Pharmacology, structure and function of cardiac L-type Ca 2+ channels

Cellular Physiology and Biochemistry

Volumn 9, Issue 4-5, 1999, Pages 242-269

  Striessnig, Jörg ^a  

^a A 6020   (Austria)

Author keywords

Biochemistry; Ca 2+ channels; Heart; Modulation

Indexed keywords

1,3,5,6 TETRAHYDRO 5 METHYL 6 PHENYL 3,6 METHANO 1,5 BENZODIAZOCINE 2,4 DIONE; 1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1,4 DIHYDROPYRIDINE; 4 (2 BENZYLBENZOYL) 2,5 DIMETHYL 1H PYRROLE 3 CARBOXYLIC ACID METHYL ESTER; BENZOTHIAZEPINE DERIVATIVE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DILTIAZEM; NIFEDIPINE; NITRIC OXIDE; OMEGA CONOTOXIN; OMEGA CONOTOXIN MVIIA; OXYGEN RADICAL; PHENYLALKYLAMINE; PROTEIN TYROSINE KINASE; VERAPAMIL;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; DRUG BINDING; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; MAMMAL; PHOSPHORYLATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

MAMMALIA;

EID: 0033165790     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016320     Document Type: Article

References (158)

1. Ringer S: A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J Physiol (Lond) 1882;4:29-42.
2. Fleckenstein A: Calcium Antagonism in Heart and Smooth Muscle. New York, Wiley, 1983.
3. Kohlhardt M: Functional differentiation of the transmembrane sodium and calcium channels in mammalian cardiac fibers by use of specific inhibitors. Recent Adv Stud Cardiac Struct Metab 1975;5:19-26.
4. Fox AP, Nowycky MC, Tsien RW: Single-channel recordings of three types of calcium channels in chick sensory neurones. J Physiol (Lond) 1987;394:173-200.
5. Carbone E, Lux HD: A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones. Nature 1984;310:501-502.
6. Nilius B, Hess P, Lansman JB, Tsien RW: A novel type of cardiac calcium channel in ventricular cells. Nature 1985;316:443-446.
7. Hess P: Calcium channels in vertebrate cells. Annu Rev Neurosci 1990;13:337-356.
8. Randall A, Tsien RW: Pharmacological dissection of multiple types of calcium channels currents in rat cerebellar granule neurons. J Neurosci 1995;15:2995-3012.
9. Birnbaumer L, Campbell KP, Catterall WA, Harpold MM, Hofmann F, Horne WA, Mori Y, Schwartz A, Snutch TP, Tanabe T, Tsien RW: The naming of voltage-gated calcium channels. Neuron 1994;13: 505-506.
10. Glossmann H, Striessnig J: Molecular properties of calcium channels. Rev Physiol Biochem Pharmacol 1990;114:1-105.
11. Triggle DJ, Janis RA: Calcium channel ligands. Annu Rev Pharmacol Toxicol 1987;27:347-369.
12. Hockerman GH, Peterson BZ, Johnson BD, Catterall WA: Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol 1997;37:361-396.
13. Mitterdorfer J, Grabner M, Kraus RL, Hering S, Prinz H, Glossmann H, Striessnig J: Molecular basis of drug interaction with L-type calcium channels. J Bioenerget Biomembr 1998;30:319-333.
14. Striessnig J, Grabner M, Mitterdorfer J, Hering S, Sinnegger MJ, Glossmann H: Structural basis of drug binding to L calcium channels. Trends Pharmacol Sci 1998;19: 108-115.
15. 2+ channels. Nature 1983;303:535-537.
16. Zheng W, Rampe D, Triggle DJ: Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel non-dihydropyridine calcium channel activator, in cardiac and vascular preparations. Mol Pharmacol 1991; 40:734-741.
17. Herzig S: Calcium channel activation by CGP48506, a new positive inotropic benzodiazocine derivative. Eur J Pharmacol 1996;295: 113-117.
18. Hess P, Lansman JB, Tsien RW: Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 1984;311:538-544.
19. Gross R, Kayser M, Schramm M, Taniel R, Thomas G: Cardiovascular effects of the calcium-agonistic dihydropyridine BAY K 8644 in conscious dogs. Arch Int Pharmacodyn Ther 1985;277:203-216.
20. Billman GE: Effect of calcium channel antagonists on susceptibility to sudden cardiac death: Protection from ventricular fibrillation. J Pharmacol Exp Ther 1989;248:1334-1342.
21. Shelton RC, Grebb JA, Freed WJ: Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644. Brain Res 1987;402: 399-402.
