 scopus 로고
    • Ex-pression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Ex-pression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993: 67: 1385-1395.
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 10
    • 0027176287 scopus 로고
    • NS3 is a serine proteinase required for processing of hepatitis C virus polyprotein
    • Tomei L, Failla C, Santolini E, De Francesco R, La Monica N. NS3 is a serine proteinase required for processing of hepatitis C virus polyprotein. J Virol 1993: 67: 40171026.
    • (1993) J Virol , vol.67 , pp. 40171026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    De Francesco, R.4    La Monica, N.5
  • 11
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/ 5 junctions
    • Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/ 5 junctions. J Virol 1993: 67: 3835-3844.
    • (1993) J Virol , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 12
    • 0028332810 scopus 로고
    • Production of nonstructural proteins of hepatitis C virus requires a putative viral proteinase encoded by NS3
    • Manabe S, Fuke I, Tanishita O, Kaji C, Gomi Y, Yoshida S et al. Production of nonstructural proteins of hepatitis C virus requires a putative viral proteinase encoded by NS3. Virology 1994: 198: 636-644.
    • (1994) Virology , vol.198 , pp. 636-644
    • Manabe, S.1    Fuke, I.2    Tanishita, O.3    Kaji, C.4    Gomi, Y.5    Yoshida, S.6
  • 14
    • 0028785460 scopus 로고
    • A novel sequence found at the 3' terminus of the hepatitis C virus genome
    • Tanaka T, Kato N, Cho MJ, Shimotohno K. A novel sequence found at the 3' terminus of the hepatitis C virus genome. Biochem Biophys Res Commun 1995: 215: 744-749.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 744-749
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Shimotohno, K.4
  • 15
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3' terminus of the hepatitis C virus
    • Tanaka T, Kato N, Cho MJ, Shimotono K. Structure of the 3' terminus of the hepatitis C virus. J Virol 1996: 70: 3307-3312.
    • (1996) J Virol , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Shimotono, K.4
  • 16
    • 0029938477 scopus 로고    scopus 로고
    • Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA
    • Kolykhalov AA, Feinstone SM, Rice CM. Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol 1996: 70: 3363-3371.
    • (1996) J Virol , vol.70 , pp. 3363-3371
    • Kolykhalov, A.A.1    Feinstone, S.M.2    Rice, C.M.3
  • 17
    • 0030812847 scopus 로고    scopus 로고
    • Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome
    • Ito T, Lai MMC. Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome. J Virol 1997: 71: 8698-8706.
    • (1997) J Virol , vol.71 , pp. 8698-8706
    • Ito, T.1    Lai, M.M.C.2
  • 18
    • 0030861248 scopus 로고    scopus 로고
    • Specific interaction of polypyrimidine tract-binding protein with the extreme S'-terminal structure of the hepatitis C virus genome, the 3'X
    • Tsuchihara K, Tanaka T, Hijikata M, Kuge S, Toyoda H, Nomoto A et al. Specific interaction of polypyrimidine tract-binding protein with the extreme S'-terminal structure of the hepatitis C virus genome, the 3'X. J Virol 1997: 71: 6720-6726.
    • (1997) J Virol , vol.71 , pp. 6720-6726
    • Tsuchihara, K.1    Tanaka, T.2    Hijikata, M.3    Kuge, S.4    Toyoda, H.5    Nomoto, A.6
  • 19
    • 0029085732 scopus 로고
    • Detection of cellular proteins and viral core protein interacting with the 5' untranslated region of hepatitis C virus RNA
    • Hwang SB, Lo S-Y, Ou J-H, Lai MMC. Detection of cellular proteins and viral core protein interacting with the 5' untranslated region of hepatitis C virus RNA. J Biomed Sci 1995: 2: 227-236.
    • (1995) J Biomed Sci , vol.2 , pp. 227-236
    • Hwang, S.B.1    Lo, S.-Y.2    Ou, J.-H.3    Lai, M.M.C.4
  • 20
    • 0029930196 scopus 로고    scopus 로고
    • Homotypic interaction and multimerization of hepatitis C virus core protein
    • Matsumoto M, Hwang SB, Jeng K-S, Zhu N, Lai MMC. Homotypic interaction and multimerization of hepatitis C virus core protein. Virology 1996: 218: 43-51.
