Differential regulation of the N-myc proto-oncogene by RORα and RVR, two orphan members of the superfamily of nuclear hormone receptors

Molecular and Cellular Biology

Volumn 17, Issue 4, 1997, Pages 1860-1867

  Dussault, Isabelle ^a   Giguère, Vincent ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; PHOSPHOPROTEIN; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; DNA SEQUENCE; EMBRYO; EMBRYONAL CARCINOMA; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 1842328569     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.4.1860     Document Type: Article

References (51)

1. Carlberg, C., R. van Huijsduijnen, J. K. Staple, J. F. DeLamarter, and M. Becker-André. 1994. RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol. Endocrinol. 8:757-770.
2. Charron, J., B. A. Malynn, P. Fisher, V. Stewart, L. Jeanotte, S. P. Goff, E. J. Robertson, and F. W. Alt. 1992. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 6:2248-2257.
3. DePinho, R. A., K. S. Hatton, A. Tesfaye, G. D. Yancopoulos, and F. W. Alt. 1987. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev. 1:1311-1326.
4. DePinho, R. A., E. Legouy, L. B. Feldman, N. E. Kohl, G. D. Yancopoulos, and F. W. Alt. 1986. Structure and expression of the murine N-myc gene. Proc. Natl. Acad. Sci. USA 83:1827-1831.
5. Downs, K. M., G. R. Martin, and J. M. Bishop. 1989. Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. Genes Dev. 3:860-869.
6. Dumas, B., H. P. Harding, H.-S. Choi, K. A. Lehman, M. Chung, M. A. Lazar, and D. D. Moore. 1994. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. Mol. Endocrinol. 8:996-1005.
7. Dussault, I., A. Moraitis, and V. Giguère. Unpublished results.
8. Forman, B., J. Chen, B. Blumberg, S. A. Kliewer, R. Henshaw, E. S. Ong, and R. M. Evans. 1994. Cross-talk among RORα1 and the Rev-erb family of orphan nuclear receptor. Mol. Endocrinol. 8:1253-1261.
9. Gazdar, A. F., S. Bader, J. Hung, Y. Kishimoto, Y. Sekido, K. Sugio, A. Virmani, J. Fleming, D. P. Carbone, and J. D. Minna. 1994. Molecular genetic changes found in human lung cancer and its precursor lesions. Cold Spring Harbor Symp. Quant. Biol. 59:565-572.
10. Giguère, V., S. H. Hollenberg, M. G. Rosenfeld, and R. M. Evans. 1986. Functional domains of the human glucocorticoid receptor. Cell 46:645-652.
11. Giguère, V., and N. A. Jenkins. Unpublished results.
12. Giguère, V., L. D. B. McBroom, and G. Flock. 1995. Determinants of target gene specificity for RORα1: monomeric DNA binding by an orphan nuclear receptor. Mol. Cell. Biol. 15:2517-2526.
13. Giguère, V., M. Shago, R. Zirngibl, P. Tate, J. Rossant, and S. Varmuza. 1990. Identification of a novel isoform of the retinoic acid receptor γ expressed in the mouse embryo. Mol. Cell. Biol. 10:2335-2340.
14. Giguère, V., M. Tini, G. Flock, E. S. Ong, R. M. Evans, and G. Otulakowski. 1994. Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan nuclear receptors. Genes Dev. 8:538-553.
15. Harding, H. P., and M. A. Lazar. 1995. The monomer-binding orphan receptor Rev-erb represses transcription as a dimer on a novel direct repeat. Mol. Cell. Biol. 15:4791-4802.
16. Hiller, S., S. Breit, Z.-Q. Wang, E. F. Wagner, and M. Schwab. 1991. Localization of regulatory elements controlling human MYCN expression. Oncogene 6:969-977.
17. Hirning, U., P. Schmid, W. A. Schulz, G. Rettenberger, and H. Hameister. 1991. A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis. Mech. Dev. 33:119-125.
18. Hirose, T., R. J. Smith, and A. M. Jetten. 1994. RORγ: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem. Biophys. Res. Commun. 205:1976-1983.
19. Hung, J., Y. Kishimoto, K. Sugio, A. Virmani, D. D. McIntire, J. D. Minna, and A. F. Gazdar. 1995. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. JAMA 273:558-563.
20. Kohl, N. E., C. E. Gee, and F. W. Alt. 1984. Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science 226: 1335-1337.
21. Kohl, N. E., N. Kanda, R. R. Schreck, G. Bruns, S. A. Latt, F. Gilbert, and F. W. Alt. 1983. Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 35:359-367.
22. Kohl, N. E., E. Legouy, R. A. DePinho, P. D. Nisen, R. K. Smith, C. E. Gee, and F. W. Alt. 1986. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature (London) 319:73-77.
23. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
24. Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (London) 304:596-602.
25. Lazar, M. A., R. A. Hodin, D. S. Darling, and W. W. Chin. 1989. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbAα transcriptional unit. Mol. Cell. Biol. 9:1128-1136.
26. Lee, W. H., A. L. Murphree, and W. F. Benedict. 1984. Expression and amplification of the N-myc gene in primary retinoblastoma. Nature (London) 309:458-460.