22. Rovnyak GKSD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang HJ, Moreland S: Calcium entry blockers and activators: Conformational and structural determinants of dihydropyrimidine calcium channel modulators. J Med Chem 1995;38:119-129.
23. Triggle DJ, Rampe D: 1,4-dihydropyridine activators and antagonists: Structural and functional distinctions. Trends Pharmacol Sci 1989; 10:507-511.
24. Hille B: Ionic Channels of Excitable Membranes. Sunderland, Sinauer, 1991.
25. Bean BP: Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state. Proc Natl Acad Sci USA 1984;81: 6388-6392.
26. Johnson BD, Hockerman GH, Scheuer T, Catterall WA: Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines. Mol Pharmacol 1996;50:1388-1400.
27. Hering S, Aczel S, Kraus RL, Berjukov S, Striessnig J, Timin EN: Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation. Proc Natl Acad Sci USA 1997; 94:13323-13328.
28. Kraus RL, Hering S, Grabner M, Ostler D, Striessnig J: Molecular mechanism of diltiazem interaction with L-type calcium channels. J Biol Chem 1998;273:27205-27212.
29. Hering S, Berjukov S, Aczel S, Timin EN: Calcium channel block and inactivation: Common molecular determinants. Trends Pharmacol Sci 1998;19:439-434.
30. Cooper CL, Vandaele S, Barhanin J, Fosset M, Lazdunski M, Hosey MM: Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue. J Biol Chem 1987;262:509-512.
31. Haase H, Striessnig J, Holtzhauer M. Vetter R, Glossmann H: A rapid procedure for the purification of cardiac 1,4-dihydropyridine receptors form porcine heart. Eur J Pharmacol 1991;207:51-59.
32. Safayhi H, Haase H, Kramer U, Bihlmayer A, Roenfeldt M, Ammon HP, Froschmayr M, Cassidy TN, Morano I, Ahlijanian M, Striessnig J: L-type calcium channels in insulin-secreting cells: Biochemical characterization and phosphorylation in RINm5F cells. Mol Endocrinol 1997;11:619-629.
33. Takimoto K, Li D, Nerbonne JM, Levitan ES: Distribution, splicing and glucocorticoid-induced expression of cardiac alpha1C and alpha1D voltage-gated calcium channel mRNAs. J Mol Cell Cardiol 1997;29:3035-3042.
34. 2+ channel (CACNL1A1) to chromosome 12p13.2-pter using a dinucleotide repeat. Genomics 1992;14:206-207.
35. Pichler M, Cassidy TN, Reimer D, Haase H, Kraus R, Ostler D, Striessnig J: Beta subunit heterogeneity in neuronal L-type calcium channels. J Biol Chem 1997;272:13877-13882.
36. McCleskey EW, Aimers W: The Ca channel in skeletal muscle is a large pore. Proc Natl Acad Sci USA 1985; 82:7149-7153.
37. + conduction and selectivity. Science 1998;280:69-77.
38. 2+ channels. Nature 1993; 366:158-161.
39. Garcia J, Nakai J, Imoto K, Beam KG: Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel. Biophys J 1997;72:2515-2523.
40. Zhang JF, Ellinor PT, Aldrich RW, Tsien RW: Molecular determinants of voltage-dependent inactivation in calcium channels. Nature 1994;372: 97-100.
41. Herlitze S, Hockerman GH, Scheuer T, Catterall WA: Molecular determinant of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel alpha 1A subunit. Proc Natl Acad Sci USA 1997;94:1512-1516.
42. Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T, Catterall WA: Modulation of calcium channels by G-protein beta gamma subunits. Nature 1996;380:258-262.
43. 2+ channel regulation by a conserved β-subunit domain. Neuron 1994;13:495-503.
44. Pragnell M, De Waard M, Tanabe T, Mori Y, Snutch TP, Campbell KP: Calcium channel β-subunit binds to a conserved motif in the I-II cytoplasmic linker of the α1-subunit. Nature 1994;368:67-70.
45. Biel M, Ruth P, Bosse E, Hullin R, Stuehmer W, Flockerzi V, Hofmann F: Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett 1990;269:409-412.
46. Gao T, Puri TS, Gerhardstein BL, Chien AJ, Green RD, Hosey MM: Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. J Biol Chem 1997;272:19401-19407.
47. Klugbauer N, Lacinova L, Marais E, Hobom M, Hofmann F: Molecular diversity of the calcium channel alpha 2 delta subunit. J Neurosci 1998;19:684-691.
48. Takahashi M, Seagar MJ, Jones JF, Reber BFX, Catterall WA: Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle. Proc Natl Acad Sci USA 1987;84:5478-5482.
