A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions

EMBO Journal

Volumn 14, Issue 22, 1995, Pages 5589-5596

  Chittenden, Thomas ^a   Flemington, Cathy ^a   Houghton, Anne B ^a   Ebb, Ronald G ^a   Gallo, Gregory J ^a   Elangovan, B ^b   Chinnadurai, G ^b   Lutz, Robert J ^a  

^a Apoptosis Technology Inc   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Apoptosis; Bcl 2 homolog; Bik; Programmed cell death

Indexed keywords

CELL PROTEIN; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; DELETION MUTANT; ETIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALIA;

EID: 0028832667     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00246.x     Document Type: Article

References (35)

1. Bakhshi,A., JensenJ.P., Goldman,P., WrightJ.J., McBride,O.W., Epstein,A.L. and Korsmeyer,S.J. (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18. Cell, 41, 899-906.
2. Boise,L.H., Gonzalez-Garcia,M., Postema,C.E., Ding,L., Lindsten,T., Turka,L.A., Mao,X., Nunez,G. and Thompson,C.B. (1993) Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
3. BoydJ.M., Malstrom,S., Subramanian,T., Venkatesh,L.K., Schaeper,U., Elangovan,B., D'sa-Eipper,C. and Chinnadurai,G. (1994) Adenovirus E1B 19kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell, 79, 341-351.
4. Boyd,J.M. et al. (1995) Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene, in press.
5. Chittenden,T., Harrington,E.A., O'Connor,R., Flemington,C., Lutz,R.J., Evan,G.I. and Guild,B. (1995) Induction of apoptosis by the Bcl-2 homologue Bak. Nature, 374, 733-736.
6. Cleary,M.L. and Sklar,J. (1985) Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl Acad. Sci. USA, 82, 7439-7443.
7. Farrow,S.N., White,J.H.M., Martinou,I., Raven,T., Pun,K.-T., Grinham,C.J., Martinou,J.-C. and Brown,R. (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature, 374, 731-733.
8. Fisher,D.E. (1994) Apoptosis in cancer therapy: crossing the threshold. Cell, 78, 539-542.
9. Hengartner,M.O. and Horvitz,H.R. (1994) C.elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell, 76, 665-676.
10. Kaelin.W.G.,Jr, Krek,W., Sellers,W.R., DeCaprio,J.A., Ajchenbaum,F., Fuchs,C.S., Chittenden,T, Li,Y., Farnham,P.J., Blanar,M.A., Livingston,D.M. and Flemington,E.K. (1992) Expression cloning of a cDNA encoding a retinoblastoma binding protein with E2F-like properties. Cell, 70, 351-364.
11. Kiefer,M.C., Brauer,M.J., Powers,V.C., Wu,J.J., Umansky,S.R., Tomei,L.D. and Barr,P.J. (1995) Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature, 374, 736-739.
12. Kolodziej,P.A. and Young,R.A. (1991) Epitope tagging and protein surveillance. Methods Enzymol., 194, 508-519.
13. Kumar,S., Kinoshita,M., Noda,M., Copeland,N.G. and Jenkins,N.A. (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev., 8, 1613-1626.
14. Miura,M., Zhu,H., Rotello,R., Hartwieg,E.A. and Yuan,J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C.elegans cell death gene ced-3. Cell, 75, 653-660.
15. Neilan,J.G., Lu,Z., Afonso,C.L., Kutish,G.F., Sussman,M.D. and Rock, D.L. (1993) An African Swine Fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1. J. Virol, 67, 4391-4394.
16. Oltvai,Z.N. and Korsmeyer,S.J. (1994) Checkpoints of dueling dimers foil death wishes. Cell, 79, 189-192.
17. Oltvai,Z.N., Milliman,C.L. and Korsmeyer,S.J. (1993) Bcl-2 heterodimerizes m vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
18. Pearson,G.R., Luka,J., Petti,L., Sample,J, Birkenbach,M., Braun,D. and Kieff,E. (1987) Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology, 160, 151-161.
19. Rao,L., Debbas,M., Sabbatini.P., Hockenbery,D., Korsmeyer,S. and White,E. (1992) The adenoviral E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl Acad Sci. USA, 89, 7742-7746.
20. Reed,J.C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6.
21. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Sato,T. et al. (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl Acad. Sci. USA, 91, 9238-9242.
23. Smith,D.B. and Johnson,K.S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene, 67, 31-40.
24. Subramanian,T., Tarodi,B., Govindarajan,R., Boyd,J.M., Yoshida,K. and Chinnadurai,G. (1993) Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1B 175R protein. Gene, 124, 173-181.
25. Tanaka,S., Saito,K. and Reed,J.C. (1993) Structure-function analysis of the bcl-2 oncoprotein. J. Biol. Chem., 268, 10920-10926.
26. Tsujimoto,Y., Cossman,J., Jaffe,E. and Croce,C. (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science, 228, 1440-1443.
27. Vaux,D.L., Weissman,I.L. and Kim,S.K. (1991) Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science, 258, 1955-1957.
28. Vaux,D.L., Haecker,G. and Strasser,A. (1994) An evolutionary perspective on apoptosis. Cell, 76, 777-779.
29. Wang,L., Miura,M, Bergeron,L., Zhu,H. and Yuan,J. (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell, 78, 739-750.
30. White,B.A. (Ed.) (1993) PCR Protocols: Current Methods and Applications. Vol. 15. Methods in Molecular Biology. Humana Press, Totowa, CT.
31. White,E., Sabbatini,P, Debbas,M, Wold,W.S.M. Kusher,D.I. and Gooding,L. (1992) The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha. Mol. Cell. Biol., 12, 2570-2580.
32. Williams,G.T. (1991) Programmed cell death: apoptosis and oncogenesis. Cell, 65, 1097-1098.
33. Williams,G.T. and Smith,C.A. (1993) Molecular regulation of apoptosis: genetic controls on cell death. Cell, 74, 777-779.
34. Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and Korsmeyer,S.J. (1995) Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death. Cell, 80, 285-291.
35. Yin,X.-M., Oltvai,Z.N. and Korsmeyer,S.J. (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature, 369, 321-323.