Selegiline treatment after transient global ischemia in gerbils enhances the survival of CA1 pyramidal cells in the hippocampus

Brain Research

Volumn 757, Issue 2, 1997, Pages 260-267

  Lahtinen, Hannele ^a,d   Koistinaho, Jari ^a   Kauppinen, Risto ^a   Haapalinna, Antti ^b   Keinänen, Riitta ^a   Sivenius, Juhani ^c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b ORION CORPORATION   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cerebral ischemia; hsp70 mRNA; l Deprenyl; Neurodegeneration; Neuronal rescue; Stroke

Indexed keywords

HEAT SHOCK PROTEIN 70; MESSENGER RNA; SELEGILINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CELL SURVIVAL; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG SCREENING; GERBIL; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

ANIMALS; CELL SURVIVAL; GERBILLINAE; HIPPOCAMPUS; HSP70 HEAT-SHOCK PROTEINS; IN SITU HYBRIDIZATION; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; PYRAMIDAL CELLS; RNA, MESSENGER; SELEGILINE;

EID: 0030994173     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00227-8     Document Type: Article

References (51)

1. Abe, K., Aoki, M., Kawagoe, J., Yoshida, T., Hattori, A., Kogure, K. and Itoyama, Y., Ischemic delayed neuronal death. A mitochondrial hypothesis, Stroke, 26 (1995) 1478-1489.
2. Ahola, T., Haapalinna, A., Heinonen, E., Hervonen, A. and Suhonen, J., Protection by L-deprenyl of intact peripheral symphatetic neurons exposed to neurotoxin 6-hydroxydopamine (6-OHDA), New Trends Clin. Neuropharmacol., 7 (1994) 287.
3. Amenta, F., Bongrani, S., Bronzetti, E., Cadel, S., Ricci, A., Valsecchi, B. and Zeng, Y.-C., Effect of long term monoamine oxidase-B inhibitor treatment on the structure of the hippocampus of the aged rats, Adv. Biosci., 87 (1993) 435-440.
4. Andou, Y., Mitani, A., Masuda, S., Arai, T. and Kataoka, K., Re-evaluation of ischemia-induced neuronal damage in hippocampal regions in the normothermic gerbil, Acta Neuropathol., 85 (1992) 10-14.
5. Ansari, K.S., Yu, P.M., Kruck, T.P.A. and Tatton, W.G., Rescue of axotomized immature rat facial motoneurons by R(-)-depreyl: stereospecificity and independence from monoamine oxidase inhibition, J. Neurosci., 13 (1993) 4042-4053.
6. Barber, A.J., Paterson, I.A., Gelowitz, D.L. and Voll, C.L., Deprenyl protects rat hippocampal pyramidal cells from ischemic insult, Soc. Neurosci. Abstr., 19 (1993) 1646.
7. Benveniste, H., Drejer, J., Schousboe, A. and Diemer, N. H., Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43 (1984) 1369-1374.
8. Biagini, G., Frasoldati, A., Fuxe, K. and Agnati, L.F., The concept of astrocyte-kinetic drugs in the treatment of neurodegenerative diseases: evidence for L-deprenyl-induced activation of reactive astrocytes, Neurochem. Int., 25 (1994) 17-22.
9. Block, G.A. and Pulsinelli, W.A., N-Methyl-D-aspartate receptor antagonists: failure to prevent ischemia-induced selective neuronal damage. In M.E. Raschle and W.J. Powers (Eds.), Cerebrovasc. Dis., Raven, New York, NY, 1987, pp. 37-44.
10. Choi, D.W., Excitotoxic cell death, J. Neurobiol., 23 (1992) 1261-1276.
11. Crain, B.J., Westerkam, W.D., Harrison, A.M. and Nadler, J.V., Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: a silver impregnation study, Neuroscience, 27 (1988) 387-402.
12. Ekblom, J., Jossan, S.S., Ebendal, T., Söderström, S., Creland, L. and Aquilonius, S.-M., mRNA expression of neurotrophins and members of the trk family in the rat brain after treatment with L-deprenyl, Acta Neurol. Scand., 89 (1994) 147-148.
