Phosphatidylinositol 3′ kinase : One of the effectors of Ras

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 351, Issue 1336, 1996, Pages 225-232

  Rodriguez Viciana, Pablo ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; RAS PROTEIN;

PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030605386     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1996.0020     Document Type: Article

References (46)

1. Albright, C. F., Giddings, B. W., Liu, J., Vito, M. & Weinberg, R. A. 1993 Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J 12, 339-47.
2. Bar Sagi, D. & Feramisco, J. R. 1986 Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science, Wash. 233, 1061-1068.
3. Burgering, B. M. T., de Vries-Smits, A. M. M., Medema, R. H., van Weeren, P. C., Tertoolen, L. G. J. & Bos, J. L. 1993 Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Molec. cell. Biol. 13, 7248-7256.
4. Campbell, K. S., Ogris, E., Burke, B., Su, W., Auger, K. R., Druker, B. J., Schaflhausen, B. S., Roberts, T. M. & Pallas, D. C. 1994 Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc. natn. Acad. Sci. U.S.A. 91, 6344-6348.
5. Carter, A. N. & Downes, C. P. 1992 Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J. Biol. Chem. 267, 14563-14567.
6. Cowley, S., Paterson, H., Kemp, P. & C.J., M. 1994 Activation of map kinase kinase is necessary and sufficient for pc12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
7. Diekman, D., Brill, S., Garrett, M., Totty, N., Hsuan, J., Monfries, C., Hall, C., Lim, L. & Hall, A. 1991 Bcr encodes a GTPase activating protein for p21rac. Nature, Lond. 351, 400-402.
8. Dilworth, S. M., Brewster, C. E., Jones, M. D., Lanfrancone, L., Pelicci, G. & Pelicci, P. G. 1994 Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature, Lond. 367, 87-90.
9. Duchesne, M., Schweighoffer, F., Parker, F., Clerc, F., Frobert, Y., Thang, M. N. & Tocque, B. 1993 Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP mediated signaling. Science, Wash. 259, 525-528.
10. Duronio, V., Welham, M. J., Abraham, S., Dryden, P. & Scrader, J. W. 1992 p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of GAP. Proc. natn. Acad. Sci. U.S.A. 89, 1587-1591.
11. Egan, S. E. & Weinberg, R. A. 1993 The pathway to signal achievement [news]. Nature, Lond. 365, 781-3.
12. Finney, R. E., Robbins, S. M. & Bishop, J. M. 1993 Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway. Curr. Biol. 3, 805-812.
13. Gold, M. R., Duronio, V., Saxena, S. P., Schrader, J. W. & Aebersold, R. 1994 Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine phosphorylated proteins. J. Biol. Chem. 269, 5403-5412.
14. Hallberg, B., Rayter, S. I. & Downward, J. 1994 Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol. Chem. 270, 3913-3916.
15. Kapeller, R., Prasad, K. V. S., Janssen, O., Hou, W., Schaffhausen, B. S., Rudd, C. E. & Cantley, L. C. 1994 Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 269.
16. Kodaki, T., Wosholski, R., Hallberg, B., Rodiriguez-Viciana, P., Downward, J. & Parker, P. J. 1994 The activation of phosphatidylinositol 3-kinase by Ras. Curr. Biol. 4, 798-806.
17. Kotani, K., Yonezawa, K., Hara, K. et al. 1994 Involvement of phosphoinositide 3-kinase in insulin or IGF-1 induced membrane ruffling. EMBO J. 13, 2313-2321.
18. Leevers, S. J., Paterson, H. F. & C. J., M. 1994 Requirement for ras in raf activation is overcome by targeting raf to the plasma-membrane. Nature, Lond. 369, 411-414.
19. Ling, L. E., Druker, B. J., Cantley, L. C. & Roberts, T. M. 1992 Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J. Virol 66, 1702-8.
20. Lowy, D. R. & Willumsen, B. M. 1993 Function and regulation of RAS. A. Rev. Biochem. 62, 851-891.
21. McCormick, F. 1993 Signal transduction: how receptors turn Ras on. Nature, Lond. 363, 15-16.