49. De Jongh KS, Warner C, Catterall WA: Subunits of purified calcium channels: Alpha 2 and delta are encoded by the same gene. J Biol Chem 1990;265:14738-14741.
50. Gurnett CA, Felix R, Campbell KP: Extracellular interaction of the voltage-dependent calcium channel alpha 2 delta and alpha 1 subunits. J Biol Chem 1997;272:18508-18512.
51. Gee NS, Brown JP, Dissanayake VUK, Offord J, Thurlow R, Woodruff GN: The novel anticonvulsant drug, gabapentin (neurontin), binds to the alpha 2 delta subunit of a calcium channel. J Biol Chem 1996; 271:5768-5776.
52. 3 H]leucine. Anal Biochem 1998;15: 236-243.
53. 3 H]gabapentin binding activity. J Biol Chem 1998;273: 25458-25465.
54. Eberst R, Dai S, Klugbauer N, Hofmann F: Identification and functional characterization of a calcium channel gamma subunit. Pflügers Arch 1997;433:633-637.
55. 2+ -channel gamma subunit.
56. Caswell AH, Brandt NR, Brunschwig JP, Purkerson S: Localization and partial characterization of the oligomeric disulfide-linked molecular weight 95,000 protein (triadin) which binds the ryanodine and dihydropyridine receptors in skeletal muscle triadic vesicles. Biochemistry 1991;30:7507-7513.
57. Zhang L, Kelley J, Schmeisser G, Kobayashi YM, Jones LR: Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J Biol Chem 1997;272: 23389-23397.
58. 2+ channels. J Biol Chem 1998;273:18930-18935.
59. 2+ channel pharmacology: Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding. J Biol Chem 1997;270:27106-27111.
60. Felix R, Gurnett CA, De Waard M, Campbell KP: Dissection of functional domains of the voltage-dependent calcium channel alpha 2 delta subunit. J Neurosci 1997;17:6884-6891.
61. 1 -subunit. FEBS Lett 1994;352: 141-145.
62. 2+ channel alpha1 subunit. Biochemistry 1995; 34:9350-9355.
63. 1C -subunit and its modulation by the β-subunit. Am Physiol Soc 1995;C732-C740.
64. Josephson IR, Varadi G: The beta subunit increases calcium currents and gating charge movements of human cardiac L-type calcium channels. Biophys J 1996;70:1285-1293.
65. Perez-Garcia MT, Kamp TJ, Marban E: Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. J Gen Physiol 1995;105:289-306.
66. Gao T, Chien AJ, Hosey MM: Complexes of the alpha 1C and beta subunits generate the necessary signal for membrane targeting of class C L-type calcium channels. J Biol Chem 1999;274:2137-2144.
67. Hullin R, Singer-Lahat D, Freichel M, Biel M, Dascal N, Hofmann F, Flockerzi V: Calcium channel β-subunit heterogeneity: Functional expression of cloned cDNA from heart, aorta and brain. EMBO J 1992;11:885-890.
68. Kamp TJ, Perez-Garcia MT, Marban E: Enhancement of ionic current and charge movement by coexpression of calcium channel beta 1A subunit with alpha 1C subunit in a human embryonic kidney cell line. J Physiol (Lond) 1996;492:89-96.
69. Neely A, Wei X, Olcese R. Birnbaumer L, Stefani E: Potentiation by the β-subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. Science 1993;262:575-578.
70. Gerster U, Neuhuber B, Groschner K, Striessnig J, Flucher BE: Current modulation and membrane targeting of the calcium channel alpha 1C subunit are independent functions of the beta subunit. J Physiol (Lond) 1999;517:353-368.
71. Zamponi GW, Soong TW, Bourinet E, Snutch TP: Beta subunit coexpression and the alpha 1 subunit domain I-II linker affect piperidine block of neuronal calcium channels. J Neurosci 1996;16:2430-2443.
72. 1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc Natl Acad Sci USA 1994;91: 10576-10580.
73. Chien AJ, Carr KM, Shirokov RE, Rios E, Hosey MM: Identification of palmitoylation sites within the L-typc calcium channel beta2a subunit and effects on channel function. J Biol Chem 1996;271:26465-26468.
74. 2+ channel beta subunit caused by palmitoylation. Proc Natl Acad Sci USA 1998;95:4690-4695.
75. Sun XH, Protasi F, Takahashi M, Takeshima H, Ferguson DG, Franzini-Armstrong C: Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. J Cell Biol 1995; 129:659-671.
76. Catterall WA, Striessnig J: Receptor sites for calcium antagonists. Trends Pharmacol Sci 1992;13:256-262.
