Nitric oxide in the penis: Physiology and pathology

Journal of Urology

Volumn 157, Issue 1, 1997, Pages 320-324

  Burnett, Arthur L ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

nitric oxide; pathology; penile induration; penis; physiology

Indexed keywords

FREE RADICAL; NITRIC OXIDE;

CONFERENCE PAPER; HISTOCHEMISTRY; HUMAN; PATHOPHYSIOLOGY; PENIS ERECTION; PEYRONIE DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031060411     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)65369-2     Document Type: Conference Paper

References (59)

1. Lue, T. F.: Physiology of erection and pathophysiology of impotence. In: Campbell's Urology, 6th ed. Edited by P. C. Walsh, A. B. Retik, T. A. Stamey and E. D. Vaughan, Jr. Philadelphia: W. B. Saunders Co., chapt. 16, pp. 709-728, 1992.
2. Moncada, S., Palmer, R. M. and Higgs, E. A.: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 42: 109, 1991.
3. Bredt, D. S. and Snyder, S. H.: Nitric oxide, a novel neuronal messenger. Neuron, 8: 3, 1992.
4. Nathan, C.: Nitric oxide as a secretory product of mammalian cells. FASEB J., 6: 3051, 1992.
5. Knowles, R. G. and Moncada, S.: Nitric oxide synthases in mammals. Biochem. J., 298: 249, 1994.
6. Sessa, W. C.: The nitric oxide synthase family of proteins. J. Vasc. Res., 31: 131, 1994.
7. Furchgott, R. F. and Zawadzki, J. V.: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288: 373, 1980.
8. Palmer, R. M., Ferrige, A. G. and Moncada, S.: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327: 524, 1987.
9. G-substituted analogues of L-arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscles and the bovine penile artery. Brit. J. Pharmacol., 104: 53, 1991.
10. Kim, N., Azadzoi, K. M., Goldstein, I. and Saenz de Tejada, I.: A nitric oxide-like factor mediates non-adrenergic noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J. Clin. Invest., 88: 112, 1991.
11. Bush, P. A., Aronson, W. J., Buga, G. M., Rajfer, J. and Ignarro, L. J.: Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J. Urol., 147: 1650, 1992.
12. Holmquist, F., Hedlund, H. and Andersson, K. E.: Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man. J. Physiol., 449: 295, 1992.
13. Ignarro, L. J., Bush, P. A., Buga, G. M., Wood, K. S., Fukoto, J. M. and Rajfer, J.: Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun., 170: 843, 1990.
14. Knispel, H. H., Goessl, C. and Beckmann, R.: Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle. Urol. Res., 20: 253, 1992.
15. Pickard, R. S., Powell, P. H. and Zar, M. A.: The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Brit. J. Pharmacol., 104: 755, 1991.
16. Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J. and Ignarro, L. J.: Nitric oxide as a mediator of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Engl. J. Med., 326: 90, 1992.
17. G-monomethyl L-arginine on the inhibitory neurotransmission of the human corpus cavernosum penis. Act a Physiol. Scand., 140: 297, 1990.
18. Sparwasser, C., Drescher, P., Will, J. A. and Madsen, P. O.: Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms. J. Urol., 152: 2159, 1994.
19. Burnett, A. L., Lowenstein, C. J., Bredt, D. S., Chang, T. S. K. and Snyder, S. H.: Nitric oxide: a physiological mediator of penile erection. Science, 257: 401, 1992.
20. Finberg, J. P., Levy, S. and Vardi, Y.: Inhibition of nerve stimulation-induced vasodilatation in corpora cavernosa of the pithed rat by blockade of nitric oxide synthase. Brit. J. Pharmacol., 108: 1038, 1993.
21. G-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol. Scand., 143: 299, 1991.