    • (1996) Virology , vol.218 , pp. 43-51
    • Matsumoto, M.1    Hwang, S.B.2    Jeng, K.-S.3    Zhu, N.4    Mmc, L.5
  • 22
    • 0027171629 scopus 로고
    • Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells
    • Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol 1993: 67: 5823-5832.
    • (1993) J Virol , vol.67 , pp. 5823-5832
    • Shih, C.M.1    Lo, S.J.2    Miyamura, T.3    Chen, S.Y.4    Lee, Y.H.5
  • 23
    • 0030561090 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication
    • Srinivas RV, Ray RB, Meyer K, Ray R. Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication. Virus Res 1996: 45: 87-92.
    • (1996) Virus Res , vol.45 , pp. 87-92
    • Srinivas, R.V.1    Ray, R.B.2    Meyer, K.3    Ray, R.4
  • 24
  • 25
    • 0029114785 scopus 로고
    • Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
    • Ray RB, Lagging LM, Meyer K, Steele R, Ray R. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res 1995: 37: 209-220.
    • (1995) Virus Res , vol.37 , pp. 209-220
    • Ray, R.B.1    Lagging, L.M.2    Meyer, K.3    Steele, R.4    Ray, R.5
  • 26
    • 0030891710 scopus 로고    scopus 로고
    • Transcriptional repression of p53 promoter by hepatitis C virus core protein
    • Ray RB, Steele R, Meyer K, Ray R. Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 1997: 272: 10983-10986.
    • (1997) J Biol Chem , vol.272 , pp. 10983-10986
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 27
    • 0032570876 scopus 로고    scopus 로고
    • Hepatitis C virus core protein represses p21WAFl/Cipl/Sidl promoter activity
    • Ray RB, Steele R, Meyer K, Ray R. Hepatitis C virus core protein represses p21WAFl/Cipl/Sidl promoter activity. Gene 1998: 208: 331-336.
    • (1998) Gene , vol.208 , pp. 331-336
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 28
    • 8944262349 scopus 로고    scopus 로고
    • Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
    • Ray RB, Lagging LM, Meyer K, Ray R. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol 1996: 70: 44384443.
    • (1996) J Virol , vol.70 , pp. 44384443
    • Ray, R.B.1    Lagging, L.M.2    Meyer, K.3    Ray, R.4
  • 29
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998: 4: 1065-1067.
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3    Yotsuyanagi, H.4    Tsutsumi, T.5    Ishibashi, K.6
  • 30
    • 0033061215 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits fas- And tumor necrosis factor alpha-mediated apoptosis via NF-kB activation
    • Marusawa H, Hijikata M, Chiba T, Shimotono K. Hepatitis C virus core protein inhibits fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kB activation. J Virol 1999: 73: 4713-4720.
    • (1999) J Virol , vol.73 , pp. 4713-4720
    • Marusawa, H.1    Hijikata, M.2    Chiba, T.3    Shimotono, K.4
  • 31
    • 0030729202 scopus 로고    scopus 로고
    • Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor
    • Chen C, You L, Hwang L, Lee Y. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor. J Virology 1997: 71: 9417-9426.
    • (1997) J Virology , vol.71 , pp. 9417-9426
    • Chen, C.1    You, L.2    Hwang, L.3    Lee, Y.4
  • 32
    • 18844480671 scopus 로고    scopus 로고
    • Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor
    • Matsumoto M, Hsieh T, Zhu N, VanArsdale T, Hwang SB, Jeng K et al. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol 1997: 71: 1301-1309.
    • (1997) J Virol , vol.71 , pp. 1301-1309
    • Matsumoto, M.1    Hsieh, T.2    Zhu, N.3    Vanarsdale, T.4    Hwang, S.B.5    Jeng, K.6
  • 33
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993: 67: 1385-1395.
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 34
    • 0027215726 scopus 로고
    • Characterization of hepatitis C virus structural proteins with a recombinant baculovirus expression system
    • Hsu HH, Donets M, Greenberg HB, Feinstone SM. Characterization of hepatitis C virus structural proteins with a recombinant baculovirus expression system. Hepatology 1993: 17: 763-771.