13. Finnegan, K.T., Skratt, J.J., Irwin, I., DeLanney, L.E. and Langston, J.W., Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B, Eur. J. Pharmacol., 184 (1990) 119-126.
14. Floyd, R., Role of oxygen free radicals in carcinogenesis and brain ischemia, FASEB J., 4 (1990) 2587-2597.
15. Folbergrova, J., Zhao, Q., Katsura, K.-I. and Siesjö, B., N-tertbutyl-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia, Proc. Natl. Acad. Sci. USA, 92 (1995) 5057-5061.
16. Gass, P., Herdegen, T., Bravo, R. and Kiessling, M., High induction threshold for transcription factor KROX-20 in the rat brain: partial co-expression with heat shock protein 70 following limbic seizures, Mol. Brain Res., 23 (1994) 292-298.
17. Gelowitz, D.L. and Paterson, J.A., L-Deprenyl reduces kainic acid-induced neuronal death in the hippocampus, Soc. Neurosci. Abstr., 20 (1994) 246.
18. Gelowitz, D.L. and Paterson, J.A., (-)-Deprenyl enhances functional recovery following kainic acid-induced neuronal death, Soc. Neurosci. Abstr., 21 (1995) 810.
19. Glover, V., Clow, A. and Sandler, M., Effects of dopaminergic drugs on superoxide dismutase: implications for senescence, J. Neural Transm. Suppl., 40 (1993) 37-45.
20. Heron, A., Pollard, H., Dessi, F., Moreau, J., Lasbennes, F., Ben-Ari, Y. and Charriaut-Marlangue, C., Regional variability in DNA fragmentation after global ischemia evidenced by combned histological and gel electrophoresis observation in the rat brain, J. Neurochem., 61 (1993) 1973-1976.
21. Hunt, C. and Morimoto, R.I., Conserved features of eukaryotic HSP70 genes revealed by comparison to the nucleotide sequence of human HSP70, Proc. Natl. Acad. Sci. USA, 82 (1985) 6455-6459.
22. Ito, U., Spatz, M., Walker, Jr., J.T. and Klatzo, I., Experimental cerebral ischemia in mongolian gerbils, Acta Neuropathol., 32 (1975) 209-223.
23. Kartsounis, L.D., Rudge, P. and Stevens, J.M., Bilateral lesions of CA1 and CA2 fields of the hippocampus are sufficient to cause a severe amnesic syndrome in humans, J. Neurol. Neurosurg. Psychiatry, 59 (1995) 95-98.
24. Kawagoe, J., Abe, K., Sato, S., Nagano, I., Nakamura, S. and Kogure, K., Distributions of heat shock protein-70 mRNA and heat shock cognate-70 mRNA after transient global ischemia in gerbil brain, J. Cereb. Blood Flow Metab., 12 (1992) 794-801.
25. Kirino, T. and Sano, K., Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus, Acta Neuropathol., 62 (1984) 209-218.
26. Kirino, T. and Sano, K., Selective vulnerability in the gerbil hippocampus following transient ischemia, Acta Neuropathol., 62 (1984) 201-208.
27. Knoll, J., The pharmacological basis of the beneficial effects of (-)deprenyl (selegiline) in Parkinson's and Alzheimer's diseases, J. Neural. Transm. Suppl., 40 (1993) 69-91.
28. Knollema, S., Aukema, W., Horn, H., Korf, J. and ter Horst, G.J., L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischemia, Stroke, 26 (1995) 1883-1887.
29. Kumar, K., Savithiry, S. and Madhukar, B.V., Comparison of α-tubulin mRNA and heat shock protein-70 mRNA in gerbil brain following 10 min of ischemia, Mol Brain Res., 20 (1993) 130-136.
30. Magyar, K., Tothfalusi, L., Lengyel, J. and Gaal, J., Neuroprotective effect of deprenyl against DSP-4 toxicity, New Trends Clin. Neuropharmacol., 1 (1994) 310.
