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Volumn 159, Issue 6, 1998, Pages 2164-2171

Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes

Author keywords

Guanylate cyclase; Impotence; Nitric oxide; Penile erection; Phosphodiesterase inhibitors

Indexed keywords

CYCLIC GMP PHOSPHODIESTERASE INHIBITOR; NITRIC OXIDE; PHENYLEPHRINE; SILDENAFIL; UNCLASSIFIED DRUG; ZAPRINAST;

EID: 0032445219     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)63299-3     Document Type: Article
Times cited : (561)

References (28)
  • 1
    • 0021021402 scopus 로고
    • Hemodynamics of erection in the monkey
    • Lue, T. F.: Hemodynamics of erection in the monkey. J. Urol., 130: 1237, 1983.
    • (1983) J. Urol. , vol.130 , pp. 1237
    • Lue, T.F.1
  • 2
    • 0028837352 scopus 로고
    • Physiology of penile erection
    • Andersson, K-E. and Wagner, G.: Physiology of penile erection. Physiol. Rev., 75: 191, 1995.
    • (1995) Physiol. Rev. , vol.75 , pp. 191
    • Andersson, K.-E.1    Wagner, G.2
  • 4
    • 0027467004 scopus 로고
    • The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection
    • Trigo-Rocha, F., Hsu, G. L., Donatucci, C. F. and Lue, T. F.: The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection. J. Urol., 149: 872, 1993.
    • (1993) J. Urol. , vol.149 , pp. 872
    • Trigo-Rocha, F.1    Hsu, G.L.2    Donatucci, C.F.3    Lue, T.F.4
  • 5
    • 0028859180 scopus 로고
    • Role of nitric oxide in the physiology of erection
    • Burnett, A. L.: Role of nitric oxide in the physiology of erection. Biol. Reprod., 52: 485, 1995.
    • (1995) Biol. Reprod. , vol.52 , pp. 485
    • Burnett, A.L.1
  • 6
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo, J. A.: Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev., 75: 725, 1995.
    • (1995) Physiol. Rev. , vol.75 , pp. 725
    • Beavo, J.A.1
  • 7
    • 0026659196 scopus 로고
    • Nitric Oxide is a potent relaxant of human and rabbit corpus cavernosum
    • Bush, P. A., Aronson, W. J., Georgette, M. B., Rajfer, J. and Ignarro, L. J.: Nitric Oxide is a potent relaxant of human and rabbit corpus cavernosum. J. Urol., 147: 1650, 1992.
    • (1992) J. Urol. , vol.147 , pp. 1650
    • Bush, P.A.1    Aronson, W.J.2    Georgette, M.B.3    Rajfer, J.4    Ignarro, L.J.5
  • 8
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J. and Ignarro, L. J.: Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med., 326: 90, 1992.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 90
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 9
    • 0027523365 scopus 로고
    • Nitric oxide and cGMP: Mediators of pelvic nerve-stimulated erection in dogs
    • Heart Circ: Physiol. 33
    • Trigo-Rocha, F., Aronson, W. J., Hohenfellner, M., Ignarro, L. J., Rajfer, J. and Lue, T. F.,.: Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Am. J. Physiol., 264 (Heart Circ: Physiol. 33): H419, 1993.
    • (1993) Am. J. Physiol. , vol.264
    • Trigo-Rocha, F.1    Aronson, W.J.2    Hohenfellner, M.3    Ignarro, L.J.4    Rajfer, J.5    Lue, T.F.6
  • 11
    • 0028136159 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterases
    • Beavo, J. A., Conti, M. and Heaslip, R. J.: Multiple cyclic nucleotide phosphodiesterases. Mol. Pharmacol., 46: 399, 1994.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 399
    • Beavo, J.A.1    Conti, M.2    Heaslip, R.J.3
  • 13
    • 0031403328 scopus 로고    scopus 로고
    • Effects of sildenafil, a type 5 cyclic GMP phosphodiesterase inhibitor on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro
    • Jeremy, J. Y., Ballard, S. A., Naylor, A. M., Miller, M. A. W. and Angelini, G. D.: Effects of sildenafil, a type 5 cyclic GMP phosphodiesterase inhibitor on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br. J. Urol., 79: 958, 1997.
    • (1997) Br. J. Urol. , vol.79 , pp. 958
    • Jeremy, J.Y.1    Ballard, S.A.2    Naylor, A.M.3    Miller, M.A.W.4    Angelini, G.D.5
  • 14
    • 0001381355 scopus 로고    scopus 로고
    • A study of sildenafil (VIAGRA™), a new oral agent for the treatment of male erectile dysfunction
    • Lue, T. F. and the Sildenafil Study Group.: A study of sildenafil (VIAGRA™), a new oral agent for the treatment of male erectile dysfunction. J. Urol., 157(suppl.): 181, 1997.
    • (1997) J. Urol. , vol.157 , Issue.SUPPL. , pp. 181
    • Lue, T.F.1
  • 15
    • 0030438222 scopus 로고    scopus 로고
    • Sildenafil, a novel oral therapy for male erectile dysfunction