    • (1993) Hepatology , vol.17 , pp. 763-771
    • Hsu, H.H.1    Donets, M.2    Greenberg, H.B.3    Feinstone, S.M.4
  • 35
    • 0026722262 scopus 로고
    • Expression and characterization of glycoprotein gp35 of hepatitis C virus using recombinant vaccinia virus
    • Kohara M, Tsukiyama-Kohara K, Maki N, Asano K, Yamaguchi K, Miki K et al. Expression and characterization of glycoprotein gp35 of hepatitis C virus using recombinant vaccinia virus. J Gen Virol 1992: 73: 2313-2318.
    • (1992) J Gen Virol , vol.73 , pp. 2313-2318
    • Kohara, M.1    Tsukiyama-Kohara, K.2    Maki, N.3    Asano, K.4    Yamaguchi, K.5    Miki, K.6
  • 37
    • 0027420380 scopus 로고
    • Analysis of hepatitis C virus capsid, El, and E2/NS1 proteins expressed in insect cells
    • Lanford RE, Notvall L, Chavez D, White R, Frenzel G, Simonsen C et al. Analysis of hepatitis C virus capsid, El, and E2/NS1 proteins expressed in insect cells. Virology 1993: 197: 225-235.
    • (1993) Virology , vol.197 , pp. 225-235
    • Lanford, R.E.1    Notvall, L.2    Chavez, D.3    White, R.4    Frenzel, G.5    Simonsen, C.6
  • 38
    • 0026590695 scopus 로고
    • Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells
    • Matsuura Y, Harada S, Suzuki R, Watanabe Y, Inoue Y, Saito I et al. Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells. J Virol 1992: 66: 14251431.
    • (1992) J Virol , vol.66 , pp. 14251431
    • Matsuura, Y.1    Harada, S.2    Suzuki, R.3    Watanabe, Y.4    Inoue, Y.5    Saito, I.6
  • 39
    • 0028151708 scopus 로고
    • Processing of El and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells
    • Matsuura Y, Suzuki T, Suzuki R, Sato M, Aizaki H, Saito I et al. Processing of El and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells. Virology 1994: 205: 141-150.
    • (1994) Virology , vol.205 , pp. 141-150
    • Matsuura, Y.1    Suzuki, T.2    Suzuki, R.3    Sato, M.4    Aizaki, H.5    Saito, I.6
  • 40
    • 3042993221 scopus 로고
    • Characterization of the putative E2 envelope glycoprotein of hepatitis C virus expressed in stably transformed Chinese hamster ovary cells
    • Ryu W-S, Choi D-Y, Yang J-Y, Kirn C-H, Kwon Y-S, So H-S et al. Characterization of the putative E2 envelope glycoprotein of hepatitis C virus expressed in stably transformed Chinese hamster ovary cells. Mol Cells 1995: 5: 563-568.
    • (1995) Mol Cells , vol.5 , pp. 563-568
    • Ryu, W.-S.1    Choi, D.-Y.2    Yang, J.-Y.3    Kirn, C.-H.4    Kwon, Y.-S.5    So, H.-S.6
  • 41
    • 0026724046 scopus 로고
    • Characterization of the hepatitis C virus E2/ NS1 gene product expressed in mammalian cells
    • Spaete RR, Alexander D, Rugroden ME, Choo Q-L, Berger K, Crawford K et al. Characterization of the hepatitis C virus E2/ NS1 gene product expressed in mammalian cells. Virology 1992: 188: 819-830.
    • (1992) Virology , vol.188 , pp. 819-830
    • Spaete, R.R.1    Alexander, D.2    Rugroden, M.E.3    Choo, Q.-L.4    Berger, K.5    Crawford, K.6
  • 42
    • 0028021952 scopus 로고
    • Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by rccombinant vaccinia and Sindbis viruses
    • Dubuisson J, Hsu HH, Cheung RC, Greenberg H, Russell DR, Rice CM. Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by rccombinant vaccinia and Sindbis viruses. J Virol 1994:68:6147-6160.
    • (1994) J Virol , vol.68 , pp. 6147-6160
    • Dubuisson, J.1    Hsu, H.H.2    Cheung, R.C.3    Greenberg, H.4    Russell, D.R.5    Rice, C.M.6
  • 43
    • 0030030042 scopus 로고    scopus 로고
    • Hepatitis C virus glycoprotein folding: Disulfide bond formation and association with calnexin
    • Dubuisson J, Rice CM. Hepatitis C virus glycoprotein folding: disulfide bond formation and association with calnexin. J Virol 1996: 70: 778-786.
