-
1
-
-
0027359388
-
Cytoplasmic dynein is required for normal nuclear segregation in yeast
-
Eshel D, Urrestarazu LA, Vissers S, Jauniaux J-C, van Vliet-Reedijk JC, Planta RJ, Gibbon IR: Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc Natl Acad Sci USA 1993, 90:11172-11176.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11172-11176
-
-
Eshel, D.1
Urrestarazu, L.A.2
Vissers, S.3
Jauniaux, J.-C.4
Van Vliet-Reedijk, J.C.5
Planta, R.J.6
Gibbon, I.R.7
-
2
-
-
0027453547
-
Disruption of mitotic spindle orientation in a yeast dynein mutant
-
Li Y, Yeh E, Hays T, Bloom K: Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc Natl Acad Sci USA 1993, 90:10096-10100.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10096-10100
-
-
Li, Y.1
Yeh, E.2
Hays, T.3
Bloom, K.4
-
3
-
-
0030750203
-
Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex
-
Carminati JL, Stearns T: Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J Cell Biol 1997, 138:629-641. The authors used green fluorescent protein-tubulin to visualize and measure microtubule dynamics in living yeast cells and found that Cytoplasmic microtubules exhibit dynamic instability. Dynein mutant cells were demonstrated to have altered dynamics and defects in cortical interactions.
-
(1997)
J Cell Biol
, vol.138
, pp. 629-641
-
-
Carminati, J.L.1
Stearns, T.2
-
4
-
-
0030931849
-
Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins
-
Cottingham FR, Hoyt MA: Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 1997, 138:1041-1053. A detailed genetic analysis was used to determine which motor proteins are important for spindle positioning. The authors found that both Kip3p and dynein play a role that is antagonized by Kip2p.
-
(1997)
J Cell Biol
, vol.138
, pp. 1041-1053
-
-
Cottingham, F.R.1
Hoyt, M.A.2
-
5
-
-
0030928162
-
Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration
-
DeZwaan TM, Ellingson E, Pellman D, Roof DM: Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration. J Cell Biol 1997, 138:1023-1040. This paper presents a detailed analysis of kip3 mutants, showing the requirement for this protein in spindle positioning. The authors used time-lapse microscopy of living yeast cells undergoing mitosis to achieve a careful and thorough characterization of the mutant phenotype.
-
(1997)
J Cell Biol
, vol.138
, pp. 1023-1040
-
-
DeZwaan, T.M.1
Ellingson, E.2
Pellman, D.3
Roof, D.M.4
-
6
-
-
0029155542
-
Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae
-
Yeh E, Skibbens RV, Cheng JW, Salmon ED, Bloom K: Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J Cell Biol 1995, 130:687-700.
-
(1995)
J Cell Biol
, vol.130
, pp. 687-700
-
-
Yeh, E.1
Skibbens, R.V.2
Cheng, J.W.3
Salmon, E.D.4
Bloom, K.5
-
7
-
-
0031878092
-
The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast
-
Miller RK, Heller KK, Frisen L, Wallack DL, Loayza D, Gammie AE, Rose MD: The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast Mol Biol Cell 1998, 9:2051-2068.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 2051-2068
-
-
Miller, R.K.1
Heller, K.K.2
Frisen, L.3
Wallack, D.L.4
Loayza, D.5
Gammie, A.E.6
Rose, M.D.7
-
8
-
-
0026728755
-
Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly
-
Hoyt MA, He L, Loo KK, Saunders WS: Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J Cell Biol 1992, 118:109-120.
-
(1992)
J Cell Biol
, vol.118
, pp. 109-120
-
-
Hoyt, M.A.1
He, L.2
Loo, K.K.3
Saunders, W.S.4
-
9
-
-
0026767250
-
Kinesin-related proteins required for assembly of the mitotic spindle
-
Roof DM, Meluh PB, Rose MD: Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 1992, 118:95-108.
-
(1992)
J Cell Biol
, vol.118
, pp. 95-108
-
-
Roof, D.M.1
Meluh, P.B.2
Rose, M.D.3
-
10
-
-
0030923317
-
Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways
-
Geiser JR, Schott EJ, Kingsbury TJ, Cole NB, Totis LJ, Bhattacharyya G, He L, Hoyt MA: Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Biol Cell 1997, 8:1035-1050.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1035-1050
-
-
Geiser, J.R.1
Schott, E.J.2
Kingsbury, T.J.3
Cole, N.B.4
Totis, L.J.5
Bhattacharyya, G.6
He, L.7
Hoyt, M.A.8
-
11
-
-
0030933383
-
The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules
-
Saunders W, Hornack D, Lengyel V, Deng C: The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules. J Cell Biol 1997, 137:417-431. The authors found that Kar3p acts to control both the number and the length of cytoplasmic microtubules in the preanaphase spindle. They also found that Kar3p is localized to spindle poles during metaphase, but its staining is lost by late anaphase.