22. Trigo-Rocha, F., Aronson, W. J., Hohenfellner, M., Ignarro, L. J., Rajfer, J. and Lue, T. F.: Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Amer. J. Physiol., 264: H419, 1993.
23. Wang, R., Domer, F. R., Sikka, S. C., Kadowitz, P. J. and Hellstrom, W. J.: Nitric oxide mediates penile erection in cats. J. Urol., 151: 234, 1994.
24. Hellstrom, W. J., Monga, M., Wang, R., Domer, F. R., Kadowitz, P. J. and Roberts, J. A.: Penile erection in the primate: induction with nitric-oxide donors. J. Urol., 151: 1723, 1994.
25. Trigo-Rocha, F., Hsu, G. L., Donatucci, C. F., Martinez-Pineiro, L., Lue, T. F. and Tanagho, E. A.: Intracellular mechanism of penile erection in monkeys. Neurourol. Urodynam., 13: 71, 1994.
26. Bush, P. A., Gonzalez, N. E. and Ignarro, L. J.: Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem. Biophys. Res. Commun., 186: 308, 1992.
27. Leone, A. M., Wiklund, N. P., Hokfelt, T., Brundin, L. and Moncada, S.: Release of nitric oxide by nerve stimulation in the human urogenital tract. Neuroreport, 5: 733, 1994.
28. Alm, P., Larsson, B., Ekblad, E., Sundler, F. and Andersson, K. E.: Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C- and N-terminal fragments of a cloned enzyme from rat brain. Acta Physiol. Scand. 148: 421, 1993.
29. Vizzard, M. A., Erdman, S. L., Forstermann, U. and de Groat, W. C.: Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat. Brain Res., 646: 279, 1994.
30. Sheng, H., Schmidt, H. H., Nakane, M., Mitchell, J. A., Pollock, J. S., Forstermann, U. and Murad, F.: Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles. Brit. J. Pharmacol., 106: 768, 1992.
31. Burnett, A. L., Tillman, S. L., Chang, T. S., Epstein, J. I., Lowenstein, C. J., Bredt, D. S., Snyder, S. H. and Walsh, P. C.: Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J. Urol., 150: 73, 1993.
32. Burnett, A. L., Saito, S. S., Maguire, M. P., Yamaguchi, H., Chang, T. S. and Hanley, D. F.: Localization of nitric oxide synthase in spinal nuclei innervating pelvic ganglia. J. Urol., 153: 212, 1995.
33. Schmidt, P. S., Gupta, S., Daley, J. and Saenz de Tejada, I.: Mechanisms of nitric oxide-induced relaxation of rabbit corpus cavernosum smooth muscle. J. Urol., part 2, 153: 442A, abstract 855, 1995.
34. --ATPase and human corpus cavernosum smooth muscle contractility. J. Urol., part 2, 153: 442A, abstract 856, 1995.
35. Seftel, A. D., Viola, K. A., Kasner, S. E. and Ganz, M. B.: Nitric oxide relaxes rabbit corpus cavernosum smooth muscle via a potassium-conductive pathway. Biochem. Biophys. Res. Commun., 219: 382, 1996.
36. Huang, P. L., Dawson, T. M., Bredt, D. S., Snyder, S. H. and Fishman, M. C.: Targeted disruption of the neuronal nitric oxide synthase gene. Cell, 75: 1273, 1993.
37. Burnett, A. L., Calvin, D. C., Chamness, S. L., Ricker, D. D., Crone, J. K. and Chang, T. S. K.: Characterization of neuronal and endothelial nitric oxide synthase (NOS) isoforms in the penis and urethra of wild type mice and transgenic mice lacking neuronal NOS. J. Urol., part 2, 153: 509A, abstract 1124, 1995.
38. Hung, A., Vernet, D. Xie, Y., Rajavashisth, T., Rodriguez, J. A., Rajfer, J. and Gonzalez-Cadavid, N. F.: Expression of the inducible nitric oxide synthase in smooth muscle cells from rat penile corpora cavernosa. J. Androl., 16: 469, 1995.
39. Moncada, S.: Nitric oxide gas: mediator, modulator, and pathophysiologic entity. J. Lab. Clin. Med., 120: 187, 1992.
40. Kim, N., Vardi, Y., Padma-Nathan, H., Daley, J., Goldstein, I. and Saenz de Tejada, I.: Oxygen tension regulates the nitric oxide pathway: physiological role in penile erection. J. Clin. Invest., 91: 437, 1993.