    • (1996) J Virol , vol.70 , pp. 778-786
    • Dubuisson, J.1    Rice, C.M.2
  • 45
    • 0031911782 scopus 로고    scopus 로고
    • A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepaptitis C virus glycoprotein E2
    • Cocquerel L, Meunier J, Pillez A, Wychowski C, Dubuisson J. A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepaptitis C virus glycoprotein E2. J Virol 1998: 72: 2183-2191.
    • (1998) J Virol , vol.72 , pp. 2183-2191
    • Cocquerel, L.1    Meunier, J.2    Pillez, A.3    Wychowski, C.4    Dubuisson, J.5
  • 46
    • 0030746468 scopus 로고    scopus 로고
    • Transfection of HepG2 cells with infectious hepatitis C virus genome
    • Dash S, Halim A, Tsuji H, Hiramatsu N, Gerber MA. Transfection of HepG2 cells with infectious hepatitis C virus genome. Am J Pathol 1997: 151: 363-373.
    • (1997) Am J Pathol , vol.151 , pp. 363-373
    • Dash, S.1    Halim, A.2    Tsuji, H.3    Hiramatsu, N.4    Gerber, M.A.5
  • 47
    • 0028791134 scopus 로고
    • Virion-like structures in Heia G cells transfected with the full-length sequence of the hepatitis C virus genome
    • Mizuno M, Yamada G, Tanaka T, Shimotohno K, Takatani M, Tsuji T. Virion-like structures in Heia G cells transfected with the full-length sequence of the hepatitis C virus genome. Gastroenterology 1995: 109: 1933-1940.
    • (1995) Gastroenterology , vol.109 , pp. 1933-1940
    • Mizuno, M.1    Yamada, G.2    Tanaka, T.3    Shimotohno, K.4    Takatani, M.5    Tsuji, T.6
  • 48
    • 0031977996 scopus 로고    scopus 로고
    • Hepatitis C virus structural proteins assemble into viruslike particles in insect cells
    • Baumert TF, Ito S, Wong DT, Liang JT. Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J Virol 1998: 72: 3827-3836.
    • (1998) J Virol , vol.72 , pp. 3827-3836
    • Baumert, T.F.1    Ito, S.2    Wong, D.T.3    Liang, J.T.4
  • 50
    • 0026025737 scopus 로고
    • Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins
    • Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K et al. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 1991: 180: 842-848.
    • (1991) Virology , vol.180 , pp. 842-848
    • Weiner, A.J.1    Brauer, M.J.2    Rosenblatt, J.3    Richman, K.H.4    Tung, J.5    Crawford, K.6
  • 52
    • 0028832632 scopus 로고
    • The NS2 protein of hepatitis C virus is a transmembrane polypeptide
    • Santolini E, Pacini L, Fipaldini C, Migliaccio G, Monica N. The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol 1995: 69: 7461-7471.
    • (1995) J Virol , vol.69 , pp. 7461-7471
    • Santolini, E.1    Pacini, L.2    Fipaldini, C.3    Migliaccio, G.4    Monica, N.5
  • 53
    • 0028241489 scopus 로고
    • Kinetic and structural analyses of hepatitis C virus polyprotein processing
    • Bartenschlager R, Ahlborn Laake L, Mous J, Jacobsen H. Kinetic and structural analyses of hepatitis C virus polyprotein processing. J Virol 1994: 68: 5045-5055.
    • (1994) J Virol , vol.68 , pp. 5045-5055
    • Bartenschlager, R.1    Ahlborn Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 54
    • 0028851296 scopus 로고
    • An amino-terminal domain of the hepatitis C virus NS3 proteinase is essential for interaction with NS4A
    • Pailla C, Tomei L, De Francesco R. An amino-terminal domain of the hepatitis C virus NS3 proteinase is essential for interaction with NS4A. J Virol 1995: 69: 1769-1777.
    • (1995) J Virol , vol.69 , pp. 1769-1777
    • Pailla, C.1    Tomei, L.2    De Francesco, R.3
  • 55
    • 0027991586 scopus 로고
    • Identification of the domain required for trans-cleavage activity of hepatitis C viral serine proteinase
    • Tanji Y, Hijikata M, Hirowatari Y, Shimotohno K. Identification of the domain required for trans-cleavage activity of hepatitis C viral serine proteinase. Gene 1994: 145: 215-219.