77. Glossmann H, Ferry DR, Goll A, Striessnig J, Zernig G: Calcium channels and calcium channel drugs: Recent biochemical and biophysical findings. Drug Res 1985; 35:1917-1935.
78. Berger W, Prinz H, Striessnig J, Kang H-C, Haugland R, Glossmann H: A complex molecular mechanism for dihydropyridine binding to L-type calcium channels as revealed by fluorescence resonance energy transfer. Biochemistry 1994;33: 11875-11883.
79. Brauns T, Prinz H, Kimball SD, Haugland RP, Striessnig J, Glossmann H: L-type calcium channels: Binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other. Biochemistry 1997;36:3625-3631.
80. Peterson BZ, Catterall WA: Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding. J Biol Chem 1995;270:18201-18204.
81. Hockerman GH, Johnson BD, Scheuer T, Catterall WA: Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels. J Biol Chem 1995; 270:22119-22122.
82. 2+ channel alpha 1C subunit gene. Hum Hered 1998;48:241-244.
83. 2+ channels. Circ Res 1997;81:526-532.
84. Welling A, Kwan YW, Bosse E, Flockerzi V, Hofman F, Kass RS: Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity. Circ Res 1993;73:974-980.
85. Hu H, Marban E: Isoform-specific inhibition of L-type calcium channels by dihydropyridmes is independent of isoform-specific gating properties. Mol Pharmacol 1998;53: 902-907.
86. Soldatov NM, Bouron A, Reuter H: Different voltage-dependent inhibition by dihydropyridines of human calcium channel splice variants. J Biol Chem 1995;270:10540-10543.
87. 2+ dependence of inactivation. J Biol Chem 1997;272: 3560-3566.
88. Neely A, Olcese R, Wei X, Birnbaumer L, Stefani E: Calcium-dependent inactivation of a cloned cardiac calcium channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes. Biophys J 1994;65:1895-1903.
89. Babitch JA: Channel hands (letter). Nature 1990;346:321-322.
90. 2+ channels. Science 1995;270:1502-1506.
91. 2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha 1C subunit. Proc Natl Acad Sci USA 1998;95:3287-3294.
92. Zuhlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H: Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 1999;399:159-162.
93. 2+ channel depends on calmodulin. Proc Natl Acad Sci USA 1999;96:2435-2438.
94. 2+ -dependent inactivation of L-type calcium channels (in process citation). Neuron 1999;22:549-558.
95. Deisseroth K, Heist EK, Tsien RW: Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 1998;392:198-202.
96. Reuter H, Scholz H: The regulation of the calcium conductance of cardiac muscle by adrenaline. J Physiol (Lond) 1977;264:49-62.
97. Yue DT, Herzig S, Marban E: Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc Natl Acad Sci USA 1990;87: 753-757.
98. Reuter H, Kokubun S, Prod'hom B: Properties and modulation of cardiac calcium channels. J Exp Biol 1986;124:191-201.
99. Mitterdorfer J, Froschmayr M, Grabner M, Moebius FF, Glossmann H, Striessnig J: Identification of PK-A phosphorylation sites in the carboxyl terminus of L-type calcium channel alpha1 subunits. Biochemistry 1996;35:9400-9406.
100. De Jongh KS, Murphy BJ, Colvin AA, Hell JW, Takahashi M, Catterall WA: Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3′,5′-cyclic monophosphate-dependent protein kinase. Biochemistry 1996;35:10392-10402.
101. Singer-Lahat D, Lotan I, Biel M, Flockerzi V, Hofmann F, Dascal N: Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation. Receptors Channels 1994;2:215-226.
102. Perez-Reyes E, Yuan W, Wei X, Bers DM: Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase. FEBS Lett 1994;342:119-123.
103. Zong X, Schreieck J, Mehrke G, Welling A, Schuster A, Bosse E, Flockerzi V, Hofmann F: On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation. Pflüger's Arch Eur J Physiol 1995;430:340-347.
104. 2+ channel alpha 1C subunit. FEBS Lett 1996;384:189-192.
105. 2+ channels with β1-adrenoceptors. Cire Res 1995;76:335-342.
106. Yoshida A, Takahashi M, Nishimura S, Takeshima H, Kokuhun S: Cyclic-AMP dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive calcium channel. FEBS Lett 1992; 309:343-349.
