Expression of wingless in the Drosophila embryo: A conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression

Development

Volumn 125, Issue 8, 1998, Pages 1469-1476

  Lessing, Derek ^a,b   Nusse, Roel ^a  

^a STANFORD UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Cubitus interuptus; Drosophila; Hedgehog; Patched; Segmentation; Wingless; Wnt

Indexed keywords

CIS ACTING ELEMENT; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ECTODERM; EMBRYO PATTERN FORMATION; GENE EXPRESSION; GENE REPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

ANIMALIA; CUBITUS; CUBITUS INTERRUPTUS; DROSOPHILA MELANOGASTER; DROSOPHILA VIRILIS; ERINACEIDAE; HEXAPODA; MELANOGASTER;

EID: 0031866079     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by Cubitus interruptus protein, a member of the GLI family of zinc finger DNA- binding proteins. Genes Dev. 10, 2003-2013.
2. Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M.-P., Schwartz, C. and Kornberg, T. B. (1997). Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
3. Baker, N. E. (1988). Localization of transcripts from the wingless gene in whole Drosophila embryos. Development 103, 289-298.
4. Beverley, S. M. and Wilson, A. C. (1984). Molecular evolution in Drosophila and higher diptera: II. A time scale for fly evolution. J. Mol. Evol. 21, 1-13.
5. Brunner, E., Peter, O., Schweizer, L. and Basler, K. (1997). pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385, 829-833.
6. Cadigan, K. M., Grossniklaus, U. and Gehring, W. J. (1994a). Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation. Proc. Natl Acad. Sci. USA 91, 6324-6328.
7. Cadigan, K. M., Grossniklaus, U. and Gehring, W. J. (1994b). Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes Dev. 8, 899-913.
8. Cherbas, L. and Cherbas, P. (1993). The arthropod initiator: the capsite consensus plays an important role in transcription. Insect Biochem. Mol. Biol. 23, 81-90.
9. DiNardo, S., Heemskerk, J., Dougan, S. and O'Farrell, P. H. (1994). The making of a maggot: patterning the Drosophila embryonic epidermis. Curr. Opin. Genet. Dev. 4, 529-534.
10. Forbes, A. J., Nakano, Y., Taylor, A. M. and Ingham, P. W. (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993 Supplement, 115-124.
11. Grossniklaus, U., Pearson, R. K. and Gehring, W. J. (1992). The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev. 6, 1030-1051.
12. Hidalgo, A. (1991). Interactions between segment polarity genes and the generation of the segmental pattern in Drosophila. Mech. Dev. 35, 77-87.
13. Hooper, J. E. (1994). Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 372, 461-464.
14. Hromas, R. and Costa, R. (1995). The hepatocyte nuclear factor-3/forkhead transcription regulatory family in development, inflammation, and neoplasia. Crit. Rev. Oncol. Hematol. 20, 129-140.
15. Ingham, P. W. (1993). Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560-562.
16. Ingham, P. W., Baker, N. E. and Martinez Arias, A. (1988). Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped. Nature 331, 73-75.
17. Ingham, P. W., Taylor, A. M. and Nakano, Y. (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.
18. Jaynes, J. B. and O'Farrell, P. H. (1991). Active repression of transcription by the Engrailed homeodomain protein. EMBO J. 10, 1427-1433.
19. Kassis, J. A., Desplan, C., Wright, D. K. and O'Farrell, P. H. (1989). Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transription unit of the Drosophila segmentation gene engrailed. Mol. Cell. Biol. 9, 4304-4311.
20. Kinzler, K. W. and Vogelstein, B. (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell Biol. 110, 634-642.
21. Kuhn, R., Schafer, U. and Schafer, M. (1988). pW-ATG-lac, P-element vectors for lacZ transcriptional gene fusions in Drosophila. Nucleic Acids Res. 16 4163.
22. Langeland, J. A. and Carroll, S. B. (1993). Conservation of regulatory elements controlling hairy pair-rule stripe formation. Development 117, 585-596.
23. Laughon, A. (1991). DNA binding specificity of homeodomains. Biochemistry 30, 11357-11367.
24. Lehmann, R. and Tautz, D. (1994) In Situ Hybridization to RNA. In Drosophila melanogaster: Practical Uses in Cell and Molecular Biology. (ed. L. S. B. Goldstein and E. A. Fyrberg), pp. 576-598. San Diego: Academic Press.
25. Marigo, V., Davy, R. A., Zuo, V., Cunningham, J. M. and Tabin, C. J. (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.
26. Martinez Aris, A. (1993) Development and patterning of the larval epidermis of Drosophila. In The Development of Drosophila melanogaster (ed. M. Bate and A. Martinez Arias), pp. 517-608. Plain View, NY: Cold Spring Harbor Laboratory Press.
27. Martinez Arias, A., Baker, N. E. and Ingham, P. W. (1988). Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103, 157-170.
28. Noordermeer, J., Johnston, P., Rijsewijk, F., Nusse, R. and Lawrence, P. A. (1992). The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development 116, 711-719.
29. Nusse, R., Theunissen, J., Wagenaar, E., Rijsewijk, F., Gennissen, A., Otte, A., Schuuring, E. and Van Ooyen, A. (1990). The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the Mouse Mammary Tumor Virus. Mol. Cell. Biol. 10, 4170-4179.
30. Nüsslein-Volhard, C. and Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
31. Ohlmeyer, J. T. and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250-2258.
32. Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S.-C., Grosschedl, R. and Bienz, M. (1997). LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 88, 777-787.
33. Rijsewijk, F., Schuerman, M., Wagenaar, E., Parren, P., Weigel, D. and Nusse, R. (1987). The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657.
34. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2 ed. Plainview, NY: Cold Spring Harbor Laboratory Press.
35. Sampedro, J., Johnston, P. and Lawrence, P. A. (1993). A role for wingless in the segmental gradient of Drosophila? Development 117, 677-687.
36. Sassone-Corsi, P. (1995). Transcription factors responsive to cAMP. Ann. Rev. Cell Dev. Biol. 11, 355-377.
37. Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B. (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121, 1625-1635.
38. Spradling, A. C. (1986) P-element-mediated transformation. In Drosophila: a Practical Approach (ed. D. B. Roberts), pp. 175-197. Oxford: IRL Press. .
39. Stone, D. M., et al. (1996). The tumor suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134.
40. Tabata, T. and Kornberg, T. B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginai discs. Cell 76, 89-102.
41. van de Wetering, M. et al. (1997). Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789-799.
42. van de Wetering, M. and devers, H. (1992). Sequence-specific interaction of the HMG box proteins TCP-1 and SRY occurs within the minor groove of a Watson-Crick double helix. EMBO J. 11, 3039-3044.
43. Von Ohlen, T., Lessing, D., Nusse, R. and Hooper, J. E. (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. USA 94, 2404-2409.
44. Yoffe, K. B., Manoukian, A. S., Wilder, E. L., Brand, A. H. and Perrimon, N. (1995). Evidence for engrailed-independent wingless autoregulation in Drosophila. Dev. Biol. 170, 636-650.
45. Zarkower, D. and Hodgkin, J. (1993). Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro. Nucleic Acids Res. 21, 3691-3698.