    • (1994) Gene , vol.145 , pp. 215-219
    • Tanji, Y.1    Hijikata, M.2    Hirowatari, Y.3    Shimotohno, K.4
  • 56
    • 0028960558 scopus 로고
    • Identification of the proteinase domain in NS3 of hepatitis C virus
    • Han DS, Hahm B, Rho H-M, Jang, SK. Identification of the proteinase domain in NS3 of hepatitis C virus. J Gen Virol 1995: 76: 985-993.
    • (1995) J Gen Virol , vol.76 , pp. 985-993
    • Han, D.S.1    Hahm, B.2    Rho, H.-M.3    Jang4
  • 57
    • 0027999994 scopus 로고
    • Specificity of the hepatitis C virus NS3 serine protease: Effects of substitutions at he 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing
    • Kolykhalov AA, Kolykhalov EV, Rice CM. Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at he 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing. J Virol 1994: 68: 7525-7533.
    • (1994) J Virol , vol.68 , pp. 7525-7533
    • Kolykhalov, A.A.1    Kolykhalov, E.V.2    Rice, C.M.3
  • 58
    • 0029814495 scopus 로고    scopus 로고
    • Activity of purified hepatitis C virus proteinase NS3 on peptide substrates
    • Steinkühler C, Urbani A, Tomei L, Biasiol G, Sardana M, Bianchi E et al. Activity of purified hepatitis C virus proteinase NS3 on peptide substrates. J Virol 1996: 70: 6694-6700.
    • (1996) J Virol , vol.70 , pp. 6694-6700
    • Steinkühler, C.1    Urbani, A.2    Tomei, L.3    Biasiol, G.4    Sardana, M.5    Bianchi, E.6
  • 59
    • 0028089739 scopus 로고
    • Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics
    • Lin C, Pragai BM, Grakoui A, Xu J, Rice CM. Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol 1994: 68: 8147-8157.
    • (1994) J Virol , vol.68 , pp. 8147-8157
    • Lin, C.1    Pragai, B.M.2    Grakoui, A.3    Xu, J.4    Rice, C.M.5
  • 60
    • 0028942494 scopus 로고
    • NS3-4A of hepatitis C virus is a chymotrypsin-like proteinase
    • Hahm B, Han DS, Back SH, Song OK, Cho MJ, Kim CJ et al. NS3-4A of hepatitis C virus is a chymotrypsin-like proteinase. J Virol 1995: 69: 2534-2539.
    • (1995) J Virol , vol.69 , pp. 2534-2539
    • Hahm, B.1    Han, D.S.2    Back, S.H.3    Song, O.K.4    Cho, M.J.5    Kim, C.J.6
  • 61
    • 0029094449 scopus 로고
    • The hepatitis C virus NS3 serine proteinase and NS4A cofactor: Establishment of a cell-free trans-processing assay
    • Lin C, Rice CM. The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay. Proc Natl Acad Sci USA 1995: 92: 7622-7626.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7622-7626
    • Lin, C.1    Rice, C.M.2
  • 62
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites
    • Grakoui A, McCourt DW, Wychowski C, Feinstone SM, Rice CM. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol 1993: 67: 2832-2843.
    • (1993) J Virol , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 63
    • 0028156982 scopus 로고
    • Molecular model of the specificity pocket of the hepatitis C virus proteinase: Implications for substrate recognition
    • Pizzi E, Tramontano A, Tomei L, La Monica N, Failla C, Sardana M et al. Molecular model of the specificity pocket of the hepatitis C virus proteinase: implications for substrate recognition. Proc Natl Acad Sci USA 1994: 91: 888-892.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 888-892
    • Pizzi, E.1    Tramontano, A.2    Tomei, L.3    La Monica, N.4    Failla, C.5    Sardana, M.6
  • 64
    • 0028290579 scopus 로고
    • Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
    • Failla C, Tomei L, De Francesco R. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol 1994: 68: 3753-3760.