22. Moodie, S. A., Willumsen, B. M., Weber, M. J. & Wolfman, A. 1993 Complexes of Ras.GTP with Raf-1 and mitogen activated protein kinase kinase. Science, Wash. 260, 1658-1661.
23. Morris, J. D., Price, B., Lloyd, A. C., Self, A. J., Marshall, C. J. & Hall, A. 1989 Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis. Oncogene 4, 27-31.
24. lyn which interact with the effector molecules phospholipase c-g2, MAP kinase, GAP and phosphatidylinositol 3-kinase. Molec. cell. Biol. 13, 5877-5887.
25. Pleiman, C. M., Hertz, W. M. & Cambier, J. C. 1994 Activation of phosphatidylinositol 3-kinase by src family kinase SH3 binding to the p85 subunit. Science, Wash. 263, 1609-1612.
26. Prasad, K. V. S., Janssen, O., Kapeller, R., Cantley, L. C. & Rudd, C. E. 1993 a The p59fyn SH3 domain mediates binding to phosphatidylinositol 3-kinase in T cells. Proc. natn Acad. Sci. U.S.A. 90, 7366-7370.
27. lck SH3 binds to PI 3-kinase but not PI 4-kinase. Molec. cell. Biol. 13, 7708-7717.
28. Rapp, U. R. 1991 The Raf serine/threonine kinases. Oncogene β, 495-500.
29. Ridley, A., Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. 1992 The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
30. Roche, S., Koegl, M. & Courtneidge, S. A. 1994 The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc. natn. Acad. Sci. U.S.A. 91, 9185-9189.
31. Rodriguez-Viciana, P., Warne, P. H., Dhand, R. et al. 1994 Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature, Lond. 370, 527-532.
32. ras with phosphatidylinositol 3-kinase. Proc. natn. Acad. Sci. U.S.A. 88, 7908-7912.
33. Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C. & Hawkins, P. T. 1994a A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein bg subunits. Cell 77, 83-93.
34. Stephens, L. R., Jackson, T. R. & Hawkins, P. T. 1993 Agonist-stimulated synthesis of phosphatidylinositol-(3,4,5)-trisphosphate: a new intracellular signalling system. Biochim. Biophys. Acta 1179, 27-75.
35. Stephens, R. M., Loeb, D. M., Copeland, T., Pawson, T., Greene, L. A. & Kaplan, D. R. 1994 A Trk receptors use redundant signal transduction pathways involving She and PLCg1 to mediate NGF responses. Neuron 12, 691-705.
36. Stokoe, D., MacDonald, S. G., Cadwallader, K., Symons, M. & Hancock, J. F. 1994 Activation of raf as a result of recruitment to the plasma-membrane. Science, Wash. 264, 1463-1467.
37. Thomason, P. A., James, S. R., Casey, P. J. & Downes, C. P. 1994 A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J. Biol. Chem. 269, 16525-8.
38. Toker, A., Meyer, M., Reddy, K. K. et al. 1994 Activation of protein kinase C family members by the novel phosphoinositides PI-3,4-P2 and PI-3,4,5-P3. J. Biol. Chem. 269, 32358-32367.
39. Van Aelst, L., Barr, M., Marcus, S., Polverino, A. & Wigler, M. 1993 Complex formation between Ras and Raf and other protein kinases. Proc. natn. Acad. Sci. U.S.A. 90, 6213-6217.
40. lck is involved in binding to phosphatidylinositol 3′-kinase from T lymphocytes. Molec. cell. Biol. 13, 7408-7417.
41. Vojtek, A. B., Hollenberg, S. M. & Cooper, J. A. 1993 Mammalian Ras interacts directly with the Serine/Threonine kinase Raf. Cell 74, 205-214.
42. Warne, P. H., Vicinia, P. R. & Downward, J. 1993 Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature, Lond. 364, 352-355.
43. Wennström, S., Hawkins, P., Cooke, F. et al. 1994 Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4, 385-393.
44. Zhang, J., King, W. G., Dillon, S., Hall, A., Feig, L. & Rittenhouse, S. 1993a Activation of platelet phosphatidylinositol 3-kinase requires the small GTP binding protein Rho. J. Biol. Chem. 268, 22251-22254.
45. Zhang, X.-F., Settleman, J., Kyriakis, J. M. et al. 1993b Normal and Oncogenic p21ras proteins bind to the aminoterminal regulatory domain of c-Raf-1. Nature, Lond. 364, 308-313.
46. Zheng, Y., Bagrodia, S. & Cerione, R. A. 1994 Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem 269, 18727-30.