-
(1997)
J Cell Biol
, vol.137
, pp. 417-431
-
-
Saunders, W.1
Hornack, D.2
Lengyel, V.3
Deng, C.4
-
12
-
-
0030974461
-
Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors
-
Saunders W, Lengyel V, Hoyt MA: Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors. Mol Biol Cell 1997, 8:1025-1033.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1025-1033
-
-
Saunders, W.1
Lengyel, V.2
Hoyt, M.A.3
-
13
-
-
0028890381
-
Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation
-
Saunders WS, Koshland D, Eshel D, Gibbons IR, Hoyt MA: Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 1995, 128:617-624.
-
(1995)
J Cell Biol
, vol.128
, pp. 617-624
-
-
Saunders, W.S.1
Koshland, D.2
Eshel, D.3
Gibbons, I.R.4
Hoyt, M.A.5
-
14
-
-
0032476715
-
Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast
-
Straight AF, Sedat JW, Murray AW: Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J Cell Biol 1998, 143:687-694. Using green fluorescent protein-labeled centromeres and microtubules, the authors followed mitosis in living wild-type yeast cells and mutants of cin8, kip1 and kip3. The precise contributions of each of these motors to spindle function was determined. Cin8p is important during the initial rapid phase of anaphase B, while Kip1 p contributes to the slow phase of spindle elongation. Kip3p appears to be important for the proper timing of spindle disassembly.
-
(1998)
J Cell Biol
, vol.143
, pp. 687-694
-
-
Straight, A.F.1
Sedat, J.W.2
Murray, A.W.3
-
15
-
-
0030847538
-
Mitosis in living budding yeast: Anaphase A but no metaphase plate
-
Straight AF, Marshall WF, Sedat JW, Murray AW: Mitosis in living budding yeast: Anaphase A but no metaphase plate. Science 1997, 277:574-578. This was the first live analysis of mitosis in yeast in which both microtubules and chromosomes were followed because they were labeled with green fluorescent protein. The authors demonstrated that yeast chromosomes do not align in a metaphase plate configuration that is typical of mammalian cells, but do exhibit both anaphase A and anaphase B type chromosome movements.
-
(1997)
Science
, vol.277
, pp. 574-578
-
-
Straight, A.F.1
Marshall, W.F.2
Sedat, J.W.3
Murray, A.W.4
-
16
-
-
0031968587
-
Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells
-
Ding DQ, Chikashige Y, Haraguchi T, Hiraoka Y: Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J Cell Sci 1998, 111:701-712.
-
(1998)
J Cell Sci
, vol.111
, pp. 701-712
-
-
Ding, D.Q.1
Chikashige, Y.2
Haraguchi, T.3
Hiraoka, Y.4
-
17
-
-
0029909273
-
Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins
-
Endow SA, Komma DJ: Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-Gfp fusion proteins. J Cell Sci 1996, 109:2429-2442.
-
(1996)
J Cell Sci
, vol.109
, pp. 2429-2442
-
-
Endow, S.A.1
Komma, D.J.2
-
18
-
-
0028245510
-
Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends
-
Endow SA, Kang SJ, Satterwhite LL, Rose MD, Skeen VP, Salmon ED: Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. EMBO J 1994, 13:2708-2713.
-
(1994)
EMBO J
, vol.13
, pp. 2708-2713
-
-
Endow, S.A.1
Kang, S.J.2
Satterwhite, L.L.3
Rose, M.D.4
Skeen, V.P.5
Salmon, E.D.6
-
19
-
-
0031656253
-
Production of M-phase and l-phase extracts from mammalian cells
-
Compton DA: Production of M-phase and l-phase extracts from mammalian cells. Methods Enzymol 1998, 298:331-339.
-
(1998)
Methods Enzymol
, vol.298
, pp. 331-339
-
-
Compton, D.A.1
-
20
-
-
0032608492
-
The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro
-
Desai A, Murray A, Mitchison TJ, Walczak CE: The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol 1999, 61:385-412.
