Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle

Biochemical and Biophysical Research Communications

Volumn 249, Issue 3, 1998, Pages 612-617

  Park, Kwangsung ^a   Moreland, Robert B ^a   Goldstein, Irwin ^a   Atala, Anthony ^b   Traish, Abdulmaged ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

cGMP; Clitoral corpus cavernosum smooth muscle cells; Female sexual dysfunction; Phosphodiesterase type 5; Sildenafil (Viagra)

Indexed keywords

CELL ENZYME; CYCLIC GMP; CYCLIC GMP PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; SILDENAFIL; ZAPRINAST;

ARTICLE; CLITORIS; CONTROLLED STUDY; CORPUS CAVERNOSUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; SMOOTH MUSCLE;

EID: 0032575623     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1998.9206     Document Type: Article

References (20)

1. van Turnhout A. A., Hage J. J., van Diest P. J. Acta Obstet. Gynecol. Scand. 74:1995;767-771.
2. Toesca A., Stolfi V. M., Cocchia D. J. Anat. 188:1996;513-520.
3. Andersson K-E., Wagner G. Physiol. Rev. 75:1995;191-236.
4. Burnett A. L. J. Urol. 157:1997;320-324.
5. Beavo J. A. Physiol. Rev. 75:1995;725-746.
6. Polson J. B., Strada S. J. Annu. Rev. Pharmacol. Toxicol. 36:1996;403-427.
7. Pyne N. J., Arshavsky V., Lochhead A. Biochem. Soc. Trans. 24:1996;1019-1022.
8. Azadzoi K. M., Tarcan T., Kim N., Siroky M. B., Krane R. J., Goldstein I. J. Urol. 159:1998;93.
9. Burnett A. L, . Calvin D. C., Silver R. I., Peppas D. S., Docimo S. G. J. Urol. 158:1997;75-78.
10. Morales A., Heaton J. P. W., Johnston B., Adams M. A. Urol. Clin. North Am. 22:1995;879-886.
11. Goldstein I., Lue T. F., Padma-Nathan H., Rosen R. C., Steers W. D., Wicker P. A. New Engl. J. Med. 338:1998;1397-1404.
12. Boolel M., Allen M. J., Ballard S. A., Gepi-Attee S. G., Muirhead G. J., Naylor A. M., Osterloh I. H., Gingell C. Int. J. Impot. Res. 8:1996;47-52.
13. Moreland R. B., Goldstein I., Traish A. M. Life Sci. 62:1998;PL309-PL318.
14. Moreland R. B., Traish A. M., McMillin M. A., Smith B., Goldstein I., Saenz de Tejada I. J. Urol. 153:1995;826-834.
15. Sadeghi-Nejad H. Int. J. Impot. Res. 1998.
16. Martins T. J., Mumby M. C., Beavo J. A. J. Biol. Chem. 257:1982;1973-1979.
17. Dixon M. Biochem. J. 55:1953;170-172.
18. Kim N. J. Clin. Invest. 91:1993;437-443.
19. Traish A. M., Palmer M. A., Goldstein I., Moreland R. B. Receptors. 5:1995;159-176.
20. Park K., Goldstein I., Andry C., Siroky M. B., Krane R. J., Azadzoi K. M. Int. J. Impot. Res. 9:1997;27-37.