Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway

Molecular and Cellular Neurosciences

Volumn 13, Issue 4, 1999, Pages 272-280

  Williams, Emma Jane ^a   Doherty, Patrick ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ENZYME; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; INSULIN; PEPTIDE; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; S6 KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; ENZYME REGULATION; GRANULE CELL; MITOGENESIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0033120296     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1999.0750     Document Type: Article

References (45)

1. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. Embo J. 15: 6541-6551.
2. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr. Biol. 4: 261-269.
3. Asai, T., Wanaka, A., Kato, H., Masana, Y., Seo, M., and Tohyama, M. (1993). Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system. Brain Res. 1-2: 174-178.
4. Barde, Y. A., Edgar, D., and Thoenen, H. (1982). Purification of a new neurotrophic factor from mammalian brain. Emboj. 5: 549-553.
5. Burgering, B. M., and Coffer, P. J. (1995). Protein kinase B (c-Akt) in phosphatidylinositol-3-OH-kinase signal transduction. Nature 376: 599-602.
6. Cantley, L. C., Auger, L. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. (1991). Oncogenes and signal transduction. Cell 64: 281-302.
7. Cardone, M. H., Roy, N., Stennick, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. (1998). Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318- 1321.
8. D'Mello, S. R., Borodezt, K., and Soltoff, S. P. (1997). Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17: 1548-1560.
9. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241.
10. Derossi, D., Williams, E. J., Green, P. J., Dunican, D. J., and Doherty, P. (1998). Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem. Biophys. Res. Commun. 251: 148-152.
11. Doherty, P., Fruns, M., Seaton, P., Dickson, G., Barton, C. H., Sears, T. A., and Walsh, F. S. (1990). A threshold effect of the major isoforms of NCAM on neurite outgrowth. Nature 343: 464-466.
12. Eilers, A., Whitfield, J., Babij, C., Rubin, L. L., and Ham, J. (1998). Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J. Neurosci. 18: 1713-1724.
13. Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R., and Johnson, E. M. Jr. (1994). Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J. Cell. Biol. 127: 1717-1727.
14. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736.
15. Hall, H., Williams, E. J., Moore, S. E., Walsh, F. S., Prochiantz, A., and Doherty, P. (1996). Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide. Curr. Biol. 6: 580-587.
16. Hatten, M. E., Lynch, M., Rydel, R. E., Sanchez, J., Joseph-Silverstein, J., Moscatelli, D., and Rifkin, D. B. (1988). In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor. Dev. Biol. 125: 280-289.
17. Herbst, J. J., Andrews, G. C., Contillo, L. G., Singleton, D. H., Genereux, P. E., Gibbs, E. M., and Lienhard, G. E. (1995). Effect of the activation of phosphatidylinositol 3-kinase by a thiophosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes. J. Biol. Chem. 270: 26000-26005.
18. Holt, K. H., Olson, L., Moye-Rowley, W. S., and Pessin, J. E. (1994). Phosphatidylinositol 3-kinase activation is mediated by high- Affinityinteractions between distinct domains within the p110 and p85 subunits. Mol. Cell. Biol. 14: 42-49.
19. Hughes, R. A., Sendtner, M., Goldfarb, M., Lindholm, D., and Thoenen, H. (1993). Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motononeurons. Neuron 10: 369-377.
20. Kanda, S., Hodgkin, M. N., Woodfield, R. J., Wakelam, M. J., Thomas, G., and Clacsson-Welsh, L. (1997). Phosphatidylinositol 3-Kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J. Biol. Chem. 272: 23347-23353.
21. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N., and Hay, N. (1997). The PI 3-kinase.Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11: 701-713.
22. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S., and Wetzker, R. (1997). Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275: 394- 397.
23. Miller, T. M., Tnasey, M. G., Johnson, E. M. Jr., and Creedon, D. J. (1997). Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells. J. Biol. Chem. 272: 9847-9853.
24. Mohammadi, M., Dikic, I., Sorokin, A., Burgess, W. H., Jaye, M., and Schlessinger, J. (1996). Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell Biol. 16: 977-989.
25. Mohammadi, M., Dionne, C. A., Li, W., Li, N., Spivak, T., Honegger, A. M., Jay, M., and Schlessinger, J. (1992). Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358: 681-684.
26. Morrison, R. S., Sharma, A., de Vellis, J., and Bradshaw, R. A. (1986). Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. Proc. Natl. Acad. Sci. USA 83: 7537-7541.
27. Oppenheim, R. W. (1991). Cell death during development of the nervous system. Anna. Rev. Neurosci. 14: 453-501.
28. Piccione, E., Case, R. D., Domchek, S. M., Hu, P., Chaudhuri, M., Backer, J. M., Schlessinger, J., and Shoelson, S. E. (1993). Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry 32: 3197-3202.
29. Prochiantz, A. (1996). Getting hydrophilic compounds into cells: Lessons from homeopeptides. Curr. Opin. Neurobiol. 6: 629-634.
30. Raffoni, S., and Bradshaw, R. A. (1992). Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 89: 9121-9125.
31. Rodriguez-Viciana, P., Marte, B. M., Warne, P. H., and Downward, J. (1996). Phosphatidylinositol 3′ kinase: One of the effectors of ras. Philos. Trans. R. Soc. Lond. B. Biol. Sic. 351: 225-231.
32. Rordorf-Nikolic, T., Van Horn, D. J., Chen, D., White, M. F., and Backer, J. M. (1995). Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J. Biol. Chem. 270: 3662-3666.
33. Saffell, J. L., Williams, E. J., Mason, I. J., Walsh, F. S., and Doherty P. (1997). Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18: 231-242.
34. Scheid, M. P., Lauener, R. W., and Duronio, V. (1995). Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem. J. 312: 159-162.
35. Skaper, D., and Walsh, F. S. (1998). Neurotrophic molecules: Strategies for designing effective therapeutic molecules in neurodegeneration. Mol. Cell. Neurosci. 12: 179-193.
36. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R. J., et al. (1993). SH2 domains recognize specific phosphopeptide sequences. Cell 72: 767-778.
37. Thoenen, H., and Barde, Y. A. (1980). Physiology of nerve growth factor. Physiol. Rev. 60: 1284-1335.
38. Ui, M., Okada, T., Hazeki, K., and Hazeki, O. (1995). Wortmannin as a unique probe for an intracellular signalling protein, phosphoinosi- tide 3-kinase. Trends Biochem. Sci. 20: 303-307.
39. Virdee, K., Bannister, A. J., Hunt, S. P., and Tolkovsky, A. M. (1997). Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J. Neurochem. 69: 550-561.
40. Vlahos, C. F., Matter, W. F., Hui, K. Y., and Brown, R. F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)- 8-phenyl-4H-1-benzopyran-4-one(LY294002). J. Biol. Chem. 269: 5241- 5248.
41. Wannaka, A., Johnson, E. M. Jr., and Milbrandt, J. (1990). Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization. Neuron 5: 267-281.
42. Williams, E. J., Dunican, D. J., Green, P. J., Howell, F. V., Derossi, D., Walsh, F. S., and Doherty, P. (1997). Selective inhibition of growth factor stimulated mitogenesis by a cell - permeable Grb2-binding peptide. J. Biol. Chem. 272: 22349-22354.
43. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
44. Yano, S., Tokumitsu, H., and Soderling, T. R. (1998). Calcium promotes cell survival through CaM-K kinase activation of the protein- kinase-B pathway. Nature 396: 584-587.
45. Yao, R., and Cooper, G. M. (1995). Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003-2006.