Engrailed and polyhomeotic interactions are required to maintain the A/P boundary of the Drosophila developing wing

Development

Volumn 125, Issue 15, 1998, Pages 2771-2780

  Maschat, Florence ^a   Serrano, Nuria ^a   Randsholt, Neel B ^b   Géraud, Gérard ^a  

^a INSTITUT JACQUES MONOD   (France)

^b CNRS   (France)

Author keywords

Compartment boundary; Drosophila; Engrailed; Polyhomeotic; Target gene; Wing development

Indexed keywords

REGULATOR PROTEIN;

ARTICLE; DROSOPHILA; EMBRYO SEGMENTATION; FORELIMB; GENE EXPRESSION; GENE INDUCTION; IMAGINAL DISC; LARVAL DEVELOPMENT; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

ANIMALS; BODY PATTERNING; CELL COMMUNICATION; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; HETEROZYGOTE; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MEMBRANE PROTEINS; MORPHOGENESIS; MUTATION; NUCLEOPROTEINS; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS; WING;

EID: 0031661090     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the Gli family of zinc finger DNA binding proteins. Genes Dev. 10, 2003-2013.
2. Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M. P., Schwartz, C. and Kornberg, T. B. (1997). Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
3. Baillie, D. L. and Chovnick, A, (1971). Studies on the genetic control of Tryptophan Pyrrolase in Drosophila melanogaster. Mol. Gen. Genet. 112, 341-353.
4. Basler, K. and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
5. Blair, S. S. (1992). engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Development 115, 21-33.
6. Busturia A. and Morata, G. (1988). Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis. Development 104, 713-720.
7. Capdevila, J., Estrada, M. P., Sanchez-Herrero, E. and Guerrero, I. (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J. 13, 71-82.
8. Capdevila, J. and Guerrero, I. (1994). Targeted expression of the signaling molecule Decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
9. de Celis, J. F. and Ruiz-Gomez, M. (1995). groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing. Development 121, 3467-3476.
10. DeCamillis, M., Cheng, N., Pierre, D. and Brock, H. W. (1992). The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. Genes Dev. 6, 223-232.
11. Desplan, C., Theis, J. and O'Farrell, P. (1985). The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature 318, 630-635.
12. Dominguez, M., Brunner, M., Hafen, E. and Basler, K. (1996). Sending and receiving the Hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.
13. Dura, J. M., Brock, H. W. and Santamaria, P. (1985). polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity. Mol. Gen. Genet. 198, 213-220.
14. Dura, J. M. and Ingham, P. H. (1988). Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene. Development 103, 733-741.
15. Dura, J. M., Randsholt, N. B., Deatrick, J., Erk, I., Santamaria, P., Freeman, J. D., Freeman, S. J., Weddell, D. and Brock, H. W. (1987). A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster. Cell 51, 829-839.
16. Eaton, S. and Kornberg, T. B. (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev. 4, 1068-1077.
17. Fauvarque, M. O., Zuber, V. and Dura, J. M. (1995). Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. Mech. Dev. 52, 343-345.
18. Franke, A., DeCamillis, M., Zink, B., Cheng, N., Brock, H. W. and Paro, R. (1992). Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11, 2941-2950.
19. Garcia-Bellido, A., Ripoll, P. and Morata, G. (1973). Developmental compartimentalization of the wing disc of Drosophila. Nat. New Biol. 245, 251-253.
20. Garcia-Bellido, A. and Santamaria, P. (1972). Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster. Genetics 72, 87-104.
21. Glaser, R. L., Wolfner, M. F. and Lis, J. T. (1986). Spatial and temporal pattern of hsp26 expression during normal development. EMBO J. 5, 747-754.
22. Guillen, I., Mullor, J. L., Capdevila, J., Sanchez-Herrero, E., Morata, G. and Guerrero, I. (1995). The function of engrailed and the specification of Drosophila wing pattern. Development 121, 3447-3456.
23. Gustavson, E., Goldbourough, A. S., Ali, Z. and Kornberg, T. (1996). The Drosophila engrailed and invected genes: partners in regulation, expression and functions. Genetics 142, 893-906.
24. Hama, C., Ali, Z. and Kornberg, T. B. (1990). Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes Dev. 4, 1079-1093.
25. Heemskerk, J., DiNardo, S., Kostriken, R. and O'Farrell, P. (1991). Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature 352, 404-352.
26. Hepker, J., Wang, Q.-T., Motzny, C. K., Holmgrem, R. and Orenic, T. V. (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.
27. Hidalgo, A. (1994). Three distinct roles for the engrailed gene in Drosophila wing development. Current Biology 4, 1087-1098.
28. Hodgson, J. W., Cheng, N. N., Sinclair, D. A. R., Kyba, M., Randsholt, N. B. and Brock, H. W. (1997). The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis. Mech. Dev. 66, 69-81.
29. Kennison, J. A. and Tamkun, J. W. (1988). Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. USA 85, 8136-8140.
30. Lawrence, P. and Morata, G. (1976). Compartments in the wing of Drosophila: A study of the engrailed gene. Dev. Biol. 50, 321-337.
31. Mann, R. S. (1994). engrailed-mediated repression of Ultrabithorax is necessary for the parasegment 6 identity in Drosophila. Development 120, 3205-3212.
32. Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J. (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.
33. Martinez-Arias, A. and White, R. A. H. (1988). Ultrabithorax and engrailed expression in Drosophila embryo mutant segmentation genes of the pair rule class. Development 102, 325-338.
34. Moazed, D. and O'Farrell, P. H. (1992). Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development 116, 805-810.
35. Paro, R. (1990). Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6, 416-421.
36. Saenz-Robles, M. T., Maschat, F., Tabata, T., Scott, M. P. and Kornberg, T. B. (1995). Selection and characterization of sequences with high affinity for the Engrailed protein of Drosophila. Mech. Dev. 53, 185-195.
37. Saget, O. and Randsholt, N. B. (1994). Transposon-induced rearrangements in the duplicated locus ph of Drosophila melanogaster can create new chimeric genes functionally identical to the wild type. Gene 149, 227-235.
38. Sanchez-Herrero, E., Couso, J. P., Capdevila, J. and Guerrero, I. (1996). The fu gene descriminates between pathways to control dpp expression in Drosophila imaginai discs. Mech. Dev. 55, 159-170.
39. Sanicola, M., Sekelsky, J., Elson, S. and Gelbart, W. M. (1995). Drawing a stripe in Drosophila imaginal disks: Negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.
40. Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B. (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121, 1626-1635.
41. Serrano, N., Brock, H. W., Demeret, C., Dura, J. M., Randsholt, N. B., Kornberg, T. B. and Maschat, F. (1995). polyhomeotic appears to be a target of Engrailed regulation in Drosophila. Development 121, 1691-1703.
42. Serrano, N., Brock, H. W. and Maschat, F. (1997). β3-tubulin is directly repressed by the Engrailed protein in Drosophila. Development 124, 2527-2536.
43. Simmonds, A. J., Brook, W. J., Cohen, S. M. and Bell, J. B. (1995). Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. Nature 376, 424-.
44. Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T. B. (1995). Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121, 3359-3369.
45. Tabata, T., Eaton, S. and Kornberg, T. B. (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment celle and is a target of engrailed regulation. Genes Dev. 6, 2635-2645.
46. Thomas, R. and Thieffry, D. (1995). Les boucles de rétroaction, rouages des réseaux de régulation biologique. Médecine /Sciences 11, 189-197.
47. Zecca, M., Basler, K. and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.