Molecular basis of proton block of L-type Ca2+ channels

Journal of General Physiology

Volumn 108, Issue 5, 1996, Pages 363-374

  Chen, Xiao Hua ^a   Bezprozvanny, Ilya ^a,b   Tsien, Richard W ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

ion channels; P region; permeation; protonation; Xenopus oocytes

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; ION CHANNEL; PROTON;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CHANNEL GATING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; OOCYTE; PH MEASUREMENT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CALCIUM CHANNELS; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; FEMALE; ION CHANNEL GATING; MUTAGENESIS; OOCYTES; PROTEIN STRUCTURE, TERTIARY; PROTONS; SENSITIVITY AND SPECIFICITY; XENOPUS;

EID: 0029904737     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.108.5.363     Document Type: Article

References (42)

1. Armstrong, C.M., and J. Neyton. 1992. Ion permeation through calcium channels: a one-site model. Ann. NY Acad. Sci. 635:18-25.
2. Chesler, M., and K. Kaila. 1992. Modulation of pH by neuronal activity. TINS (Trends Neurosci.). 15:396-402.
3. + channel revealed by cysteine mutagenesis. Neuron. 16:1037-1047.
4. Colquhoun, D., and A.G. Hawkes. 1995. The principle of the stochastic interpretation of ion-channel mechanisms. In Single Channel Recording, 2nd Ed., B. Sakmann and E. Neher, editors, Plenum, New York, 397-482.
5. Coulter, K.L., F. Perier, C.M. Radeke, and C.A. Vandenberg. 1995. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Neuron. 15: 1157-1168.
6. Daumas, P., and O.S. Andersen. 1993. Proton block of rat brain sodium channels. J. Gen. Physiol. 101:27-43.
7. + channel outer vestibule. Biophys. J. 70:A23.
8. 2+ interactions. Neuron. 15:1121-1132.
9. Falke, J.J., S.K. Drake, A.L. Hazard, and O.B. Peersen. 1994. Molecular tuning of ion binding to calcium signaling proteins. Q. Rev. Biophys. 27:219-290.
10. Heinemann, S.H., H. Teriau, W. Stuhmer, K. Imoto, and S. Numa. 1992. Calcium channel characteristics conferred on the sodium channel by single mutations. Nature (Lond.). 356:441-443.
11. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed., Sinauer Associates, Sunderland, MA.
12. Hullin, R., D. Singer-Lahat, M. Freichel, M. Biel, N. Dascal, F. Hofmann, and V. Flockerzi. 1992. Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO (Eur. Mol. Biol. Organ.) J. 11:885-890.
13. Jeffrey, G.A., and W. Saenger. 1991. Hydrogen Bonding in Biological Structures. Springer-Verlag, Berlin.
14. Katz, A.M. 1992. Physiology of the Heart. 2nd Ed., Raven Press, New York.
15. Kim, M.S., T. Morii, L.X. Sun, K. Imoto, and Y. Mori. 1993. Structural determinants of ion selectivity in brain calcium channel. FEBS Lett. 318:145-148.
16. Klöckner, U., and G. Isenberg. 1994. Calcium channel current of vascular smooth muscle cells: extracellular protons modulate gating and single channel conductance. J. Gen. Physiol. 103:665-678.
17. Krafte, D.S., and R.S. Kass. 1988. Hydrogen ion modulation of Ca channel current in cardiac ventricular cells. Evidence of multiple mechanisms. J. Gen. Physiol. 91:641-657.
18. 2+ channel pore in rat phaeochromocytoma cells. J. Physiol. (Lond.). 466:657-682.
19. Methfessel, C., V. Witzemann, T. Takahashi, M. Mishina, S. Numa, and B. Sakmann. 1986. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels. Pflugers Arch. 407:577-588.
20. Mikami, A., K. Imoto, T. Tanabe, T. Niidome, Y. Mori, H. Takeshima, S. Narumiya, and S. Numa. 1989. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (Lond.). 340:230-233.
21. Mozhayeva, G.N., A.P. Naumov, and Y.A. Negulyaev. 1981. Evidence for existence of two acid groups controlling the conductance of sodium channel. Biochim. Biophys. Acta. 643:251-255.
22. Ou-Yang, Y., T. Kristian, P. Mellergard, and B.K. Siesjo. 1994. The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture. Brain Res. 646:65-72.
23. 2+ channel. Biophys. J. 69:1801-1813.
24. Perrin, D.D., and B. Dempsey. 1974. Buffers for pH and Metal Ion Control. Chapman and Hall, London.
25. Pietrobon, D., B. Prod'hom, and P. Hess. 1988. Conformational changes associated with ion permeation in L-type calcium channels. 333:373-376.
26. Pietrobon, D., B. Prod'hom, and P. Hess. 1989. Interactions of protons with single open L-type calcium channels. J. Gen. Physiol. 94:1-21.
27. 2+ channel. Nature (Lond.). 329:243-246.
28. Prod'hom, B., D. Pietrobon, and P. Hess. 1989. Interactions of protons with single open L-type calcium channels. J. Gen. Physiol. 94: 23-42.
29. Root, M.J., and R. MacKinnon. 1993. Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron. 11:459-466.
30. Root, M.J., and R. MacKinnon. 1994. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science (Wash. DC). 265:1852-1856.
31. 2+ channel properties produced by mutations in the L-type channel pore. Biophys. J. 66:A128.
32. 1 subunits. Neuron. 11:291-303.
33. Sawyer, L., and M.N.G. James. 1982. Carboxyl-carboxylate interaction in proteins. Nature (Lond.). 295:79-81.
34. Siesjo, B.K., K. Katsura, P. Mellergard, A. Ekholm, J. Lundgren, and M.L. Smith. 1993. Acidosis-related brain damage. Prog. Brain Res. 96:23-48.
35. Tang, S., G. Mikala, A. Bahinski, A. Yatani, G. Varadi, and A. Schwartz. 1993. Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel. J. Biol. Chem. 268:13026-13029.
36. Traynelis, S.F. 1996. pH modulation of ligand-gated ion channels. In pH and Brain Function. K. Kaila and B.R. Ransom, editors. John Wiley and Sons, New York. In press.
37. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. J. Physiol. (Lond.). 433:727-763.
38. Traynelis, S.F., M. Hartley, and S.F. Heinemann. 1995. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science (Wash. DC). 268:873-876.
39. Tsien, R.W., P. Hess, E.W. McCleskey, and R.L. Rosenberg. 1987. Calcium channels: mechanisms of selectivity, permeation, and block. Annu. Rev. Biophys. Biophys. Chem. 16:265-290.
40. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
41. Yang, J., P.T. Ellinor, W.A. Sather, J.-F. Zhang, and R.W. Tsien. 1993. Molecular determinants of Ca selectivity and ion permeation in L-type Ca channels. Nature (Lond.). 366:158-161.
42. Zhang, J.-F., and S.A. Siegelbaum. 1991. Effects of external protons on single cardiac sodium channels from guinea pig ventricular myocytes. J. Gen. Physiol. 98:1065-1083.