Ca2+ channel activation by CGP 48506, a new positive inotropic benzodiazocine derivative

European Journal of Pharmacology

Volumn 295, Issue 1, 1996, Pages 113-117

  Herzig, Stefan ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Ca2+ channel; Ca2+ channel activator; CGP 48506; L type; Mode 2 gating

Indexed keywords

AZOCINE DERIVATIVE; BA 41899; CALCIUM; CALCIUM CHANNEL; CARDIOTONIC AGENT; 1,3,5,6 TETRAHYDRO 5 METHYL 6 PHENYL 3,6 METHANO 1,5 BENZODIAZOCINE 2,4 DIONE; BENZODIAZOCINE DERIVATIVE; CALCIUM CHANNEL STIMULATING AGENT; INOTROPIC AGENT; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; DRUG EFFECT; GUINEA PIG; HEART; KINETICS; METABOLISM; ANIMAL CELL; CONTROLLED STUDY; ENANTIOMER; HEART MUSCLE CELL; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

ANIMALS; AZOCINES; CALCIUM; CALCIUM CHANNELS; CARDIOTONIC AGENTS; GUINEA PIGS; HEART; KINETICS;

EID: 0029666225     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00673-7     Document Type: Article

References (15)

1. Bechem, M. and H. Hoffmann, 1993, The molecular mode of action of the Ca agonist (-) Bay K 8644 on the cardiac Ca channel, Pflüg. Arch. 424, 343.
2. Herold, P., J.W. Herzig, P. Wenk, T. Leutert, P. Zbinden, W. Fuhrer, S. Stutz, K. Schenker, M. Meier and G. Rihs, 1995, 5-Methyl-6-phenyl-1,3,5,6,-tetrahydro-3,6,-methano-1,5-benzodiazocine-2,4-dione (BA #1899); representative of a novel class of purely calcium sensitizing agents, J. Med. Chem. 38, 2946.
3. Herzig, S., P. Patil, J. Neumann, C.-M. Staschen and D.T. Yue DT, 1993, Mechanisms of β-adrenergic stimulation of cardiac Ca channels revealed by discrete-time Markov analysis of slow gating, Biophys. J. 65, 1599.
4. 2+ channels, Pflüg. Arch. 429, 531.
5. Hess, P., J.B. Lansman and R.W. Tsien, 1984, Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists, Nature 311, 538.
6. Hirano, Y., K. Suzuki, N. Yamawake and M. Hiraoka, 1994, Multiple kinetic effects of β-adrenergic stimulation on single cardiac L-type Ca channels, Am. J. Physiol. 266, C1714.
7. 3 cells, Mol. Pharmacol. 42, 666.
8. Lacerda, A.E. and A.M. Brown, 1989, Nonmodal gating of cardiac calcium channels as revealed by dihydropyridines, J. Gen. Physiol. 93, 1243.
9. Lee, K.S., E Marban and R.W. Tsien, 1985, Inactivation of calcium channels in heart cells: joint dependence on membrane potential and intracellular calcium, J. Physiol. 364, 395.
10. Markwardt, F. and B. Nilius, 1988, Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644, J. Physiol. 399, 559.
11. Rampe, D. and A.E. Lacerda, 1991, A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176, J. Pharmacol. Exp. Ther. 259, 982.
12. Sanguinetti, M.C., D.S. Krafte and R.S. Kass. 1986, Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644, J. Gen. Physiol. 88, 369.
13. 2+ channels, J. Physiol. 484, 583.
14. Yue, D.T., S. Herzig and E. Marban, 1990, β-Adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes, Proc. Natl. Acad. Sci. USA 87, 753.
15. 2+ channel current in guinea pig ventricular myocytes, Circ. Res. 76, 592.