-
(1999)
Methods Cell Biol
, vol.61
, pp. 385-412
-
-
Desai, A.1
Murray, A.2
Mitchison, T.J.3
Walczak, C.E.4
-
21
-
-
0001364217
-
In vitro assays for mitotic spindle assembly and function
-
Edited by Celis J. New York: Cold Spring Harbor Press
-
Heald R, Tournebize R, Vernos I, Murray A, Hyman A, Karsenti E: In vitro assays for mitotic spindle assembly and function. In Cell Biology; A Laboratory Handbook. Edited by Celis J. New York: Cold Spring Harbor Press; 1998, 2:326-335.
-
(1998)
Cell Biology; A Laboratory Handbook
, vol.2
, pp. 326-335
-
-
Heald, R.1
Tournebize, R.2
Vernos, I.3
Murray, A.4
Hyman, A.5
Karsenti, E.6
-
22
-
-
0030751640
-
Spindle assembly in Xenopus egg extracts: Respective roles of centrosomes and microtubule self-organization
-
Heald R, Tournebize R, Habermann A, Karsenti E, Hyman A: Spindle assembly in Xenopus egg extracts: Respective roles of centrosomes and microtubule self-organization. J Cell Biol 1997, 138:615-628. The authors used extracts from Xenopus eggs to examine spindle assembly in the presence and absence of centrosomes. They found that dynein is required for spindle pole formation in both cases, but that centrosomes serve as the dominant sites for pole formation.
-
(1997)
J Cell Biol
, vol.138
, pp. 615-628
-
-
Heald, R.1
Tournebize, R.2
Habermann, A.3
Karsenti, E.4
Hyman, A.5
-
23
-
-
0030883130
-
Pathways of spindle pole formation: Different mechanisms; conserved components
-
Merdes A, Cleveland DW: Pathways of spindle pole formation: Different mechanisms; conserved components. J Cell Biol 1997, 138:953-956.
-
(1997)
J Cell Biol
, vol.138
, pp. 953-956
-
-
Merdes, A.1
Cleveland, D.W.2
-
24
-
-
0031020735
-
XCTK2: A kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts
-
Walczak CE, Verma S, Mitchison TJ: XCTK2: A kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. J Cell Biol 1997, 136:859-870.
-
(1997)
J Cell Biol
, vol.136
, pp. 859-870
-
-
Walczak, C.E.1
Verma, S.2
Mitchison, T.J.3
-
25
-
-
13144251122
-
A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity
-
Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R: A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol 1998, 8:903-913. These investigators examined the role of motor proteins in spindle assembly using Xenopus egg extracts and DNA-coated beads. As the spindles assemble in the absence of centrosomes, their formation is highly dependent on the action of microtubule-based motors. Models are proposed that show how multiple motors function in generating the bipolar microtubule array.
-
(1998)
Curr Biol
, vol.8
, pp. 903-913
-
-
Walczak, C.E.1
Vernos, I.2
Mitchison, T.J.3
Karsenti, E.4
Heald, R.5
-
26
-
-
0030961046
-
Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes
-
Gaglio T, Dionne MA, Compton DA: Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. J Cell Biol 1997, 138:1055-1066. The authors examined the role of dynein in spindle pole formation both in somatic cells and in mitotic asters assembled in HeLa cell extracts. They found that dynein and dynactin are required to focus microtubule minus ends.
-
(1997)
J Cell Biol
, vol.138
, pp. 1055-1066
-
-
Gaglio, T.1
Dionne, M.A.2
Compton, D.A.3
-
27
-
-
0029862190
-
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole
-
Gaglio T, Saredi A, Bingham J, Hasbani J, Gill SR, Schroer TA, Compton DA: Opposing motor activities are required for the organization of the mammalian mitotic spindle pole. J Cell Biol 1996, 135:399-414.
-
(1996)
J Cell Biol
, vol.135
, pp. 399-414
-
-
Gaglio, T.1
Saredi, A.2
Bingham, J.3
Hasbani, J.4
Gill, S.R.5
Schroer, T.A.6
Compton, D.A.7
-
28
-
-
0029913484
-
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
-
Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB: Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol 1996, 132:617-633.
-
(1996)
J Cell Biol
, vol.132
, pp. 617-633
-
-
Echeverri, C.J.1
Paschal, B.M.2
Vaughan, K.T.3
Vallee, R.B.4
-
29
-
-
0030298137
-
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
-
Merdes A, Ramyar K, Vechio JD, Cleveland DW: A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 1996, 87:447-458.
-
(1996)
Cell
, vol.87
, pp. 447-458
-
-
Merdes, A.1
Ramyar, K.2
Vechio, J.D.3
Cleveland, D.W.4
-
30
-
-
0030612145
-
Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150
-
Blangy A, Arnaud L, Nigg EA: Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. J Biol Chem 1997, 272:19418-19424.