    • Boolell, M., Gepi-Attee, S., Gingell, J. C. and Allen, M. J.: Sildenafil, a novel oral therapy for male erectile dysfunction. Br. J. Urol., 78: 257, 1996.
    • (1996) Br. J. Urol. , vol.78 , pp. 257
    • Boolell, M.1    Gepi-Attee, S.2    Gingell, J.C.3    Allen, M.J.4
  • 17
    • 0025215525 scopus 로고
    • Primary sequence of cyclic nucleotide phosphodiesterase enzymes and the design of selective inhibitors
    • Beavo, J. A. and Reifsnyder, D. H.: Primary sequence of cyclic nucleotide phosphodiesterase enzymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11: 150, 1990.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 150
    • Beavo, J.A.1    Reifsnyder, D.H.2
  • 18
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities from rat brain
    • Thompson, W. J. and Appleman, M. M.: Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry, 10: 311, 1971.
    • (1971) Biochemistry , vol.10 , pp. 311
    • Thompson, W.J.1    Appleman, M.M.2
  • 19
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
    • De Lean, A., Munson, A. and Rodbard, D.: Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol., 235: E97, 1978.
    • (1978) Am. J. Physiol. , vol.235
    • De Lean, A.1    Munson, A.2    Rodbard, D.3
  • 20
    • 0025999803 scopus 로고
    • The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle
    • Pickard, R. S., Powell, P. H. and Zar, M. A.: The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Br. J. Pharmacol., 104: 755, 1991.
    • (1991) Br. J. Pharmacol. , vol.104 , pp. 755
    • Pickard, R.S.1    Powell, P.H.2    Zar, M.A.3
  • 21
    • 0026630039 scopus 로고
    • Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle
    • Knispel, H. H., Goessl, C. and Beckmann, R.: Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle. Urol. Res., 20: 253, 1992.
    • (1992) Urol. Res. , vol.20 , pp. 253
    • Knispel, H.H.1    Goessl, C.2    Beckmann, R.3
  • 22
    • 21844504218 scopus 로고
    • Phosphodiesterase isozymes of the human cavernous tissue and its functional significance
    • Stieff, C. G.: Phosphodiesterase isozymes of the human cavernous tissue and its functional significance. Akt. Urol., 26: 22, 1995.
    • (1995) Akt. Urol. , vol.26 , pp. 22
    • Stieff, C.G.1
  • 23
    • 0024306482 scopus 로고
    • Inhibition and stimulation of photoreceptor by dipyridamole and M&B 22,948
    • Gillespie, P. G. and Beavo, J. A.: Inhibition and stimulation of photoreceptor by dipyridamole and M&B 22,948. Mol. Pharm., 36: 773, 1989.
    • (1989) Mol. Pharm. , vol.36 , pp. 773
    • Gillespie, P.G.1    Beavo, J.A.2
  • 24
    • 0021920534 scopus 로고
    • cGMP phosphodiesterase in rod and cone outer segments of the retina
    • Hurwitz, R. L., Bunt-Milam, A. H., Chang, M. L. and Beavo, J. A.: cGMP phosphodiesterase in rod and cone outer segments of the retina. J. Biol. Chem., 260: 568, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 568
    • Hurwitz, R.L.1    Bunt-Milam, A.H.2    Chang, M.L.3    Beavo, J.A.4
  • 25
    • 0026566697 scopus 로고
    • The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP specific phosphodiesterase from guinea pig lung
    • Burns, F., Rodger, I. W. and Pyne N. J.: The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP specific phosphodiesterase from guinea pig lung. Biochem. J., 283: 487, 1992.
    • (1992) Biochem. J. , vol.283 , pp. 487
    • Burns, F.1    Rodger, I.W.2    Pyne, N.J.3
  • 26
    • 0025041146 scopus 로고
    • Characterization of purified bovine lung cGMP-binding cGMP phosphodiesterase
    • Thomas, M. K. Frances, S. H. and Corbin, J. D.: Characterization of purified bovine lung cGMP-binding cGMP phosphodiesterase. J. Biol. Chem., 265: 14964, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 14964
    • Thomas, M.K.1    Frances, S.H.2    Corbin, J.D.3
  • 27
    • 0030572496 scopus 로고    scopus 로고
    • Sildenafil (VIAGRA™), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
    • Terrett, N, K., Bell, A. S., Brown, D. and Ellis, P.: Sildenafil (VIAGRA™), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorg. Med. Chem. Lett., 6: 1819, 1996.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1819
    • Terrett, N.K.1    Bell, A.S.2    Brown, D.3    Ellis, P.4
  • 28
    • 0020565495 scopus 로고
    • Screening and characterization of enzyme inhibitors as drug candidates
    • Bush, K.: Screening and characterization of enzyme inhibitors as drug candidates. Drug Met. Rev., 14: 639, 1983.
    • (1983) Drug Met. Rev. , vol.14 , pp. 639
    • Bush, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.