Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, 'short' pseudocathepsin D

Journal of Biological Chemistry

Volumn 271, Issue 26, 1996, Pages 15590-15596

  Beyer, Brian M ^a   Dunn, Ben M ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; PROTEIN PRECURSOR;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ESCHERICHIA COLI; GENETIC ENGINEERING; GENETIC RECOMBINATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATHEPSIN D; ENZYME ACTIVATION; ENZYME PRECURSORS; GLYCOPROTEINS; HUMANS; KINETICS; LIVER; LYSOSOMES; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; FELIS CATUS; UNIDENTIFIED BACULOVIRUS;

EID: 0029953972     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.26.15590     Document Type: Article

References (36)

1. Barrett, A. J. (ed) (1977) in Proteinases in Mammalian Cells and Tissues, pp. 209-248, North Holland Publishing Co., New York
2. Dean, R. T., and Barrett, A. J. (1976) Essays Biochem. 1-39
3. Pillai, S., and Zull, J. (1986) J. Biol. Chem. 261, 14919-14923
4. Diment, S., Leech, M., and Stahl, P. (1988) J. Biol. Chem. 263, 6901-6907
5. Rochefort, H. (1990) Semin. Cancer Biol. 1, 153-160
6. Sanchez, L. M., Ferrando, A. A., Diez-Itza, I., Vizoso, F., and Lopez-Otin, C. (1993) Br. J. Cancer 67, 1076-1081
7. Aaltonen, M., Lipponen, P., Kosma, M., Aaltomaa, S., and Syrjanen, K. (1995) Anticancer Res. 15, 1033-1038
8. Siman, R., Mistretta, J. T., Durkin, M. J., Savage, T., Loh, S., Trusko, S., and Scott, R. W. (1993) J. Biol. Chem. 268, 16602-16609
9. Ladror, U., Snyder, S., Wang, G., Holzman, T., and Kraffl, G. (1994) J. Biol. Chem. 269, 18422-18428
10. Conner, G. E., Blobel, G., and Erickson, A. H. (1987) in Lysosomes: Their Role in Protein Breakdown (Glaumann, H., and Ballard, J., eds) pp. 151-162, Academic Press Ltd., London
11. Kornfeld, S. (1990) Biochem. Sac. Trans. 18, 367-373
12. Cantor, A. B., Baranski, T. J., and Kornfeld, S. (1992) J. Biol. Chem. 267, 23349-23356
13. Cantor, A. B., and Kornfeld, S. (1992) J. Biol. Chem. 267, 23357-23363
14. Samarel, A. M., Ferguson, A. G., Decker, R. S., and Leach, M. (1989) Am. J. Physiol. 257, C1069
15. Shewale, J., and Tang, J. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 3703-3707
16. Erickson, A. H., and Blobel, G. (1983) Biochemistry 22, 5201-5205
17. Conner, G. E., Udey, J., Pinto, C., and Sola, J. (1989) Biochemistry 28, 3530-3533
18. Conner, G. E., and Udey, J. A. (1990) DNA Cell Biol. 9, 1-9
19. Conner, G. E., and Richo, G. (1992) Biochemistry 31, 1142-1147
20. Scarborough, P. E., and Dunn, B. M. (1994) Protein Eng. 7, 495-502
21. Scarborough, P. E., Guruprasad, K., Topham, C., Richo, G. R., Conner, G. E., Blundell, T. L., and Dunn, B. M. (1993) Protein Sci. 2, 264-276
22. Gruenwald, S., and Heitz, J. (1993) in Baculovirus Expression Vector System: Procedures and Methods Manual, 2nd Ed., pp. 39-58, Pharmingen™ Corp., San Diego, CA
23. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
24. Dunn, B. M., Scarborough, P. E., Davenport, R., and Swietnicki, W. (1994) in Peptide Analysis Protocols (Pennington, M., and Dunn, B. M., eds) pp. 225-243, Humana Press Inc., Totowa, NJ
25. Hui, K. Y., Hermann, R. B., Manetta, J. V., Gygi, T., and Angleton, E. L. (1993) FEBS Lett. 327, 355-360
26. Henderson, P. (1972) J. Biol. Chem. 247, 321-333
27. Baldwin, E. T., Bhat, T. N., Gulnik, S., Hosur, M. V., Sowder, R. C., Cachau, R. E., Collins, J., Silva, A. M., and Erickson, J. W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6796-6800
28. Aikawa, J., Yamashita, T., Nishiyama, M., Horinouchi, S., and Beppu, T. (1990) J. Biol. Chem. 265, 13955-13959
29. James, M. G., and Sielecki, A. (1986) Nature 319, 33-38
30. James, M., Moore, S., Sielecki, A., Chernaia, M., and Tarasova, N. (1995) in Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications (Takahashi, K., ed) Vol. 362, pp. 11-18, Plenum Press, New York
31. Conner, G. E. (1992) J. Biol. Chem. 267, 21738-21745
32. Fotenberry, S., and Chirgwin, J. (1995) J. Biol. Chem. 270, 9778-9782
33. Koelsch, G., Mares, M., Metcalf, P., and Fusek, M. (1994) FEBS Lett. 343, 6-10
34. Marciniszyn, J., Jr., Huang, J. S., Hartsuck, J. A., and Tang, J. (1976) J. Biol. Chem. 251, 7095-7102
35. Chen, Z., Koelsch, G., Han, H., Wang, X. J., Lin, X., Hartsuck, J. A., and Tang, J. (1991) J. Biol. Chem. 266, 11718-11725
36. Fukuda, R., Horiuchi, H., Ohta, A., and Takag, M. (1994) J. Biol. Chem. 269, 9556-9561