-
(1997)
J Biol Chem
, vol.272
, pp. 19418-19424
-
-
Blangy, A.1
Arnaud, L.2
Nigg, E.A.3
-
31
-
-
0029417238
-
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
-
Blangy A, Lane HA, D'Hérin P, Harper M, Kress M, Nigg EA: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 1995, 83:1159-1169.
-
(1995)
Cell
, vol.83
, pp. 1159-1169
-
-
Blangy, A.1
Lane, H.A.2
D'Hérin, P.3
Harper, M.4
Kress, M.5
Nigg, E.A.6
-
32
-
-
0029011952
-
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle
-
Sawin KE, Mitchison TJ: Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci USA 1995, 92:4289-4293.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4289-4293
-
-
Sawin, K.E.1
Mitchison, T.J.2
-
33
-
-
0030604718
-
Kinesin-related proteins at mitotic spindle poles: Function and regulation
-
Walczak CE, Mitchison TJ: Kinesin-related proteins at mitotic spindle poles: Function and regulation. Cell 1996, 85:943-946.
-
(1996)
Cell
, vol.85
, pp. 943-946
-
-
Walczak, C.E.1
Mitchison, T.J.2
-
34
-
-
0031954955
-
Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins
-
Drummond DR, Hagan IM: Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins. J Cell Sci 1998, 111:853-865.
-
(1998)
J Cell Sci
, vol.111
, pp. 853-865
-
-
Drummond, D.R.1
Hagan, I.M.2
-
35
-
-
0032476724
-
Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
-
Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I: Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J Cell Biol 1998, 143:673-685.
-
(1998)
J Cell Biol
, vol.143
, pp. 673-685
-
-
Wittmann, T.1
Boleti, H.2
Antony, C.3
Karsenti, E.4
Vernos, I.5
-
36
-
-
0031748730
-
Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment
-
Dujardin D, Wacker UI, Moreau A, Schroer TA, Rickard JE, De Mey JR: Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J Cell Biol 1998, 141:849-862. The authors examined the localization and function of CLIP-170 at kinetochores. They found that dynein-dynactin is required for CLIP-170 targeting, which is mediated by the C-terminal domain of CLIP-170. The overexpression of this domain inhibited the association of the endogenous protein with kinetochores and caused a delay in the prometaphase alignment of chromosomes.
-
(1998)
J Cell Biol
, vol.141
, pp. 849-862
-
-
Dujardin, D.1
Wacker, U.I.2
Moreau, A.3
Schroer, T.A.4
Rickard, J.E.5
De Mey, J.R.6
-
37
-
-
0026757402
-
The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation is redistributed at anaphase onset
-
Williams BC, Karr TL, Montgomery JM, Goldberg ML: The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation is redistributed at anaphase onset. J Cell Biol 1992, 118:759-773.
-
(1992)
J Cell Biol
, vol.118
, pp. 759-773
-
-
Williams, B.C.1
Karr, T.L.2
Montgomery, J.M.3
Goldberg, M.L.4
-
38
-
-
0030770154
-
Conservation of the centromere/kinetochore protein ZW10
-
Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML: Conservation of the centromere/kinetochore protein ZW10. J Cell Biol 1997, 138:1289-1301. Mutations in the D. melanogaster ZW10 kinetochore protein cause defects in chromosome segregation. In this paper, the conservation of a ZW10 sequence in widely divergent organisms, including Caenorhabditis elegans, Arabidopsis thaliana, and humans, is demonstrated. The localization of ZW10 in mammalian tissue culture cells is similar to that observed in Drosophila embryos and RNA inhibition in C. elegans produces defects that are similar to that of the Drosophila mutant, suggesting conservation of function as well.
-
(1997)
J Cell Biol
, vol.138
, pp. 1289-1301
-
-
Starr, D.A.1
Williams, B.C.2
Li, Z.3
Etemad-Moghadam, B.4
Dawe, R.K.5
Goldberg, M.L.6
-
39
-
-
0031852650
-
ZW10 helps recruit dynactin and dynein to the kinetochore
-
Starr DA, Williams BC, Hays TS, Goldberg ML: ZW10 helps recruit dynactin and dynein to the kinetochore. J Cell Biol 1998, 142:763-774. The authors present an analysis of kinetochores in Drosophila zw10 mutants. The failure to recruit dynein and dynactin suggests that ZW10 plays a role in targeting the motor complex to kinetochores.