41. Hoffman, D., Seftel, A. D., Hampel, N. and Resnick, M. I.: Advanced glycation end-products quench cavernosal nitric oxide. J. Urol., part 2, 153: 441A. abstract 849, 1995.
42. Martin, W., McAllister, K. H. M. and Paisley, K.: NANC neuro-transmission in the bovine retractor penis muscle is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate. Neuropharmacology, 33: 1293, 1994.
43. Mills, T. M., Wiedmeier, V. T. and Stopper, V. S.: Androgen maintenance of erectile function in the rat penis. Biol. Reprod., 46: 342, 1992.
44. Chamriess, S. L., Kicker, D. D., Crone, J. K., Dembeck, C. L., Maguire, M. P., Burnett, A. L. and Chang, T. S.: The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil. Steril., 83: 1101, 1995.
45. Lugg, J. A., Rajfer, J. and Gonzalez-Cadavid, N. F.: Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology. 136: 1495, 1995.
46. Lugg, J. A., Schlunt, K., Rajfer, J. and Gonzalez-Cadavid, N. F.: Modulation of nitric oxide synthase activity in the penis by electrical stimulation of the cavernosal nerve. J. Urol., part 2, 153: 509A, abstract 1122, 1995.
47. Kimoto, Y., Kessler, R. and Constantinou, C. E.: Endothelium dependent relaxation of human corpus cavernosum by bradykinin. J. Urol., 144: 1015, 1990.
48. Azadzoi, K. M., Kim, X., Brown, M. L., Goldstein, I., Cohen, R. A. and Saenz de Tejada, I.: Endotheliurn-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J. Urol., 147: 220, 1992.
49. Knispel, H. H., Goessl, C. and Beckmann, R.: Basal and acetylcholine-stimulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle. J. Urol., 146: 1429, 1991.
50. Tamura, M., Kagawa, S., Kimura, K., Kawanishi, Y., Tsuruo, Y. and Ishimura, K.: Coexistence of nitric oxide synthase, tyrosine hydroxylase and vasoactive intestinal polypeptide in human penile tissue - a triple histochemical and immunohistochemical study. J. Urol., 158: 530, 1995.
51. Domoto, T. and Tsumori, T.: Co-localization of nitric oxide synthase and vasoactive intestinal peptide immunoreactivity in neurons of the major pelvic ganglion projecting to the rat rectum and penis. Cell Tissue Res., 278: 273, 1994.
52. Kim, Y. C., Choi, H. K., Ahn, Y. S., Kim, K. H., Hagen, P. O. and Carson, C. C.: The effect of vasoactive intestinal polypeptide (VIP) on rabbit cavernosal smooth muscle contractility. J. Androl., 15: 392, 1994.
53. Garban, H., Vernet, D., Freedman, A., Rajfer, J. and Gonzalez-Cadavid, N. F.: Effect of aging on nitric oxide-mediated penile erection in rats. Amer. J. Physiol., 268: H467, 1995.
54. Carrier, S., Hricak, H., Lee, S., Baba, K., Morgan, D. M., Nunes, L., Ross, G. Y., Phillips, T. L. and Lue, T. F.: Radiation-induced decrease in nitric oxide synthase-containing nerves in the rat penis. Radiology, 195: 95, 1995.
55. Carrier, S., Zvara, P., Nunes, L., Kour, N. W., Rehman, J. and Lue, T. F.: Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J. Urol., 153: 1722, 1995.
56. Meyer, M. F., Taher, A., Krah, H., Staubesand, J., Becker, A. J., Kirchner, M., Mayer, B., Jonas, U., Forssman, W. G. and Stief, C. G.: Intracavernous application of SIN-1 in rabbit and man: functional and toxicological results. Ann. Urol., 27: 179, 1993.
57. Truss, M. C., Becker, A. J., Djamilian, M. H., Stief, C. G. and Jonas, U.: Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction. Urology, 44: 553, 1994.
58. Mersdorf, A., Goldsmith, P. C., Diederichs, W., Padula, C. A., Lue, T. F., Fishman, I. J. and Tanagho, E. A.: Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J. Urol., 145: 749, 1991.
59. Lowenstein, C. J., Dinerman, J. L. and Snyder, S. H.: Nitric oxide: a physiologic messenger. Ann. Intern. Med., 120: 227, 1994.