107. Johnson BD, Scheuer T, Catterall WA: Voltage-dependent potentiation of L-type calcium channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc Natl Acad Sci USA 1994;91:11492-11496.
108. Gray PC, Johnson BD, Westenbroek RE, Hays LG, Yates JR, Scheuer T, Catterall WA, Murphy BJ: Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron 1998;20:1017-1026.
109. Gao T, Yatani A, Dell Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM: cAMP-dependent regulation of cardiac L-type calcium channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 1997;19:185-196.
110. Haase H, Bartel S. Karczewski P, Morano I, Krause EG: In vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines. Mol Cell Biochem 1996;163-164: 99-106.
111. Balligand JL, Kobzik L, Han X, Kaye DM, Belhassen L, O'Hara DS, Kelly RA, Smith TW, Michel T: Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995;270:14582-14586.
112. Kirstein M, Rivet-Bastide M, Hatem S, Benardeau A, Mercadier JJ, Fischmeister R: Nitric oxide regulates the calcium current in isolated human atrial myocytes (see comments). J Clin Invest 1995;95: 794-802.
113. Rivet-Bastide M, Vandecasteele G, Hatem S, Verde I, Benardeau A, Mercadier JJ, Fischmeister R: cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes. J Clin Invest 1997;99:2710-2718.
114. 2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J Biol Chem 1993;268:26286-26295.
115. Mohan P, Brutsaert DL: Positive inotropic effect of nitric oxide in myocardium. Int J Cardiol 1995; 50:233-237.
116. Han X, Shimoni Y, Giles WR: An obligatory role for nitric oxide in autonomie control of mammalian heart rate. J Physiol (Lond) 1994; 476:309-314.
117. Han X, Kobzik L, Balligand JL, Kelly RA, Smith TW: Nitric oxide synthase (NOS3)-mcdiated cholinergic modulation of calcium current in adult rabbit atrioventricular cells. Circ Res 1996;78:998-1008.
118. Han X, Kubota I, Feron O, Opel DJ, Arstall MA, Zhao YY, Huang P, Fishman MC, Michel T, Kelly RA: Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 1998;95:6510-6515.
119. Vandecasteele G, Eschenhagen T, Stolz H, Stein B, Verde I, Fischmeister R: Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase. Nat Med 1999;5:331-334.
120. 2+ current in human atrial myocytes. J Physiol (Lond) 1998;506:653-663.
121. Stea A, Soong TW, Snutch TP: Determinants of PKC-dependent modulation of a family of neuronal calcium channels. Neuron 1995; 15:929-940.
122. Bourinet E, Fournier F, Lory P, Charnet P, Nargeot J: Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes. Pflüger's Arch 1992; 421:247-255.
123. 2+ channels in Xenopus oocytes by protein kinase C. FEBS Lett 1992;306:113-118.
124. Hirano Y, Yoshinaga T, Niidome T, Katayama K, Hiraoka M: Modulation by dihydropyridines and protein kinases of the recombinant cardiac L-type Ca channel with multiple unitary current amplitudes. Receptors Channels 1996;4: 93-104.
125. Shistik E, Ivanina T, Blumenstein Y, Dascal N: Crucial role of N-terminus in function of cardiac L-type calcium channel and its modulation by protein kinase C. J Biol Chem 1998;273:17901-17909.
126. Puri TS, Gerhardstein BL, Zhao XL, Ladner MB, Hosey MM: Differential effects of subunit interactions on protein kinase A- and C-mediated phosphorylation of L-type calcium channels. Biochemistry 1997;36:9605-9615.
127. Hilborn MD, Vaillancourt RR, Rane SG: Growth factor receptor tyrosinc kinases acutely regulate neuronal sodium channels through the src signaling pathway. J Neurosci 1998;18:590-600.
128. Wischmeyer E, Doring F, Karschin A: Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation. J Biol Chem 1998; 273:34063-34068.
129. Yokoshiki H, Sumii K, Sperelakis N: Inhibition of L-type calcium current in rat ventricular cells by the tyrosine kinase inhibitor, genistein and its inactive analog, daidzein. J Mol Cell Cardiol 1996; 28:807-814.
130. 2+ current in feline atrial myocytes. Am J Physiol 1998; 275:H204-H212.
131. Hool LC, Middleton LM, Harvey RD: Genistein increases the sensitivity of cardiac ion channels to beta-adrenergic receptor stimulation. Circ Res 1998;83:33-42.