-
(1998)
J Cell Biol
, vol.142
, pp. 763-774
-
-
Starr, D.A.1
Williams, B.C.2
Hays, T.S.3
Goldberg, M.L.4
-
40
-
-
0032487444
-
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
-
Chan GK, Schaar BT, Yen TJ: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol 1998, 143:49-63. The kinetochore-binding domain of CENP-E was identified and used in a yeast two-hybrid screen to identify putative CENP-E interacting proteins. Both CENP-E and another known kinetochore protein, CENP-F, were isolated in this screen, indicating its likely specificity. In addition, hBUBR1, a human BUB1 -related kinase, was also identified, indicating a link between CENP-E and checkpoint control proteins.
-
(1998)
J Cell Biol
, vol.143
, pp. 49-63
-
-
Chan, G.K.1
Schaar, B.T.2
Yen, T.J.3
-
41
-
-
0030687987
-
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
-
Taylor SS, McKeon F: Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 1997, 89:727-735. This paper describes the identification of a murine homolog of the yeast BUB1 gene, which has been implicated in mitotic checkpoint control. Murine Bub1p localizes to kinetochores and appears to be required for checkpoint function, as well as for normal mitotic timing.
-
(1997)
Cell
, vol.89
, pp. 727-735
-
-
Taylor, S.S.1
McKeon, F.2
-
42
-
-
0030665077
-
CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
-
Wood KW, Sakowicz R, Goldstein LS, Cleveland DW: CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell 1997, 91:357-366. This paper demonstrated the requirement for CENP-E function in chromosome alignment using the Xenopus egg extract system. The authors also showed that the bacterially expressed CENP-E motor domain acts as a plus- end-directed microtubule motor in vitro.
-
(1997)
Cell
, vol.91
, pp. 357-366
-
-
Wood, K.W.1
Sakowicz, R.2
Goldstein, L.S.3
Cleveland, D.W.4
-
43
-
-
0031468113
-
CENP-E function at kinetochores is essential for chromosome alignment
-
Schaar BT, Chan GK, Maddox P, Salmon ED, Yen TJ: CENP-E function at kinetochores is essential for chromosome alignment. J Cell Biol 1997, 139:1373-1382. Through a combination of antibody microinjection and transfection of dominant-negative constructs, these authors showed that CENP-E is required for chromosome alignment on the metaphase plate. Some of the chromosomes failed to even establish bipolar microtubule connections, suggesting a role for CENP-E in this process as well.
-
(1997)
J Cell Biol
, vol.139
, pp. 1373-1382
-
-
Schaar, B.T.1
Chan, G.K.2
Maddox, P.3
Salmon, E.D.4
Yen, T.J.5
-
44
-
-
0031873388
-
Mitotic centromere-associated kinesin is important for anaphase chromosome segregation
-
Maney T, Hunter AW, Wagenbach M, Wordeman L: Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J Cell Biol 1998, 142:787-801. The authors used a combination of antisense treatment of cells and the transfection of dominant-negative constructs to show the importance of MCAK in anaphase chromosome segregation.
-
(1998)
J Cell Biol
, vol.142
, pp. 787-801
-
-
Maney, T.1
Hunter, A.W.2
Wagenbach, M.3
Wordeman, L.4
-
45
-
-
0028891856
-
Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro
-
Lombillo VA, Nislow C, Yen TJ, Gelfand VI, McIntosh JR: Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. J Cell Biol 1995, 128:107-115.
-
(1995)
J Cell Biol
, vol.128
, pp. 107-115
-
-
Lombillo, V.A.1
Nislow, C.2
Yen, T.J.3
Gelfand, V.I.4
McIntosh, J.R.5
-
46
-
-
0030031999
-
XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
-
Walczak CE, Mitchison TJ, Desai A: XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 1996, 84:37-47.
-
(1996)
Cell
, vol.84
, pp. 37-47
-
-
Walczak, C.E.1
Mitchison, T.J.2
Desai, A.3
-
47
-
-
0033534575
-
Microtubule destabilization by a subfamily of kinesins
-
Desai A, Verma S, Mitchison TJ, Walczak CE: Microtubule destabilization by a subfamily of kinesins. Cell 1999, 96:69-78. The authors used a series of in vitro assays to demonstrate that two members of the Kin I subfamily of kinesins act exclusively as microtubule- destabilizing enzymes. The mechanism of microtubule destabilization is distinct from the mechanism of motility established for other kinesins.
-
(1999)
Cell
, vol.96
, pp. 69-78
-
-
Desai, A.1
Verma, S.2
Mitchison, T.J.3
Walczak, C.E.4
|