31. Matsui, Y. and Kumagae, Y., Monoamine oxidase inhibitors prevent striatal neuronal necrosis induced by transient forebrain ischemia, Neurosci. Lett., 126 (1991) 175-178.
32. Miller, K.E., Taese, J.D. and Morrison-Bogorad, M., Expression of heat shockprotein 70 and heat shock cognat 70 messenger RNAs in rat cortex and cerebellum after heat shock or amphetamine treatment, J. Neurochem., 56 (1991) 2060-2071.
33. Nitatori, T., Sato, N., Waguri, S., Karasawa, Y., Araki, H., Shibanai, K., Kominami, E. and Uchiyama, Y., Delayed neuronal death in the CAl pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis, J. Neurosci., 15 (1995) 1001-1011.
34. Nowak Jr., T.S., Localization of 70 kDa stress protein mRNA induction in gerbil brain after ischemia, J. Cereb. Blood Flow Metab., 11 (1991) 432-439.
35. Olney, J.W., Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate, Science, 164 (1969) 719-721.
36. Petito, C.K., Feldmann, E., Pulsinelli, W.A. and Plum, E.G., Delayed hippocampal damage in humans following cardiorespiratory arrest, Neurology, 37 (1987) 1281-1286.
37. Salonen, T., Haapalinna, A., Heinonen, E., Suhonen, J. and Hervonen, A., Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral symphathetic neurons against 6-hydroxydopamine-induced neurotoxicity, Acta Neuropathol., 91 (1996) 466-474.
38. Sivenius, J., Kuhmonen, J. and Haapalinna, A., Effect of selegiline on the hippocampal CA1 layer following transient forebrain ischemia in gerbil. New Trends Clin. Neuropharmacol., 8 (1994) 325-326.
39. Sloviter, R.S. and Lowenstein, D.H., Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress, J. Neurosci., 12 (1992) 3004-3009.
40. Soriano, M.A., Ferrer, I., Rodriguez-Farre, E. and Planas, A.M., Expression of c-fos and inducible hsp-70 mRNA following a transient episode of focal ischemia that had no lethal effect on the rat brain, Brain Res., 670 (1995) 317-320.
41. Sprague, J.E. and Nichols, D.E., The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long term serotonergic deficits, J. Pharmacol. Exp. Ther., 273 (1995) 667-673.
42. Suzuki, R., Yamagushi, T., Li, C.-L. and Klatzo, I., The effects of 5-minute ischemia in mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus, Acta Neuropathol., 60 (1983) 217-222.
43. Tatton, W.G., Selegiline can mediate neuronal rescue rather than neuronal protection, Movement Disord., 8 (Suppl. 1) (1993) S20-S30.
44. Tatton, W.G. and Greenwood, C.E., Rescue of dying neurons: a new action for deprenyl in MPTP Parkinsonism, J. Neurosci. Res., 30 (1991) 666-672.
45. Tatton, W.G., Ju, W.Y.L., Holland, D.P., Tai, C. and Kwan, M., (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein syntesis, J. Neurochem., 63 (1994) 1572-1575.
46. Vass, K., Welch, W.J. and Nowak Jr., T.S., Localization of 70 kDA stress protein induction in gerbil brain after ischemia, Acta Neuropathol., 77 (1988) 128-135.
47. + in vivo, Eur. J. Pharmacol., 243 (1993) 241-247.
48. Yoshida, T., Yamada, Y., Yamamoto, T. and Kuroiwa, Y., Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency, Xenobiotica, 16 (1986) 129-136.
49. Yu, P.M., Davis, B.A., Fang, J. and Boulton, A.A., Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus, J. Neurochem., 63 (1994) 1820-1828.
50. Zhang, X. and Yu, P.H., Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl, Brain Res. Bull., 38 (1995) 307-311.
51. Zhao, Q., Pahlmark, K., Smith, M.-L. and Siesjö, B.K., Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats, Acta Physiol. Scand., 152 (1994) 349-350.