132. Wijetunge S, Hughes AD: Activation of endogenous c-Src or a related tyrosine kinase by intracellular (pY) EEI peptide increases voltage-operated calcium channel currents in rabbit ear artery cells. FEBS Lett 1996;399:63-66.
133. 2+ channels in rabbit colonie smooth muscle cells by c-Src and focal adhesion kinase. J Biol Chem 1998;273: 5337-5342.
134. Wagner JA, Sax FL, Weisman HF, Porterfield J, McIntosh C, Weisfeldt ML, Snyder SH, Epstein SE: Calcium-antagonist receptors in the atrial tissue of patients with hypertrophic cardiomyopathy. N Engl J Med 1989;320:755-761.
135. Haase H, Kresse A, Hohaus A, Schulte HD, Maier M, Osterziel KJ, Lange PE, Morano I: Expression of calcium channel subunits in the normal and diseased human myocardium. J Mol Med 1996;74: 99-104.
136. Thuringer D, Deroubaix E, Coulombe A, Coraboeuf E, Mercadier JJ: Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy. Cardiovasc Res 1996;31:747-757.
137. Li GR, Ferrier GR, Howlett SE: Calcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamsters. Am J Physiol 1995;268:H999-1005.
138. i -transients in single ventricular myocytes isolated from terminally failing human myocardium. Basic Res Cardiol 1992;87(suppl 1):235-243.
139. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ: Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure (see comments). Science 1997;276:800-806.
140. Schroder F, Handrock R, Beuckelmann DJ, Hirt S, Hullin R, Priebe L, Schwinger RH, Weil J, Herzig S: Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation 1998;98:969-976.
141. Mewes T, Ravens U: L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium. J Mol Cell Cardiol 1994;26:1307-1320.
142. Klauck TM, Faux MC, Labudda K, Langeberg LK, Jaken S, Scott JD: Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 1996;271:1589-1592.
143. Bolli R: Mechanism of myocardial 'stunning'. Circulation 1990;82: 723-738.
144. Gao WD, Liu Y, Marban E: Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implications for the mechanism of stunned myocardium. Circulation 1996;94:2597-2604.
145. Guerra L, Cerbai E, Gessi S, Borea PA, Mugelli A: The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes. Br J Pharmacol 1996; 118:1278-1284.
146. Coetzee WA, Opie LH: Effects of oxygen free radicals on isolated cardiac myocytes from guinea-pig ventricle: Electrophysiological studies. J Mol Cell Cardiol 1992; 24:651-663.
147. 2+ channels. J Gen Physiol 1994;103:647-663.
148. 2+ channels by intracellular pH. FEBS Lett 1997; 408:75-80.
149. Klockner U, Isenberg G: Calcium channel current of vascular smooth muscle cells: Extracellular protons modulate gating and single channel conductance. J Gen Physiol 1994;103:665-678.
150. 2+ channels. J Gen Physiol 1996;108:363-374.
151. Thibault O, Landfield PW: Increase in single L-type calcium channels in hippocampal neurons during aging. Science 1996;272: 1017-1020.
152. Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI: Cloning of the α1 subunit of a voltage-dependent calcium channel expressed in pancreatic β cells. Proc Natl Acad Sci USA 1992;89: 584-588.
153. Miljanich GP, Ramachandran J: Antagonists of neuronal calcium channels: Structure, function and therapeutic implications. Annu Rev Pharmacol Toxicol 1995;35: 707-734.
154. Kraus RL, Sinnegger MJ, Glossmann H, Hering S, Striessnig J: Familial hemiplegic migraine mutations change alpha1A calcium channel kinetics. J Biol Chem 1998;273:5586-5590.
155. Newcomb R, Szoke B, Palma A, Wang G, Chen XH, Hopkins W, Cong R, Miller J, Urge L, Tarezy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos J, Miljanich G: Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 1998;37:15353-15362.
156. Chuang RS, Jaffe H, Cribbs L, Perez-Reyes E, Swartz KJ: Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin (in process citation). Nat Neurosci 1998;1:668-674.
157. 2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity. Mol Pharmacol 1998;54:918-927.
158. McDonough SI, Bean BP: Mibefradil inhibition of T-type calcium channels in cerebellar Purkinje neurons. Mol Pharmacol 1998;54: 1080-1087.