    • (1994) J Virol , vol.68 , pp. 3753-3760
    • Failla, C.1    Tomei, L.2    De Francesco, R.3
  • 65
    • 0028831056 scopus 로고
    • Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
    • Tanji Y, Hijikata M, Satoh S, Kaneko T, Shimotohno K. Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol 1995: 69: 15751581.
    • (1995) J Virol , vol.69 , pp. 15751581
    • Tanji, Y.1    Hijikata, M.2    Satoh, S.3    Kaneko, T.4    Shimotohno, K.5
  • 66
    • 0029074519 scopus 로고
    • A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
    • Lin C, Thomson JA, Rice CM. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J Virol 1995: 69: 4373-4380.
    • (1995) J Virol , vol.69 , pp. 4373-4380
    • Lin, C.1    Thomson, J.A.2    Rice, C.M.3
  • 67
    • 0029655995 scopus 로고    scopus 로고
    • Identification of the sequence of NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 proteinase
    • Shimizu Y, Yamaji K, Masuho Y, Yokota T, Inoue H, Sudo K et al. Identification of the sequence of NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 proteinase. J Virol 1996: 70: 127-132.
    • (1996) J Virol , vol.70 , pp. 127-132
    • Shimizu, Y.1    Yamaji, K.2    Masuho, Y.3    Yokota, T.4    Inoue, H.5    Sudo, K.6
  • 68
    • 0029940111 scopus 로고    scopus 로고
    • A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 proteinase
    • Tomei L, Failla C, Vitale RL, Bianchi E, De Francesco R. A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 proteinase. J Gen Virol 1996: 77: 1065-1070.
    • (1996) J Gen Virol , vol.77 , pp. 1065-1070
    • Tomei, L.1    Failla, C.2    Vitale, R.L.3    Bianchi, E.4    De Francesco, R.5
  • 69
    • 0030198933 scopus 로고    scopus 로고
    • In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor
    • Koch JO, Lohmann V, Herian U, Bartenschlager R. In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor. Virology 1996: 221: 54-66.
    • (1996) Virology , vol.221 , pp. 54-66
    • Koch, J.O.1    Lohmann, V.2    Herian, U.3    Bartenschlager, R.4
  • 70
    • 0030589011 scopus 로고    scopus 로고
    • Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: Identification of sequence and critical residues of NS4A for the cofactor activity
    • Butkiewicz NJ, Wendel M, Zhang R, Jubin R, Pichardo J, Smith EB et al. Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity. Virology 1996: 225: 328-338.
    • (1996) Virology , vol.225 , pp. 328-338
    • Butkiewicz, N.J.1    Wendel, M.2    Zhang, R.3    Jubin, R.4    Pichardo, J.5    Smith, E.B.6
  • 71
    • 0029076837 scopus 로고
    • The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A
    • Satoh S, Tanji Y, Hijikata M, Kimura K, Shimotohno K. The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A. J Virol 1995: 69: 4255260.
    • (1995) J Virol , vol.69 , pp. 4255260
    • Satoh, S.1    Tanji, Y.2    Hijikata, M.3    Kimura, K.4    Shimotohno, K.5
  • 72
    • 0030592514 scopus 로고    scopus 로고
    • The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
    • Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW et al. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 1996: 87: 331-342.
    • (1996) Cell , vol.87 , pp. 331-342
    • Love, R.A.1    Parge, H.E.2    Wickersham, J.A.3    Hostomsky, Z.4    Habuka, N.5    Moomaw, E.W.6
  • 73
    • 16044364658 scopus 로고    scopus 로고
    • Crystal structure of the hepatitis virus NS3 proteinase domain complexed with a synthetic NS4A cofactor peptide
    • Kirn JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA et al. Crystal structure of the hepatitis virus NS3 proteinase domain complexed with a synthetic NS4A cofactor peptide. Cell 1996: 87: 343-355.
    • (1996) Cell , vol.87 , pp. 343-355
    • Kirn, J.L.1    Morgenstern, K.A.2    Lin, C.3    Fox, T.4    Dwyer, M.D.5    Landro, J.A.6
  • 76
    • 0028846684 scopus 로고
    • Spectroscopic characterization of rhinoviral proteinase 2A: Zn is essential for structural integrity
    • Voss T, Meyer R, Sommergruber W. Spectroscopic characterization of rhinoviral proteinase 2A: Zn is essential for structural integrity. Protein Sci 1995: 4: 2526-2531.