27. Marcu, K. B., S. A. Bossone, and A. J. Patel. 1992. Myc function and regulation. Annu. Rev. Biochem. 61:809-860.
28. Matsui, T., S. Sashihara, Y. Oh, and S. G. Waxman. 1995. An orphan nuclear receptor, mRORα, and its spatial expression in adult mouse brain. Mol. Brain Res. 33:217-226.
29. McBroom, L. D. B., G. Flock, and V. Giguère. 1995. The non-conserved hinge region and distinct amino-terminal domains of the RORα orphan nuclear receptor isoforms are required for proper DNA bending and RORα-DNA interactions. Mol. Cell. Biol. 15:796-808.
30. Miyajima, N., R. Horiuchi, Y. Shibuya, S.-I. Fukushige, K.-I. Matsubara, K. Toyoshima, and T. Yamamoto. 1989. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57:31-39.
31. Morrow, M. A., G. Lee, S. Gillis, G. D. Yancopoulos, and F. W. Alt. 1992. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes Dev. 6:61-70.
32. Mugrauer, G., F. W. Alt, and P. Ekblom. 1988. N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J. Cell Biol. 107:1325-1335.
33. Nau, M. M., B. J. Brooks, Jr., D. N. Carney, A. F. Gazdar, J. F. Battey, E. A. Sausville, and J. D. Minna. 1986. Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc. Natl. Acad. Sci. USA 83:1092-1096.
34. Noguchi, M., S. Hirohashi, F. Hara, A. Kojima, Y. Shimosato, T. Shinkai, and R. Tsuchiya. 1990. Heterogenous amplification of myc family oncogenes in small cell lung carcinoma. Cancer 66:2053-2058.
35. Ortiz, M. A., F. J. Piedrafita, M. Pfahl, and R. Maki. 1995. TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol. Endocrinol. 9:1679-1691.
36. Retnakaran, R., G. Flock, and V. Giguère. 1994. Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol. Endocrinol. 8:1234-1244.
37. Schwab, M., J. Ellison, M. Busch, W. Rosenau, H. E. Varmus, and J. M. Bishop. 1984. Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc. Natl. Acad. Sci. USA 81:4940-4944.
38. Schwab, M., H. E. Varmus, and J. M. Bishop. 1985. Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature (London) 316:160-162.
39. Spanjaard, R. A., V. P. Nguyen, and W. W. Chin. 1994. Rat Rev-erbAα, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements. Mol. Endocrinol. 8:286-295.
40. Stanton, B. R., A. S. Perkins, L. Tessarollo, D. A. Sassoon, and L. F. Parada. 1992. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6:2235-2247.
41. Tini, M., G. Otulakowski, M. L. Breitman, L.-T. Tsui, and V. Giguère. 1993. An everted repeat mediates retinoic acid induction of the γF-crystallin gene: evidence of a direct role for retinoids in lens development. Genes Dev. 7:295-307.
42. Tsuchida, Y., H. Memni, A. Inoue, K. Obana, H. W. Yang, Y. Hayashi, N. Kanda, and H. Shimatake. 1996. Genetic clinical markers of human neuroblastoma with special reference to N-myc oncogene: amplified or not amplified? An overview. Tumor Biol. 17:65-74.
43. Wada, R. K., R. C. Seeger, G. M. Brodeur, P. A. Einhorn, S. A. Rayner, M. M. Tomayko, and C. P. Reynolds. 1993. Human neuroblastoma cell lines that express N-myc without gene amplification. Cancer 72:3345-3354.
44. Wada, R. K., R. C. Seeger, C. P. Reynolds, T. Alloggiamento, J. M. Yamashiro, C. Ruland, A. C. Black, and J. D. Rosenblatt. 1992. Cell type-specific expression and negative regulation by retinoic acid of the human N-myc promoter in neuroblastoma cells. Oncogene 7:711-717.
45. Woodruff, K. A., J. D. Rosenblatt, T. B. Moore, R. H. Medzoyan, D. S. M. Pai, J. L. Noland, J. M. Yamashiro, and R. K. Wada. 1995. Cell type-specific activity of the N-myc promoter in human neuroblasma cells is mediated by a downstream silencer. Oncogene 10:1335-1341.
46. Xu, L., Y. Meng, R. Wallen, and R. A. DePinho. 1995. Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype. Oncogene 11:1865-1872.
47. Xu, L., S. D. Morgenbesser, and R. A. DePinho. 1991. Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver. Mol. Cell. Biol. 11:6007-6015.
48. Xu, L., R. Wallen, V. Patel, and R. A. DePinho. 1993. Role of first exon/ intron sequences in the regulation of myc family oncogenic potency. Oncogene 8:2547-2553.
49. Yancopoulos, G. D., P. D. Nisen, A. Tesfaye, N. E. Kohl, M. P. Goldfarb, and F. W. Alt. 1985. N-myc can cooperate with ras to transform normal cells in culture. Proc. Natl. Acad. Sci. USA 82:5455-5459.
50. Zumir, I., H. P. Harding, G. B. Atkins, A. Hörlein, C. K. Glass, M. G. Rosenfeld, and M. A. Lazar. 1996. A nuclear hormone receptor compressor mediates transcriptional silencing by receptors with distinct repression domains. Mol. Cell. Biol. 16:5458-5465.
51. Zimmerman, K., G. D. Yancopoulos, R. G. Collum, R. K. Smith, N. E. Kohl, K. A. Denis, M. N. Nau, O. N. Witte, D. Toran-Allerand, C. E. Gee, J. D. Minna, and F. W. Alt. 1986. Differential expression of myc family genes during murine development. Nature (London) 319:780-783.