    • (1995) Protein Sci , vol.4 , pp. 2526-2531
    • Voss, T.1    Meyer, R.2    Sommergruber, W.3
  • 77
    • 0027182114 scopus 로고
    • Helicases: Amino acid sequence comparison and structure-function relationship
    • Gorbalenya AE, Koonin EV. Helicases: amino acid sequence comparison and structure-function relationship. Curr Opin Struct Biol 1993: 3: 419-429.
    • (1993) Curr Opin Struct Biol , vol.3 , pp. 419-429
    • Gorbalenya, A.E.1    Koonin, E.V.2
  • 79
    • 0001601499 scopus 로고
    • NTPase activity of hepatitis C virus NS3 protein expressed in insect cells
    • Gwack Y, Wook D, Han JH, Choe J. NTPase activity of hepatitis C virus NS3 protein expressed in insect cells. Mol Cells 1995: 5: 171-175.
    • (1995) Mol Cells , vol.5 , pp. 171-175
    • Gwack, Y.1    Wook, D.2    Han, J.H.3    Choe, J.4
  • 80
    • 0029784485 scopus 로고    scopus 로고
    • A steadystate and pre-steady state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain
    • Preugschat F, Averett DR, Clarke BE, Porter DJT. A steadystate and pre-steady state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain. J Biol Cheml996: 271: 24449-24457.
    • J Biol Cheml996: 271 , pp. 924457
    • Preugschat, F.1    Averett, D.R.2    Clarke, B.E.3    Djt, P.4
  • 81
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotidestimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    • Suzich JA, Tamura JK, Palmer Hill F, Warrener P, Grakoui A, Rice CM et al. Hepatitis C virus NS3 protein polynucleotidestimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol 1993: 67: 61526158.
    • (1993) J Virol , vol.67 , pp. 61526158
    • Suzich, J.A.1    Tamura, J.K.2    Palmer Hill, F.3    Warrener, P.4    Grakoui, A.5    Rice, C.M.6
  • 82
    • 0030583249 scopus 로고    scopus 로고
    • Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein
    • Gwack Y, Kirn DW, Han JH, Choe J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun 1996: 225: 654-659.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 654-659
    • Gwack, Y.1    Kirn, D.W.2    Han, J.H.3    Choe, J.4
  • 83
    • 0028884176 scopus 로고
    • Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase
    • Jin L, Peterson DL. Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch Biochem Biophys 1995: 323: 47-53.
    • (1995) Arch Biochem Biophys , vol.323 , pp. 47-53
    • Jin, L.1    Peterson, D.L.2
  • 84
    • 0028817781 scopus 로고
    • C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity
    • Kirn DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun 1995: 215: 160-166.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 160-166
    • Kirn, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 85
    • 0029970903 scopus 로고    scopus 로고
    • The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
    • Tai C-L, Chi W-K, Chen D-S, Hwang L-H. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol 1996: 70: 8477-8484.
    • (1996) J Virol , vol.70 , pp. 8477-8484
    • Tai, C.-L.1    Chi, W.-K.2    Chen, D.-S.3    Hwang, L.-H.4
  • 86
    • 0030735535 scopus 로고    scopus 로고
    • DNA helicase activity of the hepatitis C virus nonstructural protein 3
    • Gwack Y, Kirn DW, Han JH, Choe J. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem 1997: 250: 47-54.
    • (1997) Eur J Biochem , vol.250 , pp. 47-54
    • Gwack, Y.1    Kirn, D.W.2    Han, J.H.3    Choe, J.4
  • 87
    • 0030741828 scopus 로고    scopus 로고
    • A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein
    • Heilek GM, Peterson MG. A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein. J Virol 1997: 71: 6264-6266.
    • (1997) J Virol , vol.71 , pp. 6264-6266
    • Heilek, G.M.1    Peterson, M.G.2
  • 88
    • 0013627747 scopus 로고    scopus 로고
    • Mutational analy-sis of the hepatitis C virus RNA helicase
    • Kirn DW, Kirn J, Gwack Y, Han JH, Choe J. Mutational analy-sis of the hepatitis C virus RNA helicase. J Virol 1997: 71: 9400-9409.
    • (1997) J Virol , vol.71 , pp. 9400-9409
    • Kirn, D.W.1    Kirn, J.2    Gwack, Y.3    Han, J.H.4    Choe, J.5
  • 89
    • 0029063640 scopus 로고
    • Virus nonstructural protein NS3 transforms NIH 3T3 cells
    • Sakamuro D, Furukawa T, Takegami T Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol 1995: 69: 3893-3896.
    • (1995) J Virol , vol.69 , pp. 3893-3896
    • Sakamuro, D.1    Furukawa, T.2    Takegami, T.3    Hepatitis, C.4
  • 90
    • 0029992405 scopus 로고    scopus 로고
    • Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase
    • Borowski P, Heiland M, Oehlmann K, Becker B, Kornetzky L, Feucht H et al. Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase. Eur J Biochem 1996: 237: 611-618.
    • (1996) Eur J Biochem , vol.237 , pp. 611-618
    • Borowski, P.1    Heiland, M.2    Oehlmann, K.3    Becker, B.4    Kornetzky, L.5    Feucht, H.6
  • 91
    • 0030941094 scopus 로고    scopus 로고
    • Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase
    • Borowski P, Oehlmann K, Heiland M, Laufs R. Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase. J Virol 1997:71: 2838-2843
    • (1997) J Virol , vol.71 , pp. 2838-2843
    • Borowski, P.1    Oehlmann, K.2    Heiland, M.3    Laufs, R.4
  • 93
    • 0028978937 scopus 로고
    • Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A
    • Tanji Y, Kaneko T, Satoh S, Shimotohno K. Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol 1995: 69: 3980-3986.
    • (1995) J Virol , vol.69 , pp. 3980-3986
    • Tanji, Y.1    Kaneko, T.2    Satoh, S.3    Shimotohno, K.4
  • 95
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus Ib infection
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus Ib infection. N Engl J Med 1996: 334: 77-81.
    • (1996) N Engl J Med , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6
  • 96
    • 0031050892 scopus 로고    scopus 로고
    • Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype Ib hepatitis C virus infection
    • Chayama K, Tsubota A, Kobayashi M, Okamoto K, Hashimoto M, Miyano Y et al. Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype Ib hepatitis C virus infection. Hepatology 1997: 25: 745-749.
    • (1997) Hepatology , vol.25 , pp. 745-749
    • Chayama, K.1    Tsubota, A.2    Kobayashi, M.3    Okamoto, K.4    Hashimoto, M.5    Miyano, Y.6
  • 97
    • 0031042869 scopus 로고    scopus 로고
    • Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy
    • Kurosaki M, Enomoto N, Murakami T, Sakuma I, Asahina Y, Yamamoto C et al. Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy. Hepatology 1997: 25: 750-753.
    • (1997) Hepatology , vol.25 , pp. 750-753
    • Kurosaki, M.1    Enomoto, N.2    Murakami, T.3    Sakuma, I.4    Asahina, Y.5    Yamamoto, C.6
  • 98
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale MJ Jr, Korth MJ, Tang NM, Tan S-L, Hopkins DA, Dever TE et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997: 230: 217-227.
    • (1997) Virology , vol.230 , pp. 217-227
    • Korth, M.J.1    Tang, N.M.2    Tan, S.-L.3    Hopkins, D.A.4    Dever, T.E.5
  • 99
    • 17144463221 scopus 로고    scopus 로고
    • Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
    • Gale M Jr, Blakely CM, Kwieciszewski B, Tan S-L, Dossett M, Tang NM et al. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation. Mol Cell Biol 1998: 18: 5208-5218.
    • (1998) Mol Cell Biol , vol.18 , pp. 5208-5218
    • Blakely, C.M.1    Kwieciszewski, B.2    Tan, S.-L.3    Dossett, M.4    Tang, N.M.5
  • 100
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens S-E, Tomei L, De Francesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996: 15: 12-22.
    • (1996) EMBO J , vol.15 , pp. 12-22
    • Behrens, S.-E.1    Tomei, L.2    De Francesco, R.3
  • 102
    • 1842289764 scopus 로고    scopus 로고
    • Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
    • Lohmann V, Körner F, Herian U, Bartenschlager R. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol 1997: 71: 8416-8428.
    • (1997) J Virol , vol.71 , pp. 8416-8428
    • Lohmann, V.1    Körner, F.2    Herian, U.3    Bartenschlager, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.